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Article ; Online: Acute bilateral central serous chorioretinopathy in a young male after the first dose of Oxford/AstraZeneca AZD1222 (Covishield) vaccine.

Sindhu, Meenakshi / Bamotra, Ravi Kant / Singh, Sukhdev

2023 Volume 71, Issue 2, Page(s) 666–668

Abstract: We case of acute bilateral central serous chorioretinopathy (CSCR) after receiving the first dose of Covishield vaccine in a young, otherwise healthy male with no associated risk factors. ...

Abstract	We case of acute bilateral central serous chorioretinopathy (CSCR) after receiving the first dose of Covishield vaccine in a young, otherwise healthy male with no associated risk factors.
MeSH term(s)	Humans ; Male ; ChAdOx1 nCoV-19 ; Central Serous Chorioretinopathy/diagnosis ; Acute Disease ; Risk Factors ; Visual Acuity
Chemical Substances	ChAdOx1 nCoV-19 (B5S3K2V0G8)
Language	English
Publishing date	2023-06-01
Publishing country	India
Document type	Case Reports ; Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/ijo.IJO_1629_22
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Article: Natural language processing: state of the art, current trends and challenges.

Khurana, Diksha / Koli, Aditya / Khatter, Kiran / Singh, Sukhdev

Multimedia tools and applications

2022 , Page(s) 1–32

Abstract: Natural language processing (NLP) has recently gained much attention for representing and analyzing human language computationally. It has spread its applications in various fields such as machine translation, email spam detection, information extraction, ...

Abstract	Natural language processing (NLP) has recently gained much attention for representing and analyzing human language computationally. It has spread its applications in various fields such as machine translation, email spam detection, information extraction, summarization, medical, and question answering etc. In this paper, we first distinguish four phases by discussing different levels of NLP and components of
Language	English
Publishing date	2022-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1479928-5
ISSN	1573-7721 ; 1380-7501
ISSN (online)	1573-7721
ISSN	1380-7501
DOI	10.1007/s11042-022-13428-4
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Article ; Online: Lipopolysaccharide induced altered signaling pathways in various neurological disorders.

Singh, Sukhdev / Sahu, Kuleshwar / Singh, Charan / Singh, Arti

Naunyn-Schmiedeberg's archives of pharmacology

2022 Volume 395, Issue 3, Page(s) 285–294

Abstract: Neuroinflammation is defined as an inflammatory response within the brain or spinal cord, whereas the brain's innate immune system is triggered by various inflammatory challenges such as injury, infection, exposure to toxin (LPS) and ageing, which result ...

Abstract	Neuroinflammation is defined as an inflammatory response within the brain or spinal cord, whereas the brain's innate immune system is triggered by various inflammatory challenges such as injury, infection, exposure to toxin (LPS) and ageing, which result in cognitive impairment and neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). Lipopolysaccharide (LPS) is a main structural component of the outer membrane of gram-negative bacteria, widely used systematically to stimulate the immune system and to generate profound physiological and behavioural changes. It consists of three parts: lipid A, a core oligosaccharide and an O side chain. It is reported by several scientists that, besides the systemic alteration, LPS also induces neurodegeneration by promoting neuroinflammation upon binding with the stimulation of Toll-like receptor-4 (TLR4) receptors present on glial cells. The mammalian Toll-like receptor (TLR) family consists of 13 membranes and TLR was discovered as a crucial pattern recognition receptor (PPR) involved in the recognition of pathogen-associated molecular patterns (PAMPs). Future studies will show that damage/danger-associated molecular patterns (DAMPs) are recognised by the involvement of PPRs, generated by the host itself. The stimulation of TLR4 by lipopolysaccharide phosphorylates two signalling pathways, namely the MyD88-dependent pathway and the MyD88-independent pathway. This activation subsequently triggers the release of various pro-inflammatory cytokines that are necessary to activate innate immune responses, and then promotes neuroinflammation. In this review, we critically demonstrated the epidemiology of neuroinflammation, types of TLRs, the molecular mechanism of TLR4 and management of neuroinflammation.
MeSH term(s)	Animals ; Cytokines/metabolism ; Humans ; Lipopolysaccharides/toxicity ; Nervous System Diseases/physiopathology ; Neuroinflammatory Diseases/physiopathology ; Signal Transduction/physiology ; Toll-Like Receptor 4/metabolism ; Toll-Like Receptors/metabolism
Chemical Substances	Cytokines ; Lipopolysaccharides ; TLR4 protein, human ; Toll-Like Receptor 4 ; Toll-Like Receptors
Language	English
Publishing date	2022-01-06
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-021-02198-9
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Article: Regeneration of stem cuttings of pomegranate cv. bhagwa as influenced by pgr’s and planting time

Kaur, Gurpreet / Singh, Sukhdev

Agricultural science digest. 2022 Feb., v. 42, no. 1

2022

Abstract: Pomegranate is being cultivated in the tropical and sub-tropical parts of the world for its delicious fruits. It can be propagated from seeds as well as from softwood, semi-hardwood and hardwood cuttings. The application of auxins encourages rooting in ... ...

