LIVIVO - Search results -

Search results

Result 1 - 10 of total 27

Search options

Article ; Online: Non-immunization associated with increased risk of sudden unexpected death in infancy: A national case–control study

Deschanvres, Colin / Levieux, Karine / Launay, Elise / Huby, Anne-Cécile / Scherdel, Pauline / de Visme, Sophie / Hanf, Matthieu / Gras-Le Guen, Christèle

Vaccine. 2023 Jan., v. 41, no. 2 p.391-396

2023

Abstract: In the context of vaccine scepticism, our study aimed to analyse the association between immunization status and the occurrence of sudden unexpected death in infancy (SUDI). Study design: A multi-centre case–control study was conducted between May 2015 ... ...

Institution	the OMIN Study Group
Abstract	In the context of vaccine scepticism, our study aimed to analyse the association between immunization status and the occurrence of sudden unexpected death in infancy (SUDI). Study design: A multi-centre case–control study was conducted between May 2015 and June 2017 with data from the French national SUDI registry (OMIN) for 35 French regional SUDI centres. Cases were infants under age 1 year who died from SUDI and who were registered in OMIN. Controls, matched to cases by age and sex at a 2:1 ratio, were infants admitted to Nantes University Hospital. All immunization data for diphtheria (D), tetanus (T), acellular pertussis (aP), inactivated poliovirus (IPV), Haemophilus influenzae b (Hib), hepatitis B (HB) and 13-valent pneumococcal conjugate vaccine (PCV13) were collected by a physician. Cases and controls were considered immunized if at least one dose of vaccine was administered. A total of 91 cases and 182 controls were included. The median age was 131 days (interquartile range 98–200.0) and the sex ratio (M/F) was about 1.1. For all vaccines combined (D-T-aP-IPV-Hib and PCV13), 22 % of SUDI cases versus 12 % of controls were non-immunized, which was significantly associated with SUDI after adjustment for potential adjustment factors (adjusted odds ratio 2.01 [95 % confidence interval 1.01–3.98, p = 0,047]). Non-immunization for D-T-aP-IPV-Hib-HB and PCV13 was associated with increased risk of SUDI. This result can be used to inform the general public and health professionals about this risk of SUDI in case of vaccine hesitancy.
Keywords	Haemophilus influenzae ; Streptococcus pneumoniae ; case-control studies ; confidence interval ; death ; diphtheria ; experimental design ; hepatitis B ; hospitals ; immunization ; infancy ; odds ratio ; risk ; sex ratio ; tetanus ; vaccines ; Sudden unexpected death in infancy ; Pneumococcal conjugate vaccine ; Combined hexavalent vaccine ; Vaccine delay ; Vaccine hesitancy ; OR ; aOR ; OMIN ; D ; T ; aP ; IPV ; Hib ; HB ; PCV13
Language	English
Dates of publication	2023-01
Size	p. 391-396.
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.10.087
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Non-immunization associated with increased risk of sudden unexpected death in infancy: A national case-control study.

Deschanvres, Colin / Levieux, Karine / Launay, Elise / Huby, Anne-Cécile / Scherdel, Pauline / de Visme, Sophie / Hanf, Matthieu / Gras-Le Guen, Christèle

Vaccine

2022 Volume 41, Issue 2, Page(s) 391–396

Abstract: Objective: In the context of vaccine scepticism, our study aimed to analyse the association between immunization status and the occurrence of sudden unexpected death in infancy (SUDI).: Study design: A multi-centre case-control study was conducted ... ...

