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  1. Article ; Online: Comment on Fierro et al. Severe Hypotension, Bradycardia and Asystole after Sugammadex Administration in an Elderly Patient.

    Sagliocco, Orlando / Betelli, Mauro

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 1

    Abstract: We read with great interest the case report by Fierro et al. [ ... ]. ...

    Abstract We read with great interest the case report by Fierro et al. [...].
    MeSH term(s) Aged ; Bradycardia/chemically induced ; Heart Arrest/chemically induced ; Humans ; Hypotension/chemically induced ; Sugammadex/adverse effects
    Chemical Substances Sugammadex (361LPM2T56)
    Language English
    Publishing date 2022-01-14
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58010122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comment on Fierro et al. Severe Hypotension, Bradycardia and Asystole after Sugammadex Administration in an Elderly Patient. Medicina 2021, 57 , 79

    Orlando Sagliocco / Mauro Betelli

    Medicina, Vol 58, Iss 122, p

    2022  Volume 122

    Abstract: We read with great interest the case report by Fierro et al. [.] ...

    Abstract We read with great interest the case report by Fierro et al. [.]
    Keywords n/a ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Late Worsening of COVID-19 Pneumonia: Successful Treatment with Ruxolitinib and Steroid.

    Betelli, Mauro / De Stefano, Fabio / Tedeschi, Alberto

    European journal of case reports in internal medicine

    2020  Volume 7, Issue 11, Page(s) 1938

    Abstract: We describe the case of a patient hospitalized for the second time in a month due to delayed worsening of lung lesions in COVID-19 infection without bacterial superinfection. He was treated with hydroxychloroquine, IV dexamethasone and ruxolitinib with ... ...

    Abstract We describe the case of a patient hospitalized for the second time in a month due to delayed worsening of lung lesions in COVID-19 infection without bacterial superinfection. He was treated with hydroxychloroquine, IV dexamethasone and ruxolitinib with rapid improvement of respiratory failure; 1 month after the second discharge, maintaining low-dose oral prednisone, lung consolidations were significantly reduced on control CT.
    Learning points: Modulation of immune over-response in late phases of COVID-19 can influence global outcome.Ruxolitinib and IV steroids can reverse the inflammatory process and lung lesions.
    Keywords covid19
    Language English
    Publishing date 2020-10-14
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2020_001938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Late Worsening of COVID-19 Pneumonia

    Mauro Betelli / Fabio De Stefano / Alberto Tedeschi

    European Journal of Case Reports in Internal Medicine (2020)

    Successful Treatment with Ruxolitinib and Steroid

    2020  

    Abstract: We describe the case of a patient hospitalized for the second time in a month due to delayed worsening of lung lesions in COVID-19 infection without bacterial superinfection. He was treated with hydroxychloroquine, IV dexamethasone and ruxolitinib with ... ...

    Abstract We describe the case of a patient hospitalized for the second time in a month due to delayed worsening of lung lesions in COVID-19 infection without bacterial superinfection. He was treated with hydroxychloroquine, IV dexamethasone and ruxolitinib with rapid improvement of respiratory failure; 1 month after the second discharge, maintaining low-dose oral prednisone, lung consolidations were significantly reduced on control CT.
    Keywords covid-19 ; ruxolitinib ; janus kinase inhibitors ; Medicine ; R ; covid19
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Pregnancy in systemic sclerosis.

    Betelli, Mauro / Breda, Silvia / Ramoni, Veronique / Parisi, Federico / Rampello, Stefania / Limonta, Massimiliano / Meroni, Marianna / Brucato, Antonio

    Journal of scleroderma and related disorders

    2018  Volume 3, Issue 1, Page(s) 21–29

    Abstract: This comprehensive review summarizes retrospective and prospective studies on pregnancy in systemic sclerosis in order to educate physicians on critical management issues. Fertility is normal in women with established systemic sclerosis. Their rates of ... ...

    Abstract This comprehensive review summarizes retrospective and prospective studies on pregnancy in systemic sclerosis in order to educate physicians on critical management issues. Fertility is normal in women with established systemic sclerosis. Their rates of spontaneous losses are comparable to the general population, except for patients with late diffuse systemic sclerosis and severe internal organ involvement who may have higher risks of abortion. Prematurity is clearly higher among systemic sclerosis women, similarly to other rheumatic diseases such as systemic lupus erythematosus and anti-phospholipid antibody syndrome. A placental vasculopathy has been observed in some women with systemic sclerosis. Overall, the disease generally remains stable in most pregnancies. Women with pulmonary hypertension should avoid pregnancy on account of the high maternal mortality risk. Management of systemic sclerosis patients before and during pregnancy includes evaluation of organ involvement and autoantibody analysis, preconceptional folic acid, and discontinuation of drugs with teratogenic potential (bosentan, mycophenolate mofetil, methotrexate, etc.). Management by high-risk pregnancy teams including neonatologists is very important to ensure the best outcomes.
    Language English
    Publishing date 2018-04-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2397-1991
    ISSN (online) 2397-1991
    DOI 10.1177/2397198317747440
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  6. Article ; Online: A case of Pseudomonas Aeruginosa commercial tattoo infection.

