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Article ; Online: Multi-scale isotopic heterogeneity reveals a complex magmatic evolution

Kieran A. Iles / Janet M. Hergt / Jon D. Woodhead

Frontiers in Earth Science, Vol

An example from the wallundry suite granitoids of the lachlan fold belt, Australia

2023 Volume 11

Abstract: Open-system magmatic processes are expected to impart various sorts of isotopic heterogeneity upon the igneous rocks they produce. The range of processes under the “open-system” umbrella (e.g., simple two-component mixing, magma mingling, assimilation ... ...

Abstract	Open-system magmatic processes are expected to impart various sorts of isotopic heterogeneity upon the igneous rocks they produce. The range of processes under the “open-system” umbrella (e.g., simple two-component mixing, magma mingling, assimilation with fractional crystallization) cannot usually be uniquely identified using data from a single isotope system. The use of bulk-rock, mineral separate and in situ techniques and multiple isotope systems allows the characterization of isotopic variability at different sampling scales, illuminating details of the petrogenesis of a magmatic system. This approach has been applied to granitoids of the Wallundry Suite in the Lachlan Fold Belt, Australia. The Wallundry Suite exhibits variations in mineral assemblage, mineral composition and trends in bulk-rock major and trace element compositions consistent with the involvement of liquid-crystal sorting processes such as fractional crystallization. In situ paired O-Hf isotope data from zircon in six samples show an array indicating the isotopic evolution of the melt phase. Similarly, bulk-rock Sr-Nd-Hf isotope arrays support open-system magma evolution. These data combined with the petrographic observations and major and trace element geochemical variations suggest some form of assimilation-fractional crystallization process in the petrogenesis of the Wallundry Suite. Added complexity is revealed by two observations: 1) the isotopic variations are only weakly coupled to the lithology and major element compositions of the samples; and 2) there are distinguishable differences between the Hf isotope compositions of bulk-rock samples and those of the magmatic zircons they host. To varying degrees the rocks consistently show negative ΔεHfbulk-zrc values (i.e., the bulk-rock compositions have less radiogenic Hf isotope values than their coexisting zircons). The preservation of distinctly low Nd and Hf isotope ratios in an Fe-Ti oxide mineral separate suggests that the bulk-rock vs. zircon discrepancy is caused by the presence ...
Keywords	high-temperature I-types ; assimilation ; fractional crystallisation ; hf isotopes ; disequilibium ; Science ; Q
Subject code	550
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Liver-Directed Therapy Combined with Systemic Therapy: Current Status and Future Directions.

Young, Shamar / Hannallah, Jack / Goldberg, Dan / Khreiss, Mohammad / Shroff, Rachna / Arshad, Junaid / Scott, Aaron / Woodhead, Gregory

Seminars in interventional radiology

2024 Volume 40, Issue 6, Page(s) 515–523

Abstract: In the past several decades, major advances in both systemic and locoregional therapies have been made for many cancer patients. This has led to modern cancer treatment algorithms frequently calling for active interventions by multiple subspecialists at ... ...

Abstract	In the past several decades, major advances in both systemic and locoregional therapies have been made for many cancer patients. This has led to modern cancer treatment algorithms frequently calling for active interventions by multiple subspecialists at the same time. One of the areas where this can be clearly seen is the concomitant use of locoregional and systemic therapies in patients with primary or secondary cancers of the liver. These combined algorithms have gained favor over the last decade and are largely focused on the allure of the combined ability to control systemic disease while at the same time addressing refractory/resistant clonal populations. While the general concept has gained favor and is likely to only increase in popularity with the continued establishment of viable immunotherapy treatments, for many patients questions remain. Lingering concerns over the increase in toxicity when combining treatment methods, patient selection, and sequencing remain for multiple cancer patient populations. While further work remains, some of these questions have been addressed in the literature. This article reviews the available data on three commonly treated primary and secondary cancers of the liver, namely, hepatocellular carcinoma, cholangiocarcinoma, and metastatic colorectal cancer. Furthermore, strengths and weaknesses are reviewed and future directions are discussed.
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	848341-3
ISSN	1098-8963 ; 0739-9529
ISSN (online)	1098-8963
ISSN	0739-9529
DOI	10.1055/s-0043-1777711
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Article: Size and shape of skeletal muscle M-protein.

