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Article: Qian-Zheng-San

Wang, Zhi-Yong / Qin, Li-Hua / Zhang, Wei-Guang / Zhang, Pei-Xun / Jiang, Bao-Guo

2019 Volume 14, Issue 4, Page(s) 683–691

Abstract: Qian-Zheng-San, a traditional Chinese prescription consisting of Typhonii Rhizoma, Bombyx ... However, it is unclear whether Qian-Zheng-San has therapeutic value for peripheral nerve injury ... by clamping the right sciatic nerve. Subsequently, rats in the treatment group were administered 2 mL Qian ...

Abstract	Qian-Zheng-San, a traditional Chinese prescription consisting of Typhonii Rhizoma, Bombyx Batryticatus, Scorpio, has been found to play an active therapeutic role in central nervous system diseases. However, it is unclear whether Qian-Zheng-San has therapeutic value for peripheral nerve injury. Therefore, we used Sprague-Dawley rats to investigate this. A sciatic nerve crush injury model was induced by clamping the right sciatic nerve. Subsequently, rats in the treatment group were administered 2 mL Qian-Zheng-San (1.75 g/mL) daily as systemic therapy for 1, 2, 4, or 8 weeks. Rats in the control group were not administered Qian-Zheng-San. Rats in sham group did not undergo surgery and systemic therapy. Footprint analysis was used to assess nerve motor function. Electrophysiological experiments were used to detect nerve conduction function. Immunofluorescence staining was used to assess axon counts and morphological analysis. Immunohistochemical staining was used to observe myelin regeneration of the sciatic nerve and the number of motoneurons in the anterior horn of the spinal cord. At 2 and 4 weeks postoperatively, the sciatic nerve function index, nerve conduction velocity, the number of distant regenerated axons and the axon diameter of the sciatic nerve increased in the Qian-Zheng-San treatment group compared with the control group. At 2 weeks postoperatively, nerve fiber diameter, myelin thickness, and the number of motor neurons in the lumbar spinal cord anterior horn increased in the Qian-Zheng-San treatment group compared with the control group. These results indicate that Qian-Zheng-San has a positive effect on peripheral nerve regeneration.
Language	English
Publishing date	2019-01-15
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.247472
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Qian Yang Yu Yin Granule Improves Renal Injury of Hypertension by Regulating Metabolic Reprogramming Mediated by HIF-1α/PKM2 Positive Feedback Loop.

Qian, Lichao / Ren, Shuai / Xu, Zhongchi / Zheng, Yawei / Wu, Lihua / Yang, Ying / Wang, Yixuan / Li, Jie / Yan, Shihai / Fang, Zhuyuan

Frontiers in pharmacology

2021 Volume 12, Page(s) 667433

Abstract: ... nephropathy. In this study, the effects of Qian Yang Yu Yin granule (QYYY) on spontaneously hypertensive rats ...

Abstract	Protection against hypoxia injury is an important therapeutic strategy for treating hypertensive nephropathy. In this study, the effects of Qian Yang Yu Yin granule (QYYY) on spontaneously hypertensive rats fed with high salt diet and HEK293T cells exposed to hypoxia were investigated. After eight weeks' treatment of QYYY, blood pressure, serum creatinine, serum cystatin C, blood urea nitrogen, urinary β2-microglobulin, urinary N-acetyl-β-glucosaminidase, and urinary microalbumin were assessed. The changes of hypoxia-inducible factor-1α (HIF-1α), pyruvate kinase M2 (PKM2), glucose transport 1 (GLUT1), lactate dehydrogenase A (LDH-A), connective tissue growth factor (CTGF), transforming growth factor-β1 (TGF-β1), ATP, lactate, pyruvate, and pathology were also assessed
Language	English
Publishing date	2021-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.667433
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Article ; Online: Study on Fu-Fang-Jin-Qian-Cao Inhibiting Autophagy in Calcium Oxalate-induced Renal Injury by UHPLC/Q-TOF-MS-based Metabonomics and Network Pharmacology Approaches.

Liu, Wen-Rui / Li, Mao-Ting / Zhou, Qi / Gao, Song-Yan / Hou, Jie-Bin / Yang, Guo-Bin / Liu, Nan-Mei / Jia-Yan / Yu, Jian-Peng / Cheng, Jin / Guo, Zhi-Yong

Combinatorial chemistry & high throughput screening

2024 Volume 27, Issue 1, Page(s) 90–100

Abstract: Introduction: Fu-Fang-Jin-Qian-Cao is a Chinese herbal preparation used to treat urinary calculi ... Fu-Fang-Jin-Qian-Cao can protect renal tubular epithelial cells from calcium oxalateinduced renal ... pharmacology to study the mechanism of Fu-Fang-Jin-Qian-Cao inhibiting autophagy in calcium oxalate-induced ...

