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  1. Article: Formation à l’enquête d’entourage durant la pandémie du SARS-CoV-2 - L’exemple du canton de Vaud.

    Reymond, Antoine / Ho, Luc Ka Sing / Gillieron, Stéphane / Ochs, Jonathan / Kokkinakis, Ioannis / Von Plessen, Christian

    Revue medicale suisse

    2021  Volume 17, Issue 759, Page(s) 2010–2013

    Abstract: The rapid evolution of the SARS-CoV-2 epidemic required the implementation of contact tracing at an unprecedented scale in the Swiss cantons. Hundreds of contact tracers with different professions, most without medical background, had to be recruited and ...

    Title translation Teaching contact tracing during the SARS-CoV-2 pandemic : experiences from the Swiss canton of Vaud.
    Abstract The rapid evolution of the SARS-CoV-2 epidemic required the implementation of contact tracing at an unprecedented scale in the Swiss cantons. Hundreds of contact tracers with different professions, most without medical background, had to be recruited and educated for tasks that usually are carried out by small teams of experts in communicable diseases. Teaching materials and courses about contact tracing, especially in French, were scarce. Thus, the learning team at the contact tracing centre of the canton of Vaud supported by clinicians and epidemiologists developed a method to dynamically create and apply a series of teaching modules. We describe this process and its results. The teaching materials are freely available upon contact with the authors.
    MeSH term(s) COVID-19 ; Contact Tracing ; Humans ; Pandemics ; SARS-CoV-2 ; Switzerland/epidemiology
    Language French
    Publishing date 2021-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
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  2. Article ; Online: Interpretable prediction of brain activity during conversations from multimodal behavioral signals.

    Hmamouche, Youssef / Ochs, Magalie / Prévot, Laurent / Chaminade, Thierry

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0284342

    Abstract: We present an analytical framework aimed at predicting the local brain activity in uncontrolled experimental conditions based on multimodal recordings of participants' behavior, and its application to a corpus of participants having conversations with ... ...

    Abstract We present an analytical framework aimed at predicting the local brain activity in uncontrolled experimental conditions based on multimodal recordings of participants' behavior, and its application to a corpus of participants having conversations with another human or a conversational humanoid robot. The framework consists in extracting high-level features from the raw behavioral recordings and applying a dynamic prediction of binarized fMRI-recorded local brain activity using these behavioral features. The objective is to identify behavioral features required for this prediction, and their relative weights, depending on the brain area under investigation and the experimental condition. In order to validate our framework, we use a corpus of uncontrolled conversations of participants with a human or a robotic agent, focusing on brain regions involved in speech processing, and more generally in social interactions. The framework not only predicts local brain activity significantly better than random, it also quantifies the weights of behavioral features required for this prediction, depending on the brain area under investigation and on the nature of the conversational partner. In the left Superior Temporal Sulcus, perceived speech is the most important behavioral feature for predicting brain activity, regardless of the agent, while several features, which differ between the human and robot interlocutors, contribute to the prediction in regions involved in social cognition, such as the TemporoParietal Junction. This framework therefore allows us to study how multiple behavioral signals from different modalities are integrated in individual brain regions during complex social interactions.
    MeSH term(s) Humans ; Communication ; Brain/diagnostic imaging ; Speech ; Magnetic Resonance Imaging ; Temporal Lobe
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0284342
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  3. Article: Optogenetic Modulation of Arrhythmia Triggers: Proof-of-Concept from Computational Modeling.

    Ochs, Alexander R / Boyle, Patrick M

    Cellular and molecular bioengineering

    2023  Volume 16, Issue 4, Page(s) 243–259

    Abstract: ... baseline) and increasing L-type calcium (1.0-3.5 × baseline) currents to create RRR conditions with varying ...

    Abstract Introduction: Early afterdepolarizations (EADs) are secondary voltage depolarizations associated with reduced repolarization reserve (RRR) that can trigger lethal arrhythmias. Relating EADs to triggered activity is difficult to study, so the ability to suppress or provoke EADs would be experimentally useful. Here, we use computational simulations to assess the feasibility of subthreshold optogenetic stimulation modulating the propensity for EADs (cell-scale) and EAD-associated ectopic beats (organ-scale).
    Methods: We modified a ventricular ionic model by reducing rapid delayed rectifier potassium (0.25-0.1 × baseline) and increasing L-type calcium (1.0-3.5 × baseline) currents to create RRR conditions with varying severity. We ran simulations in models of single cardiomyocytes and left ventricles from post-myocardial infarction patient MRI scans. Optogenetic stimulation was simulated using either ChR2 (depolarizing) or GtACR1 (repolarizing) opsins.
    Results: In cell-scale simulations without illumination, EADs were seen for 164 of 416 RRR conditions. Subthreshold stimulation of GtACR1 reduced EAD incidence by up to 84.8% (25/416 RRR conditions; 0.1 μW/mm
    Conclusions: Our findings suggest that optogenetics could be used to silence or provoke both EADs and EAD-associated ectopic beats. Validation in animal models could lead to exciting new experimental regimes and potentially to novel anti-arrhythmia treatments.
    Supplementary information: The online version contains supplementary material available at 10.1007/s12195-023-00781-z.
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2416037-4
    ISSN 1865-5033 ; 1865-5025
    ISSN (online) 1865-5033
    ISSN 1865-5025
    DOI 10.1007/s12195-023-00781-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Frequency-dependent behavior of paretic and non-paretic leg force during standing post stroke.