Woodhead, J L / Lowey, S

Journal of molecular biology

1982 Volume 157, Issue 1, Page(s) 149–154

MeSH term(s)	Animals ; Chickens ; Connectin ; Electrophoresis, Polyacrylamide Gel ; Microscopy, Electron ; Molecular Weight ; Muscle Proteins ; Ultracentrifugation
Chemical Substances	Connectin ; Muscle Proteins
Language	English
Publishing date	1982-05-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80229-3
ISSN	1089-8638 ; 0022-2836
ISSN (online)	1089-8638
ISSN	0022-2836
DOI	10.1016/0022-2836(82)90517-4
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Article ; Online: A Pilot Study of F-18 Fluciclovine-PET/CT as a Diagnostic Tool for Bone Metastases in Patients With Castrate Resistant Prostate Adenocarcinoma and Correlative Analysis of Blood and Bone Molecular Testing (The FACT Study).

Babiker, Hani M / Kay, Matthew D / Stuehm, Carol / Woodhead, Gregory / Kuo, Phillip H

The oncologist

2023 Volume 28, Issue 11, Page(s) e1114–e1117

Abstract: Background: Suspicious F-18 fluciclovine PET/CT findings for osseous metastases from prostate cancer (PC) were targeted for core needle biopsy. We correlated the maximum standardized uptake value (SUVmax) of biopsied lesions, with biopsy results, other ... ...

Abstract	Background: Suspicious F-18 fluciclovine PET/CT findings for osseous metastases from prostate cancer (PC) were targeted for core needle biopsy. We correlated the maximum standardized uptake value (SUVmax) of biopsied lesions, with biopsy results, other diagnostic outcomes, and blood and tissue molecular analysis (TMA). Material and methods: Patients with castrate resistant prostate cancer (CRPC) were recruited from a university oncology clinic. SUVmax, histology, blood, and TMA were correlated. Results: Fifteen patients were enrolled and 12 underwent bone biopsies. Fifty percent of bone biopsies demonstrated malignancy. Higher SUVmax was associated with positive biopsies for adenocarcinoma (P = .003), and lesions with SUVmax ≥ 5.1 were all positive for malignancy. Significant correlation between blood and somatic TMA (P = .002) was also found. Conclusion: Higher uptake of F-18 fluciclovine was associated with higher predictive value for osseous metastasis on biopsy. There was a significant correlation between blood and TMA.
MeSH term(s)	Male ; Humans ; Positron Emission Tomography Computed Tomography/methods ; Pilot Projects ; Prostate/pathology ; Prostatic Neoplasms/pathology ; Bone Neoplasms/secondary ; Adenocarcinoma
Language	English
Publishing date	2023-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1093/oncolo/oyad242
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Zs.A 4845: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Corticospinal and spinal adaptations following lower limb motor skill training: a meta-analysis with best evidence synthesis.

Woodhead, Alex / North, Jamie S / Hill, Jessica / Murphy, Colm P / Kidgell, Dawson J / Tallent, Jamie

Experimental brain research

2023 Volume 241, Issue 3, Page(s) 807–824

Abstract: ... excitability (CSE), Hoffmann's reflex (H-reflex) or muscle compound action potential (M ...

Abstract	Motor skill training alters the human nervous system; however, lower limb motor tasks have been less researched compared to upper limb tasks. This meta-analysis with best evidence synthesis aimed to determine the cortical and subcortical responses that occur following lower limb motor skill training, and whether these responses are accompanied by improvements in motor performance. Following a literature search that adhered to the PRISMA guidelines, data were extracted and analysed from six studies (n = 172) for the meta-analysis, and 11 studies (n = 257) were assessed for the best evidence synthesis. Pooled data indicated that lower limb motor skill training increased motor performance, with a standardised mean difference (SMD) of 1.09 being observed. However, lower limb motor skill training had no effect on corticospinal excitability (CSE), Hoffmann's reflex (H-reflex) or muscle compound action potential (M
MeSH term(s)	Humans ; Motor Skills/physiology ; Pyramidal Tracts/physiology ; Muscle, Skeletal/physiology ; Resistance Training ; Upper Extremity ; Evoked Potentials, Motor/physiology ; Transcranial Magnetic Stimulation
Language	English
Publishing date	2023-02-05
Publishing country	Germany
Document type	Meta-Analysis ; Review ; Journal Article
ZDB-ID	1201-4
ISSN	1432-1106 ; 0014-4819
ISSN (online)	1432-1106
ISSN	0014-4819
DOI	10.1007/s00221-023-06563-3
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Article ; Online: Generalized models for quantifying laterality using functional transcranial Doppler ultrasound.

Thompson, Paul A / Watkins, Kate E / Woodhead, Zoe V J / Bishop, Dorothy V M

Human brain mapping

2022 Volume 44, Issue 1, Page(s) 35–48

Abstract: We consider how analysis of brain lateralization using functional transcranial Doppler ultrasound (fTCD) data can be brought in line with modern statistical methods typically used in functional magnetic resonance imaging (fMRI). Conventionally, a ... ...