Abstract	Introduction: Fu-Fang-Jin-Qian-Cao is a Chinese herbal preparation used to treat urinary calculi. Fu-Fang-Jin-Qian-Cao can protect renal tubular epithelial cells from calcium oxalateinduced renal injury by inhibiting ROS-mediated autopathy. The mechanism still needs further exploration. Metabonomics is a new subject; the combination of metabolomics and network pharmacology can find pathways for drugs to act on targets more efficiently. Methods: Comprehensive metabolomics and network pharmacology to study the mechanism of Fu-Fang-Jin-Qian-Cao inhibiting autophagy in calcium oxalate-induced renal injury. Based on UHPLC-Q-TOF-MS, combined with biochemical analysis, a mice model of Calcium oxalateinduced renal injury was established to study the therapeutic effect of Fu-Fang-Jin-Qian-Cao. Based on the network pharmacology, the target signaling pathway and the protective effect of Fu- Fang-Jin-Qian-Cao on Calcium oxalate-induced renal injury by inhibiting autophagy were explored. Autophagy-related proteins LC3-II, BECN1, ATG5, and ATG7 were studied by immunohistochemistry. Results: Combining network pharmacology and metabolomics, 50 differential metabolites and 2482 targets related to these metabolites were found. Subsequently, the targets enriched in PI3KAkt, MAPK and Ras signaling pathways. LC3-II, BECN1, ATG5 and ATG7 were up-regulated in Calcium oxalate-induced renal injury. All of them could be reversed after the Fu-Fang-Jin-Qian- Cao treatment. Conclusions: Fu-Fang-Jin-Qian-Cao can reverse ROS-induced activation of the MAPK signaling pathway and inhibition of the PI3K-Akt signaling pathway, thereby reducing autophagy damage of renal tubular epithelial cells in Calcium oxalate-induced renal injury.
MeSH term(s)	Mice ; Animals ; Calcium Oxalate/metabolism ; Calcium Oxalate/pharmacology ; Calcium/metabolism ; Chromatography, High Pressure Liquid ; Network Pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Reactive Oxygen Species/metabolism ; Kidney/metabolism ; Autophagy ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/metabolism
Chemical Substances	Calcium Oxalate (2612HC57YE) ; Calcium (SY7Q814VUP) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Reactive Oxygen Species ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-01-12
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/1386207326666230515151302
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Article ; Online: Exploring the mechanism of action of Qian Lie Xing Fang during the treatment of benign prostatic hyperplasia via network pharmacology and molecular dynamics simulation analyses.

Xiang, Jingjing / Li, Zefei / Wang, Chaoyang

Medicine

2023 Volume 102, Issue 42, Page(s) e35540

Abstract: ... with Qian Lie Xing Fang (QLXF) via the warming and tonifying of kidney yang, promotion of blood circulation ...

Abstract	This study aimed to explore the historical research progress on benign prostatic hyperplasia from the perspective of traditional Chinese medicine theory and the treatment of benign prostatic hyperplasia (BPH) with Qian Lie Xing Fang (QLXF) via the warming and tonifying of kidney yang, promotion of blood circulation, and clearing of meridians. First, network pharmacology analysis was used to screen and identify possible pathways for BPH treatment with QLXF. Subsequently, molecular docking analysis helped explore the mechanism of action by which the components of QLXF affected androgen receptor (AR) and type 5 phosphodiesterase inhibitor (PDE-5) levels. Targets for treatment with QLXF were identified from the online Mendelian inheritance in man and DisGeNET databases. BPH-related genes were identified using GeneCards and online Mendelian inheritance in man databases, and their intersection was used to construct a protein-protein interaction network analysis graph. Subsequently, gene ontology and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analyses were performed. The semiflexible docking of the ingredients of QLXF acting on the 2 targets was performed via molecular docking and molecular dynamics simulation, to elucidate the mechanism of action by which the active ingredients affect AR and PDE-5 levels further. This enabled us to explore the pattern of interactions between small active ingredient molecules, the target protein, and the stability after binding at the microscopic level. Gene ontology enrichment analysis showed that QLXF affected several processes, such as DNA transcription factor binding, kinase binding, protein homodimerization activity, protein structure domain-specific binding, and protein-coupled amine receptor activity in BPH patients. KEGG results showed that chemical carcinogenic reactive oxidative species and the JAK-STAT, Pl3k-Akt, FoxO, NF-κB, and other pathways were significantly enriched. Conducting molecular docking studies to investigate the interaction of active components from QLXF with AR and PDE-5, it was found that MOL002260 may possess the potential to inhibit PDE-5 activity, while MOL010578 may exhibit the capability to inhibit AR activity. QLXF is closely associated with various biological processes and KEGG signaling pathways related to BPH. The active ingredients of QLXF were investigated for their interactions with AR and PDE-5, with a primary focus on the small molecules MOL002260 and MOL010578.
MeSH term(s)	Humans ; Male ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Network Pharmacology ; Prostatic Hyperplasia/drug therapy ; Prostatic Hyperplasia/genetics ; Databases, Genetic ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000035540
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Article ; Online: Qian Yang Yu Yin granule improves hypertensive renal damage: A potential role for TRPC6-CaMKKβ-AMPK-mTOR-mediated autophagy.