    Bartloff, Jennifer N / Ochs, Wendy L / Nichols, Kieran M / Gruben, Kreg G

    Journal of biomechanics

    2024  Volume 164, Page(s) 111953

    Abstract: Maintaining upright posture in quiet standing is an important skill that is often disrupted by stroke. Despite extensive study of human standing, current understanding is incomplete regarding the muscle coordination strategies that produce the ground-on- ... ...

    Abstract Maintaining upright posture in quiet standing is an important skill that is often disrupted by stroke. Despite extensive study of human standing, current understanding is incomplete regarding the muscle coordination strategies that produce the ground-on-foot force (F) that regulates translational and rotational accelerations of the body. Even less is understood about how stroke disrupts that coordination. Humans produce sagittal plane variations in the location (center of pressure, xCP) and orientation (Fx/Fz) of F that, along with the force of gravity, produce sagittal plane body motions. As F changes during quiet standing there is a strong correlation between the xCP and Fx/Fz time-varying signals within narrow frequency bands. The slope of the correlation varies systematically with frequency in non-disabled populations, is sensitive to changes in both environmental and neuromuscular control factors, and emerges from the interaction of body mechanics and neural control. This study characterized the xCP versus Fx/Fz relationship as frequency-dependent Intersection Point (IP) heights for the paretic and non-paretic legs of individuals with history of a stroke (n = 12) as well as in both legs of non-disabled controls (n = 22) to reveal distinguishing motor coordination patterns. No inter-leg difference of IP height was present in the control group. The paretic leg IP height was lower than the non-paretic, and differences from control legs were in opposite directions. These results quantify disrupted coordination that may characterize the paretic leg balance deficit and non-paretic leg compensatory behavior, providing a means of monitoring balance impairment and a target for therapeutic interventions.
    MeSH term(s) Humans ; Leg/physiology ; Stroke/complications ; Foot ; Lower Extremity ; Mechanical Phenomena ; Stroke Rehabilitation ; Paresis/etiology
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218076-5
    ISSN 1873-2380 ; 0021-9290
    ISSN (online) 1873-2380
    ISSN 0021-9290
    DOI 10.1016/j.jbiomech.2024.111953
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 700: Show issues Location:
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  5. Article ; Online: Comparing online versus laboratory measures of speech perception in older children and adolescents.

    McAllister, Tara / Preston, Jonathan L / Ochs, Laura / Hill, Jennifer / Hitchcock, Elaine R

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0297530

    Abstract: Given the increasing prevalence of online data collection, it is important to know how behavioral data obtained online compare to samples collected in the laboratory. This study compares online and in-person measurement of speech perception in older ... ...

    Abstract Given the increasing prevalence of online data collection, it is important to know how behavioral data obtained online compare to samples collected in the laboratory. This study compares online and in-person measurement of speech perception in older children and adolescents. Speech perception is important for assessment and treatment planning in speech-language pathology; we focus on the American English /ɹ/ sound because of its frequency as a clinical target. Two speech perception tasks were adapted for web presentation using Gorilla: identification of items along a synthetic continuum from rake to wake, and category goodness judgment of English /ɹ/ sounds in words produced by various talkers with and without speech sound disorder. Fifty typical children aged 9-15 completed these tasks online using a standard headset. These data were compared to a previous sample of 98 typical children aged 9-15 who completed the same tasks in the lab setting. For the identification task, participants exhibited smaller boundary widths (suggestive of more acute perception) in the in-person setting relative to the online setting. For the category goodness judgment task, there was no statistically significant effect of modality. The correlation between scores on the two tasks was significant in the online setting but not in the in-person setting, but the difference in correlation strength was not statistically significant. Overall, our findings agree with previous research in suggesting that online and in-person data collection do not yield identical results, but the two contexts tend to support the same broad conclusions. In addition, these results suggest that online data collection can make it easier for researchers connect with a more representative sample of participants.
    MeSH term(s) Child ; Humans ; Adolescent ; Speech Perception ; Language ; Speech Sound Disorder ; Judgment ; Sound ; Speech
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prophylactic Anticoagulation in Patients with Cancer: When and How?

