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Article ; Online: The Lung in Aerotoxic Syndrome.

Roig, Jorge / Michaelis, Susan / Burdon, Jonathan

2022 Volume 58, Issue 12, Page(s) 787–789

MeSH term(s)	Humans ; Lung/diagnostic imaging
Language	Spanish
Publishing date	2022-04-22
Publishing country	Spain
Document type	Editorial
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2022.03.021
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Article ; Online: Cell-Laden 3D Hydrogels of Type I Collagen Incorporating Bacterial Nanocellulose Fibers.

Malandain, Nanthilde / Sanz-Fraile, Hector / Farré, Ramon / Otero, Jorge / Roig, Anna / Laromaine, Anna

ACS applied bio materials

2023 Volume 6, Issue 9, Page(s) 3638–3647

Abstract: There is a growing interest in developing natural hydrogel-based scaffolds to culture cells in a three-dimensional (3D) millieu that better mimics ... ...

Abstract	There is a growing interest in developing natural hydrogel-based scaffolds to culture cells in a three-dimensional (3D) millieu that better mimics the
MeSH term(s)	Humans ; Animals ; Rats ; Collagen Type I/pharmacology ; Cell Culture Techniques, Three Dimensional ; Fibroblasts ; Gluconacetobacter xylinus ; Hydrogels/pharmacology
Chemical Substances	Collagen Type I ; Hydrogels
Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.3c00126
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Article ; Online: Relevance of Comet Assay and Phosphorylated-Hsp90α in Cancer Patients' Peripheral Blood Leukocytes as Tools to Assess Cisplatin-based Chemotherapy Clinical Response and Disease Outcome.

Sottile, Mayra L / Gómez, Laura C / Redondo, Analía / Ibarra, Jorge / García, María B / Gonzalez, Lucía / Vargas-Roig, Laura M / Nadin, Silvina B

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

2024 Volume 72, Issue 3, Page(s) 173–188

Abstract: Cisplatin (cPt) is a commonly used treatment for solid tumors. The main target of its cytotoxicity is the DNA molecule, which makes the DNA damage response (DDR) crucial for cPt-based chemotherapy. Therefore, it is essential to identify biomarkers that ... ...

Abstract	Cisplatin (cPt) is a commonly used treatment for solid tumors. The main target of its cytotoxicity is the DNA molecule, which makes the DNA damage response (DDR) crucial for cPt-based chemotherapy. Therefore, it is essential to identify biomarkers that can accurately predict the individual clinical response and prognosis. Our goal was to assess the usefulness of alkaline comet assay and immunocytochemical staining of phosphorylated Hsp90α (p-Hsp90α), γH2AX, and 53BP1 as predictive/prognostic markers. Pre-chemotherapy peripheral blood leukocytes were exposed to cPt in vitro and collected at 0, 24 (T24), and 48 (T48) hr post-drug removal. Healthy subjects were also included. Baseline DNA damage was elevated in cancer patients (variability between individuals was observed). After cPt, patients showed increased γH2AX foci/nucleus (T24 and T48). Both in healthy persons and patients, the nuclear p-Hsp90α and N/C (nuclear/cytoplasmic) ratio augmented (T24), decreasing at T48. Favorable clinical response was associated with high DNA damage and p-Hsp90α N/C ratio following cPt. For the first time, p-Hsp90α significance as a predictive marker is highlighted. Post-cPt-DNA damage was associated with longer disease-free survival and overall survival. Our findings indicate that comet assay and p-Hsp90α (a marker of DDR) would be promising prognostic/predictive tools in cP-treated cancer patients.
MeSH term(s)	Humans ; Comet Assay ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/genetics ; DNA Damage ; Leukocytes
Chemical Substances	Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	218208-7
ISSN	1551-5044 ; 0022-1554
ISSN (online)	1551-5044
ISSN	0022-1554
DOI	10.1369/00221554241236241
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Article ; Online: Irritant-induced Asthma Caused by Aerotoxic Syndrome.