Abstract	Objective: In the context of vaccine scepticism, our study aimed to analyse the association between immunization status and the occurrence of sudden unexpected death in infancy (SUDI). Study design: A multi-centre case-control study was conducted between May 2015 and June 2017 with data from the French national SUDI registry (OMIN) for 35 French regional SUDI centres. Cases were infants under age 1 year who died from SUDI and who were registered in OMIN. Controls, matched to cases by age and sex at a 2:1 ratio, were infants admitted to Nantes University Hospital. All immunization data for diphtheria (D), tetanus (T), acellular pertussis (aP), inactivated poliovirus (IPV), Haemophilus influenzae b (Hib), hepatitis B (HB) and 13-valent pneumococcal conjugate vaccine (PCV13) were collected by a physician. Cases and controls were considered immunized if at least one dose of vaccine was administered. Results: A total of 91 cases and 182 controls were included. The median age was 131 days (interquartile range 98-200.0) and the sex ratio (M/F) was about 1.1. For all vaccines combined (D-T-aP-IPV-Hib and PCV13), 22 % of SUDI cases versus 12 % of controls were non-immunized, which was significantly associated with SUDI after adjustment for potential adjustment factors (adjusted odds ratio 2.01 [95 % confidence interval 1.01-3.98, p = 0,047]). Conclusions: Non-immunization for D-T-aP-IPV-Hib-HB and PCV13 was associated with increased risk of SUDI. This result can be used to inform the general public and health professionals about this risk of SUDI in case of vaccine hesitancy.
MeSH term(s)	Humans ; Infant ; Vaccines, Combined ; Case-Control Studies ; Poliovirus Vaccine, Inactivated ; Tetanus Toxoid ; Hepatitis B/prevention & control ; Vaccines, Conjugate ; Haemophilus influenzae ; Haemophilus Vaccines ; Diphtheria-Tetanus-Pertussis Vaccine ; Hepatitis B Vaccines ; Immunization Schedule
Chemical Substances	Vaccines, Combined ; Poliovirus Vaccine, Inactivated ; Tetanus Toxoid ; Vaccines, Conjugate ; Haemophilus Vaccines ; Diphtheria-Tetanus-Pertussis Vaccine ; Hepatitis B Vaccines
Language	English
Publishing date	2022-11-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.10.087
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Leptin Induces Hypertension and Endothelial Dysfunction via Aldosterone-Dependent Mechanisms in Obese Female Mice.

Huby, Anne-Cécile / Otvos, Laszlo / Belin de Chantemèle, Eric J

Hypertension (Dallas, Tex. : 1979)

2016 Volume 67, Issue 5, Page(s) 1020–1028

Abstract: Obesity is a major risk factor for cardiovascular disease in males and females. Whether obesity triggers cardiovascular disease via similar mechanisms in both the sexes is, however, unknown. In males, the adipokine leptin highly contributes to obesity- ... ...

Abstract	Obesity is a major risk factor for cardiovascular disease in males and females. Whether obesity triggers cardiovascular disease via similar mechanisms in both the sexes is, however, unknown. In males, the adipokine leptin highly contributes to obesity-related cardiovascular disease by increasing sympathetic activity. Females secrete 3× to 4× more leptin than males, but do not exhibit high sympathetic tone with obesity. Nevertheless, females show inappropriately high aldosterone levels that positively correlate with adiposity and blood pressure (BP). We hypothesized that leptin induces hypertension and endothelial dysfunction via aldosterone-dependent mechanisms in females. Leptin control of the cardiovascular function was analyzed in female mice sensitized to leptin via the deletion of protein tyrosine phosphatase 1b (knockout) and in agouti yellow obese hyperleptinemic mice (Ay). Hypersensitivity to leptin (wild-type, 115 ± 2; protein tyrosine phosphatase 1b knockout, 124 ± 2 mm Hg; P<0.05) and obesity elevated BP (a/a, 113 ± 1; Ay, 128 ± 7 mm Hg; P<0.05) and impaired endothelial function. Chronic leptin receptor antagonism restored BP and endothelial function in protein tyrosine phosphatase 1b knockout and Ay mice. Hypersensitivity to leptin and obesity reduced BP response to ganglionic blockade in both strains and plasma catecholamine levels in protein tyrosine phosphatase 1b knockout mice. Hypersensitivity to leptin and obesity significantly increased plasma aldosterone levels and adrenal CYP11B2 expression. Chronic leptin receptor antagonism reduced aldosterone levels. Furthermore, chronic leptin and mineralocorticoid receptor blockade reduced BP and improved endothelial function in both leptin-sensitized and obese hyperleptinemic female mice. Together, these data demonstrate that leptin induces hypertension and endothelial dysfunction via aldosterone-dependent mechanisms in female mice and suggest that obesity leads to cardiovascular disease via sex-specific mechanisms.
MeSH term(s)	Aldosterone/metabolism ; Analysis of Variance ; Animals ; Cardiovascular Diseases/physiopathology ; Disease Models, Animal ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiopathology ; Female ; Hypertension/etiology ; Hypertension/physiopathology ; Leptin/blood ; Male ; Mice ; Mice, Knockout ; Mice, Obese ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Random Allocation ; Renin-Angiotensin System/physiology ; Sensitivity and Specificity ; Sex Factors ; Statistics, Nonparametric
Chemical Substances	Leptin ; Aldosterone (4964P6T9RB) ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 (EC 3.1.3.48) ; Ptpn1 protein, mouse (EC 3.1.3.48)
Language	English
Publishing date	2016-05
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.115.06642
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1488: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Heart failure in obesity: insights from proteomics in patients treated with or without weight-loss surgery.

