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Article ; Online: Élaboration d’une base de recueil nationale prospective des données cliniques sur le cancer du col utérin: utilisation de la méthode Delphi pour l’identification de variables consensuelles.

Delage de Luget, Claire / Blanc, Julie / Chantalat, Elodie / Auquier, Pascal / Carcopino, Xavier

Gynecologie, obstetrique, fertilite & senologie

2022 Volume 50, Issue 9, Page(s) 615–619

Abstract: Introduction: Cervical cancer (CC) is associated with poor prognosis and therapeutic morbidity in young women. The impact of European recommendations for treatments and follow-up of these patients must be assessed. There is no real-time CCU tracking ... ...

Title translation	Database's development for prospective national collection of clinical data on cervical cancer: A Delphi survey identifying consensual variables.
Abstract	Introduction: Cervical cancer (CC) is associated with poor prognosis and therapeutic morbidity in young women. The impact of European recommendations for treatments and follow-up of these patients must be assessed. There is no real-time CCU tracking basis. Main objective of our study was to identify the items of the clinical and therapeutic data necessary for the constitution of a national, dynamic and prospective clinical database allowing to characterize treatments and follow-up of patients with CC in France. Methods: An exhaustive bibliographic research was lead with the help of the ESGO recommendations. A list of qualitative and quantitative variables characterizing CC was established. These variables were assessed by a panel of national experts from the Francogyn group, using the Delphi survey. The rate of agreement was calculated for each variable. Results: 345 variables divided into 6 sections were identified and submitted to 26 experts. 17 experts responded to the three rounds of the Delphi method. A total of 273 items were validated. The majority of experts (90 %) also gave a favorable opinion on the addition of a quality of life section in the database. Conclusion: This is the first study identifying 273 items chosen by consensus. The items are collected in a future national gynecological database "Epigyn".
MeSH term(s)	Consensus ; Delphi Technique ; Female ; Humans ; Prospective Studies ; Quality of Life ; Uterine Cervical Neoplasms/therapy
Language	French
Publishing date	2022-06-04
Publishing country	France
Document type	Journal Article
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2022.05.004
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Article ; Online: Trachélectomie élargie pour cancer du col de l’utérus à un stade précoce par laparoscopie robot-assistée (avec vidéo).

Motton, S / Martinez, A / Chantalat, E

Gynecologie, obstetrique, fertilite & senologie

2017 Volume 45, Issue 10, Page(s) 571–572

Title translation	Robot-assisted laparoscopic radical trachelectomy for early stage cervical cancer (with video).
MeSH term(s)	Female ; Gynecologic Surgical Procedures/methods ; Humans ; Robotic Surgical Procedures/methods ; Trachelectomy/methods ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/surgery ; Video Recording
Language	French
Publishing date	2017
Publishing country	France
Document type	Journal Article
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2017.08.001
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Article: Réponse des auteurs à la lettre à propos de l’article : « Télédermatologie en milieu carcéral : étude rétrospective de 500 télé-expertises ».

Khatibi, B / Bambe, A / Chantalat, C / Resche-Rigon, M / Sanna, A / Fac, C / Bagot, M / Guibal, F

Annales de dermatologie et de venereologie

2017 Volume 144, Issue 8-9, Page(s) 544

Title translation	Authors'response to the letter on the article "Teledermatology in a prison setting: A retrospective study of 500 expert opinions".
Language	French
Publishing date	2017-08
Publishing country	France
Document type	Letter
ZDB-ID	391805-1
ISSN	2214-5451 ; 0151-9638
ISSN (online)	2214-5451
ISSN	0151-9638
DOI	10.1016/j.annder.2017.05.003
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Article ; Online: Pulmonary hypertension in sickle cell disease.

Al Kahf, Salma / Roche, Anne / Baron, Audrey / Chantalat-Auger, Christelle / Savale, Laurent

Presse medicale (Paris, France : 1983)

2023 Volume 52, Issue 4, Page(s) 104209

Abstract: Sickle cell disease (SCD) is a complex genetic disorder that has long challenged both patients and healthcare professionals. One of its chronic and debilitating complications is pulmonary hypertension (PH). SCD-associated PH is often post-capillary, ... ...

