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Article ; Online: Prevalence of Distal Symmetrical Polyneuropathy by Diabetes Prevention Program Treatment Group, Diabetes Status, Duration of Diabetes, and Cumulative Glycemic Exposure.

Lee, Christine G / Ciarleglio, Adam / Edelstein, Sharon L / Crandall, Jill P / Dabelea, Dana / Goldberg, Ronald B / Kahn, Steven E / Knowler, William C / Ma, Maxwell T / White, Neil H / Herman, William H

Diabetes care

2024 Volume 47, Issue 5, Page(s) 810–817

Abstract: ... and age (P < 0.05) on DSPN. At DPPOS year 17, the odds ratio for DSPN in comparison with ILS ... with longer diabetes duration and time-weighted HbA1c (P values <0.001).: Conclusions: The likelihood ...

Abstract	Objective: To assess associations between distal symmetric polyneuropathy (DSPN) and Diabetes Prevention Program (DPP) treatment groups, diabetes status or duration, and cumulative glycemic exposure approximately 21 years after DPP randomization. Research design and methods: In the DPP, 3,234 adults ≥25 years old at high risk for diabetes were randomized to an intensive lifestyle (ILS), metformin, or placebo intervention to prevent diabetes. After the DPP ended, 2,779 joined the Diabetes Prevention Program Outcomes Study (DPPOS). Open-label metformin was continued, placebo was discontinued, ILS was provided in the form of semiannual group-based classes, and all participants were offered quarterly lifestyle classes. Symptoms and signs of DSPN were assessed in 1,792 participants at DPPOS year 17. Multivariable logistic regression models were used to evaluate DSPN associations with treatment group, diabetes status/duration, and cumulative glycemic exposure. Results: At 21 years after DPP randomization, 66% of subjects had diabetes. DSPN prevalence did not differ by initial DPP treatment assignment (ILS 21.5%, metformin 21.5%, and placebo 21.9%). There was a significant interaction between treatment assignment to ILS and age (P < 0.05) on DSPN. At DPPOS year 17, the odds ratio for DSPN in comparison with ILS with placebo was 17.4% (95% CI 3.0, 29.3) lower with increasing 5-year age intervals. DSPN prevalence was slightly lower for those at risk for diabetes (19.6%) versus those with diabetes (22.7%) and was associated with longer diabetes duration and time-weighted HbA1c (P values <0.001). Conclusions: The likelihood of DSPN was similar across DPP treatment groups but higher for those with diabetes, longer diabetes duration, and higher cumulative glycemic exposure. ILS may have long-term benefits on DSPN for older adults.
MeSH term(s)	Humans ; Aged ; Adult ; Hypoglycemic Agents/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/prevention & control ; Prevalence ; Metformin/therapeutic use ; Polyneuropathies
Chemical Substances	Hypoglycemic Agents ; Metformin (9100L32L2N)
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc23-2009
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Zs.A 1434: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 365: Show issues

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Article ; Online: Biofilm Formation by Hospital-Acquired Resistant Bacteria Isolated from Respiratory Samples.

Ben-Amram, Hila / Azrad, Maya / Cohen-Assodi, Jackie / Sharabi-Nov, Adi / Edelstein, Shimon / Agay-Shay, Keren / Peretz, Avi

Journal of epidemiology and global health

2024

Abstract: Background: Hospital-acquired resistant infections (HARI) are infections, which develop 48 h or ... the most prevalent (35.4%) bacteria, followed by P. aeruginosa (23.5%), and ... followed by P. aeruginosa (29.4%). Biofilm production strength was significantly affected by seasonality ...