Karason, Kristjan / Girerd, Nicolas / Andersson-Asssarsson, Johanna / Duarte, Kevin / Taube, Magdalena / Svensson, Per-Arne / Huby, Anne-Cecile / Peltonen, Markku / Carlsson, Lena M / Zannad, Faiez

International journal of obesity (2005)

2022 Volume 46, Issue 12, Page(s) 2088–2094

Abstract: Background: Obesity is associated with incident heart failure (HF), but the underlying mechanisms are unclear.: Methods: We performed a nested case-control study within the Swedish-Obese-Subjects study, by identifying 411 cases who developed HF and ... ...

Abstract	Background: Obesity is associated with incident heart failure (HF), but the underlying mechanisms are unclear. Methods: We performed a nested case-control study within the Swedish-Obese-Subjects study, by identifying 411 cases who developed HF and matched them with respect to age, sex, weight-loss-surgery and length of follow-up with 410 controls who did not develop HF. In analyses corrected for multiple testing, we studied 182 plasma proteins known to be related to cardiovascular disease to investigate whether they could add to the understanding of the processes underlying obesity-related HF. Results: A total of 821 subjects were followed for 16 ± 6 years. Multivariable analysis adjusted for matching variables revealed that 32 proteins were significantly associated with HF. Twelve proteins were related to HF ≥ 80% of the time using a bootstrap resampling approach (false-discovery-rate [FDR] < 0.05): 11 were associated with increased HF-risk: TNFRSF10A, ST6GAL1, PRCP, MMP12, TIMP1, CCL3, QPCT, ANG, C1QTNF1, SERPINA5 and GAL-9; and one was related to reduced HF-risk: LPL. An further 20 proteins were associated with onset of HF 50-80% of the time using bootstrap resampling (FDR < 0.05). A pathway analysis including all significant 32 proteins suggested that these biomarkers were related to inflammation, matrix remodeling, cardiometabolic hormones and hemostasis. Three proteins, C1QTNF1, FGF-21 and CST3, reflecting dyslipidemia and kidney disease, displayed a higher association with HF in patients who did not undergo weight-loss-surgery and maintained with obesity. Conclusion:* Pathways associated with HF in obesity include inflammation, matrix remodeling, cardiometabolic hormones and hemostasis; three protein biomarkers predicting HF appeared to be obesity-specific.
MeSH term(s)	Humans ; Proteomics ; Case-Control Studies ; Heart Failure ; Obesity/complications ; Obesity/surgery ; Biomarkers ; Inflammation/complications ; Hormones
Chemical Substances	Biomarkers ; Hormones
Language	English
Publishing date	2022-08-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
DOI	10.1038/s41366-022-01194-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1325: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Reviving the use of aldosterone inhibitors in treating hypertension in obesity.

Huby, Anne-Cecile / Belin De Chantemèle, Eric J

American journal of physiology. Regulatory, integrative and comparative physiology

2015 Volume 309, Issue 9, Page(s) R1065–7

Abstract: Obesity is a multifactorial disease associated with hypertension. In the obese population, the incidence of hypertension is high and resistant hypertension is commonly observed. Mechanisms to explain the resistance to current antihypertensive treatments ... ...

