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  1. Article ; Online: Clock-modulated checkpoints in time-restricted eating.

    Li, Min-Dian

    Trends in molecular medicine

    2021  Volume 28, Issue 1, Page(s) 25–35

    Abstract: Time-restricted eating (TRE), which limits the daily meal timing to a window of 6-12 h, has been shown to reduce the risks of cardiometabolic diseases through consolidating circadian rhythms of metabolism and physiology. Recent advances indicate that ... ...

    Abstract Time-restricted eating (TRE), which limits the daily meal timing to a window of 6-12 h, has been shown to reduce the risks of cardiometabolic diseases through consolidating circadian rhythms of metabolism and physiology. Recent advances indicate that canonical circadian clocks are dispensable for the actions of TRE in the liver, and that meal timing entrains circadian rhythms in peripheral tissues in a tissue-specific manner (e.g., the liver and fat are readily entrainable, whereas the heart and kidneys are resistant). Here, we propose that TRE engages clock-modulated checkpoints (CCPs) to reset circadian rhythms of tissue functions. Elucidation of CCPs would reveal the mechanistic basis of tissue responsiveness to TRE, and facilitate the use of TRE in precision medicine for cardiometabolic diseases.
    MeSH term(s) Circadian Clocks/physiology ; Circadian Rhythm/physiology ; Eating ; Humans ; Liver
    Language English
    Publishing date 2021-11-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2021.10.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Setting fire to fat.

    Zhang, Zhihui / Li, Min-Dian

    The Journal of biological chemistry

    2019  Volume 294, Issue 30, Page(s) 11653

    Language English
    Publishing date 2019-06-13
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.AAC119.009988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Adipocyte reconstitution of

    Wang, Lan / Zeng, Fan / Huang, Rong-Feng / Lin, Shu / Zhang, Zhi-Hui / Li, Min-Dian

    Yi chuan = Hereditas

    2023  Volume 45, Issue 2, Page(s) 144–155

    Abstract: Neural regulation of adipose tissue is crucial in the homeostasis of energy metabolism. Adipose tissue neuropeptide Y (NPY) and its receptors contribute to the development of diet-induced obesity. NPY1R and NPY2R are major receptors for NPY in peripheral ...

    Abstract Neural regulation of adipose tissue is crucial in the homeostasis of energy metabolism. Adipose tissue neuropeptide Y (NPY) and its receptors contribute to the development of diet-induced obesity. NPY1R and NPY2R are major receptors for NPY in peripheral tissues including the adipose tissue. NPY receptor 4 (
    MeSH term(s) Mice ; Animals ; Obesity/genetics ; Adipocytes/metabolism ; Diet ; Adipose Tissue ; Neuropeptide Y/genetics ; Neuropeptide Y/metabolism ; Receptors, Neuropeptide Y/genetics ; Receptors, Neuropeptide Y/metabolism
    Chemical Substances Neuropeptide Y ; Receptors, Neuropeptide Y
    Language English
    Publishing date 2023-03-16
    Publishing country China
    Document type Journal Article
    ISSN 0253-9772
    ISSN 0253-9772
    DOI 10.16288/j.yczz.22-302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Time to eat reveals the hierarchy of peripheral clocks.

    Zhang, Zhihui / Shui, Guanghou / Li, Min-Dian

    Trends in cell biology

    2021  Volume 31, Issue 11, Page(s) 869–872

    Abstract: Meal timing resets trillions of cellular circadian clocks in the body. Recent advances in multiomics demonstrate that clocks in peripheral tissues are differentially reset by feeding rhythm, and modulated by the central clock and the liver clock. This ... ...

    Abstract Meal timing resets trillions of cellular circadian clocks in the body. Recent advances in multiomics demonstrate that clocks in peripheral tissues are differentially reset by feeding rhythm, and modulated by the central clock and the liver clock. This highlights the essential roles of tissue-specific regulation and intercellular signaling in clock synchronization.
    MeSH term(s) Circadian Clocks ; Circadian Rhythm/physiology ; Humans ; Liver ; Photoperiod ; Suprachiasmatic Nucleus/physiology
    Language English
    Publishing date 2021-09-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2021.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Setting fire to fat.

