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  1. Book ; Online: Feature Papers in Mathematical and Computational Applications

    Rozza, Gianluigi / Schütze, Oliver / Fantuzzi, Nicholas

    2023  

    Keywords Technology: general issues ; History of engineering & technology ; Materials science ; applied mathematics ; differential equations ; mathematical modelling ; numerical analysis ; numerical simulation
    Language English
    Size 1 electronic resource (240 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030376332
    ISBN 9783036567570 ; 3036567577
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Perspective: Daniela Novick, cytokines and their receptors.

    Ghezzi, Pietro / Fantuzzi, Giamila / Dinarello, Charles A

    Frontiers in immunology

    2023  Volume 14, Page(s) 1160651

    Abstract: This Perspective highlights the work of Dr. Daniela Novick in the field of cytokine biology. Using affinity chromatography to characterize cytokine-binding proteins, she identified soluble forms of the receptors as well as binding proteins for several ... ...

    Abstract This Perspective highlights the work of Dr. Daniela Novick in the field of cytokine biology. Using affinity chromatography to characterize cytokine-binding proteins, she identified soluble forms of the receptors as well as binding proteins for several cytokines, including tumor necrosis factor, interleukin (IL) 6, IL-18 and IL-32. Importantly, her work has been key in the development of monoclonal antibodies against interferons and cytokines. This Perspective discusses her contribution to the field and highlights her recent review on this topic.
    MeSH term(s) Female ; Humans ; Cytokines/metabolism ; Interleukin-6/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Interferons ; Antibodies, Monoclonal/therapeutic use
    Chemical Substances Cytokines ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Interferons (9008-11-1) ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-05-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1160651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cancer is a propagandist.

    Fantuzzi, Giamila

    Studies in history and philosophy of biological and biomedical sciences

    2017  Volume 63, Page(s) 28–31

    Abstract: Communication among cells (also known as cross-talk) plays a prominent role in the current knowledge of the pathophysiology of cancer and of cancer-associated conditions such as paraneoplastic syndromes and cachexia that are responsible for much of ... ...

    Abstract Communication among cells (also known as cross-talk) plays a prominent role in the current knowledge of the pathophysiology of cancer and of cancer-associated conditions such as paraneoplastic syndromes and cachexia that are responsible for much of cancer's morbidity and mortality. Yet, biomedical scientists lack an explicit unifying frame that places this exchange of molecular information at the core of their understanding of cancer as a systemic disease. Propaganda is a type of information that aims at misleading, a form of communication intended primarily to serve the messenger. The biased molecular cross-talk between cancer and non-cancer cells can be considered as a form of biological propaganda. I here propose cancer is a propagandist as a metaphor that may serve as a unifying frame to interpret both cancer and cancer-associated syndromes under the same communication-based concept and may thus serve to bring together research that is currently compartmentalized under separate disciplines.
    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1500765-0
    ISSN 1879-2499 ; 1369-8486
    ISSN (online) 1879-2499
    ISSN 1369-8486
    DOI 10.1016/j.shpsc.2017.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Auxiliary Functions as Koopman Observables

    Bramburger, Jason J. / Fantuzzi, Giovanni

    Data-Driven Analysis of Dynamical Systems via Polynomial Optimization

    2023  

    Abstract: We present a flexible data-driven method for dynamical system analysis that does not require explicit model discovery. The method is rooted in well-established techniques for approximating the Koopman operator from data and is implemented as a ... ...

    Abstract We present a flexible data-driven method for dynamical system analysis that does not require explicit model discovery. The method is rooted in well-established techniques for approximating the Koopman operator from data and is implemented as a semidefinite program that can be solved numerically. Furthermore, the method is agnostic of whether data is generated through a deterministic or stochastic process, so its implementation requires no prior adjustments by the user to accommodate these different scenarios. Rigorous convergence results justify the applicability of the method, while also extending and uniting similar results from across the literature. Examples on discovering Lyapunov functions, performing ergodic optimization, and bounding extrema over attractors for both deterministic and stochastic dynamics exemplify these convergence results and demonstrate the performance of the method.

    Comment: We have significantly expanded the presentation. This has improved the presentation and made the paper more readable. Comments welcome
    Keywords Mathematics - Dynamical Systems ; Computer Science - Machine Learning ; Mathematics - Optimization and Control
    Publishing date 2023-03-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online: Adipose Tissue and Adipokines in Health and Disease

    Fantuzzi, Giamila / Mazzone, Theodore

    2007  

    Author's details edited by Giamila Fantuzzi, Theodore Mazzone
    Keywords Diabetes ; Endocrinology ; Gastroenterology ; Human physiology ; Nutrition
    Language English
    Publisher Humana Press Inc
    Publishing place Totowa, NJ
    Document type Book ; Online
    HBZ-ID TT050387148
    ISBN 978-1-588-29721-1 ; 978-1-597-45370-7 ; 1-588-29721-7 ; 1-597-45370-6
    DOI 10.1007/978-1-59745-370-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: The Association Between Racism and Suicidality Among Young Minority Groups: A Systematic Review.

