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  1. Article ; Online: Molecularly Defined Thoracic Neoplasms.

    Roden, Anja C

    Advances in anatomic pathology

    2024  

    Abstract: Molecularly defined neoplasms are increasingly recognized, given the broader application and performance of molecular studies. These studies allow us to better characterize these neoplasms and learn about their pathogenesis. In the thorax, molecularly ... ...

    Abstract Molecularly defined neoplasms are increasingly recognized, given the broader application and performance of molecular studies. These studies allow us to better characterize these neoplasms and learn about their pathogenesis. In the thorax, molecularly defined neoplasms include tumors such as NUT carcinoma, SMARCA4-deficient undifferentiated tumor (DUT), primary pulmonary myxoid sarcoma with EWSR1::CREB1 fusion, hyalinizing clear cell carcinoma, and SMARCB1-deficient neoplasms. Overall, these tumors are rare but are now more often recognized given more widely available immunostains such as NUT (NUT carcinoma), BRG1 (SMARCA4-DUT), and INI-1 (SMARCB1-deficient neoplasm). Furthermore, cytogenetic studies for EWSR1 to support a hyalinizing clear cell carcinoma or primary pulmonary myxoid sarcoma are, in general, easily accessible. This enables pathologists to recognize and diagnose these tumors. The diagnosis of these tumors is important for clinical management and treatment. For instance, clinical trials are available for patients with NUT carcinoma, SMARCA4-DUT, and SMACRB1-deficient neoplasms. Herein, our current knowledge of clinical, morphologic, immunophenotypic, and molecular features of NUT carcinomas, SMARCA4-DUT, primary pulmonary myxoid sarcomas, hyalinizing clear cell carcinoma, and SMARCB1-deficient neoplasms will be reviewed.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212493-x
    ISSN 1533-4031 ; 1072-4109
    ISSN (online) 1533-4031
    ISSN 1072-4109
    DOI 10.1097/PAP.0000000000000439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4118: Show issues Location:
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  2. Article: The Role of Gene Fusions in Thymic Epithelial Tumors.

    Roden, Anja C

    Cancers

    2023  Volume 15, Issue 23

    Abstract: Thymic epithelial tumors (TET) are rare and large molecular studies are therefore difficult to perform. However, institutional case series and rare multi-institutional studies have identified a number of interesting molecular aberrations in TET, ... ...

    Abstract Thymic epithelial tumors (TET) are rare and large molecular studies are therefore difficult to perform. However, institutional case series and rare multi-institutional studies have identified a number of interesting molecular aberrations in TET, including gene fusions in a subset of these tumors. These gene fusions can aid in the diagnosis, shed light on the pathogenesis of a subset of tumors, and potentially may provide patients with the opportunity to undergo targeted therapy or participation in clinical trials. Gene fusions that have been identified in TET include
    Language English
    Publishing date 2023-11-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15235596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Thoracic SMARCA4-deficient undifferentiated tumor-a case of an aggressive neoplasm-case report.

    Roden, Anja C

    Mediastinum (Hong Kong, China)

    2021  Volume 5, Page(s) 39

    Abstract: Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UT) are aggressive neoplasms that most commonly occur in the mediastinum of male smokers. These tumors are characterized by an inactivating mutation ... ...

    Abstract Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UT) are aggressive neoplasms that most commonly occur in the mediastinum of male smokers. These tumors are characterized by an inactivating mutation of
    Language English
    Publishing date 2021-12-25
    Publishing country China
    Document type Case Reports
    ISSN 2522-6711
    ISSN (online) 2522-6711
    DOI 10.21037/med-20-15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Plasma Biomarkers to Monitor Bronchopulmonary Carcinoids-Are We There Yet?

    Roden, Anja C / Molina, Julian R

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2023  Volume 18, Issue 3, Page(s) 257–259

    MeSH term(s) Humans ; Lung Neoplasms ; Carcinoid Tumor/diagnosis ; Biomarkers ; Bronchi ; Biomarkers, Tumor
    Chemical Substances Biomarkers ; Biomarkers, Tumor
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2022.12.008
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  5. Article: Recent updates in salivary gland tumors of the lung.

    Roden, Anja C

    Seminars in diagnostic pathology

    2021  Volume 38, Issue 5, Page(s) 98–108

    Abstract: Salivary gland tumors are uncommon primary lesions in the lung. Their morphologic, immunophenotypic, and molecular characteristics resemble those of their counterparts in the head and neck or elsewhere. Most common primary pulmonary salivary gland tumors ...

