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  1. Article: Pseudo-AKI associated with targeted anti-cancer agents-the truth is in the eye of the filtration marker.

    Vanhoutte, Thomas / Sprangers, Ben

    Clinical kidney journal

    2023  Volume 16, Issue 4, Page(s) 603–610

    Abstract: Besides true acute kidney injury (AKI), the occurrence of pseudo-AKI has been associated with several targeted agents. To improve the management of cancer patients treated with targeted agents, we need to be aware of this and use diagnostic approaches to ...

    Abstract Besides true acute kidney injury (AKI), the occurrence of pseudo-AKI has been associated with several targeted agents. To improve the management of cancer patients treated with targeted agents, we need to be aware of this and use diagnostic approaches to differentiate between pseudo-AKI and AKI. In an article by Wijtvliet
    Language English
    Publishing date 2023-01-16
    Publishing country England
    Document type Editorial
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfad011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6587: Show issues Location:
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  2. Article: Proton pump inhibitors and adverse kidney outcomes during immune checkpoint blockade: time to sound the alarm?

    Tan, Hui Zhuan / Sprangers, Ben

    Clinical kidney journal

    2023  Volume 16, Issue 11, Page(s) 1709–1713

    Abstract: Immune checkpoint inhibitors (ICIs) have significantly altered the treatment landscape for cancer in the last decade. However, their benefits are often offset by therapy-limiting immune-related adverse events (irAEs). Acute interstitial nephritis (AIN) ... ...

    Abstract Immune checkpoint inhibitors (ICIs) have significantly altered the treatment landscape for cancer in the last decade. However, their benefits are often offset by therapy-limiting immune-related adverse events (irAEs). Acute interstitial nephritis (AIN) is the most common renal irAE, but the exact mechanisms underlying its development are poorly understood. ICI-induced immune activation against drug-derived antigens, leading to an inflammatory response within the kidney interstitium, has been postulated, evidenced by current observations of a higher incidence of ICI-associated AIN in patients receiving AIN-inducing drugs such as proton pump inhibitors (PPIs). The role of PPIs in this specific context has garnered significant attention, given their ubiquitous use and sometimes misuse. In this issue of
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Editorial
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfad205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Testing the functional reserve of the kidney before hematopoietic stem cell transplantation: doubt remains.

    De Moor, Bart / Sprangers, Ben

    Clinical kidney journal

    2023  Volume 16, Issue 6, Page(s) 905–908

    Abstract: Acute kidney injury is a common and important complication following hematopoietic stem cell transplantation. In the nephrology community, acute kidney injury is no longer viewed as a simple temporary and potentially reversible decline in kidney ... ...

    Abstract Acute kidney injury is a common and important complication following hematopoietic stem cell transplantation. In the nephrology community, acute kidney injury is no longer viewed as a simple temporary and potentially reversible decline in kidney clearance as acute kidney injury imposes a risk for immediate and future complications. Therefore, stratifying patients for the risk of acute kidney injury following stem cell transplantation would be very helpful to optimize peri-stem cell transplant management and could potentially improve outcomes in this patient population. In the current issue of
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Editorial
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfad078
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  4. Article ; Online: Aetiology and management of acute kidney injury in multiple myeloma.

    Sprangers, Ben

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2018  Volume 33, Issue 5, Page(s) 722–724

    Language English
    Publishing date 2018-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfy079
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    Zs.MO 329: Show issues

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  5. Article: Pembrolizumab-related renal toxicities: diagnosis first, treatment later.

    Sprangers, Ben

    Clinical kidney journal

    2018  Volume 12, Issue 1, Page(s) 78–80

    Abstract: Checkpoint inhibitors are increasingly used to treat different types of malignancy and have been associated with renal toxicities. In this issue, ... ...

    Abstract Checkpoint inhibitors are increasingly used to treat different types of malignancy and have been associated with renal toxicities. In this issue, Izzedine
    Language English
    Publishing date 2018-12-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfy114
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  6. Article: 'Prevention is better than cure': warning for comedications in patients receiving immune checkpoint inhibitors to avoid acute kidney injury.

    Belliere, Julie / Sprangers, Ben

    Clinical kidney journal

    2022  Volume 15, Issue 10, Page(s) 1803–1806

    Abstract: The introduction of immune checkpoint inhibitors (ICI) has resulted in significant improvement in cancer care, but has been accompanied by the occurrence of immune-related adverse events (irAEs). Also, kidney irAEs have been reported, and the most ... ...

    Abstract The introduction of immune checkpoint inhibitors (ICI) has resulted in significant improvement in cancer care, but has been accompanied by the occurrence of immune-related adverse events (irAEs). Also, kidney irAEs have been reported, and the most frequent one is acute tubulointerstitial disease which impacts renal and overall prognosis. There is an unmet need to stratify renal risk in oncologic patients, to allow individualized monitoring and therefore, early detection of ICI-related acute kidney injury (ICI-AKI). Although risk factors for ICI-AKI have been described in previous case-control studies, where 'cases' were ICI-AKI patients and 'controls' ICI-treated patients without AKI, there is limited epidemiologic knowledge concerning patients developing different irAEs. In this issue of the
    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Editorial
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfac161
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  7. Article ; Online: Cancer Drug Dosing in Chronic Kidney Disease and Dialysis.