Abstract	Pomegranate is being cultivated in the tropical and sub-tropical parts of the world for its delicious fruits. It can be propagated from seeds as well as from softwood, semi-hardwood and hardwood cuttings. The application of auxins encourages rooting in stem cutting owing to their ability to active cambium regeneration, cell division and cell multiplication. To meet the demand of pomegranate in the current situation and owing to its importance, the present study was undertaken. For regeneration of stem cuttings of pomegranate cv. Bhagwa as influenced by PGRs and planting time a study was conducted at the Department of Horticulture, Khalsa College, Amritsar during 2019-2020. The trial was undertaken with ten treatments comprising of IBA, PHB and NAA (500, 750 and 1000 ppm) each by quick dip method along with control planted in the first week of August and January. The results of the study revealed that IBA 1000 ppm (T₃) proved to be the best in terms of minimum days to first sprouting (11.06), maximum sprouting (91.10%), rooting (83.31%), number of roots per cutting (60.03), root length (11.55 cm), fresh weight of roots (1.08 g) and dry weight of roots (0.55 g). Among planting time the cuttings planted on first week of January proved to be effective in terms of sprouting (87.83%), survival (84.70%), rooting (78.81 %) and number of roots (52.06) respectively.
Keywords	agricultural sciences ; cambium ; cell division ; hardwood ; pomegranates ; softwood
Language	English
Dates of publication	2022-02
Size	p. 32-37.
Publishing place	Agricultural Research Communication Centre
Document type	Article
ISSN	0976-0547
DOI	10.18805/ag.D-5280
Database	NAL-Catalogue (AGRICOLA)

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Article: An Analysis of Income and Consumption Pattern among Agricultural Labourer Households in Rural Punjab

Sandhu, Sukhdev Singh / Toor, Jasdeep Singh

Indian journal of ecology. 2022 Mar., v. 49, no. 1

2022

Abstract: Pattern of income and consumption is an important parameter to study the economic conditions of people living in any society. The present analysis is based upon primary data which collected from three different agro-climate regions of Punjab (South-west, ...

Abstract	Pattern of income and consumption is an important parameter to study the economic conditions of people living in any society. The present analysis is based upon primary data which collected from three different agro-climate regions of Punjab (South-west, Central plain and Shivalik foot-hill). Income from casual activities in agricultural accounts more than 40 per cent of the total income for an average agricultural labourer household followed by permanent agricultural labour and non-farm employment in rural Punjab. South-west region has recorded the highest share of permanent agricultural labour income, while Central plain and Shivalik foot-hill region has recorded the highest share of casual agricultural labour income. The per capita income is the highest in South-west region of Punjab. In all regions, an average household spends higher proportion of total consumption on non-durable items followed by marriages & other socio-religious ceremonies, services and durable items. There are slightly a few point differences between the expenditure on education and intoxicants among the sampled households.
Keywords	ecology ; education ; farm labor ; off-farm employment
Language	English
Dates of publication	2022-03
Size	p. 295-301.
Publishing place	Indian Ecological Society
Document type	Article
ZDB-ID	193796-0
ISSN	0304-5250
ISSN	0304-5250
DOI	10.55362/IJE/2022/3520
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A Review on the Neuroprotective Effect of Berberine against Chemotherapy- induced Cognitive Impairment.

Sahu, Kuleshwar / Singh, Sukhdev / Devi, Bhawna / Singh, Charan / Singh, Arti

Current drug targets

2022 Volume 23, Issue 9, Page(s) 913–923

Abstract: Chemobrain is one of the major side effects of chemotherapy; despite increased research, the mechanisms underlying chemotherapy-induced cognitive changes remain unknown. Several possibly important candidate mechanisms have been identified and will be ... ...

