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Article ; Online: G-quadruplexes in cancer-related gene promoters: from identification to therapeutic targeting.

Romano, Francesca / Di Porzio, Anna / Iaccarino, Nunzia / Riccardi, Gelsomina / Di Lorenzo, Ritamaria / Laneri, Sonia / Pagano, Bruno / Amato, Jussara / Randazzo, Antonio

Expert opinion on therapeutic patents

2024 Volume 33, Issue 11, Page(s) 745–773

Abstract: ... structures called G-quadruplexes (G4s) which are widely distributed in functional regions of the human genome ...

Abstract	Introduction: Guanine-rich DNA sequences can fold into four-stranded noncanonical secondary structures called G-quadruplexes (G4s) which are widely distributed in functional regions of the human genome, such as telomeres and gene promoter regions. Compelling evidence suggests their involvement in key genome functions such as gene expression and genome stability. Notably, the abundance of G4-forming sequences near transcription start sites suggests their potential involvement in regulating oncogenes. Areas covered: This review provides an overview of current knowledge on G4s in human oncogene promoters. The most representative G4-binding ligands have also been documented. The objective of this work is to present a comprehensive overview of the most promising targets for the development of novel and highly specific anticancer drugs capable of selectively impacting the expression of individual or a limited number of genes. Expert opinion: Modulation of G4 formation by specific ligands has been proposed as a powerful new tool to treat cancer through the control of oncogene expression. Actually, most of G4-binding small molecules seem to simultaneously target a range of gene promoter G4s, potentially influencing several critical driver genes in cancer, thus producing significant therapeutic benefits.
MeSH term(s)	Humans ; G-Quadruplexes ; DNA/chemistry ; DNA/genetics ; DNA/metabolism ; Patents as Topic ; Promoter Regions, Genetic ; Antineoplastic Agents/pharmacology ; Ligands ; Neoplasms/drug therapy ; Neoplasms/genetics
Chemical Substances	DNA (9007-49-2) ; Antineoplastic Agents ; Ligands
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1186201-4
ISSN	1744-7674 ; 0962-2594 ; 1354-3776
ISSN (online)	1744-7674
ISSN	0962-2594 ; 1354-3776
DOI	10.1080/13543776.2023.2271168
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Article ; Online: Multimodal retinal imaging of m.3243A>G associated retinopathy.

Romano, Francesco / Cozzi, Mariano / Staurenghi, Giovanni / Salvetti, Anna Paola

American journal of ophthalmology case reports

2022 Volume 26, Page(s) 101411

Abstract: ... of the retinal pigment epithelial alterations occurring in m.3243A > G associated retinopathy. ...

Abstract	Retro-mode illumination imaging can provide good visualization of chorio-retinal atrophy and of the retinal pigment epithelial alterations occurring in m.3243A > G associated retinopathy.
Language	English
Publishing date	2022-03-03
Publishing country	United States
Document type	Journal Article
ISSN	2451-9936
ISSN (online)	2451-9936
DOI	10.1016/j.ajoc.2022.101411
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Article ; Online: Lumipulse G SARS-CoV-2 Ag assay evaluation using clinical samples from different testing groups.

Menchinelli, Giulia / Bordi, Licia / Liotti, Flora Marzia / Palucci, Ivana / Capobianchi, Maria Rosaria / Sberna, Giuseppe / Lalle, Eleonora / Romano, Lucio / De Angelis, Giulia / Marchetti, Simona / Sanguinetti, Maurizio / Cattani, Paola / Posteraro, Brunella

Clinical chemistry and laboratory medicine

2021 Volume 59, Issue 8, Page(s) 1468–1476

Abstract: ... the Lumipulse G SARS-CoV-2 Ag assay, may depend on specific testing scenarios.: Methods: We tested 594 ...

Abstract	Objectives: Compared to RT-PCR, lower performance of antigen detection assays, including the Lumipulse G SARS-CoV-2 Ag assay, may depend on specific testing scenarios. Methods: We tested 594 nasopharyngeal swab samples from individuals with COVID-19 (RT-PCR cycle threshold [Ct] values ≤ 40) or non-COVID-19 (Ct values >40) diagnoses. RT-PCR positive samples were assigned to diagnostic, screening, or monitoring groups of testing. Results: With a limit of detection of 1.2 × 10 Conclusions: Lumipulse assay was highly sensitive in samples with low RT-PCR Ct values, implying repeated testing to reduce consequences of false-negative results.
MeSH term(s)	COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Nucleic Acid Testing ; Humans ; Limit of Detection ; Nasopharynx/virology ; RNA, Viral/analysis ; Reagent Kits, Diagnostic ; Reverse Transcriptase Polymerase Chain Reaction/methods ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Sensitivity and Specificity
Chemical Substances	RNA, Viral ; Reagent Kits, Diagnostic
Language	English
Publishing date	2021-04-07
Publishing country	Germany
Document type	Evaluation Study ; Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2021-0182
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Article ; Online: Constraining the p-Mode-g-Mode Tidal Instability with GW170817.

