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Article ; Online: Late Infectious Complication Following Skull Base Reconstruction With Bone Cement: Two Case Reports.

Biello, Andrew R / Lim, Jae H

OTO open

2021 Volume 5, Issue 1, Page(s) 2473974X21994748

Language	English
Publishing date	2021-02-16
Publishing country	United States
Document type	Case Reports
ISSN	2473-974X
ISSN (online)	2473-974X
DOI	10.1177/2473974X21994748
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Article ; Online: Sleep quality and paranoia: The role of alexithymia, negative emotions and perceptual anomalies.

Rehman, Aliyah / Gumley, Andrew / Biello, Stephany

Psychiatry research

2017 Volume 259, Page(s) 216–222

Abstract: Recent evidence suggests that sleep problems are associated with psychotic like experiences including paranoia. However, the mechanisms underpinning this association are not well understood and thus studies modelling hypothesised mediating factors are ... ...

Abstract	Recent evidence suggests that sleep problems are associated with psychotic like experiences including paranoia. However, the mechanisms underpinning this association are not well understood and thus studies modelling hypothesised mediating factors are required. Alexithymia, the inability to recognise and describe emotions within the self may be an important candidate. In two separate studies we sought to investigate factors mediating the relationship between sleep quality and paranoia using a cross-sectional design. Healthy volunteers without a mental health diagnosis were recruited (study 1, N = 401, study 2, N = 402). Participants completed a series of measures assessing paranoia, negative emotions, alexithymia and perceptual anomalies in an online survey. In study 1, regression and mediation analyses showed that the relationship between sleep quality and paranoia was partially mediated by alexithymia, perceptual anomalies and negative affect. In contrast, study 2 found that the relationship between sleep quality and paranoia was fully mediated by negative affect, alexithymia and perceptual anomalies. The link between sleep quality and paranoia is unclear and reasons for discrepant results are discussed. Novel findings in this study include the link between alexithymia and paranoia.
MeSH term(s)	Adolescent ; Adult ; Affective Symptoms/psychology ; Aged ; Cross-Sectional Studies ; Emotions ; Female ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Paranoid Disorders/physiopathology ; Paranoid Disorders/psychology ; Perceptual Disorders/physiopathology ; Perceptual Disorders/psychology ; Regression Analysis ; Sleep ; Sleep Wake Disorders/psychology ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2017-09-28
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2017.09.066
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Zs.A 1541: Show issues

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Article ; Online: Implementing a Protocol to Reduce Opioid Prescriptions in Military Otolaryngology: A Quality Improvement Initiative.

Neighbors, CindyLee P / Noller, Michael W / Avillion, Michael P / Neighbors, John W / Spaw, Mark C / Biello, Andrew R / Theler, Jared M / Camacho, Macario

Military medicine

2021 Volume 187, Issue 1-2, Page(s) e154–e159

Abstract: Introduction: To compare pain medication refill rates for adult septoplasty and rhinoplasty patients before and after initiating a multimodal analgesic protocol for reducing opioid prescriptions (PROP).: Materials and methods: Data from 58 adult ... ...

Abstract	Introduction: To compare pain medication refill rates for adult septoplasty and rhinoplasty patients before and after initiating a multimodal analgesic protocol for reducing opioid prescriptions (PROP). Materials and methods: Data from 58 adult patients were retrieved by retrospective chart review (19 septoplasties and 10 rhinoplasties before initiating PROP in September 2018 and 21 septoplasties and 8 rhinoplasties after PROP). We selected consecutive septoplasties and rhinoplasties, at which time a new discharge order set was implemented. The new order set consisted of 10 oxycodone tabs (5 mg), 100 acetaminophen tabs (325 mg), and 28 celecoxib tabs (200 mg). The primary outcome variable was the number of initial opioid prescriptions and refills filled by any provider. Results: Among the septoplasties, there was a 46% decrease in total morphine milligram equivalent (MME) prescribed, from a mean of 202.0 mg in the non-PROP group (95% CI, 235.4, 174.6) to 108.6 mg in the PROP group (95% CI, 135.8, 81.4), with no difference in refill rates. Among the rhinoplasties, there was a 51% decrease in total MME prescribed, from a mean of 258.8 mg in the non-PROP group (95% CI, 333.4, 184.1) to 126.6 mg in the PROP group (95% CI, 168.1, 85.0) with no difference in refill rates. Conclusions: The outcomes after PROP implementation for septoplasty and rhinoplasty at our institution suggest that opioid prescription rates can be significantly decreased to manage postoperative pain, with no difference in opioid refill rates. The results also warrant further investigation into patient pain, satisfaction, provider efficiency, and healthcare costs.
MeSH term(s)	Adult ; Analgesics, Opioid/therapeutic use ; Drug Prescriptions ; Humans ; Military Personnel ; Otolaryngology ; Pain, Postoperative/drug therapy ; Practice Patterns, Physicians' ; Quality Improvement ; Retrospective Studies
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2021-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usaa484
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Article ; Online: Duodenal Adenocarcinoma at the Ligament of Treitz: Management and Outcome.