    Abstract Salivary gland tumors are uncommon primary lesions in the lung. Their morphologic, immunophenotypic, and molecular characteristics resemble those of their counterparts in the head and neck or elsewhere. Most common primary pulmonary salivary gland tumors include mucoepidermoid carcinoma, adenoid cystic carcinoma, and epithelial-myoepithelial carcinoma. The study of these neoplasms is hampered by their paucity. Therefore, studies are in general small or restricted to individual cases. Despite this challenge recent advances have been made specifically at the molecular level. Molecular alterations such as MAML2 rearrangements in mucoepidermoid carcinoma, MYB rearrangements in adenoid cystic carcinomas, and EWSR1 rearrangements in hyalinizing clear cell carcinomas and myoepithelial tumors have been identified. These molecular alterations might be helpful in the distinction of these salivary gland tumors from other neoplasms in the lung. However, the distinction from metastatic disease remains challenging. Awareness of these tumors and knowledge of available ancillary studies to confirm the diagnosis is important to avoid misdiagnosis which might lead to differences in treatment, management, and prognosis. Further studies are needed to identify biomarkers to better predict patient's outcome and for individual management and treatment of patients.
    MeSH term(s) Biomarkers, Tumor/genetics ; Carcinoma, Adenoid Cystic/genetics ; Carcinoma, Mucoepidermoid/genetics ; Humans ; Lung ; Salivary Gland Neoplasms/diagnosis ; Salivary Gland Neoplasms/genetics
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605834-6
    ISSN 1930-1111 ; 0740-2570
    ISSN (online) 1930-1111
    ISSN 0740-2570
    DOI 10.1053/j.semdp.2021.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1988: Show issues Location:
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  6. Article ; Online: Histopathological features of giant mediastinal tumors-a literature review.

    Brcic, Luka / Roden, Anja C

    Mediastinum (Hong Kong, China)

    2023  Volume 7, Page(s) 37

    Abstract: Background and objective: Mediastinal lesions are uncommon. However, because of the vital structures in the mediastinum, large lesions specifically can lead to life-threatening situations. Treatment and management vary considerably with the disease. ... ...

    Abstract Background and objective: Mediastinal lesions are uncommon. However, because of the vital structures in the mediastinum, large lesions specifically can lead to life-threatening situations. Treatment and management vary considerably with the disease. Therefore, the correct histopathologic diagnosis is important. Here we review lesions that have the potential to present as a giant lesion in the mediastinum. While we focus on the review of histopathologic, immunohistochemical (IHC), and molecular features of these lesions, clinical symptoms and characteristics and prognosis will also be discussed.
    Methods: "Giant" was arbitrarily defined as a size of at least 10 cm in greatest dimension. The 2021 World Health Organization (WHO) classification of mediastinal tumors was searched for tumors reported to be larger than 10 cm. Tumors that can present as giant mediastinal lesions based on our own experience were also included. PubMed search was then performed for these lesions.
    Key content and findings: A great variety of mediastinal lesions can present as giant mass. Those include for instance tumors of blood and lymph vessels, tumors of neurogenic origin, mesenchymal neoplasms, thymic epithelial tumors (TETs), and non-neoplastic cysts. Lesions range from benign to malignant. This review focuses on the most common lesions.
    Conclusions: Many benign and malignant lesions can become a large mass in the mediastinum. Their correct diagnosis is important for the treatment and management of the patient.
    Language English
    Publishing date 2023-10-20
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2522-6711
    ISSN (online) 2522-6711
    DOI 10.21037/med-23-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Recent developments in the pathology of primary pulmonary salivary gland-type tumours.

    Naso, Julia R / Roden, Anja C

    Histopathology

    2023  Volume 84, Issue 1, Page(s) 102–123

    Abstract: Primary pulmonary salivary gland-type tumours are rare neoplasms that are thought to arise from seromucinous glands that are located in the submucosa of large airways. These neoplasms have clinical and pathologic features that are distinct from other ... ...