Abstract	Chemobrain is one of the major side effects of chemotherapy; despite increased research, the mechanisms underlying chemotherapy-induced cognitive changes remain unknown. Several possibly important candidate mechanisms have been identified and will be studied further in the future. Chemobrain is characterized by memory loss, cognitive impairment, difficulty in language, concentration, acceleration, and learning. The major characteristic of chemobrain is oxidative stress, mitochondrial dysfunction, immune dysregulation, hormonal alteration, white matter abnormalities, and DNA damage. Berberine (BBR) is an isoquinoline alkaloid extracted from various berberine species. BBR is a small chemical that easily passes the blood-brain barrier (BBB), making it useful for treating neurodegenerative diseases. Many studies on the pharmacology of BBR have been reported in the past. Furthermore, several clinical and experimental research indicates that BBR has a variety of pharmacological effects. So, in this review, we explore the pathogenesis of chemobrain and the neuroprotective potential of BBR against chemobrain. We also introduced the therapeutic role of BBR in various neurodegenerative and neurological diseases such as Alzheimer's, Parkinson's disease, mental depression, schizophrenia, anxiety, and also some stroke.
MeSH term(s)	Berberine/pharmacology ; Berberine/therapeutic use ; Chemotherapy-Related Cognitive Impairment ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/drug therapy ; Humans ; Neuroprotective Agents/adverse effects ; Oxidative Stress
Chemical Substances	Neuroprotective Agents ; Berberine (0I8Y3P32UF)
Language	English
Publishing date	2022-03-03
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2064859-5
ISSN	1873-5592 ; 1389-4501
ISSN (online)	1873-5592
ISSN	1389-4501
DOI	10.2174/1389450123666220303094752
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Article ; Online: Quercetin ameliorates lipopolysaccharide-induced neuroinflammation and oxidative stress in adult zebrafish.

Singh, Sukhdev / Sahu, Kuleshwar / Kapil, Lakshay / Singh, Charan / Singh, Arti

Molecular biology reports

2022 Volume 49, Issue 4, Page(s) 3247–3258

Abstract: Background: Quercetin is a natural flavonoid that is known to have numerous pharmacological activities such as antioxidative, anti-inflammatory, and neuroprotective effects against various neurological disorders. Lipopolysaccharide (LPS) is a potent ... ...

Abstract	Background: Quercetin is a natural flavonoid that is known to have numerous pharmacological activities such as antioxidative, anti-inflammatory, and neuroprotective effects against various neurological disorders. Lipopolysaccharide (LPS) is a potent endotoxin, reported causing several neurological disorders. Aim: The present study was designed to investigate the possibility that quercetin ameliorates LPS induced oxidative stress and neuroinflammation in adult zebrafish. Materials and methods: Zebrafish (weighing 470-530 mg) were treated with a single injection of LPS (1 mg/kg) intraperitoneally (i.p.) followed by post-treatment with quercetin (50 and 100 mg/kg; i.p.) for 7 days. After sacrificing brain was harvested and subjected for biochemical, molecular, and histological analyses. Results: Results revealed post-treatment with quercetin was able to ameliorate the behavioral abnormalities as in novel tank diving test- time spent in the top zone (TSTZ), and the number of entries in the top zone was significantly (p < 0.01) more as compared to time spent in the bottom zone (TSBZ). In the light-dark chamber test- time spent in the light zone (TSLZ), and the number of entries in the light zone were significantly (p < 0.01) more as compared to time spent in the dark compartment (TSDC). Additionally, results of histopathology (H & E stain) studies showed less disruption in neuronal cells as compared to the LPS treated group. Moreover, the results of the molecular analysis revealed that quercetin treatment significantly (p < 0.01) decrease TNF-α and IL-1β levels as compared to LPS treated animals. Further, results of the biochemical analysis reveal that quercetin significantly (p < 0.01) reduces the level of LPO, nitrite, AChEs and increases anti-oxidant GSH. Conclusion: Quercetin treatment helps to prevent oxidative damage and neuroinflammation in LPS treated adult zebrafish.
MeSH term(s)	Animals ; Inflammation/chemically induced ; Inflammation/drug therapy ; Lipopolysaccharides/toxicity ; Neuroinflammatory Diseases ; Oxidative Stress ; Quercetin/pharmacology ; Quercetin/therapeutic use ; Zebrafish
Chemical Substances	Lipopolysaccharides ; Quercetin (9IKM0I5T1E)
Language	English
Publishing date	2022-01-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07161-2
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Article: Therapeutic effects of CoenzymeQ10, Biochanin A and Phloretin against arsenic and chromium induced oxidative stress in mouse (

Tripathi, Swapnil / Fhatima, Shabrin / Parmar, Dharati / Singh, Dhirendra Pratap / Mishra, SukhDev / Mishra, Rajeev / Singh, Gyanendra

3 Biotech

2022 Volume 12, Issue 5, Page(s) 116

Abstract: Arsenic and chromium are the most common environmental toxicants prevailing in nature. Hence, the present study endeavors to investigate the salutary effects of Coenzyme Q10 (CoQ10), Biochanin A (BCA), and Phloretin (PHL) on the combined neurotoxic ... ...

