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Article ; Online: LepRb+ cell–specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice

Min-Hyun Kim / Yuan Li / Qiantao Zheng / Lin Jiang / Martin G. Myers Jr. / Wen-Shu Wu / Liangyou Rui

The Journal of Clinical Investigation, Vol 133, Iss

2023 Volume 4

Abstract: Leptin exerts its biological actions by activating the long-form leptin receptor (LepRb). LepRb signaling impairment and leptin resistance are believed to cause obesity. The transcription factor Slug — also known as Snai2 — recruits epigenetic modifiers ... ...

Abstract	Leptin exerts its biological actions by activating the long-form leptin receptor (LepRb). LepRb signaling impairment and leptin resistance are believed to cause obesity. The transcription factor Slug — also known as Snai2 — recruits epigenetic modifiers and regulates gene expression by an epigenetic mechanism; however, its epigenetic action has not been explored in leptin resistance. Here, we uncover a proobesity function of neuronal Slug. Hypothalamic Slug was upregulated in obese mice. LepRb+ cell–specific Slug-knockout (SlugΔLepRb) mice were resistant to diet-induced obesity, type 2 diabetes, and liver steatosis and experienced decreased food intake and increased fat thermogenesis. Leptin stimulated hypothalamic Stat3 phosphorylation and weight loss to a markedly higher level in SlugΔLepRb than in Slugfl/fl mice, even before their body weight divergence. Conversely, hypothalamic LepRb+ neuron–specific overexpression of Slug, mediated by AAV-hSyn-DIO-Slug transduction, induced leptin resistance, obesity, and metabolic disorders in mice on a chow diet. At the genomic level, Slug bound to and repressed the LepRb promoter, thereby inhibiting LepRb transcription. Consistently, Slug deficiency decreased methylation of LepRb promoter H3K27, a repressive epigenetic mark, and increased LepRb mRNA levels in the hypothalamus. Collectively, these results unravel what we believe to be a previously unrecognized hypothalamic neuronal Slug/epigenetic reprogramming/leptin resistance axis that promotes energy imbalance, obesity, and metabolic disease.
Keywords	Cell biology ; Metabolism ; Medicine ; R
Subject code	630
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	American Society for Clinical Investigation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: How Is the Hungry Brain like a Sieve?

Myers, Martin G., Jr

Cell metabolism. 2013 Apr. 2, v. 17, no. 4

2013

Abstract: Whether some hypothalamic neurons have direct access to circulating metabolic cues represents a crucial question that has been intensely debated. New findings reveal that fasting promotes “leakiness” of some hypothalamic blood vessels, increasing the ... ...

Abstract	Whether some hypothalamic neurons have direct access to circulating metabolic cues represents a crucial question that has been intensely debated. New findings reveal that fasting promotes “leakiness” of some hypothalamic blood vessels, increasing the access of circulating factors to certain hypothalamic neurons that control feeding (Langlet et al., 2013).
Keywords	blood vessels ; brain ; fasting ; neurons
Language	English
Dates of publication	2013-0402
Size	p. 467-468.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2176834-1
ISSN	1932-7420 ; 1550-4131
ISSN (online)	1932-7420
ISSN	1550-4131
DOI	10.1016/j.cmet.2013.03.007
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models

Alan C. Rupp / Abigail J. Tomlinson / Alison H. Affinati / Warren T. Yacawych / Allison M. Duensing / Cadence True / Sarah R. Lindsley / Melissa A. Kirigiti / Alexander MacKenzie / Joseph Polex-Wolf / Chien Li / Lotte Bjerre Knudsen / Randy J. Seeley / David P. Olson / Paul Kievit / Martin G. Myers Jr.

The Journal of Clinical Investigation, Vol 133, Iss

2023 Volume 19

Abstract: The adipose-derived hormone leptin acts via its receptor (LepRb) in the brain to control energy balance. A potentially unidentified population of GABAergic hypothalamic LepRb neurons plays key roles in the restraint of food intake and body weight by ... ...