    Abstract Primary pulmonary salivary gland-type tumours are rare neoplasms that are thought to arise from seromucinous glands that are located in the submucosa of large airways. These neoplasms have clinical and pathologic features that are distinct from other pulmonary neoplasms. The majority of primary pulmonary salivary gland-type tumours are malignant, with the most common entities being mucoepidermoid carcinoma, adenoid cystic carcinoma, and epithelial-myoepithelial carcinoma. Less commonly seen are myoepithelial carcinoma, hyalinizing clear cell carcinoma, acinic cell carcinoma, secretory carcinoma, salivary duct carcinoma, intraductal carcinoma, and polymorphous adenocarcinoma. Benign salivary gland-type tumours of the lung include pleomorphic adenoma and sialadenoma papilliferum. Morphologic, immunophenotypic, and molecular features of these neoplasms are largely similar to salivary gland tumours elsewhere, and therefore the exclusion of metastatic disease requires clinical and radiologic correlation. However, the differential diagnostic considerations are different in the lung. The distinction of salivary gland-type tumours from their histologic mimics is important for both prognostication and treatment decisions. Overall, salivary gland type-tumours tend to have a more favourable outcome than other pulmonary carcinomas, although high-grade variants exist for many of these tumour types. Recent advances in our understanding of the spectrum of salivary gland-type tumours reported in the lung and their diversity of molecular and immunohistochemical features have helped to refine the classification of these tumours and have highlighted a few differences between salivary gland-type tumours of the lung and those primary to other sites.
    MeSH term(s) Humans ; Salivary Gland Neoplasms/pathology ; Carcinoma, Adenoid Cystic/pathology ; Adenoma, Pleomorphic/pathology ; Carcinoma/pathology ; Carcinoma, Mucoepidermoid/diagnosis ; Carcinoma, Mucoepidermoid/pathology ; Carcinoma, Acinar Cell/pathology ; Salivary Glands/pathology ; Lung/pathology ; Lung Neoplasms/pathology ; Biomarkers, Tumor/metabolism
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.15039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1328: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: Personalized treatment of malignant mesothelioma-dream or reality?

    Roden, Anja C

    Journal of thoracic disease

    2018  Volume 10, Issue Suppl 18, Page(s) S2153–S2156

    Language English
    Publishing date 2018-08-13
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.06.67
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  9. Article ; Online: Exciting Advances in the Pathogenesis of Neoplastic and Nonneoplastic Lung Diseases, Their Diagnosis, Prognosis, and Treatment.

    Roden, Anja C

    Archives of pathology & laboratory medicine

    2018  Volume 142, Issue 8, Page(s) 891–892

    MeSH term(s) Congresses as Topic ; Humans ; Lung Diseases/diagnosis ; Lung Diseases/pathology ; Lung Diseases/therapy ; Prognosis
    Language English
    Publishing date 2018-07-24
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2018-0222-ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.36: Show issues Location:
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  10. Article ; Online: Common and rare carcinomas of the thymus.

    Roden, Anja C / Szolkowska, Malgorzata

    Virchows Archiv : an international journal of pathology

    2021  Volume 478, Issue 1, Page(s) 111–128

    Abstract: Thymic carcinoma encompasses a diverse group of rare tumors that occur almost exclusively in the prevascular (anterior) mediastinum. Thymic carcinomas have a worse outcome than thymomas with a median time to death of under 3 years. These tumors lack the ... ...

    Abstract Thymic carcinoma encompasses a diverse group of rare tumors that occur almost exclusively in the prevascular (anterior) mediastinum. Thymic carcinomas have a worse outcome than thymomas with a median time to death of under 3 years. These tumors lack the typical lobulation of thymomas, exhibit commonly more cytologic atypia, are associated with a desmoplastic stromal reaction, and lack thymocytes, features that distinguish them from thymomas. The most common thymic carcinoma is squamous cell carcinoma; other subtypes include mucoepidermoid carcinoma, NUT carcinoma, and adenocarcinoma, among others. Largely due to multi-institutional and global efforts and meta-analysis of case reports and series, some of the thymic carcinoma subtypes have been studied in more detail and molecular studies have also been performed. Morphology and immunophenotype for the vast majority of thymic carcinoma subtypes are similar to their counterparts in other organs. Therefore, the distinction between thymic carcinoma and metastatic disease, which is relatively common in the prevascular mediastinum, can be challenging and in general requires clinical and radiologic correlation. Although surgical resection is the treatment of choice, only 46 to 68% of patients with thymic carcinoma can undergo resection as many other tumors present at high stage with infiltration into vital neighboring organs. These patients are usually treated with chemotherapy and/or radiation. The search for better biomarkers for prognosis and treatment of thymic carcinomas is important for improved management of these patients and possible targeted therapy.
    MeSH term(s) Adenocarcinoma/diagnosis ; Adenocarcinoma/pathology ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Humans ; Prognosis ; Thymoma/diagnosis ; Thymoma/pathology ; Thymus Neoplasms/diagnosis ; Thymus Neoplasms/pathology
    Language English
    Publishing date 2021-01-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-020-03000-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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