Roig, Jorge / Domingo, Christian / Burdon, Jonathan / Michaelis, Susan

Lung

2021 Volume 199, Issue 2, Page(s) 165–170

Abstract: Purpose: Case series on respiratory features of Aerotoxic Syndrome (AS). The term AS has been coined to describe the spectrum of clinical manifestations after aircraft fume events. Among these manifestations, neurological and respiratory symptoms are ... ...

Abstract	Purpose: Case series on respiratory features of Aerotoxic Syndrome (AS). The term AS has been coined to describe the spectrum of clinical manifestations after aircraft fume events. Among these manifestations, neurological and respiratory symptoms are the most frequently reported complaints. Methods: Three cases of AS with relevant respiratory features are presented. Results: Cough and shortness of breath for 6 to12 months were the predominant symptoms in the first two cases. The first case also developed neurological symptoms affecting his central nervous system. In the third case, the patient complained for nine years about an unbearable cough triggered by odors, smells, and a variety of indoor and outdoor irritants, among other symptoms of multiple chemical sensitivity. In all three cases, the respiratory symptoms resolved after appropriate treatment. Conclusion: Our report aims at raising awareness on AS and calls for actions to improve the management of patients suffering from this syndrome.
MeSH term(s)	Adult ; Asthma/diagnosis ; Asthma/etiology ; Aviation ; Female ; Humans ; Irritants/adverse effects ; Male ; Middle Aged ; Occupational Diseases/diagnosis ; Occupational Diseases/etiology ; Syndrome
Chemical Substances	Irritants
Language	English
Publishing date	2021-03-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	6165-7
ISSN	1432-1750 ; 0341-2040
ISSN (online)	1432-1750
ISSN	0341-2040
DOI	10.1007/s00408-021-00431-z
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Article ; Online: Efficacy of Local Hemostatic Management in Implant Surgery in Anticoagulated Patients on Warfarin: A Randomized Clinical Study.

Vassallo, Mariano / Zamberlin, Jose / Roig, Marina Diaz / Macchi, Ricardo / Aguilar, Jorge Ernesto

The International journal of oral & maxillofacial implants

2023 Volume 38, Issue 3, Page(s) 545–552

Abstract: Purpose: To compare the frequency of immediate/short-term postoperative bleeding and occurrence of hematomas using tranexamic acid (TXA), bismuth subgallate (BS), or dry gauze (DG) as a local hemostatic agent, and to explore the relation between short- ... ...

Abstract	Purpose: To compare the frequency of immediate/short-term postoperative bleeding and occurrence of hematomas using tranexamic acid (TXA), bismuth subgallate (BS), or dry gauze (DG) as a local hemostatic agent, and to explore the relation between short-term bleeding and occurrence of intraoral and extraoral hematomas and length of incision, duration of surgery, and alveolar ridge recontouring in patients who were continued on oral anticoagulation therapy. Materials and methods: Eighty surgical procedures performed in 71 patients were assigned to one of four groups (20 each): control group (patients not on oral anticoagulant therapy) and three experimental groups (patients on oral anticoagulation therapy managed with local hemostatic measures): TXAg, BSg, or DGg. Studied variables were length of incision, duration of surgery, and alveolar ridge recontouring. Short-term bleeding episodes and occurrence of intraoral and extraoral hematomas were recorded. Results: A total of 111 implants were placed. No significant differences in mean international normalized ratio, duration of surgery, and length of incision were observed among groups ( Conclusion: Implant placement in warfarin anticoagulated patients without withdrawing oral anticoagulation therapy is a safe and predictable procedure, and different local hemostatic agents (TXA, BS, and DG) are effective in managing postoperative bleeding. Development of hematomas may be higher in patients undergoing alveolar ridge recontouring. Further studies are necessary to confirm these results. Int J Oral Maxillofac Implants 2023;38:545-552. doi: 10.11607/jomi.9846.
MeSH term(s)	Humans ; Warfarin/adverse effects ; Hemostatics/therapeutic use ; Tooth Extraction/methods ; Dental Implants ; Anticoagulants/adverse effects ; Postoperative Hemorrhage/chemically induced ; Postoperative Hemorrhage/drug therapy ; Tranexamic Acid/therapeutic use
Chemical Substances	Warfarin (5Q7ZVV76EI) ; Hemostatics ; Dental Implants ; Anticoagulants ; Tranexamic Acid (6T84R30KC1)
Language	English
Publishing date	2023-06-06
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	632880-5
ISSN	1942-4434 ; 0882-2786
ISSN (online)	1942-4434
ISSN	0882-2786
DOI	10.11607/jomi.9846
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Article ; Online: Change in prefilter pressure as a key determinant in the decision to return blood in continuous renal replacement therapy: An observational study.