Ma, Siqi / Xu, Junyao / Zheng, Yawei / Li, Yin / Wang, Yixuan / Li, Haitao / Fang, Zhuyuan / Li, Jie

Journal of ethnopharmacology

2022 Volume 302, Issue Pt A, Page(s) 115878

Abstract: Ethnopharmacological relevance: Qian Yang Yu Yin granules (QYYYG) have a long history ...

Abstract	Ethnopharmacological relevance: Qian Yang Yu Yin granules (QYYYG) have a long history in the treatment of hypertensive renal damage (HRD) in China. Clinical studies have found that QYYYG stabilizes blood pressure and prevents early renal damage. However, the exact mechanism is not entirely clear. Aim of the study: To evaluate the therapeutic effect and further explore the therapeutic mechanism of QYYYG against HRD. Materials and methods: The efficacy of QYYYG in treating HRD was assessed in spontaneous hypertension rats (SHR). Renal autophagy and the TRPC6-CaMKKβ-AMPK pathway in rats were evaluated. The regulatory role of QYYYG in angiotensin II (Ang II) induced abnormal autophagy in rat podocytes was determined by detecting autophagy-related proteins, intracellular Ca Results: QYYYG alleviated HRD and reversed the abnormal expression of autophagy-related genes in the SHR. In vitro, QYYYG protected against Ang II-induced podocyte damage. Furthermore, treatment of podocytes with QYYYG reversed Ang II-induced autophagy and inhibited Ang II-stimulated TRPC6 activation, Ca Conclusions: The present study suggested that QYYYG may exert its HRD protective effects in part by regulating the abnormal autophagy of podocytes through the TRPC6-CaMKKβ-AMPK-mTOR pathway.
MeSH term(s)	Animals ; Rats ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/metabolism ; TRPC6 Cation Channel/metabolism ; AMP-Activated Protein Kinases/metabolism ; Calcium/metabolism ; Autophagy ; TOR Serine-Threonine Kinases/metabolism ; Podocytes ; Angiotensin II/metabolism ; Hypertension/drug therapy ; Hypertension/metabolism ; TRPC Cation Channels/genetics ; TRPC Cation Channels/metabolism ; TRPC Cation Channels/pharmacology
Chemical Substances	Calcium-Calmodulin-Dependent Protein Kinase Kinase (EC 2.7.11.17) ; TRPC6 Cation Channel ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; qian yang yu yin granule ; Calcium (SY7Q814VUP) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Angiotensin II (11128-99-7) ; mTOR protein, rat (EC 2.7.1.1) ; Trpc6 protein, rat ; TRPC Cation Channels
Language	English
Publishing date	2022-10-29
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115878
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Article ; Online: Cluster analysis of Qian Jing-hua's experience in treatment of lung cancer

Zhi-Li Guo / Jing-Hua Qian / Yi-Ping Fan / Kai-Tao Luo / Hong-Sheng Ding

TMR Theory and Hypothesis, Vol 1, Iss 3, Pp 54-

2018 Volume 62

Abstract: Objective to analyze the rule of drug use in treating lung cancer disease by using the theory of fuzheng and dispelling evil in traditional Chinese medicine by data mining. Methods: By following Dr. Qianjinghua's outpatient department, we collected the ... ...