Abstract	Sickle cell disease (SCD) is a complex genetic disorder that has long challenged both patients and healthcare professionals. One of its chronic and debilitating complications is pulmonary hypertension (PH). SCD-associated PH is often post-capillary, secondary to left heart disease. It can also sometimes be pre-capillary with multiple and often interrelated mechanisms including obstructive remodeling of the pulmonary vascular bed secondary to hemolysis, endothelial dysfunction, thrombosis, hypoxia, or associated risk factors like portal hypertension. Screening symptomatic patients with echocardiographic signs of PH is crucial to determine those who should undergo right heart catheterization, the cornerstone exam to diagnose and categorize patients with PH. The workup following the diagnosis relies on identifying the cause of PH to personalize treatment. Ongoing efforts are made to treat this complex condition, starting with treating the underlying disease with hydroxyurea or chronic blood exchange transfusion. Robust data on the efficacy of PAH-specific therapies are lacking in this specific population. Initiation of such therapies must be made by an expert center after a case-by-case assessment of the benefit-risk ratio according to the phenotype and the mechanisms involved in the development of PH. Efforts are also poured into studying the interventional and medical therapies used on chronic thromboembolic PH for patients presenting with a thrombotic form. The management of those patients requires a multidisciplinary approach, with conjoint efforts from PH and SCD specialists.
MeSH term(s)	Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/therapy ; Anemia, Sickle Cell/complications ; Echocardiography ; Heart Diseases/complications ; Hydroxyurea/therapeutic use
Chemical Substances	Hydroxyurea (X6Q56QN5QC)
Language	English
Publishing date	2023-11-14
Publishing country	France
Document type	Journal Article
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2023.104209
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Article ; Online: Une hypopigmentation cutanée.

Nabitz, C / Chantalat, L / Fourgeaud, C / Vignes, S

La Revue de medecine interne

2020 Volume 42, Issue 7, Page(s) 513–514

Title translation	A skin hypopigmentation.
MeSH term(s)	Atrophy/pathology ; Glucocorticoids ; Humans ; Hypopigmentation/diagnosis ; Hypopigmentation/etiology ; Hypopigmentation/pathology ; Skin/pathology
Chemical Substances	Glucocorticoids
Language	French
Publishing date	2020-12-03
Publishing country	France
Document type	Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2020.11.004
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Article ; Online: Le syndrome des grosses mains : un diagnostic méconnu.

Chantalat, L / Simon, M / Fourgeaud, C / Vignes, S

La Revue de medecine interne

2020 Volume 41, Issue 10, Page(s) 700–703

Abstract: Introduction: Puffy hand syndrome is a rare complication of intravenous drug addiction. Diagnosis is based on the patient's history and clinical examination.: Observations: A woman and two men, aged 42, 39 and 36 years old, are described. All had a ... ...

Title translation	Puffy hand syndrome: A little-known diagnosis.
Abstract	Introduction: Puffy hand syndrome is a rare complication of intravenous drug addiction. Diagnosis is based on the patient's history and clinical examination. Observations: A woman and two men, aged 42, 39 and 36 years old, are described. All had a history of intravenous drug use of heroin and oral buprenorphine misuse. Puffy hand syndrome appeared during drug addiction (n = 2) or after its withdrawal (n = 1). It was associated with acrocyanosis (n = 1) or injection scars (n = 1). Upper limb ultrasonography showed sequelae of venous (n = 3) or arterial (n = 1) thrombosis. An upper limb lymphoscintigraphy in one patient showed decreased radionuclide uptake of axillary lymph node and subdermal reflux tracer in the forearm. Treatment was based on low-stretch bandages to reduce the volume and then elastic compression sleeve for long-term stabilization. Conclusion: Puffy hand syndrome seen in intravenous drug addicts is poorly understood. It is a chronic complication despite the cessation of drug use. This syndrome has to become more widely known because its management is mandatory, although symptomatic.
MeSH term(s)	Adult ; Buprenorphine/therapeutic use ; Diagnosis, Differential ; Female ; Hand/pathology ; Heroin Dependence/complications ; Heroin Dependence/drug therapy ; Heroin Dependence/pathology ; Humans ; Lymphedema/diagnosis ; Lymphedema/etiology ; Lymphedema/pathology ; Male ; Opiate Substitution Treatment ; Substance Abuse, Intravenous/complications ; Substance Abuse, Intravenous/drug therapy ; Substance Abuse, Intravenous/pathology ; Syndrome
Chemical Substances	Buprenorphine (40D3SCR4GZ)
Language	French
Publishing date	2020-07-14
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2020.05.020
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Article: Crystal structure of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-diaminopimelate ligase from Escherichia coli.

