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Article ; Online: Leere Plätze ; Covid-19 hat die deutsche Wirtschaft fest im Griff. Soziale Kontakte werden auf ein Minimum begrenzt, Massenveranstaltungen im großen Stile abgesagt, Notfallpläne aktiviert. Versicherer könnten in ihrer Rolle als Stabilitätsanker mit ihren Produkten gerade jetzt wichtige Signale aussenden, doch sie halten sich zurück. Fragen von außen.

Stanczyk, Michael

Versicherungswirtschaft

2020 Volume 75, Issue 4, Page(s) 18–21

Keywords	covid19
Language	German
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ISSN	2662-4419
DOI	10.1007/s43239-020-0278-7
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Leere Plätze: Covid-19 hat die deutsche Wirtschaft fest im Griff. Soziale Kontakte werden auf ein Minimum begrenzt, Massenveranstaltungen im großen Stile abgesagt, Notfallpläne aktiviert. Versicherer könnten in ihrer Rolle als Stabilitätsanker mit ihren Produkten gerade jetzt wichtige Signale aussenden, doch sie halten sich zurück. Fragen von außen.

Stanczyk, Michael

Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1007/s43239-020-0278-7
Database	COVID19

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Article ; Online: National Landscape with Lenin in the Background

Xawery Stańczyk

Studia Litteraria et Historica, Iss

Imagined National Communities in the Former Eastern Bloc

2018 Volume 7

Abstract: ... Eric Hobsbawm, Michael Billig, Michael Skey, Tim Edensor and others, showed their deep understanding ...

Abstract	The paper is a critical review of two recently published monographs on the subject of the everyday and banal forms of nationalism in the post-socialist countries of Europe and Asia. The authors of the monographs, drawing on the theories of national identity and nationhood by Benedict Anderson, Ernest Gellner, Eric Hobsbawm, Michael Billig, Michael Skey, Tim Edensor and others, showed their deep understanding of the processes of nation-building, while their ethnographic approach allowed them to gather original and non-obvious data on everyday practices and discourses by which citizens of the post-socialist countries reproduce and reconstruct their identities. However, both volumes display some shortcomings resulting from their renditions of the historical background, including the ethnic policies of the socialist states, as well as from constraints of the Western liberal perspective as applied to the social reality of the former Eastern Bloc.
Keywords	nation ; nationalism ; identity ; everyday life ; socialism ; community ; Anthropology ; GN1-890 ; Ethnology. Social and cultural anthropology ; GN301-674
Subject code	390
Language	German
Publishing date	2018-12-01T00:00:00Z
Publisher	Institute of Slavic Studies, Polish Academy of Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pejzaż narodowy z Leninem w tle. Narodowe wspólnoty wyobrażone w byłym Bloku Wschodnim [National landscape with Lenin in the background. Imagined national communities in the former Eastern Bloc]

Xawery Stańczyk

Studia Litteraria et Historica, Vol 0, Iss

2018 Volume 7

Abstract: ... Eric Hobsbawm, Michael Billig, Michael Skey, Tim Edensor and others, showed their deep understanding ...

