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Article ; Online: Single-Wall Carbon Nanohorn Langmuir-Schaefer Films.

Kędzierski, Kamil / Rytel, Karol / Barszcz, Bolesław / Majchrzycki, Łukasz

Langmuir : the ACS journal of surfaces and colloids

2023 Volume 39, Issue 34, Page(s) 12124–12131

Abstract: A suspension of single-walled carbon nanohorn (SWCNH) aggregates with a size of approx. 50 nm was used to create a floating film at the water-air interface. The film was then transferred onto large-area quartz substrates using the Langmuir-Schaefer ... ...

Abstract	A suspension of single-walled carbon nanohorn (SWCNH) aggregates with a size of approx. 50 nm was used to create a floating film at the water-air interface. The film was then transferred onto large-area quartz substrates using the Langmuir-Schaefer technique at varied surface pressures. The packaging and arrangement of SWCNHs in the film can be controlled during the process. The resulting films' optical and electrical properties were investigated, and the highest electrical conductivity and figure of merit parameter values were observed for the film transferred at surface pressure near the collapse point. These films had a surface density of less than 5 μg cm
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c01396
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Study of the Stability of Palletized Cargo by Dynamic Test Method Performed on Laboratory Test Bench.

Tkaczyk, Sławomir / Drozd, Mikołaj / Kędzierski, Łukasz / Santarek, Krzysztof

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 15

Abstract: The paper presents a method and results of experimental testing of the stability of palletized cargo wrapped in stretch film in laboratory conditions and methods and parameterization of its application for proper cargo securing. Reduction of stretch film ...

Abstract	The paper presents a method and results of experimental testing of the stability of palletized cargo wrapped in stretch film in laboratory conditions and methods and parameterization of its application for proper cargo securing. Reduction of stretch film consumption is also significant for sustainable transport. It will contribute to the minimization of costs on a micro-scale (manufacturers and shippers) and a macro scale-a significant reduction in pollution of the environment and gas emissions by reducing stretch film production. The experiments have been performed following the requirements of EUMOS 40509 and 40511 standards. The proposed method of testing the stability of palletized cargo is based on tests performed on a laboratory test bench using FEF-200 sensors. The results of conducted experiments demonstrated that the selection of a proper stretch film and a cargo wrapping model could significantly reduce the risk of cargo damage through increasing cargo stabilizing forces and, at the same time, reducing stretch film consumption. The developed method can significantly reduce the cost of securing and concurrently assure required cargo security. This directly impacts the safety of all participants in the transport process in supply chains.
MeSH term(s)	Humans ; Transportation
Language	English
Publishing date	2021-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21155129
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Article ; Online: Development of new combination anti-leishmanial complexes: Triphenyl Sb(V) mono-hydroxy mono-quinolinolates.

Duffin, Rebekah N / Blair, Victoria L / Kedzierski, Lukasz / Andrews, Philip C

Journal of inorganic biochemistry

2021 Volume 219, Page(s) 111385

Abstract: In seeking to develop single entity combination anti-Leishmanial complexes six heteropletic organometallic Sb(V) hydroxido quinolinolate complexes of general formula [ ... ...

Abstract	In seeking to develop single entity combination anti-Leishmanial complexes six heteropletic organometallic Sb(V) hydroxido quinolinolate complexes of general formula [SbPh
MeSH term(s)	Animals ; Antimony/chemistry ; Antimony/pharmacology ; Antiprotozoal Agents/chemistry ; Antiprotozoal Agents/pharmacology ; Cell Line ; Crystallography, X-Ray/methods ; Humans ; Hydroxyquinolines/chemistry ; Hydroxyquinolines/pharmacology ; Leishmania major ; Leishmaniasis/drug therapy ; Leishmaniasis/metabolism ; Ligands ; Mice ; Molecular Structure ; Organometallic Compounds/chemistry ; Organometallic Compounds/pharmacology ; Reactive Oxygen Species/metabolism ; X-Ray Diffraction/methods
Chemical Substances	Antiprotozoal Agents ; Hydroxyquinolines ; Ligands ; Organometallic Compounds ; Reactive Oxygen Species ; Antimony (9IT35J3UV3)
Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2021.111385
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Article ; Online: Suppressor of Cytokine Signalling 5 (SOCS5) Modulates Inflammatory Responses during Alphavirus Infection.