Abbott, B P / Abbott, R / Abbott, T D / Acernese, F / Ackley, K / Adams, C / Adams, T / Addesso, P / Adhikari, R X / Adya, V B / Affeldt, C / Agarwal, B / Agathos, M / Agatsuma, K / Aggarwal, N / Aguiar, O D / Aiello, L / Ain, A / Ajith, P /

Allen, B / Allen, G / Allocca, A / Aloy, M A / Altin, P A / Amato, A / Ananyeva, A / Anderson, S B / Anderson, W G / Angelova, S V / Antier, S / Appert, S / Arai, K / Araya, M C / Areeda, J S / Arène, M / Arnaud, N / Arun, K G / Ascenzi, S / Ashton, G / Ast, M / Aston, S M / Astone, P / Atallah, D V / Aubin, F / Aufmuth, P / Aulbert, C / AultONeal, K / Austin, C / Avila-Alvarez, A / Babak, S / Bacon, P / Badaracco, F / Bader, M K M / Bae, S / Baker, P T / Baldaccini, F / Ballardin, G / Ballmer, S W / Banagiri, S / Barayoga, J C / Barclay, S E / Barish, B C / Barker, D / Barkett, K / Barnum, S / Barone, F / Barr, B / Barsotti, L / Barsuglia, M / Barta, D / Bartlett, J / Bartos, I / Bassiri, R / Basti, A / Batch, J C / Bawaj, M / Bayley, J C / Bazzan, M / Bécsy, B / Beer, C / Bejger, M / Belahcene, I / Bell, A S / Beniwal, D / Bensch, M / Berger, B K / Bergmann, G / Bernuzzi, S / Bero, J J / Berry, C P L / Bersanetti, D / Bertolini, A / Betzwieser, J / Bhandare, R / Bilenko, I A / Bilgili, S A / Billingsley, G / Billman, C R / Birch, J / Birney, R / Birnholtz, O / Biscans, S / Biscoveanu, S / Bisht, A / Bitossi, M / Bizouard, M A / Blackburn, J K / Blackman, J / Blair, C D / Blair, D G / Blair, R M / Bloemen, S / Bock, O / Bode, N / Boer, M / Boetzel, Y / Bogaert, G / Bohe, A / Bondu, F / Bonilla, E / Bonnand, R / Booker, P / Boom, B A / Booth, C D / Bork, R / Boschi, V / Bose, S / Bossie, K / Bossilkov, V / Bosveld, J / Bouffanais, Y / Bozzi, A / Bradaschia, C / Brady, P R / Bramley, A / Branchesi, M / Brau, J E / Briant, T / Brighenti, F / Brillet, A / Brinkmann, M / Brisson, V / Brockill, P / Brooks, A F / Brown, D D / Brunett, S / Buchanan, C C / Buikema, A / Bulik, T / Bulten, H J / Buonanno, A / Buskulic, D / Buy, C / Byer, R L / Cabero, M / Cadonati, L / Cagnoli, G / Cahillane, C / Calderón Bustillo, J / Callister, T A / Calloni, E / Camp, J B / Canepa, M / Canizares, P / Cannon, K C / Cao, H / Cao, J / Capano, C D / Capocasa, E / Carbognani, F / Caride, S / Carney, M F / Casanueva Diaz, J / Casentini, C / Caudill, S / Cavaglià, M / Cavalier, F / Cavalieri, R / Cella, G / Cepeda, C B / Cerdá-Durán, P / Cerretani, G / Cesarini, E / Chaibi, O / Chamberlin, S J / Chan, M / Chao, S / Charlton, P / Chase, E / Chassande-Mottin, E / Chatterjee, D / Chatziioannou, Katerina / Cheeseboro, B D / Chen, H Y / Chen, X / Chen, Y / Cheng, H-P / Chia, H Y / Chincarini, A / Chiummo, A / Chmiel, T / Cho, H S / Cho, M / Chow, J H / Christensen, N / Chu, Q / Chua, A J K / Chua, S / Chung, K W / Chung, S / Ciani, G / Ciobanu, A A / Ciolfi, R / Cipriano, F / Cirelli, C E / Cirone, A / Clara, F / Clark, J A / Clearwater, P / Cleva, F / Cocchieri, C / Coccia, E / Cohadon, P-F / Cohen, D / Colla, A / Collette, C G / Collins, C / Cominsky, L R / Constancio, M / Conti, L / Cooper, S J / Corban, P / Corbitt, T R / Cordero-Carrión, I / Corley, K R / Cornish, N / Corsi, A / Cortese, S / Costa, C A / Cotesta, R / Coughlin, M W / Coughlin, S B / Coulon, J-P / Countryman, S T / Couvares, P / Covas, P B / Cowan, E E / Coward, D M / Cowart, M J / Coyne, D C / Coyne, R / Creighton, J D E / Creighton, T D / Cripe, J / Crowder, S G / Cullen, T J / Cumming, A / Cunningham, L / Cuoco, E / Canton, T Dal / Dálya, G / Danilishin, S L / D'Antonio, S / Danzmann, K / Dasgupta, A / Costa, C F Da Silva / Dattilo, V / Dave, I / Davier, M / Davis, D / Daw, E J / Day, B / DeBra, D / Deenadayalan, M / Degallaix, J / De Laurentis, M / Deléglise, S / Del Pozzo, W / Demos, N / Denker, T / Dent, T / De Pietri, R / Derby, J / Dergachev, V / De Rosa, R / De Rossi, C / DeSalvo, R / de Varona, O / Dhurandhar, S / Díaz, M C / Di Fiore, L / Di Giovanni, M / Di Girolamo, T / Di Lieto, A / Ding, B / Di Pace, S / Di Palma, I / Di Renzo, F / Dmitriev, A / Doctor, Z / Dolique, V / Donovan, F / Dooley, K L / Doravari, S / Dorrington, I / Dovale Álvarez, M / Downes, T P / Drago, M / Dreissigacker, C / Driggers, J C / Du, Z / Dupej, P / Dwyer, S E / Easter, P J / Edo, T B / Edwards, M C / Effler, A / Eggenstein, H-B / Ehrens, P / Eichholz, J / Eikenberry, S S / Eisenmann, M / Eisenstein, R A / Essick, R C / Estelles, H / Estevez, D / Etienne, Z B / Etzel, T / Evans, M / Evans, T M / Fafone, V / Fair, H / Fairhurst, S / Fan, X / Farinon, S / Farr, B / Farr, W M / Fauchon-Jones, E J / Favata, M / Fays, M / Fee, C / Fehrmann, H / Feicht, J / Fejer, M M / Feng, F / Fernandez-Galiana, A / Ferrante, I / Ferreira, E C / Ferrini, F / Fidecaro, F / Fiori, I / Fiorucci, D / Fishbach, M / Fisher, R P / Fishner, J M / Fitz-Axen, M / Flaminio, R / Fletcher, M / Fong, H / Font, J A / Forsyth, P W F / Forsyth, S S / Fournier, J-D / Frasca, S / Frasconi, F / Frei, Z / Freise, A / Frey, R / Frey, V / Fritschel, P / Frolov, V V / Fulda, P / Fyffe, M / Gabbard, H A / Gadre, B U / Gaebel, S M / Gair, J R / Gammaitoni, L / Ganija, M R / Gaonkar, S G / Garcia, A / García-Quirós, C / Garufi, F / Gateley, B / Gaudio, S / Gaur, G / Gayathri, V / Gemme, G / Genin, E / Gennai, A / George, D / George, J / Gergely, L / Germain, V / Ghonge, S / Ghosh, Abhirup / Ghosh, Archisman / Ghosh, S / Giacomazzo, B / Giaime, J A / Giardina, K D / Giazotto, A / Gill, K / Giordano, G / Glover, L / Goetz, E / Goetz, R / Goncharov, B / González, G / Gonzalez Castro, J M / Gopakumar, A / Gorodetsky, M L / Gossan, S E / Gosselin, M / Gouaty, R / Grado, A / Graef, C / Granata, M / Grant, A / Gras, S / Gray, C / Greco, G / Green, A C / Green, R / Gretarsson, E M / Groot, P / Grote, H / Grunewald, S / Gruning, P / Guidi, G M / Gulati, H K / Guo, X / Gupta, A / Gupta, M K / Gushwa, K E / Gustafson, E K / Gustafson, R / Halim, O / Hall, B R / Hall, E D / Hamilton, E Z / Hamilton, H F / Hammond, G / Haney, M / Hanke, M M / Hanks, J / Hanna, C / Hannam, M D / Hannuksela, O A / Hanson, J / Hardwick, T / Harms, J / Harry, G M / Harry, I W / Hart, M J / Haster, C-J / Haughian, K / Healy, J / Heidmann, A / Heintze, M C / Heitmann, H / Hello, P / Hemming, G / Hendry, M / Heng, I S / Hennig, J / Heptonstall, A W / Hernandez, F J / Heurs, M / Hild, S / Hinderer, T / Hoak, D / Hochheim, S / Hofman, D / Holland, N A / Holt, K / Holz, D E / Hopkins, P / Horst, C / Hough, J / Houston, E A / Howell, E J / Hreibi, A / Huerta, E A / Huet, D / Hughey, B / Hulko, M / Husa, S / Huttner, S H / Huynh-Dinh, T / Iess, A / Indik, N / Ingram, C / Inta, R / Intini, G / Isa, H N / Isac, J-M / Isi, M / Iyer, B R / Izumi, K / Jacqmin, T / Jani, K / Jaranowski, P / Johnson, D S / Johnson, W W / Jones, D I / Jones, R / Jonker, R J G / Ju, L / Junker, J / Kalaghatgi, C V / Kalogera, V / Kamai, B / Kandhasamy, S / Kang, G / Kanner, J B / Kapadia, S J / Karki, S / Karvinen, K S / Kasprzack, M / Katolik, M / Katsanevas, S / Katsavounidis, E / Katzman, W / Kaufer, S / Kawabe, K / Keerthana, N V / Kéfélian, F / Keitel, D / Kemball, A J / Kennedy, R / Key, J S / Khalili, F Y / Khamesra, B / Khan, H / Khan, I / Khan, S / Khan, Z / Khazanov, E A / Kijbunchoo, N / Kim, Chunglee / Kim, J C / Kim, K / Kim, W / Kim, W S / Kim, Y-M / King, E J / King, P J / Kinley-Hanlon, M / Kirchhoff, R / Kissel, J S / Kleybolte, L / Klimenko, S / Knowles, T D / Koch, P / Koehlenbeck, S M / Koley, S / Kondrashov, V / Kontos, A / Korobko, M / Korth, W Z / Kowalska, I / Kozak, D B / Krämer, C / Kringel, V / Krishnan, B / Królak, A / Kuehn, G / Kumar, P / Kumar, R / Kumar, S / Kuo, L / Kutynia, A / Kwang, S / Lackey, B D / Lai, K H / Landry, M / Lang, R N / Lange, J / Lantz, B / Lanza, R K / Lartaux-Vollard, A / Lasky, P D / Laxen, M / Lazzarini, A / Lazzaro, C / Leaci, P / Leavey, S / Lee, C H / Lee, H K / Lee, H M / Lee, H W / Lee, K / Lehmann, J / Lenon, A / Leonardi, M / Leroy, N / Letendre, N / Levin, Y / Li, J / Li, T G F / Li, X / Linker, S D / Littenberg, T B / Liu, J / Liu, X / Lo, R K L / Lockerbie, N A / London, L T / Longo, A / Lorenzini, M / Loriette, V / Lormand, M / Losurdo, G / Lough, J D / Lovelace, G / Lück, H / Lumaca, D / Lundgren, A P / Lynch, R / Ma, Y / Macas, R / Macfoy, S / Machenschalk, B / MacInnis, M / Macleod, D M / Magaña Hernandez, I / Magaña-Sandoval, F / Magaña Zertuche, L / Magee, R M / Majorana, E / Maksimovic, I / Man, N / Mandic, V / Mangano, V / Mansell, G L / Manske, M / Mantovani, M / Marchesoni, F / Marion, F / Márka, S / Márka, Z / Markakis, C / Markosyan, A S / Markowitz, A / Maros, E / Marquina, A / Martelli, F / Martellini, L / Martin, I W / Martin, R M / Martynov, D V / Mason, K / Massera, E / Masserot, A / Massinger, T J / Masso-Reid, M / Mastrogiovanni, S / Matas, A / Matichard, F / Matone, L / Mavalvala, N / Mazumder, N / McCann, J J / McCarthy, R / McClelland, D E / McCormick, S / McCuller, L / McGuire, S C / McIver, J / McManus, D J / McRae, T / McWilliams, S T / Meacher, D / Meadors, G D / Mehmet, M / Meidam, J / Mejuto-Villa, E / Melatos, A / Mendell, G / Mendoza-Gandara, D / Mercer, R A / Mereni, L / Merilh, E L / Merzougui, M / Meshkov, S / Messenger, C / Messick, C / Metzdorff, R / Meyers, P M / Miao, H / Michel, C / Middleton, H / Mikhailov, E E / Milano, L / Miller, A L / Miller, A / Miller, B B / Miller, J / Millhouse, M / Mills, J / Milovich-Goff, M C / Minazzoli, O / Minenkov, Y / Ming, J / Mishra, C / Mitra, S / Mitrofanov, V P / Mitselmakher, G / Mittleman, R / Moffa, D / Mogushi, K / Mohan, M / Mohapatra, S R P / Montani, M / Moore, C J / Moraru, D / Moreno, G / Morisaki, S / Mours, B / Mow-Lowry, C M / Mueller, G / Muir, A W / Mukherjee, Arunava / Mukherjee, D / Mukherjee, S / Mukund, N / Mullavey, A / Munch, J / Muñiz, E A / Muratore, M / Murray, P G / Nagar, A / Napier, K / Nardecchia, I / Naticchioni, L / Nayak, R K / Neilson, J / Nelemans, G / Nelson, T J N / Nery, M / Neunzert, A / Nevin, L / Newport, J M / Ng, K Y / Ng, S / Nguyen, P / Nguyen, T T / Nichols, D / Nielsen, A B / Nissanke, S / Nitz, A / Nocera, F / Nolting, D / North, C / Nuttall, L K / Obergaulinger, M / Oberling, J / O'Brien, B D / O'Dea, G D / Ogin, G H / Oh, J J / Oh, S H / Ohme, F / Ohta, H / Okada, M A / Oliver, M / Oppermann, P / Oram, Richard J / O'Reilly, B / Ormiston, R / Ortega, L F / O'Shaughnessy, R / Ossokine, S / Ottaway, D J / Overmier, H / Owen, B J / Pace, A E / Pagano, G / Page, J / Page, M A / Pai, A / Pai, S A / Palamos, J R / Palashov, O / Palomba, C / Pal-Singh, A / Pan, Howard / Pan, Huang-Wei / Pang, B / Pang, P T H / Pankow, C / Pannarale, F / Pant, B C / Paoletti, F / Paoli, A / Papa, M A / Parida, A / Parker, W / Pascucci, D / Pasqualetti, A / Passaquieti, R / Passuello, D / Patil, M / Patricelli, B / Pearlstone, B L / Pedersen, C / Pedraza, M / Pedurand, R / Pekowsky, L / Pele, A / Penn, S / Perez, C J / Perreca, A / Perri, L M / Pfeiffer, H P / Phelps, M / Phukon, K S / Piccinni, O J / Pichot, M / Piergiovanni, F / Pierro, V / Pillant, G / Pinard, L / Pinto, I M / Pirello, M / Pitkin, M / Poggiani, R / Popolizio, P / Porter, E K / Possenti, L / Post, A / Powell, J / Prasad, J / Pratt, J W W / Pratten, G / Predoi, V / Prestegard, T / Principe, M / Privitera, S / Prodi, G A / Prokhorov, L G / Puncken, O / Punturo, M / Puppo, P / Pürrer, M / Qi, H / Quetschke, V / Quintero, E A / Quitzow-James, R / Rabeling, D S / Radkins, H / Raffai, P / Raja, S / Rajan, C / Rajbhandari, B / Rakhmanov, M / Ramirez, K E / Ramos-Buades, A / Rana, Javed / Rapagnani, P / Raymond, V / Razzano, M / Read, J / Regimbau, T / Rei, L / Reid, S / Reitze, D H / Ren, W / Ricci, F / Ricker, P M / Riles, K / Rizzo, M / Robertson, N A / Robie, R / Robinet, F / Robson, T / Rocchi, A / Rolland, L / Rollins, J G / Roma, V J / Romano, R / Romel, C L / Romie, J H / Rosińska, D / Ross, M P / Rowan, S / Rüdiger, A / Ruggi, P / Rutins, G / Ryan, K / Sachdev, S / Sadecki, T / Sakellariadou, M / Salconi, L / Saleem, M / Salemi, F / Samajdar, A / Sammut, L / Sampson, L M / Sanchez, E J / Sanchez, L E / Sanchis-Gual, N / Sandberg, V / Sanders, J R / Sarin, N / Sassolas, B / Saulson, P R / Sauter, O / Savage, R L / Sawadsky, A / Schale, P / Scheel, M / Scheuer, J / Schmidt, P / Schnabel, R / Schofield, R M S / Schönbeck, A / Schreiber, E / Schuette, D / Schulte, B W / Schutz, B F / Schwalbe, S G / Scott, J / Scott, S M / Seidel, E / Sellers, D / Sengupta, A S / Sentenac, D / Sequino, V / Sergeev, A / Setyawati, Y / Shaddock, D A / Shaffer, T J / Shah, A A / Shahriar, M S / Shaner, M B / Shao, L / Shapiro, B / Shawhan, P / Shen, H / Shoemaker, D H / Shoemaker, D M / Siellez, K / Siemens, X / Sieniawska, M / Sigg, D / Silva, A D / Singer, L P / Singh, A / Singhal, A / Sintes, A M / Slagmolen, B J J / Slaven-Blair, T J / Smith, B / Smith, J R / Smith, R J E / Somala, S / Son, E J / Sorazu, B / Sorrentino, F / Souradeep, T / Spencer, A P / Srivastava, A K / Staats, K / Steinke, M / Steinlechner, J / Steinlechner, S / Steinmeyer, D / Steltner, B / Stevenson, S P / Stocks, D / Stone, R / Stops, D J / Strain, K A / Stratta, G / Strigin, S E / Strunk, A / Sturani, R / Stuver, A L / Summerscales, T Z / Sun, L / Sunil, S / Suresh, J / Sutton, P J / Swinkels, B L / Szczepańczyk, M J / Tacca, M / Tait, S C / Talbot, C / Talukder, D / Tanner, D B / Tápai, M / Taracchini, A / Tasson, J D / Taylor, J A / Taylor, R / Tewari, S V / Theeg, T / Thies, F / Thomas, E G / Thomas, M / Thomas, P / Thorne, K A / Thrane, E / Tiwari, S / Tiwari, V / Tokmakov, K V / Toland, K / Tonelli, M / Tornasi, Z / Torres-Forné, A / Torrie, C I / Töyrä, D / Travasso, F / Traylor, G / Trinastic, J / Tringali, M C / Trozzo, L / Tsang, K W / Tse, M / Tso, R / Tsuna, D / Tsukada, L / Tuyenbayev, D / Ueno, K / Ugolini, D / Urban, A L / Usman, S A / Vahlbruch, H / Vajente, G / Valdes, G / van Bakel, N / van Beuzekom, M / van den Brand, J F J / Van Den Broeck, C / Vander-Hyde, D C / van der Schaaf, L / van Heijningen, J V / van Veggel, A A / Vardaro, M / Varma, V / Vass, S / Vasúth, M / Vecchio, A / Vedovato, G / Veitch, J / Veitch, P J / Venkateswara, K / Venugopalan, G / Verkindt, D / Vetrano, F / Viceré, A / Viets, A D / Vinciguerra, S / Vine, D J / Vinet, J-Y / Vitale, S / Vo, T / Vocca, H / Vorvick, C / Vyatchanin, S P / Wade, A R / Wade, L E / Wade, M / Walet, R / Walker, M / Wallace, L / Walsh, S / Wang, G / Wang, H / Wang, J Z / Wang, W H / Wang, Y F / Ward, R L / Warner, J / Was, M / Watchi, J / Weaver, B / Wei, L-W / Weinert, M / Weinstein, A J / Weiss, R / Wellmann, F / Wen, L / Wessel, E K / Weßels, P / Westerweck, J / Wette, K / Whelan, J T / Whiting, B F / Whittle, C / Wilken, D / Williams, D / Williams, R D / Williamson, A R / Willis, J L / Willke, B / Wimmer, M H / Winkler, W / Wipf, C C / Wittel, H / Woan, G / Woehler, J / Wofford, J K / Wong, W K / Worden, J / Wright, J L / Wu, D S / Wysocki, D M / Xiao, S / Yam, W / Yamamoto, H / Yancey, C C / Yang, L / Yap, M J / Yazback, M / Yu, Hang / Yu, Haocun / Yvert, M / Zadrożny, A / Zanolin, M / Zelenova, T / Zendri, J-P / Zevin, M / Zhang, J / Zhang, L / Zhang, M / Zhang, T / Zhang, Y-H / Zhao, C / Zhou, M / Zhou, Z / Zhu, S J / Zhu, X J / Zimmerman, A B / Zucker, M E / Zweizig, J / Weinberg, N N