Abstract	Obesity is a multifactorial disease associated with hypertension. In the obese population, the incidence of hypertension is high and resistant hypertension is commonly observed. Mechanisms to explain the resistance to current antihypertensive treatments are still poorly understood. Emerging knowledge of the role of aldosterone in controlling blood pressure in obesity may have therapeutic benefit. Mineralocorticoid receptor (MR) inhibitors are currently used as the fourth line of treatment. Clinical studies summarized in this short review suggest that MR antagonists have a strong efficacy in decreasing blood pressure in the hypertensive obese population and could be used as a primary antihypertensive in obesity.
MeSH term(s)	Aldosterone/metabolism ; Animals ; Evidence-Based Medicine ; Humans ; Hypertension/drug therapy ; Hypertension/etiology ; Hypertension/metabolism ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Models, Biological ; Molecular Targeted Therapy/methods ; Obesity/complications ; Obesity/drug therapy ; Obesity/metabolism ; Receptors, Mineralocorticoid/metabolism ; Treatment Outcome
Chemical Substances	Mineralocorticoid Receptor Antagonists ; Receptors, Mineralocorticoid ; Aldosterone (4964P6T9RB)
Language	English
Publishing date	2015-07-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603839-6
ISSN	1522-1490 ; 0363-6119
ISSN (online)	1522-1490
ISSN	0363-6119
DOI	10.1152/ajpregu.00133.2015
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.89: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Early hybrid cardiac rehabilitation in congenital heart disease: the QUALIREHAB trial.

Amedro, Pascal / Gavotto, Arthur / Huguet, Helena / Souilla, Luc / Huby, Anne-Cecile / Matecki, Stefan / Cadene, Anne / De La Villeon, Gregoire / Vincenti, Marie / Werner, Oscar / Bredy, Charlene / Lavastre, Kathleen / Abassi, Hamouda / Cohen, Sarah / Hascoet, Sebastien / Dauphin, Claire / Chalard, Aurelie / Dulac, Yves / Souletie, Nathalie /

Bouvaist, Helene / Douchin, Stephanie / Lachaud, Matthias / Ovaert, Caroline / Soulatges, Camille / Combes, Nicolas / Thambo, Jean-Benoit / Iriart, Xavier / Bajolle, Fanny / Bonnet, Damien / Ansquer, Helene / Delpey, Jean-Guillaume / Cohen, Laurence / Picot, Marie-Christine / Guillaumont, Sophie

European heart journal

2024 Volume 45, Issue 16, Page(s) 1458–1473

Abstract: Background and aims: Cardiopulmonary fitness in congenital heart disease (CHD) decreases faster than in the general population resulting in impaired health-related quality of life (HRQoL). As the standard of care seems insufficient to encourage and ... ...

Abstract	Background and aims: Cardiopulmonary fitness in congenital heart disease (CHD) decreases faster than in the general population resulting in impaired health-related quality of life (HRQoL). As the standard of care seems insufficient to encourage and maintain fitness, an early hybrid cardiac rehabilitation programme could improve HRQoL in CHD. Methods: The QUALIREHAB multicentre, randomized, controlled trial evaluated and implemented a 12-week centre- and home-based hybrid cardiac rehabilitation programme, including multidisciplinary care and physical activity sessions. Adolescent and young adult CHD patients with impaired cardiopulmonary fitness were randomly assigned to either the intervention (i.e. cardiac rehabilitation) or the standard of care. The primary outcome was the change in HRQoL from baseline to 12-month follow-up in an intention-to-treat analysis. The secondary outcomes were the change in cardiovascular parameters, cardiopulmonary fitness, and mental health. Results: The expected number of 142 patients was enroled in the study (mean age 17.4 ± 3.4 years, 52% female). Patients assigned to the intervention had a significant positive change in HRQoL total score [mean difference 3.8; 95% confidence interval (CI) 0.2; 7.3; P = .038; effect size 0.34], body mass index [mean difference -0.7 kg/m2 (95% CI -1.3; -0.1); P = .022; effect size 0.41], level of physical activity [mean difference 2.5 (95% CI 0.1; 5); P = .044; effect size 0.39], and disease knowledge [mean difference 2.7 (95% CI 0.8; 4.6); P = .007; effect size 0.51]. The per-protocol analysis confirmed these results with a higher magnitude of differences. Acceptability, safety, and short-time effect of the intervention were good to excellent. Conclusions: This early hybrid cardiac rehabilitation programme improved HRQoL, body mass index, physical activity, and disease knowledge, in youth with CHD, opening up the possibility for the QUALIREHAB programme to be rolled out to the adult population of CHD and non-congenital cardiac disease.
MeSH term(s)	Adolescent ; Female ; Humans ; Male ; Young Adult ; Cardiac Rehabilitation/methods ; Exercise ; Exercise Therapy ; Heart Defects, Congenital ; Quality of Life
Language	English
Publishing date	2024-03-02
Publishing country	England
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehae085
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 640: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study.

