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  1. Article ; Online: The push-pull of serial dependence effects: Attraction to the prior response and repulsion from the prior stimulus.

    Sadil, Patrick / Cowell, Rosemary A / Huber, David E

    Psychonomic bulletin & review

    2023  Volume 31, Issue 1, Page(s) 259–273

    Abstract: In the "serial dependence" effect, responses to visual stimuli appear biased toward the last trial's stimulus. However, several kinds of serial dependence exist, with some reflecting prior stimuli and others reflecting prior responses. One-factor ... ...

    Abstract In the "serial dependence" effect, responses to visual stimuli appear biased toward the last trial's stimulus. However, several kinds of serial dependence exist, with some reflecting prior stimuli and others reflecting prior responses. One-factor analyses consider the prior stimulus alone or the prior response alone and can consider both variables only via separate analyses. We demonstrate that one-factor analyses are potentially misleading and can reach conclusions that are opposite from the truth if both dependencies exist. To address this limitation, we developed two-factor analyses (model comparison with hierarchical Bayesian modeling and an empirical "quadrant analysis"), which consider trial-by-trial combinations of prior response and prior stimulus. Two-factor analyses can tease apart the two dependencies if applied to a sufficiently large dataset. We applied these analyses to a new study and to four previously published studies. When applying a model that included the possibility of both dependencies, there was no evidence of attraction to the prior stimulus in any dataset, but there was evidence of attraction to the prior response in all datasets. Two of the datasets contained sufficient constraint to determine that both dependencies were needed to explain the results. For these datasets, the dependency on the prior stimulus was repulsive rather than attractive. Our results are consistent with the claim that both dependencies exist in most serial dependence studies (the two-dependence model was not ruled out for any dataset) and, furthermore, that the two dependencies work against each other.
    MeSH term(s) Humans ; Visual Perception/physiology ; Bayes Theorem ; Factor Analysis, Statistical
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2031311-1
    ISSN 1531-5320 ; 1069-9384
    ISSN (online) 1531-5320
    ISSN 1069-9384
    DOI 10.3758/s13423-023-02320-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A modeling framework for determining modulation of neural-level tuning from non-invasive human fMRI data.

    Sadil, Patrick / Cowell, Rosemary A / Huber, David E

    Communications biology

    2022  Volume 5, Issue 1, Page(s) 1244

    Abstract: ... to any experimental paradigm testing several points along a continuous feature dimension (e.g., direction of motion ... isoluminant hue) across two conditions (e.g., with/without attention, before/after learning). ...

    Abstract Many neuroscience theories assume that tuning modulation of individual neurons underlies changes in human cognition. However, non-invasive fMRI lacks sufficient resolution to visualize this modulation. To address this limitation, we developed an analysis framework called Inferring Neural Tuning Modulation (INTM) for "peering inside" voxels. Precise specification of neural tuning from the BOLD signal is not possible. Instead, INTM compares theoretical alternatives for the form of neural tuning modulation that might underlie changes in BOLD across experimental conditions. The most likely form is identified via formal model comparison, with assumed parametric Normal tuning functions, followed by a non-parametric check of conclusions. We validated the framework by successfully identifying a well-established form of modulation: visual contrast-induced multiplicative gain for orientation tuned neurons. INTM can be applied to any experimental paradigm testing several points along a continuous feature dimension (e.g., direction of motion, isoluminant hue) across two conditions (e.g., with/without attention, before/after learning).
    MeSH term(s) Humans ; Magnetic Resonance Imaging/methods ; Neurons/physiology ; Attention/physiology ; Visual Perception
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Journal Article
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-022-04000-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Zika virus infection of retinal cells and the developing mouse eye induces host responses that contrasts to the brain and dengue virus infection.

    Cowell, E / Kris, L P / Bracho-Granado, G / Jaber, H / Smith, J R / Carr, J M

    Journal of neurovirology

    2023  Volume 29, Issue 2, Page(s) 187–202

    Abstract: Zika virus (ZIKV) infection causes ocular and neurological pathologies with ZIKV-induction of developmental abnormalities following in utero infection a major concern. The study here has compared ZIKV and the related dengue virus (DENV) infection in the ... ...