Abstract	National landscape with Lenin in the background. Imagined national communities in the former Eastern Bloc The paper is a critical review of two recently published monographs on the subject of the everyday and banal forms of nationalism in the post-socialist countries of Europe and Asia. The authors of the monographs, drawing on the theories of national identity and nationhood by Benedict Anderson, Ernest Gellner, Eric Hobsbawm, Michael Billig, Michael Skey, Tim Edensor and others, showed their deep understanding of the processes of nation-building, while their ethnographic approach allowed them to gather original and non-obvious data on everyday practices and discourses by which citizens of the post-socialist countries reproduce and reconstruct their identities. However, both volumes display some shortcomings resulting from their renditions of the historical background, including the ethnic policies of the socialist states, as well as from constraints of the Western liberal perspective as applied to the social reality of the former Eastern Bloc. Pejzaż narodowy z Leninem w tle. Narodowe wspólnoty wyobrażone w byłym Bloku Wschodnim Celem artykułu jest krytyczna recenzja dwóch opublikowanych ostatnio monografii na temat codziennych, banalnych form nacjonalizmu w krajach postsocjalistycznych Europy i Azji. Autorzy obu monografii, bazując na teoriach narodu i tożsamości narodowej Benedicta Andersona, Ernesta Gellnera, Erica Hobsbawma, Michaela Billiga, Michaela Skeya, Tima Edensora i innych badaczy, wykazali się głębokim zrozumieniem procesów konstruowania narodu, natomiast dzięki przeprowadzeniu badań etnograficznych zebrali oryginalny i nieoczywisty materiał dotyczący codziennych praktyk i dyskursów, poprzez które obywatele krajów postsocjalistycznych reprodukują i rekonstruują swoje tożsamości. Jednak oba tomy wykazują pewne mankamenty wynikające z ukazania zjawisk na skromnym tle historycznym, chociażby w kwestii polityk etnicznych państw socjalistycznych, jak również ograniczenia związane z nakładaniem liberalnej perspektywy zachodniej na realia społeczne byłego Bloku Wschodniego.
Keywords	nation ; nationalism ; identity ; everyday life ; socialism ; community ; Anthropology ; GN1-890 ; Ethnology. Social and cultural anthropology ; GN301-674
Subject code	390
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	Institute of Slavic Studies, Polish Academy of Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Corrigendum to "A multicenter retrospective study of calcineurin inhibitors in nephrotic syndrome secondary to podocyte gene variants." Kidney Int. 2023;103:962-972.

Malakasioti, Georgia / Iancu, Daniela / Milovanova, Anastasiia / Tsygin, Alexey / Horinouchi, Tomoko / Nagano, China / Nozu, Kandai / Kamei, Koichi / Fujinaga, Shuichiro / Iijima, Kazumoto / Kang, Hee Gyung / Sinha, Rajiv / Basu, Biswanath / Morello, William / Montini, Giovanni / Waters, Aoife / Boyer, Olivia / Yıldırım, Zeynep Yürük / Yel, Sibel /

Kidney international

2024 Volume 105, Issue 1, Page(s) 213–214

Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Published Erratum
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2023.10.006
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Article ; Online: Efficacy and Safety of the TYK2/JAK1 Inhibitor Brepocitinib for Active Psoriatic Arthritis: A Phase IIb Randomized Controlled Trial.

Mease, Philip / Helliwell, Philip / Silwinska-Stanczyk, Paula / Miakisz, Malgorzata / Ostor, Andrew / Peeva, Elena / Vincent, Michael S / Sun, Qiankun / Sikirica, Vanja / Winnette, Randall / Qiu, Ruolun / Li, Gang / Feng, Gang / Beebe, Jean S / Martin, David A

Arthritis & rheumatology (Hoboken, N.J.)

2023 Volume 75, Issue 8, Page(s) 1370–1380

Abstract: Objective: Brepocitinib is a TYK2/JAK1 inhibitor in development for the treatment of several immunologic diseases. The efficacy and safety of oral brepocitinib were assessed in participants with moderately-to-severely active psoriatic arthritis (PsA) ... ...