Abstract	Objective to analyze the rule of drug use in treating lung cancer disease by using the theory of fuzheng and dispelling evil in traditional Chinese medicine by data mining. Methods: By following Dr. Qianjinghua's outpatient department, we collected the prescription for the treatment of lung cancer by using frequency analysis, association rule analysis and cluster analysis. Results: 746 prescriptions were included in this study, commonly used drugs 170 flavors. Traditional Chinese medicine with a high frequency of use were Baihuasheshecao (Hedyotis diffusa), Maorenshen (Actinidia valvata Dunn), Shishangbai (Selaginella doederleinii Hieron), Shijianchuan (Salvia chinensis Benth), Huangqi (Astragali Radix), Sanyeqing (Tetrastlgma hemsleyanum), Baimaoteng (HerbaSolani), Zhuling (Polyporus), Nvzhenzi (Ligustrum lucidum Ait) etc. Through the analysis of association rule, we find out the core prescription according to the support degree (10 %, 20 %, 30 %) and the confidence degree, and set the correlation degree to 8 and punishment degree to 2. Finally: The core prescription efficacy of the drug group was analyzed and the theoretical connotation of preventive treatment of disease was obtained. Conclusion: The core prescription of preventive treatment of disease is to clear up heat and detoxification on the basis of strengthening the spleen, replenishing qi and tonifying kidney. The use of blood supplements and yin tonics throughout the course is reduced during treatments. The treatments also pay attention to the function of spleen and stomach of lung cancer patients, and adjust heat and detoxification force according to different conditions of patients and pay attention to the relief of patients’ emotions.
Keywords	Data mining technology ; Lung cancer ; Help the right and remove evil spirits ; Association rules ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	TMR publishing group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of Fusu mixture (Wen-Shen-Qian-Yang Method) on sepsis-induced acute respiratory distress syndrome.

Zhang, Li / Long, Kunlan / Wang, Chunxia / Zhang, Xuemei / Yang, Hongjing / Chen, Jun / Li, Xue / Gao, Peiyang / Zhang, Song

Medicine

2020 Volume 99, Issue 29, Page(s) e21066

Abstract: Introduction: Sepsis is the most common etiology of acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Capillary leakage caused by lung endothelial injury is the central cause of ARDS. The results of research in modern medicine in ... ...

Abstract	Introduction: Sepsis is the most common etiology of acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Capillary leakage caused by lung endothelial injury is the central cause of ARDS. The results of research in modern medicine in reducing endothelial damage and restoring endothelial functions are limited. In the previous clinical observations, we found that the Fusu mixture not only improves the clinical symptoms but also reduces the leakage of pulmonary capillaries. Therefore, the purpose of this study is to determine the clinical efficacy of the Fusu mixture combined with Western medicine in the treatment of ARDS caused by sepsis and to explore the mechanism of traditional Chinese medicine. Methods: This is a prospective, single-center, randomized, single-blind, and controlled clinical study involving 620 eligible patients. The patients will be randomly divided into 2 groups: the Western medicine treatment group and the combination of Chinese and Western medicine treatment group. After 14 days of intervention, the clinical efficacy and safety of the Fusu mixture on sepsis-induced ARDS patients will be observed. The primary outcome will be measured as 28-day mortality. The secondary outcome indices include inflammatory markers (CRP, PCT, IL-6, TNF - α), APACHE II score, SOFA score, days without a ventilator, blood gas analysis (Lac, PaO2 / FiO2), intensive care unit hospital stay time, intensive care unit mortality. Simultaneously, the analysis of the exploratory results will be carried out to analyze the possible mechanism of Fusu mixture in the treatment of sepsis-induced ARDS by the high-throughput sequencing and bioinformatics. Discussion: The purpose of this study is to evaluate the clinical efficacy of Fusu mixture in the treatment of sepsis-induced ARDS and explore its possible mechanism of action. If successful, it will provide evidence-based adjuvant therapy for the clinical treatment of ARDS.
MeSH term(s)	Adult ; Blood Gas Analysis ; Capillary Leak Syndrome/complications ; Capillary Leak Syndrome/etiology ; Female ; Humans ; Male ; Medicine, Chinese Traditional/methods ; Medicine, Chinese Traditional/standards ; Middle Aged ; Prospective Studies ; Respiratory Distress Syndrome/drug therapy ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/physiopathology ; Sepsis/complications ; Sepsis/drug therapy ; Sepsis/physiopathology ; Single-Blind Method ; Treatment Outcome
Language	English
Publishing date	2020-04-16
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000021066
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Article ; Online: Therapeutic effects of Lactobacillus casei Qian treatment in activated carbon-induced constipated mice.