    Abstract Zika virus (ZIKV) infection causes ocular and neurological pathologies with ZIKV-induction of developmental abnormalities following in utero infection a major concern. The study here has compared ZIKV and the related dengue virus (DENV) infection in the eye and brain. In vitro, both ZIKV and DENV could infect cell lines representing the retinal pigmented epithelium, endothelial cells, and Mueller cells, with distinct innate responses in each cell type. In a 1-day old mouse challenge model, both ZIKV and DENV infected the brain and eye by day 6 post-infection (pi). ZIKV was present at comparable levels in both tissues, with RNA increasing with time post-infection. DENV infected the brain, but RNA was detected in the eye of less than half of the mice challenged. NanoString analysis demonstrated comparable host responses in the brain for both viruses, including induction of mRNA for myosin light chain-2 (Mly2), and numerous antiviral and inflammatory genes. Notably, mRNA for multiple complement proteins were induced, but C2 and C4a were uniquely induced by ZIKV but not DENV. Consistent with the viral infection in the eye, DENV induced few responses while ZIKV induced substantial inflammatory and antiviral responses. Compared to the brain, ZIKV in the eye did not induce mRNAs such as C3, downregulated Retnla, and upregulated CSF-1. Morphologically, the ZIKV-infected retina demonstrated reduced formation of specific retinal layers. Thus, although ZIKV and DENV can both infect the eye and brain, there are distinct differences in host cell and tissue inflammatory responses that may be relevant to ZIKV replication and disease.
    MeSH term(s) Animals ; Mice ; Zika Virus/genetics ; Zika Virus Infection/genetics ; Zika Virus Infection/pathology ; Dengue/pathology ; Dengue Virus ; Endothelial Cells/metabolism ; Antiviral Agents/pharmacology ; Brain/pathology
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1283265-0
    ISSN 1538-2443 ; 1355-0284
    ISSN (online) 1538-2443
    ISSN 1355-0284
    DOI 10.1007/s13365-023-01123-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dynamic kernel matching for non-conforming data

    Jared Ostmeyer / Lindsay Cowell / Scott Christley

    PLoS ONE, Vol 18, Iss 3, p e

    A case study of T cell receptor datasets.

    2023  Volume 0265313

    Abstract: Most statistical classifiers are designed to find patterns in data where numbers fit into rows and columns, like in a spreadsheet, but many kinds of data do not conform to this structure. To uncover patterns in non-conforming data, we describe an ... ...

    Abstract Most statistical classifiers are designed to find patterns in data where numbers fit into rows and columns, like in a spreadsheet, but many kinds of data do not conform to this structure. To uncover patterns in non-conforming data, we describe an approach for modifying established statistical classifiers to handle non-conforming data, which we call dynamic kernel matching (DKM). As examples of non-conforming data, we consider (i) a dataset of T-cell receptor (TCR) sequences labelled by disease antigen and (ii) a dataset of sequenced TCR repertoires labelled by patient cytomegalovirus (CMV) serostatus, anticipating that both datasets contain signatures for diagnosing disease. We successfully fit statistical classifiers augmented with DKM to both datasets and report the performance on holdout data using standard metrics and metrics allowing for indeterminant diagnoses. Finally, we identify the patterns used by our statistical classifiers to generate predictions and show that these patterns agree with observations from experimental studies.
    Keywords Medicine ; R ; Science ; Q
    Subject code 006
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Evaluation of community nurse-led traumatic tube displacements.

    Stenson, Sophie / Capener, Rebecca / Barker, Julie / Hynes, Helen / Barron, Edmund / Shakespeare, Catherine / Brampton-Mortley, Su / Skelton, Jill / Cowell, Laurie / Hubbard, Gary P

    British journal of community nursing

    2024  Volume 29, Issue 4, Page(s) 162–170

    Abstract: ... of feeding tubes (i.e. internal bumper/balloon removed intact), and evidence to support the safe replacement ...

    Abstract Home enteral tube feeding (HEF) has many benefits and is largely safe practice. Some complications have historically required intervention in the acute setting, including traumatic displacement of feeding tubes (i.e. internal bumper/balloon removed intact), and evidence to support the safe replacement of these tubes in the community is lacking. To address this, a service enabling community homecare nurses (CHN) to replace traumatically displaced feeding tubes was designed and evaluated. Adult patients presenting with a traumatically displaced feeding tube over 29 months were included in the service evaluation. Baseline characteristics and outcomes at day 1, 7 and 6 months post-replacement were recorded. A total of 71 tube replacements were performed by CHNs in 60 patients. No clinical complications were recorded at any follow-up points. A simple cost analysis estimated savings of £235 754.40. These results suggest that nurse-led replacement of traumatically displaced feeding tubes in adults in the community is low-risk and offers potential cost savings.
    MeSH term(s) Adult ; Humans ; Gastrostomy ; Nurse's Role ; Enteral Nutrition/methods ; Intubation, Gastrointestinal ; Nurses
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2146386-4
    ISSN 1462-4753
    ISSN 1462-4753
    DOI 10.12968/bjcn.2024.29.4.162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Diadochokinetic rate in Saudi and Bahraini Arabic speakers: Dialect and the influence of syllable type.