Abstract	Objective: Brepocitinib is a TYK2/JAK1 inhibitor in development for the treatment of several immunologic diseases. The efficacy and safety of oral brepocitinib were assessed in participants with moderately-to-severely active psoriatic arthritis (PsA) for up to 52 weeks. Methods: In this placebo-controlled, dose-ranging, phase IIb study, participants were randomized to receive 10 mg, 30 mg, or 60 mg of brepocitinib once daily or placebo, advancing to 30 mg or 60 mg of brepocitinib once daily at week 16. The primary endpoint was the response rate according to the American College of Rheumatology criteria for 20% improvement (ACR20) in disease activity at week 16. Secondary endpoints included response rates according to the ACR50/ACR70 response criteria, 75% and 90% improvement in the Psoriasis Area and Severity Index (PASI75/PASI90) score, and minimal disease activity (MDA) at weeks 16 and 52. Adverse events were monitored throughout the study. Results: Overall, 218 participants were randomized and treated. At week 16, the brepocitinib 30 mg and 60 mg once daily groups had significantly greater ACR20 response rates (66.7% [P = 0.0197] and 74.6% [P = 0.0006], respectively), versus the placebo group (43.3%), and significantly higher ACR50/ACR70, PASI75/PASI90, and MDA response rates. Response rates were maintained or improved through week 52. Adverse events were mostly mild/moderate; serious adverse events (15) in 12 participants (5.5%) included infections in 6 participants (2.8%) in the brepocitinib 30 mg and 60 mg once daily groups. No major adverse cardiovascular events or deaths occurred. Conclusion: Treatment with brepocitinib at dosages of 30 mg and 60 mg once daily was superior to placebo at reducing signs and symptoms of PsA. Brepocitinib was generally well tolerated throughout the 52-week study, with a safety profile consistent with those found in other brepocitinib clinical trials.
MeSH term(s)	Humans ; Antibodies, Monoclonal/therapeutic use ; Antirheumatic Agents/therapeutic use ; Arthritis, Psoriatic/drug therapy ; Double-Blind Method ; Immunologic Factors/therapeutic use ; Janus Kinase 1 ; Treatment Outcome ; TYK2 Kinase/therapeutic use
Chemical Substances	Antibodies, Monoclonal ; Antirheumatic Agents ; Immunologic Factors ; JAK1 protein, human (EC 2.7.10.2) ; Janus Kinase 1 (EC 2.7.10.2) ; TYK2 Kinase (EC 2.7.10.2) ; TYK2 protein, human (EC 2.7.10.2)
Language	English
Publishing date	2023-06-22
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.42519
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Article ; Online: A multicenter retrospective study of calcineurin inhibitors in nephrotic syndrome secondary to podocyte gene variants.

Malakasioti, Georgia / Iancu, Daniela / Milovanova, Anastasiia / Tsygin, Alexey / Horinouchi, Tomoko / Nagano, China / Nozu, Kandai / Kamei, Koichi / Fujinaga, Shuichiro / Iijima, Kazumoto / Sinha, Rajiv / Basu, Biswanath / Morello, William / Montini, Giovanni / Waters, Aoife / Boyer, Olivia / Yıldırım, Zeynep Yürük / Yel, Sibel / Dursun, İsmail /

McCarthy, Hugh J / Vivarelli, Marina / Prikhodina, Larisa / Besouw, Martine T P / Chan, Eugene Yu-Hin / Huang, Wenyan / Kemper, Markus J / Loos, Sebastian / Prestidge, Chanel / Wong, William / Zlatanova, Galia / Ehren, Rasmus / Weber, Lutz T / Chehade, Hassib / Hooman, Nakysa / Tkaczyk, Marcin / Stańczyk, Małgorzata / Miligkos, Michael / Tullus, Kjell

Kidney international

2023 Volume 103, Issue 5, Page(s) 962–972

Abstract: While 44-83% of children with steroid-resistant nephrotic syndrome (SRNS) without a proven genetic cause respond to treatment with a calcineurin inhibitor (CNI), current guidelines recommend against the use of immunosuppression in monogenic SRNS. This is ...

Abstract	While 44-83% of children with steroid-resistant nephrotic syndrome (SRNS) without a proven genetic cause respond to treatment with a calcineurin inhibitor (CNI), current guidelines recommend against the use of immunosuppression in monogenic SRNS. This is despite existing evidence suggesting that remission with CNI treatment is possible and can improve prognosis in some cases of monogenic SRNS. Herein, our retrospective study assessed response frequency, predictors of response and kidney function outcomes among children with monogenic SRNS treated with a CNI for at least three months. Data from 203 cases (age 0-18 years) were collected from 37 pediatric nephrology centers. Variant pathogenicity was reviewed by a geneticist, and 122 patients with a pathogenic and 19 with a possible pathogenic genotype were included in the analysis. After six months of treatment and at last visit, 27.6% and 22.5% of all patients respectively, demonstrated partial or full response. Achievement of at least partial response at six months of treatment conferred a significant reduction in kidney failure risk at last follow-up compared to no response (hazard ratio [95% confidence interval] 0.25, [0.10-0.62]). Moreover, risk of kidney failure was significantly lower when only those with a follow-up longer than two years were considered (hazard ratio 0.35, [0.14-0.91]). Higher serum albumin level at CNI initiation was the only factor related to increased likelihood of significant remission at six months (odds ratio [95% confidence interval] 1.16, [1.08-1.24]). Thus, our findings justify a treatment trial with a CNI also in children with monogenic SRNS.
MeSH term(s)	Child ; Humans ; Infant, Newborn ; Infant ; Child, Preschool ; Adolescent ; Nephrotic Syndrome/drug therapy ; Nephrotic Syndrome/genetics ; Nephrotic Syndrome/pathology ; Calcineurin Inhibitors/adverse effects ; Immunosuppressive Agents/adverse effects ; Retrospective Studies ; Podocytes/pathology ; Renal Insufficiency/chemically induced
Chemical Substances	Calcineurin Inhibitors ; Immunosuppressive Agents
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2023.02.022
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Article ; Online: Comparability of antimüllerian hormone levels among commercially available immunoassays.

