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  1. Article: Metastatic Pancreatic Cancer: Where Are We?

    Hernández-Blanquisett, Abraham / Quintero-Carreño, Valeria / Martínez-Ávila, María Cristina / Porto, María / Manzur-Barbur, María Carolina / Buendía, Emiro

    Oncology reviews

    2024  Volume 17, Page(s) 11364

    Abstract: Pancreatic cancer is one of the most lethal neoplasms worldwide; it is aggressive in nature and has a poor prognosis. The overall survival rate for pancreatic cancer is low. Most patients present non-specific symptoms in the advanced stages, which ... ...

    Abstract Pancreatic cancer is one of the most lethal neoplasms worldwide; it is aggressive in nature and has a poor prognosis. The overall survival rate for pancreatic cancer is low. Most patients present non-specific symptoms in the advanced stages, which generally leads to late diagnosis, at which point there is no option for curative surgery. The treatment of metastatic pancreatic cancer includes systemic therapy, in some cases radiotherapy, and more recently, molecular targeted therapies, which can positively impact cancer control and improve quality of life. This review provides an overview of the molecular landscape of pancreatic cancer based on the most recent literature, as well as current treatment options for patients with metastatic pancreatic cancer.
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2390302-8
    ISSN 1970-5565 ; 1970-5565 ; 1970-5557
    ISSN (online) 1970-5565
    ISSN 1970-5565 ; 1970-5557
    DOI 10.3389/or.2023.11364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hemocromatosis no ligada al gen HFE: a propósito de un caso.

    Martínez-Ávila, María Cristina / Toro-Trujillo, Esteban / Alvarez-Londoño, Angelina

    Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru

    2022  Volume 41, Issue 4, Page(s) 261–264

    Abstract: Hereditary hemochromatosis (HH) consists of a progressive iron overload that leads to an abnormal accumulation of iron in different target organs; and, if not treated in time, can cause multi-organ dysfunction. Various genetic mutations associated with ... ...

    Title translation Non-HFE hemochromatosis: a case report.
    Abstract Hereditary hemochromatosis (HH) consists of a progressive iron overload that leads to an abnormal accumulation of iron in different target organs; and, if not treated in time, can cause multi-organ dysfunction. Various genetic mutations associated with HH have been described, the most frequent is associated with the HFE-gene, which is found in 90% of cases. At present, therapeutic phlebotomy continues to be the treatment of choice for the management of this pathology. We report the case of a patient under follow-up for severe liver fibrosis, with persistence of a high ferrokinetic profile, who five years later was diagnosed with HH not associated to a mutation in the HFE-gene; He was managed with periodic phlebotomies, rapidly presenting a significant clinical improvement and decrease of ferritin levels.
    MeSH term(s) Hemochromatosis/complications ; Hemochromatosis/diagnosis ; Hemochromatosis/genetics ; Hemochromatosis Protein/genetics ; Humans ; Iron Overload/diagnosis ; Iron Overload/genetics ; Male ; Mutation ; Phlebotomy
    Chemical Substances Hemochromatosis Protein
    Language Spanish
    Publishing date 2022-06-02
    Publishing country Peru
    Document type Case Reports ; Journal Article
    ZDB-ID 2058591-3
    ISSN 1609-722X ; 1609-722X
    ISSN (online) 1609-722X
    ISSN 1609-722X
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  3. Article: Concurrent Dengue-Malaria Infection: The Importance of Acute Febrile Illness in Endemic Zones.

    González-Macea, Orlando / Martínez-Ávila, María Cristina / Pérez, Marien / Tibocha Gordon, Ingrid / Arroyo Salgado, Bárbara

    Clinical medicine insights. Case reports

    2023  Volume 16, Page(s) 11795476221144585

    Abstract: Context: Acute febrile disease (AFI) in endemic tropical areas is a frequent reason for consulting the emergency services. Infection by 2 or more etiological agents may modify clinical and laboratory parameters, making diagnosis and treatment a ... ...

    Abstract Context: Acute febrile disease (AFI) in endemic tropical areas is a frequent reason for consulting the emergency services. Infection by 2 or more etiological agents may modify clinical and laboratory parameters, making diagnosis and treatment a challenge.
    Case report: We report the case of a patient who came from Africa and consults in Colombia, with AFI with thrombocytopenia that was eventually diagnosed to have concurrent infection with
    Conclusions: Dengue-malaria coinfection infection reports are scarce; it should be suspected in patients living or returning from areas where both diseases are endemic or during dengue outbreaks. This case serves as a reminder of this important condition that causes high morbidity and mortality if it is not early diagnosed and treated.
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2580498-4
    ISSN 1179-5476
    ISSN 1179-5476
    DOI 10.1177/11795476221144585
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  4. Article: Toxic Hepatitis Associated With the Use of Contraceptives: A Diagnosis to Bear in Mind.