Gordon, E / Flouret, B / Chantalat, L / van Heijenoort, J / Mengin-Lecreulx, D / Dideberg, O

The Journal of biological chemistry

2000 Volume 276, Issue 14, Page(s) 10999–11006

Abstract: UDP-N-acetylmuramoyl-l-alanyl-d-glutamate:meso-diaminopimelate ligase is a cytoplasmic enzyme ... that catalyzes the addition of meso-diaminopimelic acid to nucleotide precursor UDP-N-acetylmuramoyl-l-alanyl-d ... of the Escherichia coli enzyme in the presence of the final product of the enzymatic reaction, UDP-MurNAc-l-Ala-gamma-d ...

Abstract	UDP-N-acetylmuramoyl-l-alanyl-d-glutamate:meso-diaminopimelate ligase is a cytoplasmic enzyme that catalyzes the addition of meso-diaminopimelic acid to nucleotide precursor UDP-N-acetylmuramoyl-l-alanyl-d-glutamate in the biosynthesis of bacterial cell-wall peptidoglycan. The crystal structure of the Escherichia coli enzyme in the presence of the final product of the enzymatic reaction, UDP-MurNAc-l-Ala-gamma-d-Glu-meso-A(2)pm, has been solved to 2.0 A resolution. Phase information was obtained by multiwavelength anomalous dispersion using the K shell edge of selenium. The protein consists of three domains, two of which have a topology reminiscent of the equivalent domain found in the already established three-dimensional structure of the UDP-N-acetylmuramoyl-l-alanine: D-glutamate-ligase (MurD) ligase, which catalyzes the immediate previous step of incorporation of d-glutamic acid in the biosynthesis of the peptidoglycan precursor. The refined model reveals the binding site for UDP-MurNAc-l-Ala-gamma-d-Glu-meso-A(2)pm, and comparison with the six known MurD structures allowed the identification of residues involved in the enzymatic mechanism. Interestingly, during refinement, an excess of electron density was observed, leading to the conclusion that, as in MurD, a carbamylated lysine residue is present in the active site. In addition, the structural determinant responsible for the selection of the amino acid to be added to the nucleotide precursor was identified.
MeSH term(s)	Amino Acid Sequence ; Crystallization ; Escherichia coli/chemistry ; Escherichia coli/enzymology ; Molecular Sequence Data ; Peptide Synthases/chemistry ; Peptidoglycan/chemistry ; Peptidoglycan/metabolism ; Protein Conformation ; Sequence Alignment
Chemical Substances	Peptidoglycan ; Peptide Synthases (EC 6.3.2.-) ; UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase (EC 6.3.2.13)
Language	English
Publishing date	2000-12-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M009835200
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Article ; Online: Des veines anormales.

