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Article ; Online: Obstructive jaundice caused by IgG4-related disease with multiorgan involvement.

Yu, Gwo-Kuang / Wang, Shen-Nien

The Kaohsiung journal of medical sciences

2023 Volume 39, Issue 5, Page(s) 546–547

MeSH term(s)	Humans ; Jaundice, Obstructive/diagnostic imaging ; Jaundice, Obstructive/etiology ; Immunoglobulin G4-Related Disease/diagnosis ; Immunoglobulin G4-Related Disease/diagnostic imaging ; Pancreatitis ; Immunoglobulin G ; Autoimmune Diseases
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2023-03-20
Publishing country	China (Republic : 1949- )
Document type	Letter
ZDB-ID	639302-0
ISSN	2410-8650 ; 0257-5655
ISSN (online)	2410-8650
ISSN	0257-5655
DOI	10.1002/kjm2.12668
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Zs.B 3187: Show issues

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Article: The Current and Prospective Adjuvant Therapies for Hepatocellular Carcinoma.

Du, Jeng-Shiun / Hsu, Shih-Hsien / Wang, Shen-Nien

Cancers

2024 Volume 16, Issue 7

Abstract: Hepatocellular carcinoma (HCC) stands as the most prevalent form of primary liver cancer and is highly invasive and easily recurs. For HCC, chemotherapy shows limited effect. The gold standard for HCC treatment includes curative surgical resection or ... ...

Abstract	Hepatocellular carcinoma (HCC) stands as the most prevalent form of primary liver cancer and is highly invasive and easily recurs. For HCC, chemotherapy shows limited effect. The gold standard for HCC treatment includes curative surgical resection or liver transplantation. However, the recurrence rate at 5 years after liver resection is estimated at approximately 70% and even at 5 years after liver transplantation, it is 20%. Therefore, improving survival outcomes after curative surgical resection of liver cancer is crucial. This review highlights the importance of identifying risk factors for HCC recurrence following radical surgical resection and adjuvant therapy options that may reduce the recurrence risk and improve overall survival, including local adjuvant therapy (e.g., transcatheter arterial chemoembolization and radiotherapy), adjuvant systemic therapy (e.g., small molecule targeted therapy and immunotherapy), and other adjuvant therapies (e.g., chemotherapy). However, further research is needed to refine the use of these therapies and optimize their effectiveness in preventing HCC recurrence.
Language	English
Publishing date	2024-04-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16071422
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Article ; Online: Optimal Post-Operative Nalbuphine Dose Regimen: A Randomized Controlled Trial in Patients with Laparoscopic Cholecystectomy.

Chen, Guan-Yu / Kuo, Kung-Kai / Chuang, Shih-Chang / Tseng, Kuang-Yi / Wang, Shen-Nien / Chang, Wen-Tsan / Cheng, Kuang-I

Medicina (Kaunas, Lithuania)

2024 Volume 60, Issue 2

Abstract: ... ...

Abstract	Background
MeSH term(s)	Humans ; Nalbuphine/adverse effects ; Analgesics, Opioid/adverse effects ; Cholecystectomy, Laparoscopic/adverse effects ; Pain, Postoperative/drug therapy ; Analgesia
Chemical Substances	Nalbuphine (L2T84IQI2K) ; Analgesics, Opioid
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina60020195
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Zs.A 6270: Show issues

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Article ; Online: Impact of bromodomain-containing protein 4 (BRD4) and intestine-specific homeobox (ISX) expression on the prognosis of patients with hepatocellular carcinoma' for better clarity.

Chuang, Kai-Ting / Wang, Shen-Nien / Hsu, Shih-Hsien / Wang, Li-Ting

Cancer medicine

2021 Volume 10, Issue 16, Page(s) 5545–5556

Abstract: Epigenetic regulation is important for cancer tumor metastasis and progression, including lung and liver cancer. However, the mechanism of epigenetic regulation in liver cancer leaves much to be discussed. According to a previous study, p300/CBP- ... ...

Abstract	Epigenetic regulation is important for cancer tumor metastasis and progression, including lung and liver cancer. However, the mechanism of epigenetic regulation in liver cancer leaves much to be discussed. According to a previous study, p300/CBP-associated factor (PCAF) mediated epithelial-mesenchymal transition (EMT) and promotes cancer metastasis by recruiting intestine-specific homeobox (ISX) and bromodomain-containing protein 4 (BRD4) in lung cancer. To figure out whether the three genes are also expressed in patients with hepatocellular carcinoma (HCC) or not, and their correlation with patients' outcome, BRD4, PCAF, and ISX messenger RNA (mRNA) expression levels in 377 patients with HCC were investigated using quantitative polymerase chain reaction and confocal fluorescence imaging. The correlation of the gene expression (PCAF, ISX, and BRD4) in liver cancer is also being investigated. Here, we show that the mRNA expression of PCAF, BRD4, and ISX in 377 paired specimens from patients with HCC, and the adjacent normal tissues exhibited a tumor-specific expression pattern, highly correlated with disease pathogenesis, patient survival time, progression stage, and poor prognosis. The results show that ISX and BRD4 can potentially be a target for improving the survival rate.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Child ; Epigenesis, Genetic ; Female ; Follow-Up Studies ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Hepatectomy ; Homeodomain Proteins/genetics ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Rate ; Transcription Factors/genetics ; Young Adult ; p300-CBP Transcription Factors/genetics
Chemical Substances	BRD4 protein, human ; Biomarkers, Tumor ; Cell Cycle Proteins ; Homeodomain Proteins ; Isx protein, human ; Transcription Factors ; p300-CBP Transcription Factors (EC 2.3.1.48) ; p300-CBP-associated factor (EC 2.3.1.48)
Language	English
Publishing date	2021-06-25
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.4094
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Article ; Online: Comparison of laparoscopic common bile duct exploration plus cholecystectomy and endoscopic retrograde cholangiopancreatography followed by laparoscopic cholecystectomy for elderly patients with common bile duct stones and gallbladder stones.

Wu, Po-Hsuan / Yu, Min-Wei / Chuang, Shih-Chang / Wang, Shen-Nien / Kuo, Kung-Kai / Chang, Wen-Tsan / Chuang, Shu-Hung / Su, Wen-Lung / Huang, Jian-Wei / Chen, Ling-An

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2024

Abstract: Background: Common bile duct (CBD) stones commonly occur in cholecystectomy cases. The management options include laparoscopic CBD exploration (LCBDE) or endoscopic retrograde cholangiopancreatography (ERCP) followed by laparoscopic cholecystectomy (LC). ...

Abstract	Background: Common bile duct (CBD) stones commonly occur in cholecystectomy cases. The management options include laparoscopic CBD exploration (LCBDE) or endoscopic retrograde cholangiopancreatography (ERCP) followed by laparoscopic cholecystectomy (LC). Although ERCP is fully developed, it has complications, and LCBDE is a proven alternative. This study aimed to evaluate the safety and efficacy of these treatments in elderly individuals aged ≥70 years. Methods: A retrospective study between January 2015 and July 2022 included 160 elderly patients (aged ≥70 years) diagnosed with cholelithiasis and choledocholithiasis. The patients were divided into 1-stage (LCBDE [n = 80]) or 2-stage (ERCP followed by LC [n = 80]) treatment groups. Data collected encompassed comorbidities, symptoms, bile duct clearance, postoperative complications, and long-term outcomes for systematic analysis. Results: This study analyzed 160 patients treated for CBD stones, comparing 1-stage and 2-stage groups. The 1-stage group had more female patients than the 2-stage group (57.5% vs 37.5%, respectively). The 1-stage group had a mean age of 80.55 ± 7.00 years, which was higher than the mean age in the 2-stage group. American Society of Anesthesiologists classification, Charlson Comorbidity Index, and laboratory findings were similar. Pancreatitis and cholangitis occurred after ERCP in the 2-stage group. Stone clearance rates (92.35% [1-stage group] vs 95.00% [2-stage group]) and biliary leakage incidence (7.5% [1-stage group] vs 3.0% [2-stage group]) were similar, as were postoperative complications and long-term recurrence rates (13.0% [1-stage group] vs 12.5% [2-stage group]). Conclusion: Our research indicates that both the combination of LCBDE and LC and the sequence of ERCP followed by LC are equally efficient and secure when treating CBD stones in elderly patients. Consequently, the 1-stage procedure may be considered the preferred treatment approach for this demographic.
Language	English
Publishing date	2024-03-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1016/j.gassur.2024.02.026
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Zs.A 5207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 354: Show issues

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Article ; Online: HDAC6 promotes aggressive development of liver cancer by improving egfr mRNA stability.

Dai, Hong-Ying / Chang, Long-Sen / Yang, Sheau-Fang / Wang, Shen-Nien / Su, Shu-Jem / Yeh, Yao-Tsung

Neoplasia (New York, N.Y.)

2022 Volume 35, Page(s) 100845

MeSH term(s)	Humans ; RNA Stability/genetics ; Liver Neoplasms/genetics ; ELAV-Like Protein 1/metabolism ; Histone Deacetylase 6/genetics
Chemical Substances	ELAV-Like Protein 1 ; HDAC6 protein, human (EC 3.5.1.98) ; Histone Deacetylase 6 (EC 3.5.1.98)
Language	English
Publishing date	2022-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1483840-0
ISSN	1476-5586 ; 1522-8002
ISSN (online)	1476-5586
ISSN	1522-8002
DOI	10.1016/j.neo.2022.100845
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Zs.A 5203: Show issues

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Article ; Online: Alternative Laparoscopic Intracorporeal Pringle Maneuver by Huang's Loop.

Huang, Jian-Wei / Su, Wen-Lung / Wang, Shen-Nien

World journal of surgery

2018 Volume 42, Issue 10, Page(s) 3312–3315

Abstract: Aim: This paper aims to describe an intracorporeal tourniquet method for laparoscopic Pringle maneuver (PM).: Methods: One shortened Foley tube with side-hole on the tip was put into the abdomen. Then, the tail was pulled out through the side-hole to ...

Abstract	Aim: This paper aims to describe an intracorporeal tourniquet method for laparoscopic Pringle maneuver (PM). Methods: One shortened Foley tube with side-hole on the tip was put into the abdomen. Then, the tail was pulled out through the side-hole to make a loop to encircle porta hepatis for inflow control. Result: It is easy to keep the tension by a metallic clip, and when released, the clip can be removed and the loop loosened. Conclusion: Therefore, PM could be performed inside the abdomen without special instrument nor extra trocar port. The intracorporeal Pringle maneuver with Huang's loop could be routinely used during laparoscopic liver resection even for a laparoscopic beginner because it is so easily learnt, safe, and effective.
MeSH term(s)	Abdominal Cavity/surgery ; Hepatectomy/instrumentation ; Hepatectomy/methods ; Humans ; Laparoscopy/methods ; Liver/surgery
Language	English
Publishing date	2018-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-018-4584-z
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Article: Homeobox Genes and Hepatocellular Carcinoma.

Liu, Kwei-Yan / Wang, Li-Ting / Hsu, Shih-Hsien / Wang, Shen-Nien

Cancers

2019 Volume 11, Issue 5

Abstract: Hepatocellular carcinoma (HCC) is the sixth most common type of cancer, and is the third leading cause of cancer-related deaths each year. It involves a multi-step progression and is strongly associated with chronic inflammation induced by the intake of ... ...

Abstract	Hepatocellular carcinoma (HCC) is the sixth most common type of cancer, and is the third leading cause of cancer-related deaths each year. It involves a multi-step progression and is strongly associated with chronic inflammation induced by the intake of environmental toxins and/or viral infections (i.e., hepatitis B and C viruses). Although several genetic dysregulations are considered to be involved in disease progression, the detailed regulatory mechanisms are not well defined. Homeobox genes that encode transcription factors with homeodomains control cell growth, differentiation, and morphogenesis in embryonic development. Recently, more aberrant expressions of Homeobox genes were found in a wide variety of human cancer, including HCC. In this review, we summarize the currently available evidence related to the role of Homeobox genes in the development of HCC. The objective is to determine the roles of this conserved transcription factor family and its potential use as a therapeutic target in future investigations.
Language	English
Publishing date	2019-05-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers11050621
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Article ; Online: HCV Core Protein-ISX Axis Promotes Chronic Liver Disease Progression via Metabolic Remodeling and Immune Suppression.

Wang, Li-Ting / Wang, Shen-Nien / Chiou, Shyh-Shin / Tsai, Jhih-Peng / Chai, Chee-Yin / Tseng, Li-Wen / Lee, Jin-Ching / Lin, Ming-Hong / Huang, Shau-Ku / Hsu, Shih-Hsien

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023 Volume 10, Issue 23, Page(s) e2300644

Abstract: Chronic hepatitis C virus (HCV) infection is an important public health issue. However, knowledge on how the virus remodels the metabolic and immune response toward hepatic pathologic environment is limited. The transcriptomic and multiple evidences ... ...

Abstract	Chronic hepatitis C virus (HCV) infection is an important public health issue. However, knowledge on how the virus remodels the metabolic and immune response toward hepatic pathologic environment is limited. The transcriptomic and multiple evidences reveal that the HCV core protein-intestine-specific homeobox (ISX) axis promotes a spectrum of metabolic, fibrogenic, and immune modulators (e.g., kynurenine, PD-L1, and B7-2), regulating HCV-infection relevant pathogenic phenotype in vitro and in vivo. In a transgenic mice model, the HCV core protein-ISX axis enhance metabolic disturbance (particularly lipid and glucose metabolism) and immune suppression, and finally, chronic liver fibrosis in a high-fat diet (HFD)-induced disease model. Mechanistically, cells with HCV JFH-1 replicons upregulate ISX and, consequently, the expressions of metabolic, fibrosis progenitor, and immune modulators via core protein-induced nuclear factor-κB signaling. Conversely, cells with specific ISX shRNAi inhibit HCV core protein-induced metabolic disturbance and immune suppression. Clinically, the HCV core level is significantly correlated with ISX, IDOs, PD-L1, and B7-2 levels in HCC patients with HCV infection. Therefore, it highlights the significance of HCV core protein-ISX axis as an important mechanism in the development of HCV-induced chronic liver disease and can be a specific therapeutic target clinically.
MeSH term(s)	Mice ; Animals ; Carcinoma, Hepatocellular ; Hepatitis C, Chronic/metabolism ; Hepatitis C, Chronic/pathology ; B7-H1 Antigen/metabolism ; Liver Neoplasms ; Hepatitis C/metabolism ; Mice, Transgenic ; Disease Progression
Chemical Substances	B7-H1 Antigen
Language	English
Publishing date	2023-06-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202300644
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Article ; Online: Thyroid Abscess Associated With Pyriform Sinus Fistula.

Wang, Wen-Ching / Shen, Hsiu-Nien

Mayo Clinic proceedings

2021 Volume 96, Issue 11, Page(s) 2854–2855

MeSH term(s)	Abscess ; Adult ; Anti-Bacterial Agents/administration & dosage ; Cautery/methods ; Deglutition Disorders/diagnosis ; Deglutition Disorders/etiology ; Dissection/methods ; Fistula/diagnostic imaging ; Fistula/etiology ; Fistula/surgery ; Humans ; Male ; Pharyngitis/diagnosis ; Pharyngitis/etiology ; Prevotella/isolation & purification ; Pyriform Sinus/diagnostic imaging ; Pyriform Sinus/pathology ; Secondary Prevention ; Thyroid Gland/diagnostic imaging ; Thyroid Gland/pathology ; Tomography, X-Ray Computed/methods ; Treatment Outcome ; Viridans Streptococci/isolation & purification
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-10-29
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2021.08.023
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