Abstract	The adipose-derived hormone leptin acts via its receptor (LepRb) in the brain to control energy balance. A potentially unidentified population of GABAergic hypothalamic LepRb neurons plays key roles in the restraint of food intake and body weight by leptin. To identify markers for candidate populations of LepRb neurons in an unbiased manner, we performed single-nucleus RNA-Seq of enriched mouse hypothalamic LepRb cells, identifying several previously unrecognized populations of hypothalamic LepRb neurons. Many of these populations displayed strong conservation across species, including GABAergic Glp1r-expressing LepRb (LepRbGlp1r) neurons, which expressed more Lepr than other LepRb cell populations. Ablating Lepr from LepRbGlp1r cells provoked hyperphagic obesity without impairing energy expenditure. Similarly, improvements in energy balance caused by Lepr reactivation in GABA neurons of otherwise Lepr-null mice required Lepr expression in GABAergic Glp1r-expressing neurons. Furthermore, restoration of Glp1r expression in LepRbGlp1r neurons in otherwise Glp1r-null mice enabled food intake suppression by the GLP1R agonist, liraglutide. Thus, the conserved GABAergic LepRbGlp1r neuron population plays crucial roles in the suppression of food intake by leptin and GLP1R agonists.
Keywords	Endocrinology ; Metabolism ; Medicine ; R
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	American Society for Clinical Investigation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Protocol to extract actively translated mRNAs from mouse hypothalamus by translating ribosome affinity purification

Xingfa Han / Laura L. Burger / David Garcia-Galiano / Suzanne M. Moenter / Martin G. Myers, Jr, / David P. Olson / Carol F. Elias

STAR Protocols, Vol 2, Iss 2, Pp 100589- (2021)

2021

Abstract: Summary: Here, we present an in-depth protocol for extracting ribosome-bound mRNAs in low-abundance cells of hypothalamic nuclei. mRNAs are extracted from the micropunched tissue using refined translating ribosome affinity purification. Isolated RNAs can ...

Abstract	Summary: Here, we present an in-depth protocol for extracting ribosome-bound mRNAs in low-abundance cells of hypothalamic nuclei. mRNAs are extracted from the micropunched tissue using refined translating ribosome affinity purification. Isolated RNAs can be used for sequencing or transcript quantification. This protocol enables the identification of actively translated mRNAs in varying physiological states and can be modified for use in any neuronal subpopulation labeled with a ribo-tag. We use leptin receptor-expressing neurons as an example to illustrate the protocol.For complete details on the use and execution of this protocol, please refer to Han et al. (2020).
Keywords	Gene Expression ; Neuroscience ; Protein Biochemistry ; Science (General) ; Q1-390
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: A global database of dissolved organic matter (DOM) concentration measurements in coastal waters (CoastDOM v1)

Lønborg, Christian / Carreira, Cátia / Abril, Gwenaël / Agustí, Susana / Amaral, Valentina / Andersson, Agneta / Arístegui, Javier / Bhadury, Punyasloke / Bif, Mariana B. / Borges, Alberto V. / Bouillon, Steven / Calleja, Maria Ll. / Cotovicz Jr., Luiz C. / Cozzi, Stefano / Doval, Maryló / Duarte, Carlos M. / Eyre, Bradley / Fichot, Cédric G. / García-Martín, E. Elena /

Garzon-Garcia, Alexandra / Giani, Michele / Gonçalves-Araujo, Rafael / Gruber, Renee / Hansell, Dennis A. / Hashihama, Fuminori / He, Ding / Holding, Johnna M. / Hunter, William R. / Ibánhez, J. Severino P. / Ibello, Valeria / Jiang, Shan / Kim, Guebuem / Klun, Katja / Kowalczuk, Piotr / Kubo, Atsushi / Lee, Choon-Weng / Lopes, Cláudia B. / Maggioni, Federica / Magni, Paolo / Marrase, Celia / Martin, Patrick / McCallister, S. Leigh / McCallum, Roisin / Medeiros, Patricia M. / Morán, Xosé Anxelu G. / Muller-Karger, Frank E. / Myers-Pigg, Allison / Norli, Marit / Oakes, Joanne M. / Osterholz, Helena / Park, Hyekyung / Lund Paulsen, Maria / Rosentreter, Judith A. / Ross, Jeff D. / Rueda-Roa, Digna / Santinelli, Chiara / Shen, Yuan / Teira, Eva / Tinta, Tinkara / Uher, Guenther / Wakita, Masahide / Ward, Nicholas / Watanabe, Kenta / Xin, Yu / Yamashita, Youhei / Yang, Liyang / Yeo, Jacob / Yuan, Huamao / Zheng, Qiang / Álvarez-Salgado, Xosé Antón