    Alshahwan, Majid I / Cowell, Patricia E / Whiteside, Sandra P

    Saudi journal of biological sciences

    2019  Volume 27, Issue 1, Page(s) 303–308

    Abstract: Arabic is spoken by more than 420 million people worldwide and still there are a limited number of studies on dialects of the Gulf Arabic regions where most selected respondents are male speakers. This study aimed to explore and establish normative data ... ...

    Abstract Arabic is spoken by more than 420 million people worldwide and still there are a limited number of studies on dialects of the Gulf Arabic regions where most selected respondents are male speakers. This study aimed to explore and establish normative data for the Diadochokinetic Rate (DDK) for two dialects (Saudi Arabia's
    Language English
    Publishing date 2019-09-19
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2515206-3
    ISSN 2213-7106 ; 1319-562X
    ISSN (online) 2213-7106
    ISSN 1319-562X
    DOI 10.1016/j.sjbs.2019.09.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Vav proteins do not influence dengue virus replication but are associated with induction of phospho-ERK, IL-6, and viperin mRNA following DENV infection

    Cowell, Evangeline / Jaber, Hawraa / Kris, Luke P / Fitzgerald, Madeleine G / Sanders, Valeria M / Norbury, Aidan J / Eyre, Nicholas S / Carr, Jillian M

    Microbiology spectrum

    2023  Volume 12, Issue 1, Page(s) e0239123

    Abstract: ... blocking Vav signaling didn't affect DENV replication but prevented DENV-induction of p-ERK and enhanced IL ...

    Abstract Importance: Dengue disease is characterized by an inflammatory-mediated immunopathology, with elevated levels of circulating factors including TNF-α and IL-6. If the damaging inflammatory pathways could be blocked without loss of antiviral responses or exacerbating viral replication, then this would be of potential therapeutic benefit. The study here has investigated the Vav guanine exchange factors as a potential alternative signaling pathway that may drive dengue virus (DENV)-induced inflammatory responses, with a focus on Vav1 and 2. While Vav proteins were positively associated with mRNA for inflammatory cytokines, blocking Vav signaling didn't affect DENV replication but prevented DENV-induction of p-ERK and enhanced IL-6 (inflammatory) and viperin (antiviral) mRNA. These initial data suggest that Vav proteins could be a target that does not compromise control of viral replication and should be investigated further for broader impact on host inflammatory responses, in settings such as antibody-dependent enhancement of infection and in different cell types.
    MeSH term(s) Humans ; Dengue Virus/genetics ; Interleukin-6 ; RNA, Messenger ; Virus Replication ; Dengue ; Antiviral Agents
    Chemical Substances Interleukin-6 ; RNA, Messenger ; Antiviral Agents
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02391-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A hierarchical Bayesian state trace analysis for assessing monotonicity while factoring out subject, item, and trial level dependencies.

    Sadil, Patrick / Cowell, Rosemary A / Huber, David E

    Journal of mathematical psychology

    2019  Volume 90, Page(s) 118–131

    Abstract: ... measurement error, allowing both frequentist and Bayesian analyses of monotonicity (e.g., Davis-Stober, Morey ... not allow a non-monotonic relation between the condition effects (i.e., same vs. different rank orders ...

    Abstract State trace analyses assess the latent dimensionality of a cognitive process by asking whether the means of two dependent variables conform to a monotonic function across a set of conditions. Using an assumption of independence between the measures, recently proposed statistical tests address bivariate measurement error, allowing both frequentist and Bayesian analyses of monotonicity (e.g., Davis-Stober, Morey, Gretton, & Heathcote, 2016; Kalish, Dunn, Burdakov, & Sysoev, 2016). However, inference can be biased by unacknowledged dependencies between measures, particularly when the data are insufficient to overwhelm an incorrect prior assumption of independence. To address this limitation, we developed a hierarchical Bayesian model that explicitly models the separate roles of subject, item, and trial-level dependencies between two measures. Assessment of monotonicity is then performed by fitting separate models that do or do not allow a non-monotonic relation between the condition effects (i.e., same vs. different rank orders). The Widely Applicable Information Criterion (WAIC) and Pseudo Bayesian Model Averaging - cross validation measures of model fit - are used for model comparison, providing an inferential conclusion regarding the dimensionality of the latent psychological space. We validated this new state trace analysis technique using model recovery simulation studies, which assumed different ground truths regarding monotonicity and the direction/magnitude of the subject- and trial-level dependence. We also provide an example application of this new technique to a visual object learning study that compared performance on a visual retrieval task (forced choice part recognition) versus a verbal retrieval task (cued recall).
    Language English
    Publishing date 2019-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 0022-2496
    ISSN 0022-2496
    DOI 10.1016/j.jmp.2019.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cerebellar Asymmetry and Cortical Connectivity in Monozygotic Twins with Discordant Handedness.