Physical review letters

2019 Volume 122, Issue 6, Page(s) 61104

Abstract: We analyze the impact of a proposed tidal instability coupling p modes and g modes within neutron ... we compute the Bayes factor (lnB_{!pg}^{pg}) comparing our p-g model to a standard one. We find ... that the observed signal is consistent with waveform models that neglect p-g effects, with lnB_{!pg}^{pg}=0.03_{-0 ...

Abstract	We analyze the impact of a proposed tidal instability coupling p modes and g modes within neutron stars on GW170817. This nonresonant instability transfers energy from the orbit of the binary to internal modes of the stars, accelerating the gravitational-wave driven inspiral. We model the impact of this instability on the phasing of the gravitational wave signal using three parameters per star: an overall amplitude, a saturation frequency, and a spectral index. Incorporating these additional parameters, we compute the Bayes factor (lnB_{!pg}^{pg}) comparing our p-g model to a standard one. We find that the observed signal is consistent with waveform models that neglect p-g effects, with lnB_{!pg}^{pg}=0.03_{-0.58}^{+0.70} (maximum a posteriori and 90% credible region). By injecting simulated signals that do not include p-g effects and recovering them with the p-g model, we show that there is a ≃50% probability of obtaining similar lnB_{!pg}^{pg} even when p-g effects are absent. We find that the p-g amplitude for 1.4 M_{⊙} neutron stars is constrained to less than a few tenths of the theoretical maximum, with maxima a posteriori near one-tenth this maximum and p-g saturation frequency ∼70 Hz. This suggests that there are less than a few hundred excited modes, assuming they all saturate by wave breaking. For comparison, theoretical upper bounds suggest ≲10^{3} modes saturate by wave breaking. Thus, the measured constraints only rule out extreme values of the p-g parameters. They also imply that the instability dissipates ≲10^{51} erg over the entire inspiral, i.e., less than a few percent of the energy radiated as gravitational waves.
Language	English
Publishing date	2019-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.122.061104
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Article: New Brilliant Blue G Derivative as Pharmacological Tool in Retinal Surgery.

Spadaro, Angelo / Rao, Marco / Lorenti, Miriam / Romano, Mario Rosario / Augello, Antonio / Eandi, Chiara Maria / Platania, Chiara Bianca Maria / Drago, Filippo / Bucolo, Claudio

Frontiers in pharmacology

2020 Volume 11, Page(s) 708

Abstract: Our study was aimed at assessing the retinal binding of a new synthetic Brilliant Blue G (BBG ... derivative (pure benzyl-Brilliant Blue G; PBB) ophthalmic formulation, to improve vitreoretinal surgery ...

Abstract	Our study was aimed at assessing the retinal binding of a new synthetic Brilliant Blue G (BBG) derivative (pure benzyl-Brilliant Blue G; PBB) ophthalmic formulation, to improve vitreoretinal surgery procedure. Protein affinity of the new molecule was evaluated
Language	English
Publishing date	2020-05-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.00708
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Article ; Online: Study of the MDM2 -410T-G polymorphism (rs2279744) by pyrosequencing in mothers of Down Syndrome subjects.

Salemi, Michele / Salluzzo, Maria Grazia / Barone, Concetta / Romano, Corrado

Human cell

2020 Volume 33, Issue 3, Page(s) 476–478

Abstract: ... in humans. MDM2 gene expression has a potential role as a risk factor for human aneuploidy. -410T-G ... polymorphism was detected by pyrosequencing technology. The distribution of MDM2-410T-G polymorphism showed no ... significant difference among mothers of subjects with DS and controls. Our results suggest that MDM2 -410T-G ...

Abstract	Trisomy 21 or Down syndrome (DS) is the most frequent genetic etiology of intellectual disability in humans. MDM2 gene expression has a potential role as a risk factor for human aneuploidy. -410T-G (rs2279744) functional polymorphism in MDM2 gene impacts on the mechanisms of chromosomal non-disjunction. We analyzed, within a case-control study, such polymorphism in mothers of subjects with DS. Nucleotide polymorphism was detected by pyrosequencing technology. The distribution of MDM2-410T-G polymorphism showed no significant difference among mothers of subjects with DS and controls. Our results suggest that MDM2 -410T-G polymorphism is not a risk factor for DS in mothers.
MeSH term(s)	Aneuploidy ; Case-Control Studies ; Down Syndrome/genetics ; Female ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Mothers ; Negative Results ; Polymorphism, Single Nucleotide/genetics ; Proto-Oncogene Proteins c-mdm2/genetics ; Risk Factors
Chemical Substances	MDM2 protein, human (EC 2.3.2.27) ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27)
Language	English
Publishing date	2020-05-18
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1149134-6
ISSN	1749-0774 ; 0914-7470
ISSN (online)	1749-0774
ISSN	0914-7470
DOI	10.1007/s13577-020-00374-2
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Article ; Online: Crosstalk between nuclear and G protein-coupled estrogen receptors.