    Blanquicett, Alejandro / Martinez-Ávila, Maria Cristina / Mondol, Zulay / Imbeth Acosta, Pedro

    Cureus

    2022  Volume 14, Issue 1, Page(s) e21220

    Abstract: Drug-induced liver injury (DILI) is a rare condition with a high burden of morbidity and risk of severe complications that may even require liver transplantation to survive. There are no pathognomonic diagnostic tests for this condition, thus being a ... ...

    Abstract Drug-induced liver injury (DILI) is a rare condition with a high burden of morbidity and risk of severe complications that may even require liver transplantation to survive. There are no pathognomonic diagnostic tests for this condition, thus being a challenge it is considered a diagnosis of exclusion. We present the case of a patient who, after starting intramuscular contraceptives, presented with acute alteration of liver function that requires the ruling out of multiple pathologies that could be the cause of the biochemical findings. With the pharmacological suspension and initiation of support measures, full recovery was achieved.
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.21220
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  5. Article ; Online: Late Infective Endocarditis Associated with an Atrial Septal Defect Occluder Device.

    Mejía Sanjuanelo, Ana Milena / Manzur Barbur, María Carolina / Martínez-Ávila, María Cristina / García Domínguez, Juan Camilo

    European journal of case reports in internal medicine

    2022  Volume 9, Issue 3, Page(s) 3238

    Abstract: The Amplatzer septal occluder is one of several percutaneous devices used for the closure of secundum atrial septal defects. The main complications are related to the procedure, with infection being the least common. We present the case of a 67-year-old ... ...

    Abstract The Amplatzer septal occluder is one of several percutaneous devices used for the closure of secundum atrial septal defects. The main complications are related to the procedure, with infection being the least common. We present the case of a 67-year-old woman with a secundum atrial septal defect, who, 3 years after repair with an Amplatzer occluder, was admitted with sepsis and bacteraemia following recent hospitalization in an intensive care unit. Transoesophageal echocardiography showed the presence of a mobile echogenic structure in the left atrium suggestive of a vegetation. Few cases of late endocarditis involving the Amplatzer device have been reported, even though partial endothelization is one of the risk factors. There are no guidelines for the prevention, diagnosis or management of this complication.
    Learning points: The Amplatzer septal occluder is one of several alternatives for the closure of atrial septal defects and has few related complications, with infection being the least common.Device-related endocarditis presents either early (<6 months) or late (>6 months).In our case, transoesophageal echocardiography played a key role in the diagnosis of late endocarditis.
    Language English
    Publishing date 2022-03-15
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2022_003238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Menstrual cycle disturbances after COVID-19 vaccination.

    Rodríguez Quejada, Luisa / Toro Wills, María Fernanda / Martínez-Ávila, María Cristina / Patiño-Aldana, Andrés Felipe

    Women's health (London, England)

    2022  Volume 18, Page(s) 17455057221109375

    Abstract: Introduction: After COVID-19 vaccination, women of reproductive age reported changes in their menstrual cycle.: Materials and methods: A retrospective study was carried out after a survey on social networks that included women aged 18-41 years with ... ...

    Abstract Introduction: After COVID-19 vaccination, women of reproductive age reported changes in their menstrual cycle.
    Materials and methods: A retrospective study was carried out after a survey on social networks that included women aged 18-41 years with normal cycles according to International Federation of Gynecology and Obstetrics and who were vaccinated (complete schedule for two doses, except J&J/Janssen or incomplete with a single dose). Women with following conditions were excluded: pregnant or lactating women; history of diseases that cause menstrual irregularities or early menopause: anorexia, bulimia, polycystic ovary syndrome, hypothyroidism, obesity, or low weight; hysterectomized or oophorectomized patients; and high performance athletes.
    Results: Overall, 950 women completed the survey between July and September 2021. In total, 408 women met the inclusion criteria, and 184 reported the following characteristics: frequency (normal 43.47%, infrequent 25%, and frequent 31.53%), regularity (regular 51.08%, irregular 42.93%, and absent/amenorrhea 5.97%), duration (normal 65.21%, prolonged 26.08%, absent/amenorrhea 8.69%), and volume (heavy 41.84%, light 20.65%, and absent/amenorrhea 6.52%).
    Conclusions: SARS-CoV-2 infection and COVID-19 vaccination can influence the menstrual cycle and cause alterations.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Female ; Humans ; Menstrual Cycle ; Menstruation Disturbances/chemically induced ; Retrospective Studies ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274503-8
    ISSN 1745-5065 ; 1745-5057
    ISSN (online) 1745-5065
    ISSN 1745-5057
    DOI 10.1177/17455057221109375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6629: Show issues Location:
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  7. Article ; Online: Acute ST-segment elevation myocardial infarction: to be or not to be?

    Barbur, Maria Carolina Manzur / Martínez-Ávila, Maria Cristina / Madero, Angélica Imitola / Nuñez, José Fernando García / Dominguez, Juan Camilo Garcia

    Archive of clinical cases

    2022  Volume 9, Issue 1, Page(s) 19–23

    Abstract: Calcium has a significant effect on cells in the myocardium, affecting conduction, intracellular signaling and contraction of muscle fibers. In fact, calcium levels could affect myocardial action potential and affect heart conduction. Hypocalcemia ... ...