    Shirali, Anushree C / Sprangers, Ben

    Advances in chronic kidney disease

    2022  Volume 29, Issue 2, Page(s) 208–216.e1

    Abstract: Patients with malignancies have a high prevalence of kidney disease and are often treated with antineoplastic agents that undergo kidney metabolism or excretion or clearance via renal replacement therapies. Thus, the dosing of these agents, including ... ...

    Abstract Patients with malignancies have a high prevalence of kidney disease and are often treated with antineoplastic agents that undergo kidney metabolism or excretion or clearance via renal replacement therapies. Thus, the dosing of these agents, including classic chemotherapeutic drugs, targeted therapies, and immunotherapy, must take into account patients' kidney function. In this review, we will discuss the pitfalls of accurate measurement of kidney function and how kidney disease affects both pharmacodynamic and pharmacokinetic properties of drugs. Lastly, we will discuss specific agents and summarize current dosing strategies for use in patients with chronic kidney disease and end-stage kidney disease.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Glomerular Filtration Rate ; Humans ; Kidney ; Neoplasms/complications ; Neoplasms/drug therapy ; Renal Dialysis ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/therapy ; Renal Replacement Therapy
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1548-5609 ; 1548-5595
    ISSN (online) 1548-5609
    ISSN 1548-5595
    DOI 10.1053/j.ackd.2021.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4627: Show issues Location:
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  8. Article: Revisiting the role of acute kidney injury in patients on immune checkpoint inhibitors: a good prognosis renal event with a significant impact on survival.

    García-Carro, Clara / Jhaveri, Kenar D / Sprangers, Ben

    Clinical kidney journal

    2023  Volume 16, Issue 5, Page(s) 773–775

    Abstract: In the last decade, immune checkpoint inhibitors (ICI) have become a cornerstone in the treatment of a wide range of malignancies. It is well established that ICI are associated with multiple immune-related adverse events, a spectrum of autoimmune ... ...

    Abstract In the last decade, immune checkpoint inhibitors (ICI) have become a cornerstone in the treatment of a wide range of malignancies. It is well established that ICI are associated with multiple immune-related adverse events, a spectrum of autoimmune toxicities, that can also affect the kidney. In this issue of
    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Editorial
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfad035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Kidney Transplantation in Patients With Monoclonal Gammopathy of Renal Significance.

    Sprangers, Ben / Hegenbart, Ute / Wetzels, Jack F M

    Transplantation

    2023  Volume 107, Issue 5, Page(s) 1056–1068

    Abstract: Monoclonal gammopathy of renal significance (MGRS) defines disorders characterized by direct or indirect kidney injury caused by a monoclonal immunoglobulin produced by a B-cell or plasma-cell clone that does not meet current hematologic criteria for ... ...

    Abstract Monoclonal gammopathy of renal significance (MGRS) defines disorders characterized by direct or indirect kidney injury caused by a monoclonal immunoglobulin produced by a B-cell or plasma-cell clone that does not meet current hematologic criteria for therapy. MGRS-associated kidney diseases are diverse and can result in the development of end-stage kidney disease. The current paradigm states that the underlying hematologic condition should be treated and in deep remission before kidney transplantation can be performed because recurrence has been reported for all MGRS-associated kidney diseases. However, we suggest that decisions regarding kidney transplantation in MGRS patients should be individualized considering many factors such as the subtype of MGRS-associated kidney disease, patient age and comorbidity, presence and risk of extrarenal complications, estimated waiting time, the availability of a living kidney donor, and previous hematological treatment and response. Thus, kidney transplantation should be considered even in treatment-naive patients, with hematological treatment initiated after successful kidney transplantation.
    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Kidney ; Paraproteinemias/complications ; Kidney Diseases/etiology ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/surgery ; Kidney Failure, Chronic/complications ; Monoclonal Gammopathy of Undetermined Significance/complications
    Language English
    Publishing date 2023-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 509: Show issues

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  10. Article: Checkpoint inhibitor therapy-associated acute kidney injury: time to move on to evidence-based recommendations.

    Perazella, Mark A / Sprangers, Ben

    Clinical kidney journal

    2021  Volume 14, Issue 5, Page(s) 1301–1306

    Abstract: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment since their introduction ∼15 years ago. However, these monoclonal antibodies are associated with immune-related adverse events that can also affect the kidney, resulting in acute ... ...

    Abstract Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment since their introduction ∼15 years ago. However, these monoclonal antibodies are associated with immune-related adverse events that can also affect the kidney, resulting in acute kidney injury (AKI), which is most commonly due to acute tubulointerstitial nephritis (ATIN). Limited data are available on the true occurrence of ICI-associated AKI. Furthermore, evidence to guide the optimal management of ICI-associated AKI in clinical practice is lacking. In this issue, Oleas
    Language English
    Publishing date 2021-03-10
    Publishing country England
    Document type Editorial
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfab052
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