Abstract	Background: Hospital-acquired resistant infections (HARI) are infections, which develop 48 h or more after admission to a healthcare facility. HARI pose a considerably acute challenge, due to limited treatment options. These infections are associated bacterial biofilms, which act as a physical barrier to diverse external stresses, such as desiccation, antimicrobials and biocides. We assessed the influence of multiple factors on biofilm production by HARI -associated bacteria. Methods: Bacteria were isolated from samples of patients with respiratory HARI who were hospitalized during 2020-2022 in north Israel. Following antibiotic susceptibility testing by disc diffusion or broth microdilution, biofilm formation capacities of resistant bacteria (methicillin-resistant staphylococcus aureus, extended spectrum beta-lactamase-producing Escherichia coli and Klebsiela pneumonia, and multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii) was assessed using the crystalline violet staining method. Data regarding season, time to infection, bacterial species, patient age and gender, year, and medical department were collected from the patient medical records. Results: Among the 226 study isolates, K. pneumonia was the most prevalent (35.4%) bacteria, followed by P. aeruginosa (23.5%), and methicillin-resistant staphylococcus aureus (MRSA) (21.7%). A significantly higher rate of HARI was documented in 2022 compared to 2020-2021. The majority of isolates (63.3%) were strong biofilm producers, with K. pneumonia (50.3%) being most dominant, followed by P. aeruginosa (29.4%). Biofilm production strength was significantly affected by seasonality and hospitalization length, with strong biofilm production in autumn and in cases where hospitalization length exceeded 30 days. Conclusion: Biofilm production by HARI bacteria is influenced by bacterial species, season and hospitalization length.
Language	English
Publishing date	2024-04-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2645324-1
ISSN	2210-6014 ; 2210-6014
ISSN (online)	2210-6014
ISSN	2210-6014
DOI	10.1007/s44197-024-00215-7
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Article: Neuro-Oncology Clinicians' Attitudes and Perspectives on Medical Assistance in Dying.

Climans, Seth A / Mason, Warren P / Variath, Caroline / Edelstein, Kim / Bell, Jennifer A H

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2021 Volume 48, Issue 6, Page(s) 772–778

Abstract: ... Fisher's exact P-values 0.007, < 0.001, and 0.049, respectively).: Conclusion: While there are differing ...

Abstract	Background: Medical assistance in dying (MAiD), also known as physician-assisted death, is currently legal in several locations across the globe. Brain cancer or its treatments can lead to cognitive impairment, which can impact decision-making capacity for MAiD. Objective: We sought to explore neuro-oncology clinicians' attitudes and perspectives on MAiD, including interpretation of decision-making capacity for patient MAiD eligibility. Methods: An online survey was distributed to members of national and international neuro-oncology societies. We asked questions about decision-making capacity and MAiD, in part using hypothetical patient scenarios. Multiple choice and free-text responses were captured. Results: There were 125 survey respondents. Impaired cognition was identified as the most important factor that would signal a decline in patient capacity. At least 26% of survey respondents had moral objections to MAiD. Respondents thought that different hypothetical patients had capacity to make a decision about MAiD (range 18%-58%). In other hypothetical scenarios, fewer clinicians were willing to support a MAiD decision for a patient with an oligodendroglioma (26%) vs. glioblastoma (41%-70%, depending on the scenario). Time since diagnosis, performance status, and patient age seemed to affect support for MAiD decisions (Fisher's exact P-values 0.007, < 0.001, and 0.049, respectively). Conclusion: While there are differing opinions on the moral permissibility of MAiD in general and for neuro-oncology patients, most clinicians agree that capacity must be assessed carefully before a decision is made. End-of-life discussions should happen early, before the capacity is lost. Our results can inform assessments of patient capacity in jurisdictions where MAiD is legal.
MeSH term(s)	Attitude of Health Personnel ; Canada ; Humans ; Medical Assistance ; Physicians ; Suicide, Assisted/psychology ; Surveys and Questionnaires
Language	English
Publishing date	2021-07-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
DOI	10.1017/cjn.2021.186
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Zs.A 1203: Show issues

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Article ; Online: Vaccine-induced and hybrid immunity to SARS-CoV-2 after three or four doses of BNT162b2 - results from 22 months follow-up of a healthcare workers cohort, Israel, 2020-2022.

Edelstein, Michael / Wiegler Beiruti, Karine / Ben-Amram, Hila / Beer, Netta / Sussan, Christian / Batya, Perachel / Zarka, Salman / Abu Jabal, Kamal

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2023 Volume 135, Page(s) 57–62

Abstract: ... than a third dose (4285 vs 2845 arbitrary unit/ml 1-2 months after infection/vaccination, P = 0.03). In 16-18 ... P = 0.6). IgG levels plateaued 16-22 months after dose two.: Conclusion: Three BNT162b2 doses ...