    Shevell, Lauren / Ochs, Madeleine / Schaefer, Jordan

    Current oncology reports

    2023  Volume 25, Issue 3, Page(s) 201–209

    Abstract: Purpose of review: Cancer-associated thrombosis is a leading cause of death among patients with cancer. Historically, thromboprophylaxis efforts have focused on the highest risk patients with cancer, including post-operative patients and hospitalized ... ...

    Abstract Purpose of review: Cancer-associated thrombosis is a leading cause of death among patients with cancer. Historically, thromboprophylaxis efforts have focused on the highest risk patients with cancer, including post-operative patients and hospitalized patients. This review covers not only thromboprophylaxis for these groups but also emerging data supporting prophylaxis in ambulatory medical oncology patients.
    Recent findings: Several leading guidelines, backed by clinical trial data, now support the use of direct oral anticoagulants for select high-risk outpatients for primary thromboprophylaxis. However, uptake of these findings remains low. Pharmacologic venous thromboembolism prophylaxis strategies continue to improve. However, it remains challenging to balance competing risks of bleeding and thrombosis. The morbidity and mortality associated with cancer associated thrombosis may be preventable. Understanding advancements in risk prediction, anticoagulant options, and implementation of existing data, is critical to provide optimal patient care.
    MeSH term(s) Humans ; Anticoagulants/therapeutic use ; Venous Thromboembolism/drug therapy ; Neoplasms/drug therapy ; Hemorrhage/chemically induced ; Thrombosis/drug therapy
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-01-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057359-5
    ISSN 1534-6269 ; 1523-3790
    ISSN (online) 1534-6269
    ISSN 1523-3790
    DOI 10.1007/s11912-023-01358-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5521: Show issues Location:
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  7. Book ; Thesis: Glutamin-Synthetasen in Brassica napus (L.)

    Ochs, Günther

    Isolation gewebespezifischer Isoformen und molekularboilogische Untersuchung des plastidären Enzyms

    1993  

    Author's details von Günther Ochs
    Language Undetermined
    Size VI, 209 S, Ill., graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @Mainz, Univ., Diss. : 1994
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Thesis: Glutamin-Synthetasen in Brassica napus (L.)

    Ochs, Günther

    Isolation gewebespezifischer Isoformen und molekularboilogische Untersuchung des plastidären Enzyms

    1993  

    Author's details von Günther Ochs
    Keywords Raps ; Isoenzym ; Isolierung ; Glutaminsynthetase
    Language German
    Size 3 Mikrofiches, Ill., graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @Mainz, Univ., Diss. : 1994
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Book ; Thesis: Glutamin-Synthetasen in Brassica napus (L.)

    Ochs, Günther

    Isolation gewebespezifischer Isoformen und molekularbiologische Untersuchung des plastidären Enzyms

    1993  

    Author's details Günther Ochs
    Keywords Raps ; Isoenzym ; Isolierung ; Glutaminsynthetase
    Language Undetermined
    Size VI, 209 Bl, Ill., graph. Darst
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @Mainz, Univ., Diss. : 1994
    Note Mikrofiche-Ausg.: 3 Mikrofiches : 24x
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Commentary: Technoference or parental phubbing? A call for greater conceptual and operational clarity of parental smartphone use around children.

    Frackowiak, Michal / Ochs, Carli / Wolfers, Lara / Vanden Abeele, Mariek

    Journal of child psychology and psychiatry, and allied disciplines

    2023  

    Abstract: Recent years have seen a widespread integration of technology into the daily lives of families. Psychological science has recently started to focus on the use of smartphones by parents while they are engaged in parenting activities, a behavior known ... ...

    Abstract Recent years have seen a widespread integration of technology into the daily lives of families. Psychological science has recently started to focus on the use of smartphones by parents while they are engaged in parenting activities, a behavior known under the terms "phubbing," "technoference," "parental screen distraction," and various other terms. We argue that understanding the real impact of co-present smartphone use by parents is inhibited by problems related to the conceptualization and methodology employed in empirical studies. In the present commentary, we identify the features of current research that may contribute to the theory crisis and hamper the progress of psychological research. Specifically, we discuss the implications of (a) inconsistent conceptualization of the phenomenon and (b) suboptimal operationalizations that may prevent us from understanding what is being studied and call for greater consideration of definitional clarity and valid operationalization in future research.
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 218136-8
    ISSN 1469-7610 ; 0021-9630 ; 0373-8086
    ISSN (online) 1469-7610
    ISSN 0021-9630 ; 0373-8086
    DOI 10.1111/jcpp.13917
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