Romano, Shannon N / Gorelick, Daniel A

General and comparative endocrinology

2017 Volume 261, Page(s) 190–197

Abstract: In 2005, two groups independently discovered that the G protein-coupled receptor GPR30 binds ... 2005), Thomas et al. (2005). GPR30 is now referred to as GPER, the G-protein coupled estrogen receptor ...

Abstract	In 2005, two groups independently discovered that the G protein-coupled receptor GPR30 binds estradiol in cultured cells and, in response, initiates intracellular signaling cascades Revankar et al. (2005), Thomas et al. (2005). GPR30 is now referred to as GPER, the G-protein coupled estrogen receptor Prossnitz and Arterburn (2015). While studies in animal models are illuminating GPER function, there is controversy as to whether GPER acts as an autonomous estrogen receptor in vivo, or whether GPER interacts with nuclear estrogen receptor signaling pathways in response to estrogens. Here, we review the evidence that GPER acts as an autonomous estrogen receptor in vivo and discuss experimental approaches to test this hypothesis directly. We propose that the degree to which GPER influences nuclear estrogen receptor signaling likely depends on cell type, developmental stage and pathology.
MeSH term(s)	Animals ; Cell Nucleus/metabolism ; Estradiol/metabolism ; Estrogens/metabolism ; Humans ; Receptor Cross-Talk/physiology ; Receptors, Estrogen/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction/physiology
Chemical Substances	Estrogens ; Receptors, Estrogen ; Receptors, G-Protein-Coupled ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2017-04-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1851-x
ISSN	1095-6840 ; 0016-6480
ISSN (online)	1095-6840
ISSN	0016-6480
DOI	10.1016/j.ygcen.2017.04.013
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Article ; Online: G protein-coupled estrogen receptor regulates embryonic heart rate in zebrafish.

Romano, Shannon N / Edwards, Hailey E / Souder, Jaclyn Paige / Ryan, Kevin J / Cui, Xiangqin / Gorelick, Daniel A

PLoS genetics

2017 Volume 13, Issue 10, Page(s) e1007069

Abstract: ... Estrogens also activate the G protein-coupled estrogen receptor (GPER), however the function of GPER in vivo ...

Abstract	Estrogens act by binding to estrogen receptors alpha and beta (ERα, ERβ), ligand-dependent transcription factors that play crucial roles in sex differentiation, tumor growth and cardiovascular physiology. Estrogens also activate the G protein-coupled estrogen receptor (GPER), however the function of GPER in vivo is less well understood. Here we find that GPER is required for normal heart rate in zebrafish embryos. Acute exposure to estrogens increased heart rate in wildtype and in ERα and ERβ mutant embryos but not in GPER mutants. GPER mutant embryos exhibited reduced basal heart rate, while heart rate was normal in ERα and ERβ mutants. We detected gper transcript in discrete regions of the brain and pituitary but not in the heart, suggesting that GPER acts centrally to regulate heart rate. In the pituitary, we observed gper expression in cells that regulate levels of thyroid hormone triiodothyronine (T3), a hormone known to increase heart rate. Compared to wild type, GPER mutants had reduced levels of T3 and estrogens, suggesting pituitary abnormalities. Exposure to exogenous T3, but not estradiol, rescued the reduced heart rate phenotype in gper mutant embryos, demonstrating that T3 acts downstream of GPER to regulate heart rate. Using genetic and mass spectrometry approaches, we find that GPER regulates maternal estrogen levels, which are required for normal embryonic heart rate. Our results demonstrate that estradiol plays a previously unappreciated role in the acute modulation of heart rate during zebrafish embryonic development and suggest that GPER regulates embryonic heart rate by altering maternal estrogen levels and embryonic T3 levels.
MeSH term(s)	Animals ; Embryo, Nonmammalian/drug effects ; Embryo, Nonmammalian/physiology ; Embryonic Development/drug effects ; Estradiol/administration & dosage ; Estrogens/analysis ; Gene Expression Regulation, Developmental/drug effects ; Heart Rate/physiology ; Mutation ; Pituitary Gland/drug effects ; Pituitary Gland/metabolism ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction/drug effects ; Triiodothyronine/analysis ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Chemical Substances	Estrogens ; Receptors, Estrogen ; Receptors, G-Protein-Coupled ; Zebrafish Proteins ; gper1 protein, zebrafish ; Triiodothyronine (06LU7C9H1V) ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2017-10-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1007069
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Article ; Online: Lumipulse G SARS-CoV-2 Ag Assay Evaluation for SARS-CoV-2 Antigen Detection Using 594 Nasopharyngeal Swab Samples from Different Testing Groups

Menchinelli, Giulia / Bordi, Licia / Marzialiotti, Flora / Palucci, Ivana / Capobianchi, Maria R. / Sberna, Giuseppe / Lalle, Eleonora / Romano, Lucio / De Angelis, Giulia / Marchetti, Simona / Sanguinetti, Maurizio / Cattani, Paola / Posteraro, Brunella

medRxiv

Abstract: Compared to RT-PCR, lower performance of antigen detection assays, including the Lumipulse G SARS ...