Abstract	Objectives: SARS-CoV-2 remains a global health concern 3 years after its emergence. Safe and effective vaccines mitigate the pandemic impact, but the optimal schedule remains unclear, especially in a context where a high proportion of the population is infected. Methods: We periodically measured anti-spike SARS-CoV-2 immunoglobulin (Ig)G titers using a quantitative assay in an Israeli healthcare worker cohort who all received at least two BNT162b2 doses and either received further doses and/or were subsequently infected up to 22 months after dose two, and compared geometric mean concentrations according to number of doses received and infection status using analysis of variance. Results: Among the 993 included participants, infection after dose two led to higher geometric mean concentration IgG titers than a third dose (4285 vs 2845 arbitrary unit/ml 1-2 months after infection/vaccination, P = 0.03). In 16-18 months after dose two, those infected and those who received three or four vaccine doses all had IgG geometric mean concentration levels above 500 arbitrary unit/ml with no significant differences among groups (P = 0.6). IgG levels plateaued 16-22 months after dose two. Conclusion: Three BNT162b2 doses provide long-term immunogenicity comparable to breakthrough infection after dose two. Dose four transiently increases IgG levels and may be especially important for providing additional protection to vulnerable individuals during periods of increased transmission risk.
MeSH term(s)	Humans ; Israel/epidemiology ; SARS-CoV-2 ; BNT162 Vaccine ; Follow-Up Studies ; COVID-19/prevention & control ; Vaccines ; Health Personnel ; Adaptive Immunity ; Immunoglobulin G ; Antibodies, Viral
Chemical Substances	BNT162 Vaccine ; Vaccines ; Immunoglobulin G ; Antibodies, Viral
Language	English
Publishing date	2023-08-11
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2023.08.009
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Zs.A 4516: Show issues

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Article ; Online: Association between self-reported masking behavior and SARS-CoV-2 infection wanes from Pre-Delta to Omicron-predominant periods - North Carolina COVID-19 Community Research Partnership (NC-CCRP).

Tjaden, Ashley H / Gibbs, Michael / Runyon, Michael / Weintraub, William S / Taylor, Yhenneko J / Edelstein, Sharon L

American journal of infection control

2022 Volume 51, Issue 3, Page(s) 261–267

Abstract: ... interaction between mask use and time period (P < .001). Prior to July 2021, the odds of a reported infection ...

Abstract	Background: Wearing a face mask is a primary public health method to reduce SARS-CoV-2 transmission. Methods: We performed a nested case-control analysis within the North Carolina COVID-19 Community Research Partnership (NC-CCRP) of adults who completed daily surveillance surveys, April 2020 - February 2022. We assessed the association between self-reported mask wearing behavior during nonhousehold interactions and COVID-19 infection during 3 pandemic periods using conditional logistic regression models of risk of infection that were adjusted for demographics, vaccination status, and recent known exposure to COVID-19. Results: Among 3,901 cases and 27,813 date-matched controls, there was a significant interaction between mask use and time period (P < .001). Prior to July 2021, the odds of a reported infection were 66% higher (aOR = 1.66, 95% CI = 1.43-1.91) among participants reporting ≥1 day not wearing a mask compared to those who reported no days (1,592 cases, 11,717 controls). During the Delta-predominant period, the results were similar (aOR = 1.53, 95% CI = 1.23-1.89; 659 cases, 4,649 controls). This association was attenuated during the Omicron-predominant period, where odds of an infection was 16% higher (aOR = 1.16, 95% CI = 1.03-1.32; 1,563 cases, 10,960 controls). Conclusions: While the effect of not wearing a mask remains significant, during the Omicron-predominant period we observed a decrease in the association between self-reported mask wearing and risk of SARS-CoV-2 infection.
MeSH term(s)	Adult ; Humans ; Self Report ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; North Carolina/epidemiology ; Masks
Language	English
Publishing date	2022-10-07
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2022.09.027
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Zs.A 1773: Show issues

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Article ; Online: Motivations and Barriers to Routine HIV Testing Among Men Who Have Sex with Men in New York City.