    Zhang, Zhihui / Li, Min-Dian

    The Journal of biological chemistry

    2019  Volume 294, Issue 25, Page(s) 9720–9721

    Abstract: Adropin is a liver-secreted peptide that is crucial for metabolic health. However, the molecular functions and clinical significance of adropin have not been adequately explored. ... ...

    Abstract Adropin is a liver-secreted peptide that is crucial for metabolic health. However, the molecular functions and clinical significance of adropin have not been adequately explored. Butler
    MeSH term(s) Animals ; Diet ; Male ; Peptides ; Primates ; Sugars ; Weight Gain
    Chemical Substances Peptides ; Sugars
    Language English
    Publishing date 2019-06-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.H119.009488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Zhong hua ren min gong he guo shi ci dian

    Li, Yuming / Xu, Fang / Meng, Jianhua

    1990  

    Author's details Li yu ming zhu bian; xu fang, meng jian hua fu zhu bian
    Keywords China
    Language Chinese
    Size 49, 773 p, 19 cm
    Edition Bei jing di 2 ban
    Publisher Zhong guo guo ji guang bo chu ban she
    Publishing place Bei jing
    Document type Book
    Note Includes index ; Title page dated 1989
    ISBN 7800351912 ; 9787800351914
    Database Former special subject collection: coastal and deep sea fishing

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  7. Article: Targeting leptin-positive adipocytes by expressing the Cre recombinase transgene under the endogenous leptin gene.

    Zeng, Fan / Wang, Lan / Wan, Xiao-Qin / Huang, Rong-Feng / Zhang, Zhi-Hui / Li, Min-Dian

    Yi chuan = Hereditas

    2022  Volume 44, Issue 10, Page(s) 950–957

    Abstract: Adipose tissue plays an important role in metabolic physiology through energy storage and endocrine functions. Spatial transcriptomics is revealing the complexity of cell types and their interaction in the adipose tissue with regards to development, ... ...

    Abstract Adipose tissue plays an important role in metabolic physiology through energy storage and endocrine functions. Spatial transcriptomics is revealing the complexity of cell types and their interaction in the adipose tissue with regards to development, homeostasis and disease. Emerging evidence suggests the existence of different subtypes of mature adipocytes that may have distinct functions, the markers of which include leptin (LEP), adiponectin (ADIPOQ), perilipin-1/4 (PLIN), and serum amyloid A (SAA), marking different adipocyte subtypes. Currently, Adipoq-Cre is widely used to study adipocyte biology, however, there is no Cre line that specifically targets LEP
    MeSH term(s) Mice ; Animals ; Leptin/genetics ; Leptin/metabolism ; Adipocytes/metabolism ; Integrases/genetics ; Integrases/metabolism ; Transgenes
    Chemical Substances Leptin ; Cre recombinase (EC 2.7.7.-) ; Integrases (EC 2.7.7.-)
    Language English
    Publishing date 2022-11-16
    Publishing country China
    Document type Journal Article
    ISSN 0253-9772
    ISSN 0253-9772
    DOI 10.16288/j.yczz.22-236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Regulation of the urea cycle by CPS1 O-GlcNAcylation in response to dietary restriction and aging.

    Wu, Jing / Liu, Jiayu / Lapenta, Kalina / Desrouleaux, Reina / Li, Min-Dian / Yang, Xiaoyong

    Journal of molecular cell biology

    2022  Volume 14, Issue 3

    Abstract: O-linked N-acetyl-glucosamine glycosylation (O-GlcNAcylation) of intracellular proteins is a dynamic process broadly implicated in age-related disease, yet it remains uncharacterized whether and how O-GlcNAcylation contributes to the natural aging ... ...