Abstract	Arsenic and chromium are the most common environmental toxicants prevailing in nature. Hence, the present study endeavors to investigate the salutary effects of Coenzyme Q10 (CoQ10), Biochanin A (BCA), and Phloretin (PHL) on the combined neurotoxic impact of arsenic and chromium in the
Language	English
Publishing date	2022-04-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-022-03171-w
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Article ; Online: Antilipase activity guided fractionation of Vinca major

Sukhdev Singh / Singh Shamsher Kanwar

Journal of King Saud University: Science, Vol 30, Iss 4, Pp 433-

2018 Volume 439

Abstract: Methanolic extract of flowers of Vinca major (VFE) reduced the activity of porcine pancreatic lipase (PPL) which was reported in our previous study. To identify the antilipase molecule(s) in the VFE, the antilipase activity-guided fractionation for the ... ...

Abstract	Methanolic extract of flowers of Vinca major (VFE) reduced the activity of porcine pancreatic lipase (PPL) which was reported in our previous study. To identify the antilipase molecule(s) in the VFE, the antilipase activity-guided fractionation for the purification of lipase inhibitory molecule(s) by Silica Gel and Sephadex G-50 column chromatography was attempted, and the final anti-lipase fraction was examined by ESI-MS and FT-IR spectroscopy. Two molecules namely, Majoridine and Akuammine were elucidated to be present in the flowers of V. major which possessed high PPL inhibition activity. Further, both molecules were looked in silico for their interactions with PPL and other important proteins of lipid metabolism using molecular docking studies. Majoridine and Akuammine demonstrated significant binding interactions with active site residues of PPL. Keywords: Vinca major, Fractionation, ESI-MS, FT-IR, Majoridine, Akuammine, Docking
Keywords	Science (General) ; Q1-390
Subject code	540
Language	English
Publishing date	2018-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Quercetin ameliorates lipopolysaccharide-induced neuroinflammation and oxidative stress in adult zebrafish

Singh, Sukhdev / Sahu, Kuleshwar / Kapil, Lakshay / Singh, Charan / Singh, Arti

Molecular biology reports. 2022 Apr., v. 49, no. 4

2022

Abstract: BACKGROUND: Quercetin is a natural flavonoid that is known to have numerous pharmacological activities such as antioxidative, anti-inflammatory, and neuroprotective effects against various neurological disorders. Lipopolysaccharide (LPS) is a potent ... ...

Abstract	BACKGROUND: Quercetin is a natural flavonoid that is known to have numerous pharmacological activities such as antioxidative, anti-inflammatory, and neuroprotective effects against various neurological disorders. Lipopolysaccharide (LPS) is a potent endotoxin, reported causing several neurological disorders. AIM: The present study was designed to investigate the possibility that quercetin ameliorates LPS induced oxidative stress and neuroinflammation in adult zebrafish. MATERIALS AND METHODS: Zebrafish (weighing 470–530 mg) were treated with a single injection of LPS (1 mg/kg) intraperitoneally (i.p.) followed by post-treatment with quercetin (50 and 100 mg/kg; i.p.) for 7 days. After sacrificing brain was harvested and subjected for biochemical, molecular, and histological analyses. RESULTS: Results revealed post-treatment with quercetin was able to ameliorate the behavioral abnormalities as in novel tank diving test- time spent in the top zone (TSTZ), and the number of entries in the top zone was significantly (p < 0.01) more as compared to time spent in the bottom zone (TSBZ). In the light–dark chamber test- time spent in the light zone (TSLZ), and the number of entries in the light zone were significantly (p < 0.01) more as compared to time spent in the dark compartment (TSDC). Additionally, results of histopathology (H & E stain) studies showed less disruption in neuronal cells as compared to the LPS treated group. Moreover, the results of the molecular analysis revealed that quercetin treatment significantly (p < 0.01) decrease TNF-α and IL-1β levels as compared to LPS treated animals. Further, results of the biochemical analysis reveal that quercetin significantly (p < 0.01) reduces the level of LPO, nitrite, AChEs and increases anti-oxidant GSH. CONCLUSION: Quercetin treatment helps to prevent oxidative damage and neuroinflammation in LPS treated adult zebrafish.
Keywords	Danio rerio ; adults ; antioxidants ; brain ; endotoxins ; histology ; histopathology ; lipopolysaccharides ; molecular biology ; neurons ; nitrites ; oxidative stress ; quercetin
Language	English
Dates of publication	2022-04
Size	p. 3247-3258.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07161-2
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