Kobrak, Paul / Remien, Robert H / Myers, Julie E / Salcuni, Paul / Edelstein, Zoe / Tsoi, Benjamin / Sandfort, Theodorus

AIDS and behavior

2022 Volume 26, Issue 11, Page(s) 3563–3575

Abstract: In-depth qualitative interviews explored the experiences and understandings of men 18-39 years old who have sex with men that could facilitate or prevent HIV testing and routine HIV testing. For many men who tested frequently, testing and routine testing ...

Abstract	In-depth qualitative interviews explored the experiences and understandings of men 18-39 years old who have sex with men that could facilitate or prevent HIV testing and routine HIV testing. For many men who tested frequently, testing and routine testing were motivated by awareness of the benefit of prompt treatment; public health and provider encouragement to test periodically; responsibility towards sexual partners; and wanting to share a recent HIV-negative test result when seeking sex online. For some men, any testing was impeded by anxiety around possible HIV diagnosis that made testing a stressful occasion that required time and energy to prepare for. This anxiety was often compounded by stigma related to sex between men, having condomless sex, or having HIV. Routine testing could be further stigmatized as some men felt judged by testing providers or partners if they asked for a test or said they tested frequently. We describe efforts to promote testing and routine testing by countering fear and stigma associated with HIV and testing.
MeSH term(s)	Adolescent ; Adult ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; HIV Testing ; Homosexuality, Male ; Humans ; Male ; Motivation ; New York City/epidemiology ; Sexual Behavior ; Sexual Partners ; Sexual and Gender Minorities ; Young Adult
Language	English
Publishing date	2022-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1339885-4
ISSN	1573-3254 ; 1090-7165
ISSN (online)	1573-3254
ISSN	1090-7165
DOI	10.1007/s10461-022-03679-5
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Zs.A 6451: Show issues

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Article ; Online: Kidney Energetics and Cyst Burden in Autosomal Dominant Polycystic Kidney Disease: A Pilot Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation

2024

Abstract: ... I ratio (0.586±0.205 vs. 0.424±0.171 (mg/kg lean/min) / (μIU/mL), p=0.04), lower median [p25, p75 ... cortical perfusion (1.93 [1.80, 2.09 vs. 0.68 [0.47, 1.04] mL/min/g, p<0.001) and lower median [p25, p75 ...

Abstract	Rationale & objective: In this pilot study, we hypothesized that autosomal dominant polycystic kidney disease (ADPKD) is characterized by impaired kidney oxidative metabolism that associates with kidney size and cyst burden. Study design: Cross-sectional study. Setting & participants: Twenty adults with ADPKD (31±6 years of age, 65% women, BMI: 26.8 [22.7, 30.4] kg/m Predictors: ADPKD status (yes/no) and severity (Mayo Classifications). Outcomes: HtTKV and cyst burden by MRI, kidney oxidative metabolism and perfusion by Analytical approach: Chi-square/Fisher's exact tests used for categorical variables and t-tests/ Mann-Whitney U tests for continuous variables. Pearson correlation used to estimate the relationships between variables. Results: Compared to NWC, participants with ADPKD exhibited lower mean±SD M/I ratio (0.586±0.205 vs. 0.424±0.171 (mg/kg lean/min) / (μIU/mL), p=0.04), lower median [p25, p75] cortical perfusion (1.93 [1.80, 2.09 vs. 0.68 [0.47, 1.04] mL/min/g, p<0.001) and lower median [p25, p75] total kidney oxidative metabolism (0.17 [0.16,0.19] vs. 0.14 [0.12, 0.15] min Limitations: Small sample size and cross-sectional design. Conclusion: Adults with ADPKD and preserved kidney function exhibited impaired renal perfusion and kidney oxidative metabolism across a wide range of cysts and kidney enlargements.
Language	English
Publishing date	2024-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/j.ajkd.2024.02.016
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Zs.A 1669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 468: Show issues

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Article: Self-Reported SARS-CoV-2 Vaccination Is Consistent with Electronic Health Record Data among the COVID-19 Community Research Partnership.