Biello, Andrew R / Lin-Hurtubise, Kevin M / Condon, Freeman J / Allen, Evan J

Hawai'i journal of health & social welfare

2019 Volume 78, Issue 10, Page(s) 316–319

Abstract: Primary small bowel neoplasms at the ligament of Treitz are extremely rare and require advanced surgical technique for extirpation. The insidious onset of disease allows for a delayed presentation, often accompanied by moderate-size growth of the ... ...

Abstract	Primary small bowel neoplasms at the ligament of Treitz are extremely rare and require advanced surgical technique for extirpation. The insidious onset of disease allows for a delayed presentation, often accompanied by moderate-size growth of the neoplasm, causing intestinal bleeding and bowel obstruction. The partial retroperitoneal location of these tumors pose a unique challenge for surgical resection. We present an unusual case of a primary small bowel adenocarcinoma at the Ligament of Treitz, requiring segmental resection of the fourth portion of the duodenum plus the proximal jejunum.
MeSH term(s)	Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Anastomosis, Surgical/methods ; Duodenal Neoplasms/diagnostic imaging ; Duodenal Neoplasms/pathology ; Duodenal Neoplasms/surgery ; Humans ; Jejunal Neoplasms/diagnostic imaging ; Jejunal Neoplasms/pathology ; Jejunal Neoplasms/surgery ; Male ; Middle Aged ; Tomography, X-Ray Computed ; Treatment Outcome
Language	English
Publishing date	2019-07-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2983566-5
ISSN	2641-5224 ; 2641-5216
ISSN (online)	2641-5224
ISSN	2641-5216
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Article: Clinician perceptions of sleep problems, and their treatment, in patients with non-affective psychosis.

Rehman, Aliyah / Waite, Felicity / Sheaves, Bryony / Biello, Stephany / Freeman, Daniel / Gumley, Andrew

Psychosis

2016 Volume 9, Issue 2, Page(s) 129–139

Abstract: Aims and method: ...

Abstract	Aims and method:
Language	English
Publishing date	2016-07-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2478582-9
ISSN	1752-2447 ; 1752-2439
ISSN (online)	1752-2447
ISSN	1752-2439
DOI	10.1080/17522439.2016.1206955
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Article ; Online: Unilateral vs Bilateral Supraglottoplasty: A Meta-analysis of Rates of Return to Surgery and Supraglottic Stenosis.

Avillion, Michael P / Neighbors, Cindy Lee P / Biello, Andrew / Anderson, Lauren C / Liming, Bryan J / Camacho, Macario

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2019 Volume 161, Issue 5, Page(s) 742–753

Abstract: Objective: To perform a systematic review with meta-analysis of data to determine the rates of repeat surgery and supraglottic stenosis in unilateral versus bilateral supraglottoplasty for laryngomalacia.: Data sources: PubMed/Medline, Cochrane ... ...

Abstract	Objective: To perform a systematic review with meta-analysis of data to determine the rates of repeat surgery and supraglottic stenosis in unilateral versus bilateral supraglottoplasty for laryngomalacia. Data sources: PubMed/Medline, Cochrane Central, Scopus, Google Scholar, Web of Science, and Embase. Review methods: Databases were searched through January 30, 2018. Studies with unilateral or bilateral supraglottoplasty techniques for laryngomalacia were included. The need for repeat (revision or completion) surgery and rates of supraglottic stenosis were primary outcomes. Data were substratified and a meta-analysis performed. Results: A total of 251 articles were reviewed, and 20 articles met inclusion criteria (1186 patients: 663 bilateral, 523 unilateral). Regarding the need to return to surgery, the rate of revision for bilateral surgery was 4.1%, compared to the revision and combined revision/completion rates for unilateral surgery which respectively were 1.1% (odds ratio [OR] 0.27; 95% CI 0.11-0.67; Conclusion: Unilateral supraglottoplasty has a significantly higher rate of repeat surgery, mainly attributed to contralateral surgery, when compared with bilateral supraglottoplasty. There is a small but statistically significant risk of supraglottic stenosis in bilateral procedures. The benefit of a unilateral procedure should be weighed against the cost of subjecting patients to a 4-fold increased risk of repeat surgery.
MeSH term(s)	Glottis/surgery ; Humans ; Laryngomalacia/complications ; Laryngomalacia/surgery ; Laryngostenosis/etiology ; Laryngostenosis/surgery ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Reoperation
Language	English
Publishing date	2019-06-11
Publishing country	England
Document type	Comparative Study ; Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1177/0194599819847644
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Article: A multiscale model for tropical intraseasonal oscillations.

Majda, Andrew J / Biello, Joseph A

Proceedings of the National Academy of Sciences of the United States of America

2004 Volume 101, Issue 14, Page(s) 4736–4741

Abstract: The tropical intraseasonal 40- to 50-day oscillation (TIO) is the dominant component of variability in the tropical atmosphere with remarkable planetary-scale circulation generated as envelopes of complex multiscale processes. A new multiscale model is ... ...