Chantalat, L / Fourgeaud, C / Simon, M / Vignes, S

La Revue de medecine interne

2019 Volume 41, Issue 7, Page(s) 502–503

Title translation	Abnormal veins.
MeSH term(s)	Aged, 80 and over ; Cardiovascular Abnormalities/diagnosis ; Cardiovascular Abnormalities/pathology ; Collateral Circulation/physiology ; Female ; Humans ; Shoulder/blood supply ; Shoulder/pathology ; Veins/abnormalities ; Veins/pathology
Language	French
Publishing date	2019-12-26
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2019.12.010
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Article ; Online: [No title information]

Martiano, M / Chantalat, L / Simon, M / Fourgeaud, C / Vignes, S

La Revue de medecine interne

2020 Volume 41, Issue 9, Page(s) 637–638

Title translation	Des vésicules cutanées.
MeSH term(s)	Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/therapy ; Carcinoma, Ductal, Breast/radiotherapy ; Carcinoma, Ductal, Breast/therapy ; Combined Modality Therapy/adverse effects ; Diagnosis, Differential ; Female ; Humans ; Lymphangiectasis/diagnosis ; Lymphangiectasis/etiology ; Mastectomy ; Radiation Injuries/diagnosis ; Radiotherapy, Conformal/adverse effects ; Skin Diseases, Vesiculobullous/diagnosis ; Skin Diseases, Vesiculobullous/etiology ; Tamoxifen/administration & dosage
Chemical Substances	Tamoxifen (094ZI81Y45)
Language	French
Publishing date	2020-04-28
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2020.03.007
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Article ; Online: Percutaneous cryoablation of abdominal wall endometriosis: An analysis of 38 patients.

Bachour, Rafy / Sengmanivong, Nithida / Vidal, Fabien / Goumarre, Céline / Lapègue, Franck / Destombes, Louise / Gandois, Hélène Chiavassa / Gac, Yann Tanguy Le / Chantalat, Elodie / Capdet, Jérome / Blais, Donatien / Guenego, Adrien / Sans, Nicolas / Bilfeld, Marie Faruch

Diagnostic and interventional imaging

2024

Abstract: Purpose: The purpose of this study was to evaluate the efficacy of percutaneous cryoablation in the treatment of abdominal wall endometriosis (AWE) nodules.: Materials and methods: Thirty-eight women treated for symptomatic AWE nodules with ... ...

Abstract	Purpose: The purpose of this study was to evaluate the efficacy of percutaneous cryoablation in the treatment of abdominal wall endometriosis (AWE) nodules. Materials and methods: Thirty-eight women treated for symptomatic AWE nodules with percutaneous cryoablation under ultrasound and computed tomography (CT) guidance between May 2020 and July 2023 were retrospectively included. Pain was estimated using visual analog scale (VAS) and assessed at baseline, three months, six months, and 12 months after percutaneous cryoablation. Baseline VAS score, volume of AWE nodule and magnetic resonance imaging (MRI) features of AWE nodules were compared to those obtained after percutaneous cryoablation. Major complications, if any, were noted. Results: Thirty-eight women with a median age of 35.5 years (interquartile range [IQR]: 32, 39; range: 24-48 years) and a total of 60 AWE nodules were treated. Percutaneous cryoablation was performed under local or regional anesthesia in 30 women (30/38; 79%). Significant decreases between initial median VAS score (7; IQR: 6, 8; range: 3-10) and median VAS score after treatment at three months (0; IQR: 0, 5; range; 0-8) (P < 0.001), six months (0; IQR: 0, 1; range; 0-10) (P < 0.001) and 12 months (0; IQR: 0, 2; range: 0-7) (P < 0.001) were observed. Percutaneous cryoablation resulted in effective pain relief in 31 out of 38 women (82%) at six months and 15 out of 18 women (83%) at 12 months. Contrast-enhanced MRI at six-month follow-up showed a significant decrease in the volume of AWE nodules and the absence of AWE nodule enhancement after treatment by comparison with baseline MRI (P < 0.001). No major complications were reported. Conclusion: Percutaneous cryoablation is an effective, minimally invasive intervention for the treatment of AWE nodules that conveys minimal or no morbidity.
Language	English
Publishing date	2024-03-10
Publishing country	France
Document type	Journal Article
ZDB-ID	2648283-6
ISSN	2211-5684 ; 2211-5684
ISSN (online)	2211-5684
ISSN	2211-5684
DOI	10.1016/j.diii.2024.02.010
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