Su, H Irene / Sammel, Mary D / Homer, Michael V / Bui, Kim / Haunschild, Carolyn / Stanczyk, Frank Z

Fertility and sterility

2014 Volume 101, Issue 6, Page(s) 1766–72.e1

Abstract: Objective: To compare antimüllerian hormone (AMH) levels among three commercially available AMH immunoassays: AMH Gen II (Beckman Coulter), Ultrasensitive AMH (Ansh Labs), and picoAMH (Ansh Labs).: Design: Cross-sectional.: Setting: Academic ... ...

Abstract	Objective: To compare antimüllerian hormone (AMH) levels among three commercially available AMH immunoassays: AMH Gen II (Beckman Coulter), Ultrasensitive AMH (Ansh Labs), and picoAMH (Ansh Labs). Design: Cross-sectional. Setting: Academic reproductive endocrinology program. Patient(s): 90 newly diagnosed breast cancer patients before cancer treatment. Intervention(s): None. Main outcome measure(s): Proportion of detectable AMH levels by immunoassay, and comparability among assays. Result(s): At a mean age of 38.1 years, the median (interquartile range) AMH level for the cohort was 0.92 [1.35] ng/mL for the Gen II assay, 1.68 [2.30] ng/mL for the Ultrasensitive assay, and 1.52 [2.41] ng/mL for the picoAMH assay. Significantly higher proportions of detectable AMH levels were observed with the picoAMH kit (97%) compared with both the Gen II (84%) and Ultrasensitive (92%) assays. Although the AMH results were highly correlated among the assays (r = 0.92-0.99), the Gen II AMH levels were consistently lower than both Ultrasensitive and picoAMH levels. Moreover, as AMH levels increased, the magnitude of difference grew larger between Gen II and each of the other two assays. Conclusion(s): Measurement of AMH levels with the picoAMH kit maximized detection at very low levels, particularly in contrast with the Gen II kit. Conversion of AMH levels from different immunoassays using regression equations is potentially highly inaccurate.
MeSH term(s)	Adult ; Anti-Mullerian Hormone/blood ; Biomarkers/blood ; Breast Neoplasms/blood ; Cross-Sectional Studies ; Female ; Humans ; Immunoassay/standards ; Observer Variation ; Predictive Value of Tests ; Regression Analysis ; Reproducibility of Results
Chemical Substances	Biomarkers ; Anti-Mullerian Hormone (80497-65-0)
Language	English
Publishing date	2014-04-14
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2014.02.046
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Article ; Online: Pituitary and ovarian hormone activity during the 7-day hormone-free interval of various combined oral contraceptive regimens.

Cho, Michael / Atrio, Jessica / Lim, Aaron H / Azen, Colleen / Stanczyk, Frank Z

Contraception

2014 Volume 90, Issue 1, Page(s) 94–96

Abstract: Objective: The objective was to investigate changes in luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) and progesterone (P) during the hormone-free interval (HFI) of 6 combined oral contraceptives (COCs).: Design: Blood ... ...