Tjaden, Ashley H / Fette, Lida M / Edelstein, Sharon L / Gibbs, Michael / Hinkelman, Amy N / Runyon, Michael / Santos, Roberto P / Weintraub, William S / Yukich, Joshua / Uschner, Diane / The Covid-Community Research Partnership Study Group

Vaccines

2022 Volume 10, Issue 7

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2022-06-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10071016
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Article ; Online: Changes in Quality of Life Following SARS-CoV-2 Infection Among Jewish and Arab Populations in Israel: A Cross-Sectional Study.

Elsinga, Jelte / Kuodi, Paul / Shibli, Haneen / Gorelik, Yanay / Zayyad, Hiba / Wertheim, Ofir / Abu Jabal, Kamal / Dror, Amiel / Nazzal, Saleh / Glikman, Daniel / Edelstein, Michael

International journal of public health

2023 Volume 68, Page(s) 1605970

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Humans ; Arabs ; Jews ; Israel/epidemiology ; Cross-Sectional Studies ; Quality of Life ; Pandemics ; COVID-19 ; SARS-CoV-2
Language	English
Publishing date	2023-06-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2274130-6
ISSN	1661-8564 ; 1661-8556
ISSN (online)	1661-8564
ISSN	1661-8556
DOI	10.3389/ijph.2023.1605970
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Zs.A 843: Show issues

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Article ; Online: Persistence of antibody responses to COVID-19 vaccines among participants in the COVID-19 Community Research Partnership.

Berry, Andrea A / Tjaden, Ashley H / Renteria, Jone / Friedman-Klabanoff, DeAnna / Hinkelman, Amy N / Gibbs, Michael A / Ahmed, Amina / Runyon, Michael S / Schieffelin, John / Santos, Robert P / Oberhelman, Richard / Bott, Matthew / Correa, Adolfo / Edelstein, Sharon L / Uschner, Diane / Wierzba, Thomas F

Vaccine: X

2023 Volume 15, Page(s) 100371

Abstract: Introduction: High levels of immunity to SARS-CoV-2 in the community correlate with protection from COVID-19 illness. Measuring COVID-19 antibody seroprevalence and persistence may elucidate the level and length of protection afforded by vaccination and ...

Abstract	Introduction: High levels of immunity to SARS-CoV-2 in the community correlate with protection from COVID-19 illness. Measuring COVID-19 antibody seroprevalence and persistence may elucidate the level and length of protection afforded by vaccination and infection within a population. Methods: We measured the duration of detectable anti-spike antibodies following COVID-19 vaccination in a multistate, longitudinal cohort study of almost 13,000 adults who completed daily surveys and submitted monthly dried blood spots collected at home. Results: Overall, anti-spike antibodies persisted up to 284 days of follow-up with seroreversion occurring in only 2.4% of the study population. In adjusted analyses, risk of seroreversion increased with age (adults aged 55-64: adjusted hazard ratio [aHR] 2.19 [95% confidence interval (CI): 1.22, 3.92] and adults aged > 65: aHR 3.59 [95% CI: 2.07, 6.20] compared to adults aged 18-39). Adults with diabetes had a higher risk of seroreversion versus nondiabetics (aHR 1.77 [95% CI: 1.29, 2.44]). Decreased risk of seroreversion was shown for non-Hispanic Black versus non-Hispanic White (aHR 0.32 [95% CI: 0.13, 0.79]); college degree earners versus no college degree (aHR 0.61 [95% CI: 0.46, 0.81]); and those who received Moderna mRNA-1273 vaccine versus Pfizer-BioNTech BNT162b2 (aHR 0.35 [95% CI: 0.26, 0.47]). An interaction between healthcare worker occupation and sex was detected, with seroreversion increased among male, non-healthcare workers. Conclusion: We established that a remote, longitudinal, multi-site study can reliably detect antibody durability following COVID-19 vaccination. The survey platform and measurement of antibody response using at-home collection at convenient intervals allowed us to explore sociodemographic factors and comorbidities and identify predictors of antibody persistence, which has been demonstrated to correlate with protection against disease. Our findings may help inform public health interventions and policies to protect those at highest risk for severe illness and assist in determining the optimal timing of booster doses.Clinical trials registry: NCT04342884.
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article
ISSN	2590-1362
ISSN (online)	2590-1362
DOI	10.1016/j.jvacx.2023.100371
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