Abstract	Compared to RT-PCR, lower performance of antigen detection assays, including the Lumipulse G SARS-CoV-2 Ag assay, may depend on specific testing scenarios. We tested 594 nasopharyngeal swab samples from individuals with COVID-19 (RT-PCR cycle threshold [Ct] values ≤40) or non-COVID-19 (Ct values ≤40) diagnoses. RT-PCR positive samples were assigned to diagnostic, screening, or monitoring groups of testing. With a limit of detection of 1.2 × 10<sup>4</sup> SARS-CoV-2 RNA copies/ml, Lumipulse showed positive percent agreement (PPA) of 79.9% (155/194) and negative percent agreement of 99.3% (397/400), whereas PPAs were 100% for samples with Ct values of <18 or 18–<25 and 92.5% for samples with Ct values of 25–<30. By three groups, Lumipulse showed PPA of 87.0% (60/69), 81.1% (43/53), or 72.2% (52/72), respectively, whereas PPA was 100% for samples with Ct values of <18 or 18–<25, and was 94.4%, 80.0%, or 100% for samples with Ct values of 25–<30, respectively. RT-PCR positive samples were also tested for SARS-CoV-2 subgenomic RNA and, by three groups, testing showed that PPA was 63.8% (44/69), 62.3% (33/53), or 33.3% (24/72), respectively. PPAs dropped to 55.6%, 20.0%, or 41.7% for samples with Ct values of 25–<30, respectively. All 101 samples with a subgenomic RNA positive result had a Lumipulse assay’s antigen positive result, whereas only 54 (58.1%) of remaining 93 samples had a Lumipulse assay’s antigen positive result. In conclusion, Lumipulse assay was highly sensitive in samples with low RT-PCR Ct values, implying repeated testing to reduce consequences of false-negative results.
Keywords	covid19
Language	English
Publishing date	2021-01-29
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.01.26.21250533
Database	COVID19

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Article ; Online: Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes.

Chaturantabut, Saireudee / Shwartz, Arkadi / Evason, Kimberley J / Cox, Andrew G / Labella, Kyle / Schepers, Arnout G / Yang, Song / Acuña, Mariana / Houvras, Yariv / Mancio-Silva, Liliana / Romano, Shannon / Gorelick, Daniel A / Cohen, David E / Zon, Leonard I / Bhatia, Sangeeta N / North, Trista E / Goessling, Wolfram

Gastroenterology

2019 Volume 156, Issue 6, Page(s) 1788–1804.e13

Abstract: ... dimethylbenzanthrazene). Proliferation of human hepatocytes was measured in a coculture system. We measured levels of G ...

Abstract	Background & aims: Patients with cirrhosis are at high risk for hepatocellular carcinoma (HCC) and often have increased serum levels of estrogen. It is not clear how estrogen promotes hepatic growth. We investigated the effects of estrogen on hepatocyte proliferation during zebrafish development, liver regeneration, and carcinogenesis. We also studied human hepatocytes and liver tissues. Methods: Zebrafish were exposed to selective modifiers of estrogen signaling at larval and adult stages. Liver growth was assessed by gene expression, fluorescent imaging, and histologic analyses. We monitored liver regeneration after hepatocyte ablation and HCC development after administration of chemical carcinogens (dimethylbenzanthrazene). Proliferation of human hepatocytes was measured in a coculture system. We measured levels of G-protein-coupled estrogen receptor (GPER1) in HCC and nontumor liver tissues from 68 patients by immunohistochemistry. Results: Exposure to 17β-estradiol (E2) increased proliferation of hepatocytes and liver volume and mass in larval and adult zebrafish. Chemical genetic and epistasis experiments showed that GPER1 mediates the effects of E2 via the phosphoinositide 3-kinase-protein kinase B-mechanistic target of rapamycin pathway: gper1-knockout and mtor-knockout zebrafish did not increase liver growth in response to E2. HCC samples from patients had increased levels of GPER1 compared with nontumor tissue samples; estrogen promoted proliferation of human primary hepatocytes. Estrogen accelerated hepatocarcinogenesis specifically in male zebrafish. Chemical inhibition or genetic loss of GPER1 significantly reduced tumor development in the zebrafish. Conclusions: In an analysis of zebrafish and human liver cells and tissues, we found GPER1 to be a hepatic estrogen sensor that regulates liver growth during development, regeneration, and tumorigenesis. Inhibitors of GPER1 might be developed for liver cancer prevention or treatment. Transcript profiling: The accession number in the Gene Expression Omnibus is GSE92544.
MeSH term(s)	9,10-Dimethyl-1,2-benzanthracene ; Animals ; Carcinogenesis/drug effects ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; Estradiol/pharmacology ; Estrogens/pharmacology ; Female ; Gene Expression/drug effects ; Hepatocytes ; Humans ; Liver/growth & development ; Liver/metabolism ; Liver Cirrhosis/metabolism ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Liver Regeneration ; Male ; Organ Size/drug effects ; Phosphatidylinositol 3-Kinase/metabolism ; Receptors, Estrogen/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Sex Factors ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Tumor Burden/drug effects ; Zebrafish ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Chemical Substances	Estrogens ; GPER1 protein, human ; Receptors, Estrogen ; Receptors, G-Protein-Coupled ; Zebrafish Proteins ; gper1 protein, zebrafish ; Estradiol (4TI98Z838E) ; 9,10-Dimethyl-1,2-benzanthracene (57-97-6) ; MTOR protein, human (EC 2.7.1.1) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; mTOR protein, zebrafish (EC 2.7.11.1)
Language	English
Publishing date	2019-01-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2019.01.010
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