Zhao, Xin / Suo, Hua-Yi / Qian, Yu / Li, Gui-Jie / Liu, Zhen-Hu / Li, Jian

Molecular medicine reports

2015 Volume 12, Issue 2, Page(s) 3191–3199

Abstract: In the present study, the therapeutic effects of Lactobacillus casei Qian (LC-Qian), the key ... were treated with LC-Qian for nine days by oral administration. The body weight, defecation status ... Lactobacillus bulgaricus (LB)-treated, LC-Qian (L)-and LC-Qian (H)-treated mice was 93, 231, 121, 194, 172 and 157 min ...

Abstract	In the present study, the therapeutic effects of Lactobacillus casei Qian (LC-Qian), the key microorganism in Tibetan yak yoghurt, on activated carbon-induced constipation were determined in vivo. ICR mice were treated with LC-Qian for nine days by oral administration. The body weight, defecation status, gastrointestinal transit and defecation time of mice were assessed, and the serum levels of motilin (MTL), gastrin (Gas), endothelin (ET), somatostatin (SS), acetylcholinesterase (AChE), substance P (SP) and vasoactive intestinal peptide (VIP) were further evaluated. Bisacodyl was used as the positive control. The time until the first black stool defecation following carbon intake of the normal, control, 100 mg/kg bisacodyl-treated, Lactobacillus bulgaricus (LB)-treated, LC-Qian (L)-and LC-Qian (H)-treated mice was 93, 231, 121, 194, 172 and 157 min, respectively. Following treatment with LC-Qian, the gastrointestinal transit was increased to 52.4% [LC-Qian (L)] and 65.8% [LC-Qian (H)], while that in the group treated with the common lactic acid bacteria of LB was 40.3%. The MTL, Gas, ET, AChE, SP and VIP serum levels were significantly increased and levels of SS were reduced in mice following LC-Qian treatment compared with those in the control mice (P<0.05). Reverse transcription quantitative polymerase chain reaction indicated that LC-Qian raised the c-Kit, GDNF as well as SCF mRNA expression levels and reduced the TRPV1 and NOS expression levels in tissue of the small intestine in mice. These results suggested that lactic acid bacteria prevent constipation in mice, among which LC-Qian was the most effective.
MeSH term(s)	Acetylcholinesterase/genetics ; Acetylcholinesterase/metabolism ; Animals ; Body Weight/drug effects ; Carbon ; Constipation/chemically induced ; Constipation/diet therapy ; Constipation/genetics ; Constipation/physiopathology ; Defecation/drug effects ; Endothelins/genetics ; Endothelins/metabolism ; Female ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; Gastrins/genetics ; Gastrins/metabolism ; Gastrointestinal Transit/drug effects ; Gene Expression/drug effects ; Glial Cell Line-Derived Neurotrophic Factor/genetics ; Glial Cell Line-Derived Neurotrophic Factor/metabolism ; Intestine, Small/drug effects ; Intestine, Small/metabolism ; Intestine, Small/physiopathology ; Lactobacillus casei/physiology ; Mice ; Mice, Inbred ICR ; Motilin/genetics ; Motilin/metabolism ; Probiotics/pharmacology ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Somatostatin/genetics ; Somatostatin/metabolism ; Substance P/genetics ; Substance P/metabolism ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism ; Vasoactive Intestinal Peptide/genetics ; Vasoactive Intestinal Peptide/metabolism
Chemical Substances	Endothelins ; GPI-Linked Proteins ; Gastrins ; Glial Cell Line-Derived Neurotrophic Factor ; TRPV Cation Channels ; TRPV1 protein, mouse ; Substance P (33507-63-0) ; Vasoactive Intestinal Peptide (37221-79-7) ; Somatostatin (51110-01-1) ; Motilin (52906-92-0) ; Carbon (7440-44-0) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1) ; Acetylcholinesterase (EC 3.1.1.7) ; Ache protein, mouse (EC 3.1.1.7)
Language	English
Publishing date	2015-08
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1791-3004
ISSN (online)	1791-3004
DOI	10.3892/mmr.2015.3737
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Article ; Online: Qian lie an suppository (prostant) for chronic prostatitis: A systematic review and meta-analysis of randomized controlled trials.

Hui-Juan, Cao / Shi-Bing, Liang / Jian-Ping, Liu / Bin, Wang / Hai-Song, Li / Ji-Sheng, Wang / Si-Qi, Guan / Yu-Tian, Zhu / Heng-Heng, Dai / Chun-Yu, Zhou

Medicine

2019 Volume 98, Issue 14, Page(s) e15072

Abstract: ... for the treatment of CP is limited.: Objectives: This review evaluated the effectiveness and safety of Qian Lie ...

Abstract	Background: Chronic prostatitis (CP) is an inflammation of the prostate gland that seriously affects the quality of life of patients. The existing evidence of antibiotics and α-blockers for the treatment of CP is limited. Objectives: This review evaluated the effectiveness and safety of Qian Lie An Suppository (Prostant) in treating CP. Methods: Randomized controlled trials comparing Prostant (alone or plus the control) with placebo, conventional drugs, or nonpharmaceutical therapies for CP were included in this article through searching from 6 databases. Data were analyzed using RevMan 5.3 software. Meta-analysis was performed when the clinical or statistical heterogeneity was found acceptable among trials. Estimate effects were present with risk ratio (RR) or mean difference and their 95% confidence interval (CI) for dichotomies or continuous variables. Quality of the evidence for each primary outcome was assessed using GRADE criteria. Results: Totally 21 trials involving 3359 participants were included. There were 2 included trials had unclear risk of bias, and the remaining trials had high risk of bias. Meta-analyses showed the number of cured patients in the Prostant group was 2 times more than that of the placebo (RR 2.05, 95%CI 1.10 to 3.81) or antibiotics (RR 1.95, 95%CI 1.18 to 3.23) groups. Similar results were found when Prostant in combination with antibiotics or hyperthermia compared with the antibiotics (RR 1.78, 95% CI 1.10-2.89) or hyperthermia (RR 1.72, 95% CI 1.23-2.40) alone. However, there was no difference in the number of cured patients between Prostant and α-blockers or hyperthermia therapy. No severe adverse event was reported in all included trials. The main adverse events in Prostant group were reported (in 8 included trials) as diarrhea and anal discomfort. Conclusions: Low-quality evidence showed that the Prostant may have add-on effect for patients with CP on increasing the number of cured patients, relieving pain, and improving the quality of life. There is not sufficient evidence to determine the effectiveness and safety of Prostant for the treatment of CP compared with placebo, antibiotics, α-blockers or the hyperthermia therapy.
MeSH term(s)	Administration, Rectal ; Anti-Bacterial Agents/therapeutic use ; Chronic Disease ; Drug Therapy, Combination ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/adverse effects ; Humans ; Male ; Prostatitis/drug therapy ; Quality of Life ; Randomized Controlled Trials as Topic ; Suppositories
Chemical Substances	Anti-Bacterial Agents ; Drugs, Chinese Herbal ; Suppositories ; prostant
Language	English
Publishing date	2019-04-03
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000015072
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Article ; Online: Noise does not equal bias in assessing the evolutionary history of the angiosperm flora of China: A response to Qian (2019)

Lu, Li‐Min / Hu, Hai‐Hua / Peng, Dan‐Xiao / Liu, Bing / Ye, Jian‐Fei / Yang, Tuo / Li, Hong‐Lei / Sun, Miao / Smith, Stephen A. / Soltis, Pamela S. / Soltis, Douglas E. / Chen, Zhi‐Duan

Journal of biogeography. 2020 Oct., v. 47, no. 10 p.2286-2291

2020

Abstract: In response to our paper on the evolutionary history of the Chinese flora, Qian suggests ... al (2018). Here, we consider Qian's specific criticisms, explore the extent of uncertainty ...

Abstract	In response to our paper on the evolutionary history of the Chinese flora, Qian suggests that certain features of the divergence time estimation employed might have led to biased conclusions in Lu et al (2018). Here, we consider Qian's specific criticisms, explore the extent of uncertainty in the data and demonstrate that (i) no systematic bias toward dates that are too young or too old is detected in Lu et al.; (ii) constraint of the crown age of angiosperms does not bias the generic ages estimated by Lu et al.; and (iii) ages derived from the Chinese regional phylogeny do not bias the conclusions reported by Lu et al. All these analyses confirm that the conclusions reported previously are robust. We argue that, like many large‐scale biodiversity analyses, sources of noise in divergence time estimation are to be expected, but these should not be confused with bias.
Keywords	Angiospermae ; biodiversity ; biogeography ; flora ; phylogeny ; uncertainty ; China
Language	English
Dates of publication	2020-10
Size	p. 2286-2291.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	NAL-AP-2-clean ; LETTER
ZDB-ID	188963-1
ISSN	0305-0270
ISSN	0305-0270
DOI	10.1111/jbi.13947
Database	NAL-Catalogue (AGRICOLA)

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