Mateos-Dávila, Almudena / Betbesé Roig, Antonio Jorge / Santos Rodríguez, José Alberto / Guix-Comellas, Eva Maria

Nursing in critical care

2023

Abstract: Background: During continuous renal replacement therapy (CRRT), circuit coagulation is an important event that can result in suboptimal outcomes. Nurses must remain alert throughout the treatment and observe machine pressures. Transmembrane pressure ( ... ...

Abstract	Background: During continuous renal replacement therapy (CRRT), circuit coagulation is an important event that can result in suboptimal outcomes. Nurses must remain alert throughout the treatment and observe machine pressures. Transmembrane pressure (TMP) is commonly used for monitoring but it is sometimes too late to return blood to the patient. Aim: To compare the capacity of prefilter pressure (FP) versus TMP to predict the risk of circuit coagulation in adult patients with acute renal failure on CRRT. Study design: An observational, longitudinal, prospective study. This study was carried out in a tertiary referral hospital over 2 years. Data collected included the following variables: TMP, filter or FP, effluent pressure, venous and arterial pressure, filtration fraction, and ultrafiltration constant of each circuit. Means and their trends over time were collected, for both diffusive and convective therapy and for two membrane types. Results: A total of 151 circuits (24 polysulfone and 127 acrylonitrile) were analysed, from 71 patients (n = 22 [34%] women; mean age, 66.5 [36-84] years). Of the total treatments, 80 were diffusive, and the rest were convective or mixed. In the diffusive circuits, a progressive rise in FP was observed without an increase in TMP and with an increasing trend in effluent pressure. Circuit lifespan was between 2 and 90 h. In 11% (n = 17) of the cases, the blood could not be returned to the patient. Conclusion: These findings allowed the creation of graphs that indicate the appropriate point to return blood to the patient. FP was a major determinant in this decision; in most cases, TMP was not a reliable parameter. Our findings are applicable to convective, diffusive, and mixed treatments as well as both types of membranes used in this acute setting. Relevance to clinical practice: This study provides two clear reference graphs showing risk scales for the assessment of circuit pressures in CRRT. The graphs proposed here can be used to evaluate any machine on the market and the two types of membranes used in this acute setting. Both convective and diffusive circuits can be assessed, allowing safer evaluation in patients who change treatment.
Language	English
Publishing date	2023-06-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2011956-2
ISSN	1478-5153 ; 1362-1017
ISSN (online)	1478-5153
ISSN	1362-1017
DOI	10.1111/nicc.12933
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Article ; Online: Comparison of diluted vs concentrated regional citrate anticoagulation in continuous renal replacement therapy: A quasi-experimental study.

Mateos-Dávila, Almudena / Betbesé Roig, Antonio Jorge / Santos Rodríguez, José Alberto / Guix-Comellas, Eva Maria

Nursing in critical care

2023

Abstract: Background: The incidence of coagulation of continuous renal replacement therapy circuits remains high. To the best of our knowledge, no scholar has published a protocol to avoid management errors when different types of citrates coexist in the same ... ...