Girerd, Nicolas / Levy, Daniel / Duarte, Kevin / Ferreira, Joao Pedro / Ballantyne, Christie / Collier, Timothy / Pizard, Anne / Björkman, Jens / Butler, Javed / Clark, Andrew / Cleland, John G / Delles, Christian / Diez, Javier / González, Arantxa / Hazebroek, Mark / Ho, Jennifer / Huby, Anne-Cécile / Hwang, Shih-Jen / Latini, Roberto /

Mariottoni, Beatrice / Mebazaa, Alexandre / Pellicori, Pierpaolo / Sattar, Naveed / Sever, Peter / Staessen, Jan A / Verdonschot, Job / Heymans, Stephane / Rossignol, Patrick / Zannad, Faiez

Circulation. Heart failure

2023 Volume 16, Issue 5, Page(s) e009694

Abstract: Background: We sought to identify protein biomarkers of new-onset heart failure (HF) in 3 independent cohorts (HOMAGE cohort [Heart Omics and Ageing], ARIC study [Atherosclerosis Risk in Communities], and FHS [Framingham Heart Study]) and assess if and ... ...

Abstract	Background: We sought to identify protein biomarkers of new-onset heart failure (HF) in 3 independent cohorts (HOMAGE cohort [Heart Omics and Ageing], ARIC study [Atherosclerosis Risk in Communities], and FHS [Framingham Heart Study]) and assess if and to what extent they improve HF risk prediction compared to clinical risk factors alone. Methods: A nested case-control design was used with cases (incident HF) and controls (without HF) matched on age and sex within each cohort. Plasma concentrations of 276 proteins were measured at baseline in ARIC (250 cases/250 controls), FHS (191/191), and HOMAGE cohort (562/871). Results: In single protein analysis, after adjusting for matching variables and clinical risk factors (and correcting for multiple testing), 62 proteins were associated with incident HF in ARIC, 16 in FHS, and 116 in HOMAGE cohort. Proteins associated with incident HF in all cohorts were BNP (brain natriuretic peptide), NT-proBNP (N-terminal pro-B-type natriuretic peptide), eukaryotic translation initiation factor 4E-BP1 (4E-binding protein 1), hepatocyte growth factor (HGF), Gal-9 (galectin-9), TGF-alpha (transforming growth factor alpha), THBS2 (thrombospondin-2), and U-PAR (urokinase plasminogen activator surface receptor). The increment in Conclusions: A multiprotein biomarker approach improves prediction of incident HF when added to natriuretic peptides and clinical risk factors.
MeSH term(s)	Humans ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Biomarkers ; Longitudinal Studies ; Risk Factors ; Aging ; Atherosclerosis/diagnosis ; Atherosclerosis/epidemiology ; Natriuretic Peptide, Brain ; Peptide Fragments
Chemical Substances	Biomarkers ; Natriuretic Peptide, Brain (114471-18-0) ; Peptide Fragments
Language	English
Publishing date	2023-05-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429459-7
ISSN	1941-3297 ; 1941-3289
ISSN (online)	1941-3297
ISSN	1941-3289
DOI	10.1161/CIRCHEARTFAILURE.122.009694
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6745: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Noninvasive Prenatal Diagnosis of a Paternally Inherited MEN1 Pathogenic Splicing Variant.

The Journal of clinical endocrinology and metabolism

2021 Volume 107, Issue 4, Page(s) e1367–e1373

Abstract: Context: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease caused by mutations in the tumor suppressor gene MEN1. The uncertainty of pathogenicity of MEN1 variants complexifies the selection of the patients likely to benefit ... ...