Kedzierski, Lukasz / Tan, Abigail Er Qi / Foo, Isabelle Jia Hui / Nicholson, Sandra E / Fazakerley, John K

Viruses

2022 Volume 14, Issue 11

Abstract: CNS viral infections are one of the major causes of morbidity and mortality worldwide and a significant global public health concern. Uncontrolled inflammation and immune responses in the brain, despite their protective roles, can also be harmful. The ... ...

Abstract	CNS viral infections are one of the major causes of morbidity and mortality worldwide and a significant global public health concern. Uncontrolled inflammation and immune responses in the brain, despite their protective roles, can also be harmful. The suppressor of cytokine signalling (SOCS) proteins is one of the key mechanisms controlling inflammatory and immune responses across all tissues including the brain. SOCS5 is highly expressed in the brain but there is little understanding of its role in the CNS. Using a mouse model of encephalitis, we demonstrate that lack of SOCS5 results in changes in the pathogenesis and clinical outcome of a neurotropic virus infection. Relative to wild-type mice, SOCS5-deficient mice had greater weight loss, dysregulated cytokine production and increased neuroinflammatory infiltrates composed predominantly of CD11b
MeSH term(s)	Animals ; Mice ; Alphavirus Infections ; Cytokines/metabolism ; Signal Transduction ; Suppressor of Cytokine Signaling Proteins/genetics
Chemical Substances	Cytokines ; Suppressor of Cytokine Signaling Proteins ; Socs5 protein, mouse
Language	English
Publishing date	2022-11-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14112476
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Article ; Online: Leishmaniasis.

Kedzierski, Lukasz

Human vaccines

2011 Volume 7, Issue 11, Page(s) 1204–1214

Abstract: Leishmaniasis is a disease that ranges in severity from skin lesions to serious disfigurement and fatal systemic infection. WHO has classified the disease as emerging and uncontrolled and estimates that the infection results in two million new cases a ... ...

Abstract	Leishmaniasis is a disease that ranges in severity from skin lesions to serious disfigurement and fatal systemic infection. WHO has classified the disease as emerging and uncontrolled and estimates that the infection results in two million new cases a year. There are 12 million people currently infected worldwide, and leishmaniasis threatens 350 million people in 88 countries. Vaccination remains the best hope for control of all forms of the disease, and the development of a safe, effective and affordable antileishmanial vaccine is a critical global public-health priority. However, to date, no such vaccine is available despite substantial efforts by many laboratories. Main obstacle in vaccine design is the transition from the laboratory to the field and extrapolation of data from animal models to humans. This review discusses recent findings in the antileishmania vaccine field and current difficulties hampering vaccine implementation.
MeSH term(s)	Animals ; Dogs ; Humans ; Leishmania/immunology ; Leishmaniasis, Cutaneous/immunology ; Leishmaniasis, Cutaneous/prevention & control ; Leishmaniasis, Visceral/immunology ; Leishmaniasis, Visceral/prevention & control ; Mice ; Protozoan Proteins/genetics ; Protozoan Proteins/immunology ; Protozoan Vaccines/genetics ; Protozoan Vaccines/immunology ; Vaccination ; Vaccines, DNA/genetics ; Vaccines, DNA/immunology
Chemical Substances	Protozoan Proteins ; Protozoan Vaccines ; Vaccines, DNA
Language	English
Publishing date	2011-11
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1554-8619
ISSN (online)	1554-8619
DOI	10.4161/hv.7.11.17752
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Article ; Online: Robust SARS-CoV-2 antibody and T cell immunity following three COVID-19 vaccine doses in inflammatory bowel disease patients receiving anti-TNF or alternative treatments.