Abstract	We consider how analysis of brain lateralization using functional transcranial Doppler ultrasound (fTCD) data can be brought in line with modern statistical methods typically used in functional magnetic resonance imaging (fMRI). Conventionally, a laterality index is computed in fTCD from the difference between the averages of each hemisphere's signal within a period of interest (POI) over a series of trials. We demonstrate use of generalized linear models (GLMs) and generalized additive models (GAM) to analyze data from individual participants in three published studies (N = 154, 73 and 31), and compare this with results from the conventional POI averaging approach, and with laterality assessed using fMRI (N = 31). The GLM approach was based on classic fMRI analysis that includes a hemodynamic response function as a predictor; the GAM approach estimated the response function from the data, including a term for time relative to epoch start (simple GAM), plus a categorical index corresponding to individual epochs (complex GAM). Individual estimates of the fTCD laterality index are similar across all methods, but error of measurement is lowest using complex GAM. Reliable identification of cases of bilateral language appears to be more accurate with complex GAM. We also show that the GAM-based approach can be used to efficiently analyze more complex designs that incorporate interactions between tasks.
MeSH term(s)	Humans ; Functional Laterality/physiology ; Brain/diagnostic imaging ; Brain/physiology ; Ultrasonography, Doppler, Transcranial/methods ; Language ; Magnetic Resonance Imaging
Language	English
Publishing date	2022-11-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.26138
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Article ; Online: Synthesis, structure elucidation, and chemiluminescent activity of new 9-substituted 10-(ω-(succinimidyloxycarbonyl)alkyl)acridinium esters.

Smith, Keith / Mu, Xiaojing / Li, Zhaoqiang / Holland, Andy M / Woodhead, J Stuart / El-Hiti, Gamal A

Luminescence : the journal of biological and chemical luminescence

2023 Volume 38, Issue 4, Page(s) 487–496

Abstract: Several new acridinium esters 2-9 having their central acridinium ring bearing a 9-(2,5-dimethylphenoxycarbonyl), 9-(2,6-bis(trifluoromethyl)phenoxycarbonyl) or 9-(2,6-dinitrophenoxycarbonyl) group, and a 10-methyl, 10-(3-(succinimidyloxycarbonyl)propyl), ...

Abstract	Several new acridinium esters 2-9 having their central acridinium ring bearing a 9-(2,5-dimethylphenoxycarbonyl), 9-(2,6-bis(trifluoromethyl)phenoxycarbonyl) or 9-(2,6-dinitrophenoxycarbonyl) group, and a 10-methyl, 10-(3-(succinimidyloxycarbonyl)propyl), 10-(5-(succinimidyloxycarbonyl)pentyl), or 10-(10-(succinimidyloxycarbonyl)decyl) group, have been synthesized and their chemiluminescent properties have been tested. The 2,5-dimethylphenyl acridinium esters emit light slowly (glow) when treated with alkaline hydrogen peroxide, while the 2,6-dinitrophenyl and 2,6-bis(trifluoromethyl)phenyl esters emit light rapidly (flash). The substituent at the 10 position affects the hydrolytic stabilities of the compounds.
MeSH term(s)	Luminescent Measurements ; Esters/chemistry ; Acridines/chemistry ; Hydrogen Peroxide
Chemical Substances	Esters ; Acridines ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2023-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1470995-8
ISSN	1522-7243 ; 1522-7235 ; 1099-1271
ISSN (online)	1522-7243
ISSN	1522-7235 ; 1099-1271
DOI	10.1002/bio.4474
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Article ; Online: Ethnic inequalities among NHS staff in England: workplace experiences during the COVID-19 pandemic.

Rhead, Rebecca / Harber-Aschan, Lisa / Onwumere, Juliana / Polling, Catherine / Dorrington, Sarah / Ehsan, Annahita / Stevelink, Sharon A M / Khunti, Kamlesh / Mir, Ghazala / Morriss, Richard / Wessely, Simon / Woodhead, Charlotte / Hatch, Stephani

Occupational and environmental medicine

2024 Volume 81, Issue 3, Page(s) 113–121

Abstract: Objectives: This study aims to determine how workplace experiences of National Health Service (NHS) staff varied by ethnicity during the COVID-19 pandemic and how these experiences are associated with mental and physical health at the time of the study.! ...