    Abstract O-linked N-acetyl-glucosamine glycosylation (O-GlcNAcylation) of intracellular proteins is a dynamic process broadly implicated in age-related disease, yet it remains uncharacterized whether and how O-GlcNAcylation contributes to the natural aging process. O-GlcNAc transferase (OGT) and the opposing enzyme O-GlcNAcase (OGA) control this nutrient-sensing protein modification in cells. Here, we show that global O-GlcNAc levels are increased in multiple tissues of aged mice. In aged liver, carbamoyl phosphate synthetase 1 (CPS1) is among the most heavily O-GlcNAcylated proteins. CPS1 O-GlcNAcylation is reversed by calorie restriction and is sensitive to genetic and pharmacological manipulations of the O-GlcNAc pathway. High glucose stimulates CPS1 O-GlcNAcylation and inhibits CPS1 activity. Liver-specific deletion of OGT potentiates CPS1 activity and renders CPS1 irresponsive to further stimulation by a prolonged fasting. Our results identify CPS1 O-GlcNAcylation as a key nutrient-sensing regulatory step in the urea cycle during aging and dietary restriction, implying a role for mitochondrial O-GlcNAcylation in nutritional regulation of longevity.
    MeSH term(s) Acetylglucosamine/metabolism ; Aging ; Animals ; Glycosylation ; Liver/metabolism ; Mice ; Protein Processing, Post-Translational ; Urea/metabolism
    Chemical Substances Urea (8W8T17847W) ; Acetylglucosamine (V956696549)
    Language English
    Publishing date 2022-03-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2500949-7
    ISSN 1759-4685 ; 1674-2788
    ISSN (online) 1759-4685
    ISSN 1674-2788
    DOI 10.1093/jmcb/mjac016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Circadian signatures of adipose tissue in diet-induced obesity.

    Xin, Haoran / Zhang, Jianxin / Huang, Rongfeng / Li, Lihua / Lam, Sin Man / Shui, Guanghou / Deng, Fang / Zhang, Zhihui / Li, Min-Dian

    Frontiers in physiology

    2022  Volume 13, Page(s) 953237

    Abstract: High-fat diet (HFD) feeding rewires circadian rhythms of peripheral organs including the liver and adipose tissue. While the liver has been extensively studied, it remains largely unknown whether and how HFD organizes circadian biology in adipose tissue. ...

    Abstract High-fat diet (HFD) feeding rewires circadian rhythms of peripheral organs including the liver and adipose tissue. While the liver has been extensively studied, it remains largely unknown whether and how HFD organizes circadian biology in adipose tissue. Here, we took a systems approach to profile the diurnal transcriptome of adipose tissue in diet-induced obese mice either fed a low-fat diet (LFD) that reduces weight or still fed HFD. We detected about 200 and 2,500 diurnal genes in HFD and LFD, respectively. Pathway analysis revealed that rhythmic pathways in HFD are represented by circadian rhythm, ribosome biogenesis, and nucleosome organization, whereas those in LFD are represented by myeloid cell function. Remarkably, the majority of the circadian clock genes, except
    Language English
    Publishing date 2022-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.953237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Leptin and beyond: an odyssey to the central control of body weight.

    Li, Min-Dian

    The Yale journal of biology and medicine

    2010  Volume 84, Issue 1, Page(s) 1–7

    Abstract: The 2010 Lasker Award for basic medical research was shared by Douglas Coleman and Jeffery Friedman for their discovery of leptin, a breakthrough that revealed insight into the genetic basis of obesity. This mini-review aims to review landmark studies on ...

    Abstract The 2010 Lasker Award for basic medical research was shared by Douglas Coleman and Jeffery Friedman for their discovery of leptin, a breakthrough that revealed insight into the genetic basis of obesity. This mini-review aims to review landmark studies on the physiologic system of body weight control. The basic research on the leptin system has broad implications for the genetic control of body weight, thus contributing to solve the global obesity crisis.
    MeSH term(s) Animals ; Awards and Prizes ; Body Weight/genetics ; Endocrine System/physiology ; Homeostasis ; Humans ; Hypothalamus/physiology ; Leptin/genetics ; Leptin/metabolism ; Neural Pathways/physiology ; Obesity/genetics
    Chemical Substances Leptin
    Language English
    Publishing date 2010-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 200515-3
    ISSN 1551-4056 ; 0044-0086
    ISSN (online) 1551-4056
    ISSN 0044-0086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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