    Rudes, Giorgia / Fantuzzi, Claudia

    Journal of transcultural nursing : official journal of the Transcultural Nursing Society

    2021  Volume 33, Issue 2, Page(s) 228–238

    Abstract: Introduction: The World Health Organization states that suicide is the second leading cause of death among youngs, and racism has been proven to have detrimental effects on both physical and mental health. These two plagues represent a public health ... ...

    Abstract Introduction: The World Health Organization states that suicide is the second leading cause of death among youngs, and racism has been proven to have detrimental effects on both physical and mental health. These two plagues represent a public health priority, especially for susceptible minorities.
    Method: This systematic review analyzed 23 studies from multiple database searches, to understand the relationship between racism and suicidality in young minority groups.
    Results: The review demonstrated the correlation between racism and suicidality with the consequent development of mental disorders. There is strong evidence that the main suicide risk factor is acculturation, interpreted as the assimilation of the dominant culture with the loss of values from one's cultural background.
    Discussion: Health care professionals should not underestimate the risk of suicidality associated with racism. Prevention is crucial and it should be implemented from a young age, in schools, through a joint intervention with children and their families, aiming toward integration without acculturation.
    MeSH term(s) Acculturation ; Child ; Humans ; Minority Groups/psychology ; Racism/psychology ; Suicidal Ideation ; Suicide
    Language English
    Publishing date 2021-09-23
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 1291524-5
    ISSN 1552-7832 ; 1043-6596
    ISSN (online) 1552-7832
    ISSN 1043-6596
    DOI 10.1177/10436596211046983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: C-reactive protein as the biomarker of choice to monitor the effects of exercise on inflammation in Parkinson's disease.

    Mehta, Niyati / Luthra, Nijee S / Corcos, Daniel M / Fantuzzi, Giamila

    Frontiers in immunology

    2023  Volume 14, Page(s) 1178448

    Abstract: Parkinson's disease (PD), a heterogeneous disease with no disease-modifying treatments available, is the fastest growing neurological disease worldwide. Currently, physical exercise is the most promising treatment to slow disease progression, with ... ...

    Abstract Parkinson's disease (PD), a heterogeneous disease with no disease-modifying treatments available, is the fastest growing neurological disease worldwide. Currently, physical exercise is the most promising treatment to slow disease progression, with evidence suggesting it is neuroprotective in animal models. The onset, progression, and symptom severity of PD are associated with low grade, chronic inflammation which can be quantified by measuring inflammatory biomarkers. In this perspective, we argue that C-reactive protein (CRP) should be used as the primary biomarker for monitoring inflammation and therefore disease progression and severity, particularly in studies examining the impact of an intervention on the signs and symptoms of PD. CRP is the most studied biomarker of inflammation, and it can be detected using relatively well-standardized assays with a wide range of detection, allowing for comparability across studies while generating robust data. An additional advantage of CRP is its ability to detect inflammation irrespective of its origin and specific pathways, an advantageous characteristic when the cause of inflammation remains unknown, such as PD and other chronic, heterogeneous diseases.
    MeSH term(s) Animals ; Parkinson Disease/diagnosis ; Parkinson Disease/metabolism ; C-Reactive Protein/metabolism ; Biomarkers ; Inflammation/complications ; Exercise ; Disease Progression
    Chemical Substances C-Reactive Protein (9007-41-4) ; Biomarkers
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1178448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The background method: theory and computations.

    Fantuzzi, Giovanni / Arslan, Ali / Wynn, Andrew

    Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

    2022  Volume 380, Issue 2225, Page(s) 20210038

    Abstract: The background method is a widely used technique to bound mean properties of turbulent flows rigorously. This work reviews recent advances in the theoretical formulation and numerical implementation of the method. First, we describe how the background ... ...

    Abstract The background method is a widely used technique to bound mean properties of turbulent flows rigorously. This work reviews recent advances in the theoretical formulation and numerical implementation of the method. First, we describe how the background method can be formulated systematically within a broader 'auxiliary function' framework for bounding mean quantities, and explain how symmetries of the flow and constraints such as maximum principles can be exploited. All ideas are presented in a general setting and are illustrated on Rayleigh-Bénard convection between stress-free isothermal plates. Second, we review a semidefinite programming approach and a timestepping approach to optimizing bounds computationally, revealing that they are related to each other through convex duality and low-rank matrix factorization. Open questions and promising directions for further numerical analysis of the background method are also outlined. This article is part of the theme issue 'Mathematical problems in physical fluid dynamics (part 1)'.
    Language English
    Publishing date 2022-04-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208381-4
    ISSN 1471-2962 ; 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    ISSN (online) 1471-2962
    ISSN 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    DOI 10.1098/rsta.2021.0038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The sound of health.

    Fantuzzi, Giamila

    Frontiers in immunology

    2014  Volume 5, Page(s) 351

    Language English
    Publishing date 2014-07-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2014.00351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Health versus disease as the catalyst for biomedical research: the science of adipokines as a case in point.

    Fantuzzi, Giamila

    Frontiers in endocrinology

    2014  Volume 5, Page(s) 136

    Language English
    Publishing date 2014-08-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2014.00136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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