Abstract	Background: The incidence of coagulation of continuous renal replacement therapy circuits remains high. To the best of our knowledge, no scholar has published a protocol to avoid management errors when different types of citrates coexist in the same Intensive Care Unit. Aim: To assess the safety and efficacy of the unification of two protocols with different concentrations of citrate solution. Study desing: A prospective, quasi-experimental study was carried out in the intensive care unit of a tertiary referral hospital (in Barcelona, Spain), over 3 years. Consecutive adult patients requiring continuous renal replacement therapy with citrate were included. The sample was divided into two groups, a control group (concentrated citrate) and an intervention group (diluted citrate). The decision to initiate anticoagulation with diluted (18 mmol/L) or concentrated (136 mmol/L) citrate was made based on the machine available and the decision of the doctor responsible for the patient. It was not possible to randomize the sample. Both protocols were matched with a starting citrate dose of 3.5 mmol/L, and a dialysis solution was used. Post-filter replacement was not used, and the citrate solution was the only fluid administered pre-filter. Results: The analysis included 59 circuits in the concentrated citrate group and 40 circuits in the diluted citrate group. An increased need for electrolyte replacement was observed in the diluted group (p < .001). The concentrated citrate group had a longer filter life (p < .05), and there was a slight trend toward alkalosis. Conclusion: The diluted citrate group had a higher incidence of electrolyte replacement. The concentrated citrate group had longer circuit lifespan and a trend toward metabolic alkalosis, although this was not statistically significant. If these conclusions are considered, the protocol can be unified. Relevance to clinical practice: The present work aims to provide information on the differences in the use of regional anticoagulation with diluted or concentrated citrate. The objective is to pay special attention to aspects that can lead to complications. The unified protocol proposed in this paper could be extrapolated to any machine on the market that uses either of these two types of citrate concentration.
Language	English
Publishing date	2023-10-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2011956-2
ISSN	1478-5153 ; 1362-1017
ISSN (online)	1478-5153
ISSN	1362-1017
DOI	10.1111/nicc.12991
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Article ; Online: Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts.

Martínez-Hernández, Néstor J / Milián-Medina, Lara / Mas-Estellés, Jorge / Monroy-Antón, José L / López-Villalobos, José L / Hervás-Marín, David / Roig-Bataller, Amparo / Mata-Roig, Manuel

Journal of visualized experiments : JoVE

2023 , Issue 194

Abstract: One of the main key aspects in ensuring that a transplant evolves correctly is the sterility of the medium. Decellularized tracheal transplantation involves implanting an organ that was originally in contact with the environment, thus not being sterile ... ...

Abstract	One of the main key aspects in ensuring that a transplant evolves correctly is the sterility of the medium. Decellularized tracheal transplantation involves implanting an organ that was originally in contact with the environment, thus not being sterile from the outset. While the decellularization protocol (through detergent exposition [2% sodium dodecyl sulfate], continuous stirring, and osmotic shocks) is conducted in line with aseptic measures, it does not provide sterilization. Therefore, one of the main challenges is ensuring sterility prior to in vivo implantation. Although there are established gamma radiation sterilization protocols for inorganic materials, there are no such measures for organic materials. Additionally, the protocols in place for inorganic materials cannot be applied to organic materials, as the established radiation dose (25 kGy) would completely destroy the implant. This paper studies the effect of an escalated radiation dose in a decellularized rabbit trachea. We maintained the dose range (kGy) and tested escalated doses until finding the minimal dose at which sterilization is achieved. After determining the dose, we studied effects of it on the organ, both histologically and biomechanically. We determined that while 0.5 kGy did not achieve sterility, doses of both 1 kGy and 2 kGy did, with 1 kGy, therefore, being the minimal dose necessary to achieve sterilization. Microscopic studies showed no relevant changes compared to non-sterilized organs. Axial biomechanical characteristics were not altered at all, and only a slight reduction in the force per unit of length that the organ can radially tolerate was observed. We can therefore conclude that 1 kGy achieves complete sterilization of decellularized rabbit trachea with a minimal, if any, effects on the organ.
MeSH term(s)	Animals ; Rabbits ; Gamma Rays ; Trachea ; Mechanical Phenomena ; Transplantation, Homologous/methods ; Sterilization/methods
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/64432
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Article ; Online: Analysis of Heart Rate Variability in Individuals Affected by Amyotrophic Lateral Sclerosis.