    Maloberti, Alessandro / Betelli, Mauro / Perego, Maria R / Foresti, Sergio / Scarabelli, Gabriele / Grassi, Guido

    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia

    2015  Volume 153, Issue 2, Page(s) 301–302

    MeSH term(s) Adult ; Female ; Humans ; Pseudomonas Infections/diagnosis ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/isolation & purification ; Tattooing/adverse effects
    Language English
    Publishing date 2015-11-18
    Publishing country Italy
    Document type Case Reports ; Letter
    ZDB-ID 604114-0
    ISSN 1827-1820 ; 0026-4741 ; 0392-0488
    ISSN (online) 1827-1820
    ISSN 0026-4741 ; 0392-0488
    DOI 10.23736/S0392-0488.17.04937-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Brachial and central blood pressure in HIV-infected subjects.

    Maloberti, Alessandro / Dozio, Dario / Betelli, Mauro / Bandera, Alessandra / Squillace, Nicola / Gori, Andrea / Castoldi, Giovanna / Stella, Andrea / Mancia, Giuseppe / Giannattasio, Cristina

    Hypertension research : official journal of the Japanese Society of Hypertension

    2015  Volume 38, Issue 6, Page(s) 405–412

    Abstract: HIV infected subjects present an unfavorable cardiovascular (CV) risk profile that is determined by the infection itself, highly active anti-retroviral therapy (HAART) and other factors, such as chronic kidney disease (CKD). Information is scant and ... ...

    Abstract HIV infected subjects present an unfavorable cardiovascular (CV) risk profile that is determined by the infection itself, highly active anti-retroviral therapy (HAART) and other factors, such as chronic kidney disease (CKD). Information is scant and contradictory on whether these factors are associated with arterial stiffness and blood pressure (BP) alteration. Our study aimed to evaluate those parameters in HIV-positive subjects both with and without HAART and with and without CKD, which was defined as the presence of microalbuminuria with a normal glomerular filtration rate. We enrolled 94 HIV-infected subjects without known CV risk factors and compared them with 37 control subjects. We recorded brachial and central BP (pulse wave analysis) and pulse wave velocity ( SphygmoCor). HIV-positive subjects of similar ages and with similar BP values showed central pulse pressure values that were significantly greater than those of controls; this was also the case for the Aix value. Central systolic and pulse pressure values and Aix were significantly greater in HIV-positive subjects with HAART and CKD than in the other HIV-positive subgroups and control subjects. PWV was also superimposable between groups when the data were analyzed relative to the presence of HAART and CKD. Our study shows that the unfavorable CV risk profile associated with HIV infection includes an increase in both central BP and Aix. The central BP increase seems to be favored by renal damage, which apparently has a role in the early stages of the disease.
    MeSH term(s) Adult ; Blood Flow Velocity/physiology ; Blood Pressure/physiology ; Blood Pressure Determination ; Female ; Glomerular Filtration Rate/physiology ; HIV Infections/complications ; HIV Infections/physiopathology ; Humans ; Kidney/physiopathology ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/physiopathology ; Male ; Middle Aged ; Pulsatile Flow/physiology
    Language English
    Publishing date 2015-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/hr.2015.25
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    Zs.A 3898: Show issues Location:
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  8. Article ; Online: Arterial hypertension and dyslipidemia in a HIV-positive patient treated with antiretroviral therapy

    Alessandro Maloberti / Paolo Villa / Dario Dozio / Francesca Citterio / Giorgia Grosso / Mauro Betelli / Francesca Cesana / Cristina Giannattasio

    Clinical Management Issues, Vol 6, Iss 1, Pp 5-

    2012  Volume 14

    Abstract: The introduction of antiretroviral therapy (ART) has substantially modified the clinical history and epidemiology of HIV infection with an important decline in infective causes of death and an increase in non-infective comorbidities particularly in ... ...