    Rosch, R E / Cowell, P E / Gurd, J M

    Cerebellum (London, England)

    2017  Volume 17, Issue 2, Page(s) 191–203

    Abstract: Handedness differentiates patterns of neural asymmetry and interhemispheric connectivity in cortical systems that underpin manual and language functions. Contemporary models of cerebellar function incorporate complex motor behaviour and higher-order ... ...

    Abstract Handedness differentiates patterns of neural asymmetry and interhemispheric connectivity in cortical systems that underpin manual and language functions. Contemporary models of cerebellar function incorporate complex motor behaviour and higher-order cognition, expanding upon earlier, traditional associations between the cerebellum and motor control. Structural MRI defined cerebellar volume asymmetries and correlations with corpus callosum (CC) size were compared in 19 pairs of adult female monozygotic twins strongly discordant for handedness (MZHd). Volume and asymmetry of cerebellar lobules were obtained using automated parcellation.CC area and regional widths were obtained from midsagittal planimetric measurements. Within the cerebellum and CC, neurofunctional distinctions were drawn between motor and higher-order cognitive systems. Relationships amongst regional cerebellar asymmetry and cortical connectivity (as indicated by CC widths) were investigated. Interactions between hemisphere and handedness in the anterior cerebellum were due to a larger right-greater-than-left hemispheric asymmetry in right-handed (RH) compared to left-handed (LH) twins. In LH twins only, anterior cerebellar lobule volumes (IV, V) for motor control were associated with CC size, particularly in callosal regions associated with motor cortex connectivity. Superior posterior cerebellar lobule volumes (VI, Crus I, Crus II, VIIb) showed no correlation with CC size in either handedness group. These novel results reflected distinct patterns of cerebellar-cortical relationships delineated by specific CC regions and an anterior-posterior cerebellar topographical mapping. Hence, anterior cerebellar asymmetry may contribute to the greater degree of bilateral cortical organisation of frontal motor function in LH individuals.
    MeSH term(s) Adult ; Aged ; Cerebellum/diagnostic imaging ; Cerebellum/physiology ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/physiology ; Corpus Callosum/diagnostic imaging ; Female ; Functional Laterality/genetics ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neural Pathways/diagnostic imaging ; Neural Pathways/physiology ; Statistics, Nonparametric ; Twins, Monozygotic
    Language English
    Publishing date 2017-10-24
    Publishing country United States
    Document type Journal Article ; Twin Study
    ZDB-ID 2112586-7
    ISSN 1473-4230 ; 1473-4222
    ISSN (online) 1473-4230
    ISSN 1473-4222
    DOI 10.1007/s12311-017-0889-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: IL-17 receptor A functions to help maintain barrier integrity and limit activation of immunopathogenic response to

    Brackman, Lee C / Dixon, Beverly R E A / Bernard, Margaret / Revetta, Frank / Cowell, Rebecca P / Meenderink, Leslie M / Washington, M Kay / Piazuelo, M Blanca / Algood, Holly M Scott

    Infection and immunity

    2023  Volume 92, Issue 1, Page(s) e0029223

    Abstract: Activation of Th17 cell responses, including the production of IL-17A and IL-21, contributes to host defense and inflammatory responses by coordinating adaptive and innate immune responses. IL-17A and IL-17F signal through a multimeric receptor, which ... ...

    Abstract Activation of Th17 cell responses, including the production of IL-17A and IL-21, contributes to host defense and inflammatory responses by coordinating adaptive and innate immune responses. IL-17A and IL-17F signal through a multimeric receptor, which includes the IL-17 receptor A (IL-17RA) subunit and the IL-17RC subunit. IL-17RA is expressed by many cell types, and data from previous studies suggest that loss of IL-17 receptor is required to limit immunopathology in the
    MeSH term(s) Mice ; Animals ; Interleukin-17/genetics ; Interleukin-17/metabolism ; Helicobacter pylori/physiology ; Receptors, Interleukin-17/genetics ; Receptors, Interleukin-17/metabolism ; Gastric Mucosa/metabolism ; Gastritis ; Inflammation/metabolism ; Immunoglobulin A/metabolism ; Helicobacter Infections
    Chemical Substances Interleukin-17 ; Receptors, Interleukin-17 ; Immunoglobulin A
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00292-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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