Maset-Roig, Rosa / Caplliure-Llopis, Jordi / de Bernardo, Nieves / Privado, Jesús / Alarcón-Jiménez, Jorge / Martín-Ruiz, Julio / Botella-Navas, Marta / Villarón-Casales, Carlos / Sancho-Cantus, David / de la Rubia Ortí, José Enrique

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 7

Abstract: Introduction: Amyotrophic lateral sclerosis (ALS) produces alterations in the autonomic nervous system (ANS), which explains the cardiac manifestations observed in patients. The assessment of heart rate variability (HRV) is what best reflects the ... ...

Abstract	Introduction: Amyotrophic lateral sclerosis (ALS) produces alterations in the autonomic nervous system (ANS), which explains the cardiac manifestations observed in patients. The assessment of heart rate variability (HRV) is what best reflects the activity of the ANS on heart rate. The Polar H7 Bluetooth Objective: The goal of this study is to determine HRV using Polar H7 Bluetooth technology in ALS patients, comparing the obtained measurements with values from healthy individuals. Method: The sample consisted of 124 participants: 68 diagnosed with ALS and 56 healthy individuals. Using Polar H7 Bluetooth technology and the ELITE HRV application, various HRV measurements were determined for all participants, specifically the HRV index, RMSSD, RMSSD LN, SDNN index, PNN50, LF, HF, LF/HF ratio, HR average, and HF peak frequency. Results: Statistically significant differences were observed between ALS patients and healthy individuals in the HRV index, RMSSD, RMSSD LN, SDNN index, PNN50, HF, and LF, where healthy individuals exhibited higher scores. For the HR average, the ALS group showed a higher value. Values were similar when comparing men and women with ALS, with only a higher HF peak frequency observed in women. Conclusion: The Polar H7 Bluetooth
MeSH term(s)	Male ; Humans ; Female ; Amyotrophic Lateral Sclerosis ; Heart Rate ; Autonomic Nervous System ; Health Status ; Heart
Language	English
Publishing date	2024-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24072355
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Article ; Online: The genus Epipompilus in Argentina (Hymenoptera

Arturo ROIG ALSINA / Jorge BARNECHE

Revista de la Sociedad Entomológica Argentina, Vol 76, Iss 3-4, Pp 33-

Pompilidae)

2017 Volume 38

Abstract: Cuatro especies de Epipompilus están presentes en la Argentina: E. platensis sp. n., E. tucumanus Evans, E. jocosus Evans, y E. excelsus (Bradley), siendo las dos últimas nuevos registros para este país. La nueva especie E. platensis se describe sobre ... ...

Abstract	Cuatro especies de Epipompilus están presentes en la Argentina: E. platensis sp. n., E. tucumanus Evans, E. jocosus Evans, y E. excelsus (Bradley), siendo las dos últimas nuevos registros para este país. La nueva especie E. platensis se describe sobre especímenes de Buenos Aires en la Argentina y de Santa Catarina en Brasil. Se clarifica la incorrecta asociación de sexos en la descripción original de E. jocosus. Se presentan descripciones, notas taxonómicas, ilustraciones y una clave para las especies.
Keywords	Zoology ; QL1-991
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Sociedad Entomológica Argentina
Document type	Article ; Online
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