Zhang, Eva / Nguyen, Thi H O / Allen, Lilith F / Kedzierski, Lukasz / Rowntree, Louise C / Chang, So Young / Zhang, Wuji / Habel, Jennifer R / Foo, Isabelle J / Menon, Tejas / Mitchell, Jeni / Leong, Rupert W / Bond, Katherine / Williamson, Deborah A / Kedzierska, Katherine / Christensen, Britt

Gut

2024 Volume 73, Issue 4, Page(s) 712–714

MeSH term(s)	Humans ; COVID-19 Vaccines ; COVID-19/prevention & control ; SARS-CoV-2 ; T-Lymphocytes ; Tumor Necrosis Factor Inhibitors ; Antibodies, Viral ; Inflammatory Bowel Diseases/drug therapy ; Vaccination
Chemical Substances	COVID-19 Vaccines ; Tumor Necrosis Factor Inhibitors ; Antibodies, Viral
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Letter
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2022-329136
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Article ; Online: Leishmaniasis Vaccine: Where are We Today?

Kedzierski, Lukasz

Journal of global infectious diseases

2010 Volume 2, Issue 2, Page(s) 177–185

Abstract	Leishmaniasis is a disease that ranges in severity from skin lesions to serious disfigurement and fatal systemic infection. WHO has classified the disease as emerging and uncontrolled and estimates that the infection results in two million new cases a year. There are 12 million people currently infected worldwide, and leishmaniasis threatens 350 million people in 88 countries. Current treatment is based on chemotherapy, which relies on a handful of drugs with serious limitations such as high cost, toxicity, difficult route of administration and lack of efficacy in endemic areas. Vaccination remains the best hope for control of all forms of the disease, and the development of a safe, effective and affordable antileishmanial vaccine is a critical global public-health priority. Extensive evidence from studies in animal models indicates that solid protection can be achieved by immunization with defined subunit vaccines or live-attenuated strains of Leishmania. However, to date, no such vaccine is available despite substantial efforts by many laboratories. The major impediment in vaccine design is the translation of data from animal models to human disease, and the transition from the laboratory to the field. Furthermore, a thorough understanding of protective immune responses and generation and maintenance of the immunological memory, the most important and least-studied aspect of antiparasitic vaccine development, during Leishmania infection is needed. This review focuses on recent findings in antileishmania vaccine field and highlights current difficulties facing vaccine development and implementation.
Language	English
Publishing date	2010-04-10
Publishing country	India
Document type	Journal Article
ZDB-ID	2545454-7
ISSN	0974-8245 ; 0974-777X
ISSN (online)	0974-8245
ISSN	0974-777X
DOI	10.4103/0974-777X.62881
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Article ; Online: The thiol-based reduction of Bi(V) and Sb(V) anti-leishmanial complexes.

Duffin, Rebekah N / Stephens, Liam J / Blair, Victoria L / Kedzierski, Lukasz / Andrews, Philip C

Journal of inorganic biochemistry

2021 Volume 221, Page(s) 111470

Abstract: Low molecular weight thiols including trypanothione and glutathione play an important function in the cellular growth, maintenance and reduction of oxidative stress in Leishmania species. In particular, parasite specific trypanothione has been ... ...

Abstract	Low molecular weight thiols including trypanothione and glutathione play an important function in the cellular growth, maintenance and reduction of oxidative stress in Leishmania species. In particular, parasite specific trypanothione has been established as a prime target for new anti-leishmania drugs. Previous studies into the interaction of the front-line Sb(V) based anti-leishmanial drug meglumine antimoniate with glutathione, have demonstrated that a reduction pathway may be responsible for its effective and selective nature. The new suite of organometallic complexes, of general formula [MAr
MeSH term(s)	Antimony/chemistry ; Bismuth/chemistry ; Coordination Complexes/chemistry ; Glutathione/analogs & derivatives ; Glutathione/chemistry ; Half-Life ; Oxidation-Reduction ; Spermidine/analogs & derivatives ; Spermidine/chemistry ; Trypanocidal Agents/chemistry
Chemical Substances	Coordination Complexes ; Trypanocidal Agents ; trypanothione (96304-42-6) ; Antimony (9IT35J3UV3) ; Glutathione (GAN16C9B8O) ; Bismuth (U015TT5I8H) ; Spermidine (U87FK77H25)
Language	English
Publishing date	2021-04-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2021.111470
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Article ; Online: Leishmaniasis vaccine

Lukasz Kedzierski

Journal of Global Infectious Diseases, Vol 2, Iss 2, Pp 177-

Where are we today?