Abstract	Context: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease caused by mutations in the tumor suppressor gene MEN1. The uncertainty of pathogenicity of MEN1 variants complexifies the selection of the patients likely to benefit from specific care. Objective: MEN1-mutated patients should be offered tailored tumor screening and genetic counseling. We present a patient with hyperparathyroidism for whom genetic analysis identified a variant of uncertain significance in the MEN1 gene (NM_130799.2): c.654G > T p.(Arg218=). Additional functional genetic tests were performed to classify the variant as pathogenic and allowed prenatal testing. Design: Targeted next generation sequencing identified a synonymous variant in the MEN1 gene in a 26-year-old male with symptomatic primary hyperparathyroidism. In silico and in vitro genetic tests were performed to assess variant pathogenicity. Results: Genetic testing of the proband's unaffected parents showed the variant occurred de novo. Transcript study showed a splicing defect leading to an in-frame deletion. The classification of the MEN1 variant as pathogenic confirmed the diagnosis of MEN1 and recommended an adapted medical care and follow-up. Pathogenic classification also allowed to propose a genetic counseling to the proband and his wife. Noninvasive prenatal diagnosis was performed with a personalized medicine-based protocol by detection of the paternally inherited variant in maternal plasmatic cell free DNA, using digital PCR. Conclusion: We showed that functional genetic analysis can help to assess the pathogenicity of a MEN1 variant with crucial consequences for medical care and genetic counseling decisions.
MeSH term(s)	Adult ; Female ; Genetic Testing ; Humans ; Hyperparathyroidism/genetics ; Male ; Multiple Endocrine Neoplasia Type 1/genetics ; Noninvasive Prenatal Testing ; Paternal Inheritance ; Pregnancy
Language	English
Publishing date	2021-12-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgab894
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.134: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Potential spironolactone effects on collagen metabolism biomarkers in patients with uncontrolled blood pressure.

Ferreira, João Pedro / Rossignol, Patrick / Pizard, Anne / Machu, Jean-Loup / Collier, Timothy / Girerd, Nicolas / Huby, Anne-Cécile / Gonzalez, Arantxa / Diez, Javier / López, Begoña / Sattar, Naveed / Cleland, John G / Sever, Peter S / Zannad, Faiez

Heart (British Cardiac Society)

2018 Volume 105, Issue 4, Page(s) 307–314

Abstract: Background: An increase in myocardial collagen content may contribute to the development of heart failure; this might be inhibited or reversed by mineralocorticoid receptor antagonists (MRAs). We investigated changes in serum concentrations of the ... ...

Abstract	Background: An increase in myocardial collagen content may contribute to the development of heart failure; this might be inhibited or reversed by mineralocorticoid receptor antagonists (MRAs). We investigated changes in serum concentrations of the collagen synthesis biomarkers N-terminal propeptide of procollagen type III (PIIINP) (primary outcome) and C-terminal propeptide of procollagen type I (PICP) (secondary outcome) after non-randomised initiation of spironolactone as add-on therapy among patients with resistant hypertension enrolled in the 'Anglo-Scandinavian Cardiac Outcomes' trial (ASCOT). Methods: An age/sex matching plus propensity-scored logistic regression model incorporating variables related to the outcome and spironolactone treatment was created to compare patients treated with spironolactone for a 9-month period versus matched controls. A within-person analysis comparing changes in serum biomarker concentrations in the 9 months before versus after spironolactone treatment was also performed. Results: Patients included in the between-person analysis (n=146) were well matched: the mean age was 63±7 years and 11% were woman. Serum concentrations of PIIINP and PICP rose in 'controls' and fell during spironolactone treatment (adjusted means +0.52 (-0.05 to 1.09) vs -0.41 (-0.97 to 0.16) ng/mL, p=0.031 for PIIINP and +4.54(-1.77 to 10.9) vs -6.36 (-12.5 to -0.21) ng/mL, p=0.023 for PICP). For the within-person analysis (n=173), spironolactone treatment was also associated with a reduction in PICP (beta estimate=-11.82(-17.53 to -6.10) ng/mL, p<0.001) but not in PIIINP levels. Conclusions: Treatment with spironolactone was associated with a reduction in serum biomarkers of collagen synthesis independently of blood pressure in patients with hypertension, suggesting that spironolactone might exert favourable effects on myocardial collagen synthesis and fibrosis. Whether this effect might contribute to slowing the progression to heart failure is worth investigating.
MeSH term(s)	Aged ; Biological Availability ; Biomarkers/blood ; Blood Pressure/drug effects ; Collagen/biosynthesis ; Collagen/metabolism ; Drug Monitoring/methods ; Drug Resistance ; Female ; Heart Failure/etiology ; Heart Failure/metabolism ; Heart Failure/prevention & control ; Humans ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/metabolism ; Male ; Middle Aged ; Mineralocorticoid Receptor Antagonists/administration & dosage ; Mineralocorticoid Receptor Antagonists/pharmacokinetics ; Outcome Assessment, Health Care ; Peptide Fragments/blood ; Procollagen/blood ; Spironolactone/administration & dosage ; Spironolactone/pharmacokinetics
Chemical Substances	Biomarkers ; Mineralocorticoid Receptor Antagonists ; Peptide Fragments ; Procollagen ; procollagen Type III-N-terminal peptide ; procollagen type I carboxy terminal peptide ; Spironolactone (27O7W4T232) ; Collagen (9007-34-5)
Language	English
Publishing date	2018-08-18
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2018-313182
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui IV Zs.40: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 112: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis.