    Abstract Calcium has a significant effect on cells in the myocardium, affecting conduction, intracellular signaling and contraction of muscle fibers. In fact, calcium levels could affect myocardial action potential and affect heart conduction. Hypocalcemia manifest on ECG with arrythmias or QT prolongation, in some extraordinary cases, it could present with variations in the ST segment, which requires the study of differential diagnoses of cardiac origin, such as acute myocardial infarction with ST elevation (STEMI) or pericarditis. We expose a case of a 28-year-old male patient who arrived at the emergency department with chest pain and was misdiagnosed with STEMI, after a complex process finally it was a severe hypocalcemia mimicking acute myocardial infarction.
    Language English
    Publishing date 2022-04-06
    Publishing country Romania
    Document type Case Reports
    ZDB-ID 2788093-X
    ISSN 2360-6975 ; 2360-6975
    ISSN (online) 2360-6975
    ISSN 2360-6975
    DOI 10.22551/2022.34.0901.10198
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  8. Article ; Online: Encefalitis como complicación neurológica por dengue.

    Lora-Andosilla, Mario / Almanza-Hurtado, Amilkar / Rodríguez-Yáñez, Tomás / Martínez-Ávila, María Cristina / Dueñas-Castell, Carmelo

    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia

    2022  Volume 39, Issue 1, Page(s) 91–94

    Abstract: We present the case of a 32-year-old male, previously healthy, with a 5-day history of fever, frontal-occipital headache, retro-ocular pain, rash, petechiae, myalgia, arthralgia, and abdominal pain. Blood tests with leukopenia, severe thrombocytopenia, ... ...

    Title translation Encephalitis as neurological complication due dengue.
    Abstract We present the case of a 32-year-old male, previously healthy, with a 5-day history of fever, frontal-occipital headache, retro-ocular pain, rash, petechiae, myalgia, arthralgia, and abdominal pain. Blood tests with leukopenia, severe thrombocytopenia, transaminitis, long clotting times. Severe dengue with associated coagulopathy was diagnosed, indicating transfer to ICU. Presents torpid evolution, altered state of consciousness, psychomotor agitation, and aggressiveness. Structural, ischemic-hemorrhagic alterations, bacterial and fungal infections were ruled out. Finally diagnosing dengue encephalitis, confirmed by DENV PCR in CSF. Support measures are provided with favorable evolution. Encephalitis is the most serious neurological complication after dengue virus infection.
    MeSH term(s) Adult ; Dengue/complications ; Dengue/diagnosis ; Encephalitis/complications ; Fever ; Humans ; Male ; Purpura ; Severe Dengue/complications ; Severe Dengue/diagnosis ; Thrombocytopenia
    Language Spanish
    Publishing date 2022-06-23
    Publishing country Chile
    Document type Case Reports ; Journal Article
    ZDB-ID 2048815-4
    ISSN 0717-6341 ; 0716-1018
    ISSN (online) 0717-6341
    ISSN 0716-1018
    DOI 10.4067/S0716-10182022000100091
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  9. Article ; Online: Concurrent Dengue-Malaria Infection

    Orlando González-Macea / María Cristina Martínez-Ávila / Marien Pérez / Ingrid Tibocha Gordon / Bárbara Arroyo Salgado

    Clinical Medicine Insights: Case Reports, Vol

    The Importance of Acute Febrile Illness in Endemic Zones

    2023  Volume 16

    Abstract: Context: Acute febrile disease (AFI) in endemic tropical areas is a frequent reason for consulting the emergency services. Infection by 2 or more etiological agents may modify clinical and laboratory parameters, making diagnosis and treatment a challenge. ...

    Abstract Context: Acute febrile disease (AFI) in endemic tropical areas is a frequent reason for consulting the emergency services. Infection by 2 or more etiological agents may modify clinical and laboratory parameters, making diagnosis and treatment a challenge. Case report: We report the case of a patient who came from Africa and consults in Colombia, with AFI with thrombocytopenia that was eventually diagnosed to have concurrent infection with Plasmodium falciparum malaria and dengue. Conclusions: Dengue-malaria coinfection infection reports are scarce; it should be suspected in patients living or returning from areas where both diseases are endemic or during dengue outbreaks. This case serves as a reminder of this important condition that causes high morbidity and mortality if it is not early diagnosed and treated.
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: TINU: A Multisystemic Inflammatory Disorder-Case Report and Literature Review.

    Montejo-Hernández, Juan / Rico-Fontalvo, Jorge / Cabrales, Jose / Anand, Shuchi / Martínez-Ávila, María Cristina / Duran-Merino, Claudia / Arias-Restrepo, Luis / Gómez Duran, Camilo Andrés

    Case reports in nephrology

    2024  Volume 2024, Page(s) 3909755

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627652-5
    ISSN 2090-665X ; 2090-6641
    ISSN (online) 2090-665X
    ISSN 2090-6641
    DOI 10.1155/2024/3909755
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