2010 Volume 185

Abstract	Leishmaniasis is a disease that ranges in severity from skin lesions to serious disfigurement and fatal systemic infection. WHO has classified the disease as emerging and uncontrolled and estimates that the infection results in two million new cases a year. There are 12 million people currently infected worldwide, and leishmaniasis threatens 350 million people in 88 countries. Current treatment is based on chemotherapy, which relies on a handful of drugs with serious limitations such as high cost, toxicity, difficult route of administration and lack of efficacy in endemic areas. Vaccination remains the best hope for control of all forms of the disease, and the development of a safe, effective and affordable antileishmanial vaccine is a critical global public-health priority. Extensive evidence from studies in animal models indicates that solid protection can be achieved by immunization with defined subunit vaccines or live-attenuated strains of Leishmania. However, to date, no such vaccine is available despite substantial efforts by many laboratories. The major impediment in vaccine design is the translation of data from animal models to human disease, and the transition from the laboratory to the field. Furthermore, a thorough understanding of protective immune responses and generation and maintenance of the immunological memory, the most important and least-studied aspect of antiparasitic vaccine development, during Leishmania infection is needed. This review focuses on recent findings in antileishmania vaccine field and highlights current difficulties facing vaccine development and implementation.
Keywords	Immune response ; Leishmania ; Vaccine ; Infectious and parasitic diseases ; RC109-216 ; Internal medicine ; RC31-1245 ; Medicine ; R
Subject code	630
Language	English
Publishing date	2010-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Immature Brain Cortical Neurons Have Low Transcriptional Competence to Activate Antiviral Defences and Control RNA Virus Infections.

Narayanan, Divya / Moily, Nagaraj / McQuilten, Hayley A / Kedzierska, Katherine / Mackenzie, Jason M / Kedzierski, Lukasz / Fazakerley, John K

Journal of innate immunity

2022 Volume 15, Issue 1, Page(s) 50–66

Abstract: Virus infections of the central nervous system (CNS) cause important diseases of humans and animals. As in other tissues, innate antiviral responses mediated by type I interferons (IFNs) are crucially important in controlling CNS virus infections. The ... ...

Abstract	Virus infections of the central nervous system (CNS) cause important diseases of humans and animals. As in other tissues, innate antiviral responses mediated by type I interferons (IFNs) are crucially important in controlling CNS virus infections. The maturity of neuronal populations is an established critical factor determining the outcome of CNS virus infection. Using primary cultures of mouse cortical neurons, we investigated the relationships between neuronal maturation, type I IFN responses, and the outcome of Semliki Forest virus infection. The virus replicated better, infected more cells, and produced higher titres of infectious viruses in immature neurons. Complete transcriptome analysis demonstrated that resting immature neurons have low transcriptional competence to mount antiviral responses. They had no detectable transcription of the genes Ddx58 and Ifih1, which encode key RNA virus cytoplasmic sensors RIG-I and MDA5, and very low expression of genes encoding key regulators of associated signalling pathways. Upon infection, immature neurons failed to mount an antiviral response as evidenced by their failure to produce chemokines, IFNs, and other cytokines. Treatment of immature neurons with exogenous IFNβ prior to infection resulted in antiviral responses and lower levels of virus replication and infectious virus production. In contrast, resting mature neurons generated a robust antiviral response. This was augmented by pretreatment with IFNβ. Infection of mature neurons derived from IFNAR-/- mice did not make an antiviral response and replicated virus to high levels.
MeSH term(s)	Humans ; Mice ; Animals ; Interferon Type I ; Brain ; Neurons ; Antiviral Agents ; Virus Diseases ; RNA Virus Infections ; Immunity, Innate
Chemical Substances	Interferon Type I ; Antiviral Agents
Language	English
Publishing date	2022-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2454158-8
ISSN	1662-8128 ; 1662-811X
ISSN (online)	1662-8128
ISSN	1662-811X
DOI	10.1159/000525291
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