    Abstract The introduction of antiretroviral therapy (ART) has substantially modified the clinical history and epidemiology of HIV infection with an important decline in infective causes of death and an increase in non-infective comorbidities particularly in cardiovascular complications. HIV infection has been related to an increased cardiovascular risk due to the presence of three factors: classic cardiovascular risk factors (shared with the general population), HIV infection itself (indirectly due to the inflammation and directly due to viral molecule) and ART-related chronic metabolic alterations. We describe a peculiar case of metabolic alteration in an HIV infected patient on ART with particular attention to the diagnosis and therapeutic aspects. Giving the higher cardiovascular risk of this specific population it is advisable that the clinician performs a frequent re-assessment of risk factors and cardiovascular organ damage. An early detection of metabolic alteration must lead to an aggressive specific therapy; this must be done by taking care of the HIV-infected subject fragility and the interactions with ART.
    Keywords HIV ; Antiretroviral therapy ; Dyslipidemia ; Arterial hypertension ; Cardiovascular risk ; Medicine (General) ; R5-920
    Language English
    Publishing date 2012-03-01T00:00:00Z
    Publisher SEEd
    Document type Article ; Online
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  9. Article ; Online: Metabolic syndrome in human immunodeficiency virus-positive subjects: prevalence, phenotype, and related alterations in arterial structure and function.

    Maloberti, Alessandro / Giannattasio, Christina / Dozio, Dario / Betelli, Mauro / Villa, Paulo / Nava, Stefano / Cesana, Francesca / Facchetti, Rita / Giupponi, Luca / Castagna, Francesco / Sabbatini, Francesca / Bandera, Alessandra / Gori, Andre / Grassi, Guido / Mancia, Giuseppe

    Metabolic syndrome and related disorders

    2013  Volume 11, Issue 6, Page(s) 403–411

    Abstract: Background: Human immunodeficiency virus (HIV) infection itself and highly active antiretroviral treatment (HAART) have been proposed to be associated with a higher prevalence of metabolic syndrome, but, to date, prevalence and phenotype of metabolic ... ...

    Abstract Background: Human immunodeficiency virus (HIV) infection itself and highly active antiretroviral treatment (HAART) have been proposed to be associated with a higher prevalence of metabolic syndrome, but, to date, prevalence and phenotype of metabolic syndrome among HIV subjects and the related structural and functional vascular alterations are not conclusively defined.
    Methods: We analyzed the data of 108 HIV-infected subjects without known cardiovascular risk factors: 72 were on HAART (group A, age 46.5±7.5 years, clinical blood pressure 125.7/74.9±11.6/7.8 mmHg) and there 36 in a naïve group (group B, age 40.7±7.9 years, blood pressure 126/75.8±9.8/7.7 mmHg). A total of 224 healthy subjects served as controls (group C, age 44.9±6.9 years, blood pressure 123.7/75.7±9.8/7.1 mmHg). Arterial stiffness was measured by aorto-femoral pulse wave velocity (PWV, sfigmocor), and carotid intima media thickness (IMT) was measured by a semiautomatic echotracking system (Esaote-WTS).
    Results: Metabolic syndrome was more frequent in HIV-positive subjects than in controls (19.4%, 13.8%, 4.5% for groups A, B, and C; P<0.001), with no significant difference between HAART and naïve. In metabolic syndrome subjects, group A displayed lipid profile alterations more frequently (91%, 50%, 57% for groups A, B, and C; P<0.05), whereas others metabolic syndrome components were equally represented in the three groups. In metabolic syndrome subjects, IMT was similar [556±108, 542±164, and 564±110.4 μm for groups A, B, and C; P=not significant (NS)], whereas PWV was significantly greater in HAART subjects when compared with controls (10.8±1.8, 9.±1.1, 9.3±1 cm/sec for groups A, B, and C; P=0.02 for A vs. C). Moreover, in this group (metabolic syndrome+HAART), PWV was higher than in subjects on HAART but without metabolic syndrome.
    Conclusions: HIV subjects showed a higher prevalence and a different pattern of metabolic syndrome components. HAART, more than HIV infection per se, appeared to be responsible for the increased prevalence of metabolic syndrome and arterial function derangement.
    MeSH term(s) Adult ; Antiretroviral Therapy, Highly Active ; Arteries/pathology ; Blood Pressure ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Electrocardiography ; Female ; HIV Infections/complications ; Humans ; Male ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/genetics ; Metabolic Syndrome/pathology ; Middle Aged ; Phenotype ; Prevalence ; Risk Factors ; Vascular Stiffness
    Language English
    Publishing date 2013-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2151220-6
    ISSN 1557-8518 ; 1540-4196
    ISSN (online) 1557-8518
    ISSN 1540-4196
    DOI 10.1089/met.2013.0008
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    Zs.A 5950: Show issues Location:
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