Abstract	The tropical intraseasonal 40- to 50-day oscillation (TIO) is the dominant component of variability in the tropical atmosphere with remarkable planetary-scale circulation generated as envelopes of complex multiscale processes. A new multiscale model is developed here that clearly demonstrates the fashion in which planetary-scale circulations sharing many features in common with the observational record for the TIO are generated on intraseasonal time scales through the upscale transfer of kinetic and thermal energy generated by wave trains of organized synoptic-scale circulations having features in common with observed superclusters. The appeal of the multiscale models developed below is their firm mathematical underpinnings, simplicity, and analytic tractability while remaining self-consistent with key features of the observational record. The results below demonstrate, in a transparent fashion, the central role of organized vertically tilted synoptic-scale circulations in generating a planetary circulation resembling the TIO.
Language	English
Publishing date	2004-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.0401034101
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Article ; Online: Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability.

Ferguson, Amy / Lyall, Laura M / Ward, Joey / Strawbridge, Rona J / Cullen, Breda / Graham, Nicholas / Niedzwiedz, Claire L / Johnston, Keira J A / MacKay, Daniel / Biello, Stephany M / Pell, Jill P / Cavanagh, Jonathan / McIntosh, Andrew M / Doherty, Aiden / Bailey, Mark E S / Lyall, Donald M / Wyse, Cathy A / Smith, Daniel J

EBioMedicine

2018 Volume 35, Page(s) 279–287

Abstract: Background: Circadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder.: Methods: We ... ...

Abstract	Background: Circadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder. Methods: We conducted a genome-wide association study (GWAS) of low relative amplitude (RA), an objective measure of rest-activity cycles derived from the accelerometer data of 71,500 UK Biobank participants. Polygenic risk scores (PRS) for low RA were used to investigate potential associations with psychiatric phenotypes. Outcomes: Two independent genetic loci were associated with low RA, within genomic regions for Neurofascin (NFASC) and Solute Carrier Family 25 Member 17 (SLC25A17). A secondary GWAS of RA as a continuous measure identified a locus within Meis Homeobox 1 (MEIS1). There were no significant genetic correlations between low RA and any of the psychiatric phenotypes assessed. However, PRS for low RA was significantly associated with mood instability across multiple PRS thresholds (at PRS threshold 0·05: OR = 1·02, 95% CI = 1·01-1·02, p = 9·6 × 10 Interpretation: Overall, our findings contribute new knowledge on the complex genetic architecture of circadian rhythmicity and suggest a putative biological link between disrupted circadian function and mood disorder phenotypes, particularly mood instability, but also major depressive disorder and neuroticism. Funding: Medical Research Council (MR/K501335/1).
MeSH term(s)	Adult ; Aged ; Biological Specimen Banks ; Circadian Rhythm/genetics ; Genome-Wide Association Study ; Humans ; Mental Disorders/genetics ; Middle Aged ; Mood Disorders/genetics ; Multifactorial Inheritance/genetics ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/genetics
Language	English
Publishing date	2018-08-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2018.08.004
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Article ; Online: Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood InstabilityResearch in context

Amy Ferguson / Laura M. Lyall / Joey Ward / Rona J. Strawbridge / Breda Cullen / Nicholas Graham / Claire L. Niedzwiedz / Keira J.A. Johnston / Daniel MacKay / Stephany M. Biello / Jill P. Pell / Jonathan Cavanagh / Andrew M. McIntosh / Aiden Doherty / Mark E.S. Bailey / Donald M. Lyall / Cathy A. Wyse / Daniel J. Smith

EBioMedicine, Vol 35, Iss , Pp 279-

2018 Volume 287

Abstract	Background: Circadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder. Methods: We conducted a genome-wide association study (GWAS) of low relative amplitude (RA), an objective measure of rest-activity cycles derived from the accelerometer data of 71,500 UK Biobank participants. Polygenic risk scores (PRS) for low RA were used to investigate potential associations with psychiatric phenotypes. Outcomes: Two independent genetic loci were associated with low RA, within genomic regions for Neurofascin (NFASC) and Solute Carrier Family 25 Member 17 (SLC25A17). A secondary GWAS of RA as a continuous measure identified a locus within Meis Homeobox 1 (MEIS1). There were no significant genetic correlations between low RA and any of the psychiatric phenotypes assessed. However, PRS for low RA was significantly associated with mood instability across multiple PRS thresholds (at PRS threshold 0·05: OR = 1·02, 95% CI = 1·01–1·02, p = 9·6 × 10−5), and with major depressive disorder (at PRS threshold 0·1: OR = 1·03, 95% CI = 1·01–1·05, p = 0·025) and neuroticism (at PRS threshold 0·5: Beta = 0·02, 95% CI = 0·007–0·04, p = 0·021). Interpretation: Overall, our findings contribute new knowledge on the complex genetic architecture of circadian rhythmicity and suggest a putative biological link between disrupted circadian function and mood disorder phenotypes, particularly mood instability, but also major depressive disorder and neuroticism. Funding: Medical Research Council (MR/K501335/1). Keywords: Circadian rhythmicity, Mood instability, Relative amplitude, Gwas, Polygenic risk score
Keywords	Medicine ; R ; Medicine (General) ; R5-920
Subject code	150
Language	English
Publishing date	2018-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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