Huby, Anne-Cécile / Antonova, Galina / Groenendyk, Jake / Gomez-Sanchez, Celso E / Bollag, Wendy B / Filosa, Jessica A / Belin de Chantemèle, Eric J

Circulation

2015 Volume 132, Issue 22, Page(s) 2134–2145

Abstract: Background: In obesity, the excessive synthesis of aldosterone contributes to the development and progression of metabolic and cardiovascular dysfunctions. Obesity-induced hyperaldosteronism is independent of the known regulators of aldosterone ... ...

Abstract	Background: In obesity, the excessive synthesis of aldosterone contributes to the development and progression of metabolic and cardiovascular dysfunctions. Obesity-induced hyperaldosteronism is independent of the known regulators of aldosterone secretion, but reliant on unidentified adipocyte-derived factors. We hypothesized that the adipokine leptin is a direct regulator of aldosterone synthase (CYP11B2) expression and aldosterone release and promotes cardiovascular dysfunction via aldosterone-dependent mechanisms. Methods and results: Immunostaining of human adrenal cross-sections and adrenocortical cells revealed that adrenocortical cells coexpress CYP11B2 and leptin receptors. Measurements of adrenal CYP11B2 expression and plasma aldosterone levels showed that increases in endogenous (obesity) or exogenous (infusion) leptin dose-dependently raised CYP11B2 expression and aldosterone without elevating plasma angiotensin II, potassium or corticosterone. Neither angiotensin II receptors blockade nor α and β adrenergic receptors inhibition blunted leptin-induced aldosterone secretion. Identical results were obtained in cultured adrenocortical cells. Enhanced leptin signaling elevated CYP11B2 expression and plasma aldosterone, whereas deficiency in leptin or leptin receptors blunted obesity-induced increases in CYP11B2 and aldosterone, ruling out a role for obesity per se. Leptin increased intracellular calcium, elevated calmodulin and calmodulin-kinase II expression, whereas calcium chelation blunted leptin-mediated increases in CYP11B2, in adrenocortical cells. Mineralocorticoid receptor blockade blunted leptin-induced endothelial dysfunction and increases in cardiac fibrotic markers. Conclusions: Leptin is a newly described regulator of aldosterone synthesis that acts directly on adrenal glomerulosa cells to increase CYP11B2 expression and enhance aldosterone production via calcium-dependent mechanisms. Furthermore, leptin-mediated aldosterone secretion contributes to cardiovascular disease by promoting endothelial dysfunction and the expression of profibrotic markers in the heart.
MeSH term(s)	Adipocytes/secretion ; Adrenal Cortex/cytology ; Adrenal Cortex/secretion ; Aldosterone/secretion ; Animals ; Cell Line, Tumor ; Cells, Cultured ; Endothelium, Vascular/secretion ; Female ; Fibrosis/pathology ; Heart Diseases/metabolism ; Heart Diseases/pathology ; Humans ; Leptin/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Obese ; Rats ; Rats, Inbred WKY ; Rats, Zucker
Chemical Substances	Leptin ; Aldosterone (4964P6T9RB)
Language	English
Publishing date	2015-12-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.115.018226
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui IV Zs.60: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito