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  1. Article ; Online: The link between obesity and autoimmunity.

    Matarese, Giuseppe

    Science (New York, N.Y.)

    2023  Volume 379, Issue 6639, Page(s) 1298–1300

    Abstract: Overnutrition could lead to loss of self-tolerance by impinging on immune regulation. ...

    Abstract Overnutrition could lead to loss of self-tolerance by impinging on immune regulation.
    MeSH term(s) Humans ; Autoimmunity ; Obesity/complications ; Obesity/immunology ; Overnutrition/complications ; Overnutrition/immunology ; Self Tolerance ; Autoimmune Diseases/etiology
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.ade0113
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  2. Article ; Online: Novel acquisitions in cell immunometabolism.

    Norata, Giuseppe Danilo / Matarese, Giuseppe

    Molecular aspects of medicine

    2021  Volume 77, Page(s) 100945

    MeSH term(s) Energy Metabolism ; Humans ; Signal Transduction
    Language English
    Publishing date 2021-02-05
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2021.100945
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  3. Article ; Online: The folate way to T cell fate.

    de Candia, Paola / Matarese, Giuseppe

    Immunity

    2022  Volume 55, Issue 1, Page(s) 1–3

    Abstract: The role of folate-dependent one carbon (1C) metabolism in ... ...

    Abstract The role of folate-dependent one carbon (1C) metabolism in CD4
    MeSH term(s) Cell Differentiation ; Folic Acid ; Lymphocyte Activation
    Chemical Substances Folic Acid (935E97BOY8)
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2021.12.009
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  4. Article ; Online: Reimagining an immunological dogma.

    de Candia, Paola / Matarese, Giuseppe

    Nature immunology

    2021  Volume 22, Issue 11, Page(s) 1355–1358

    Language English
    Publishing date 2021-10-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-01046-5
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  5. Article ; Online: Cellular and molecular signaling towards T cell immunological self-tolerance.

    Carbone, Fortunata / Russo, Claudia / Colamatteo, Alessandra / La Rocca, Claudia / Fusco, Clorinda / Matarese, Alessandro / Procaccini, Claudio / Matarese, Giuseppe

    The Journal of biological chemistry

    2024  Volume 300, Issue 4, Page(s) 107134

    Abstract: The binding of a cognate antigen to T cell receptor (TCR) complex triggers a series of intracellular events controlling T cell activation, proliferation, and differentiation. Upon TCR engagement, different negative regulatory feedback mechanisms are ... ...

    Abstract The binding of a cognate antigen to T cell receptor (TCR) complex triggers a series of intracellular events controlling T cell activation, proliferation, and differentiation. Upon TCR engagement, different negative regulatory feedback mechanisms are rapidly activated to counterbalance T cell activation, thus preventing excessive signal propagation and promoting the induction of immunological self-tolerance. Both positive and negative regulatory processes are tightly controlled to ensure the effective elimination of foreign antigens while limiting surrounding tissue damage and autoimmunity. In this context, signals deriving from co-stimulatory molecules (i.e., CD80, CD86), co-inhibitory receptors (PD-1, CTLA-4), the tyrosine phosphatase CD45 and cytokines such as IL-2 synergize with TCR-derived signals to guide T cell fate and differentiation. The balance of these mechanisms is also crucial for the generation of CD4
    Language English
    Publishing date 2024-03-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2024.107134
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  6. Article ; Online: Hormonal control of trained immunity: aldosterone at the crossroad between activation of innate immunity and cardiovascular diseases.

    Matarese, Giuseppe / Norata, Giuseppe Danilo

    Cardiovascular research

    2019  Volume 116, Issue 2, Page(s) 256–257

    MeSH term(s) Aldosterone ; Cardiovascular Diseases ; Humans ; Immunity, Innate ; Lipogenesis
    Chemical Substances Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2019-07-25
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvz191
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  7. Article ; Online: Where Mitochondria Meet Autoimmunity: The Treg Cell Link.

    Procaccini, Claudio / Matarese, Giuseppe

    Cell metabolism

    2020  Volume 32, Issue 4, Page(s) 507–509

    Abstract: Although a crucial role for mitochondrial metabolism in controlling T regulatory (Treg) cell function has been recognized, its contribution during autoimmunity has not yet been fully elucidated. In this issue of Cell Metabolism, Alissafi and colleagues ... ...

    Abstract Although a crucial role for mitochondrial metabolism in controlling T regulatory (Treg) cell function has been recognized, its contribution during autoimmunity has not yet been fully elucidated. In this issue of Cell Metabolism, Alissafi and colleagues demonstrate that during autoimmunity, Treg cell functional alterations associate with mitochondrial oxidative stress, dysfunctional mitophagy, and enhanced DNA damage response, culminating with their cell death.
    MeSH term(s) Autoimmunity ; Mitochondria/metabolism ; Mitophagy ; Oxidative Stress ; T-Lymphocytes, Regulatory/metabolism
    Language English
    Publishing date 2020-09-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2020.08.006
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  8. Article ; Online: Divide and hide: proliferating β-cells control immune tolerance in autoimmune diabetes.

    Galgani, Mario / Matarese, Giuseppe

    Nature metabolism

    2019  Volume 1, Issue 5, Page(s) 499–500

    Language English
    Publishing date 2019-10-14
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-019-0068-1
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  9. Article ; Online: The key role of inflammation in the pathogenesis and management of obesity and CVD.

    Boutari, Chrysoula / Hill, Michael A / Procaccini, Claudio / Matarese, Giuseppe / Mantzoros, Christos S

    Metabolism: clinical and experimental

    2023  Volume 145, Page(s) 155627

    MeSH term(s) Humans ; Obesity/complications ; Obesity/therapy ; Inflammation/therapy ; Inflammation/etiology ; Cardiovascular Diseases/therapy ; Cardiovascular Diseases/complications ; Risk Factors
    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 80230-x
    ISSN 1532-8600 ; 0026-0495
    ISSN (online) 1532-8600
    ISSN 0026-0495
    DOI 10.1016/j.metabol.2023.155627
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  10. Article ; Online: Mycobacterium tuberculosis Antigen 85B modifies BCG-induced anti-tuberculosis immunity and favors pathogen survival.

    Piccaro, Giovanni / Aquino, Gabriella / Gigantino, Vincenzo / Tirelli, Valentina / Sanchez, Massimo / Iorio, Egidio / Matarese, Giuseppe / Cassone, Antonio / Palma, Carla

    Journal of leukocyte biology

    2024  

    Abstract: Tuberculosis is one of the deadliest infectious diseases worldwide. Mycobacterium tuberculosis (Mtb) has developed strategies not only to evade from host immunity but also to manipulate it for its survival. We investigated whether Mtb exploited the ... ...

    Abstract Tuberculosis is one of the deadliest infectious diseases worldwide. Mycobacterium tuberculosis (Mtb) has developed strategies not only to evade from host immunity but also to manipulate it for its survival. We investigated whether Mtb exploited the immunogenicity of Ag85B, one of its major secretory proteins, to redirect host anti-TB immunity to its advantage. We found that administration of Ag85B protein to mice vaccinated with Bacillus Calmette-Guérin (BCG) impaired the protection elicited by vaccination causing a more severe infection when mice were challenged with Mtb. Ag85B administration reduced BCG-induced CD4 T cell activation and IFN-γ, CCL-4 and IL-22 production in response to Mtb-infected cells. On the other hand, it promoted robust Ag85B-responsive IFN-γ-producing CD4 T cells, expansion of a subset of IFN-γ/IL-10-producing CD4+FOXP3+Treg cells, differential activation of IL-17/IL-22 responses and activation of regulatory and exhaustion pathways, including programmed death-ligand 1 expression on macrophages. All this resulted in impaired intracellular Mtb growth control by systemic immunity, both at pre- and post-Mtb challenge. Interestingly, Mtb infection itself generated Ag85B-reactive inflammatory immune cells incapable of clearing Mtb in both unvaccinated and BCG-vaccinated mice. Our data suggest that Mtb can exploit the strong immunogenicity of Ag85B to promote its own survival and spread. Since Ag85B is normally secreted by replicating bacteria and it is commonly found in the lungs of the Mtb-infected host, our findings may advance the understanding on the mechanisms of Mtb pathogenesis and immune evasion.
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1093/jleuko/qiae014
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