Abstract	Objectives: This study aims to determine how workplace experiences of National Health Service (NHS) staff varied by ethnicity during the COVID-19 pandemic and how these experiences are associated with mental and physical health at the time of the study. Methods: An online Inequalities Survey was conducted by the Tackling Inequalities and Discrimination Experiences in Health Services study in collaboration with NHS CHECK. This Inequalities Survey collected measures relating to workplace experiences (such as personal protective equipment (PPE), risk assessments, redeployments and discrimination) as well as mental health (Patient Health Questionnaire (PHQ-9), Generalised Anxiety Disorder 7 (GAD-7)), and physical health (PHQ-15) from NHS staff working in the 18 trusts participating with the NHS CHECK study between February and October 2021 (N=4622). Results: Regression analysis of this cross-sectional data revealed that staff from black and mixed/other ethnic groups had greater odds of experiencing workplace harassment (adjusted OR (AOR) 2.43 (95% CI 1.56 to 3.78) and 2.38 (95% CI 1.12 to 5.07), respectively) and discrimination (AOR 4.36 (95% CI 2.73 to 6.96) and 3.94 (95% CI 1.67 to 9.33), respectively) compared with white British staff. Staff from black ethnic groups also had greater odds than white British staff of reporting PPE unavailability (AOR 2.16 (95% CI 1.16 to 4.00)). Such workplace experiences were associated with negative physical and mental health outcomes, though this association varied by ethnicity. Conversely, understanding employment rights around redeployment, being informed about and having the ability to inform redeployment decisions were associated with lower odds of poor physical and mental health. Conclusions: Structural changes to the way staff from ethnically minoritised groups are supported, and how their complaints are addressed by leaders within the NHS are urgently required.
MeSH term(s)	Humans ; COVID-19 ; State Medicine ; Pandemics ; Cross-Sectional Studies ; Workplace
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1180733-7
ISSN	1470-7926 ; 1351-0711
ISSN (online)	1470-7926
ISSN	1351-0711
DOI	10.1136/oemed-2023-108976
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Article: Two Epidemics of Sore Throat and Their Relation to the Milk Supply.

Cotterill, J M / Woodhead, G Sims

Transactions. Medico-Chirurgical Society of Edinburgh

2018 Volume 7, Page(s) 220–227

Language	English
Publishing date	2018-03-19
Publishing country	Scotland
Document type	Journal Article
ISSN	0267-2790
ISSN	0267-2790
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Article ; Online: Optimisation of COVID-19 diagnostic pathways in acute hospital admissions to prevent nosocomial transmission.

Livingstone, Robert / Woodhead, Alexander / Bhandari, Megha / Dias, James / Smith, Trevor / Havelock, Tom / Stammers, Matthew

The clinical respiratory journal

2022 Volume 16, Issue 9, Page(s) 618–622

Abstract: Introduction: In the management of acute hospital admissions during the COVID-19 pandemic, safe patient cohorting depends on robust admission diagnostic strategies. It is essential that screening strategies are sensitive and rapid, to prevent nosocomial ...

Abstract	Introduction: In the management of acute hospital admissions during the COVID-19 pandemic, safe patient cohorting depends on robust admission diagnostic strategies. It is essential that screening strategies are sensitive and rapid, to prevent nosocomial transmission of COVID-19 and maintain patient flow. Methods: We retrospectively identified all COVID-19 positive and suspected cases at our institution screened by reverse transcription polymerase chain reaction (RT-PCR) between 4 April and 28 June 2020. Using RT-PCR positivity within 7 days as our reference standard, we assessed sensitivity and net-benefit of three admission screening strategies: single admission RT-PCR, composite admission RT-PCR and CXR and repeat RT-PCR with 48 h. Results: RT-PCR single-test sensitivity was 91.5% (87.8%-94.4%) versus 97.7% (95.4%-99.1%) (p = 0.025) for RT-PCR/CXR composite testing and 95.1% (92.1%-97.2%) (p = 0.03) for repeated RT-PCR. Net-benefit was 0.83 for single RT-PCR versus 0.89 for RT-PCR/CXR and 0.87 for repeated RT-PCR at 0.02% threshold probability. Conclusion: The RT-PCR/CXR composite testing strategy was highly sensitive when screening patients at the point of hospital admission. Real-world sensitivity of this approach was comparable to repeat RT-PCR testing within 48 h; however, faster facilitating improved patient flow.
MeSH term(s)	COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Cross Infection/diagnosis ; Cross Infection/epidemiology ; Cross Infection/prevention & control ; Hospitals ; Humans ; Pandemics/prevention & control ; Retrospective Studies ; SARS-CoV-2/genetics ; Sensitivity and Specificity
Language	English
Publishing date	2022-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.13530
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