Abstract	Objective: The objective was to investigate changes in luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) and progesterone (P) during the hormone-free interval (HFI) of 6 combined oral contraceptives (COCs). Design: Blood samples were obtained from 62 women. Results: When COCs were grouped by ethinyl estradiol (EE) dose, there was a significant positive mean slope for LH and FSH during the HFI for the 30- and 35 mcg-EE doses, whereas 20 showed a gradual nonsignificant slope. All E2 slopes were significant. P remained suppressed with all doses. Conclusion: A more rapid rebound of gonadotropin levels is found with higher doses of EE during the HFI. Implications: This study showed a more rapid rebound of pituitary hormone levels among women using higher-EE-dosage formulations, which was demonstrated by the statistically significant slope for mean LH and FSH from day 1 to day 7 of the HFI. The degree of suppression did not vary across progestin generations. It remains to be established whether women who experience side effects during their HFI may benefit from using a COC with a lower EE dose to minimize changes in endogenous pituitary hormone levels.
MeSH term(s)	Adolescent ; Adult ; Contraceptives, Oral, Combined/administration & dosage ; Estradiol/blood ; Ethinyl Estradiol/administration & dosage ; Female ; Follicle Stimulating Hormone/blood ; Humans ; Linear Models ; Luteinizing Hormone/blood ; Progesterone/blood ; Prospective Studies ; Young Adult
Chemical Substances	Contraceptives, Oral, Combined ; Ethinyl Estradiol (423D2T571U) ; Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E) ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2014-07
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	80106-9
ISSN	1879-0518 ; 0010-7824
ISSN (online)	1879-0518
ISSN	0010-7824
DOI	10.1016/j.contraception.2014.01.021
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Article ; Online: Effect of protease inhibitors on steady-state pharmacokinetics of oral norethindrone contraception in HIV-infected women.

Atrio, Jessica / Stanczyk, Frank Z / Neely, Michael / Cherala, Ganesh / Kovacs, Andrea / Mishell, Daniel R

Journal of acquired immune deficiency syndromes (1999)

2013 Volume 65, Issue 1, Page(s) 72–77

Abstract: Objective: Pharmacokinetic interactions exist between combined oral contraceptives and protease inhibitors (PI). However, such information is lacking for progestin-only oral contraception. We sought to define the steady-state pharmacokinetic interaction ...

Abstract	Objective: Pharmacokinetic interactions exist between combined oral contraceptives and protease inhibitors (PI). However, such information is lacking for progestin-only oral contraception. We sought to define the steady-state pharmacokinetic interaction between norethindrone (NET) and PI in HIV-infected women. Methods and design: We conducted an open-label, prospective, nonrandomized trial to characterize the steady-state pharmacokinetics of serum NET in HIV-infected women receiving PI compared with a control group of HIV-infected women receiving other noninteracting drugs. After 21 days of 0.35 mg of NET ingestion once daily, serial serum samples were obtained at 0, 1, 2, 3, 4, 6, 8, 12, 24, 48, and 72 hours. The area under the curve between 0 and 72 hours after ingestion was calculated by trapezoidal approximation. Results: Thirty-five women were enrolled, 2 withdrew. Sixteen women in the PI group and 17 controls completed the study. NET half-life and maximum concentration were not significantly different between the 2 groups. Minimum concentration of NET was significantly higher in the PI group (P = 0.01). The ratio of the geometric mean NET area under the curve in the PI group compared with controls was 1.5 (90% confidence interval: 1.21 to 1.86). NET serum concentrations were significantly higher in HIV-infected women taking a PI compared with controls (P = 0.004). Conclusions: Coadministration of PI inhibits NET metabolism as shown by higher serum NET area under the curve levels, a surrogate marker for therapeutic contraceptive efficacy. This study supports the increased utilization of progestin-only pills in HIV-infected women receiving certain PI regimens.
MeSH term(s)	Adult ; Contraceptives, Oral, Synthetic/blood ; Contraceptives, Oral, Synthetic/pharmacokinetics ; Drug Interactions ; Female ; HIV Infections/drug therapy ; HIV Infections/metabolism ; HIV Protease Inhibitors/pharmacology ; HIV Protease Inhibitors/therapeutic use ; Humans ; Norethindrone/blood ; Norethindrone/pharmacokinetics
Chemical Substances	Contraceptives, Oral, Synthetic ; HIV Protease Inhibitors ; Norethindrone (T18F433X4S)
Language	English
Publishing date	2013-09-11
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0b013e3182a9b3f1
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