eISSN: 1866-3516

2024

Abstract: ... e.g. chlorophyll a , inorganic nutrients) and the inorganic carbon system (e.g. dissolved inorganic ...

Abstract	Measurements of dissolved organic carbon (DOC), nitrogen (DON), and phosphorus (DOP) concentrations are used to characterize the dissolved organic matter (DOM) pool and are important components of biogeochemical cycling in the coastal ocean. Here, we present the first edition of a global database (CoastDOM v1; available at https://doi.org/10.1594/PANGAEA.964012 , Lønborg et al., 2023) compiling previously published and unpublished measurements of DOC, DON, and DOP in coastal waters. These data are complemented by hydrographic data such as temperature and salinity and, to the extent possible, other biogeochemical variables (e.g. chlorophyll a , inorganic nutrients) and the inorganic carbon system (e.g. dissolved inorganic carbon and total alkalinity). Overall, CoastDOM v1 includes observations of concentrations from all continents. However, most data were collected in the Northern Hemisphere, with a clear gap in DOM measurements from the Southern Hemisphere. The data included were collected from 1978 to 2022 and consist of 62 338 data points for DOC, 20 356 for DON, and 13 533 for DOP. The number of measurements decreases progressively in the sequence DOC > DON > DOP, reflecting both differences in the maturity of the analytical methods and the greater focus on carbon cycling by the aquatic science community. The global database shows that the average DOC concentration in coastal waters (average ± standard deviation (SD): 182±314 µmol C L −1 median: 103 µmol C L −1 ) is 13-fold higher than the average coastal DON concentration ( 13.6±30.4 µmol N L −1 median: 8.0 µmol N L −1 ), which is itself 39-fold higher than the average coastal DOP concentration ( 0.34±1.11 µmol P L −1 median: 0.18 µmol P L −1 ). This dataset will be useful for identifying global spatial and temporal patterns in DOM and will help facilitate the reuse of DOC, DON, and DOP data in studies aimed at better characterizing local biogeochemical processes; closing nutrient budgets; estimating carbon, nitrogen, and phosphorous ...
Subject code	333
Language	English
Publishing date	2024-02-27
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice

Henriette Frikke-Schmidt / Karin Hultman / Joseph W. Galaske / Sebastian B. Jørgensen / Martin G. Myers, Jr. / Randy J. Seeley

Molecular Metabolism, Vol 21, Iss , Pp 13-

2019 Volume 21

Abstract: Objective: Analogues of GDF15 (Growth Differentiation Factor 15) are promising new anti-obesity therapies as pharmacological treatment with GDF15 results in dramatic reductions of food intake and body weight. GDF15 exerts its central anorexic effects by ... ...

Abstract	Objective: Analogues of GDF15 (Growth Differentiation Factor 15) are promising new anti-obesity therapies as pharmacological treatment with GDF15 results in dramatic reductions of food intake and body weight. GDF15 exerts its central anorexic effects by binding to the GFRAL receptor exclusively expressed in the Area Postrema (AP) and the Nucleus of the Solitary Tract (NTS) of the hindbrain. We sought to determine if GDF15 is an indispensable factor for other interventions that cause weight loss and which are also known to act via these hindbrain regions. Methods: To explore the role of GDF15 on food choice we performed macronutrient intake studies in mice treated pharmacologically with GDF15 and in mice having either GDF15 or GFRAL deleted. Next we performed vertical sleeve gastrectomy (VSG) surgeries in a cohort of diet-induced obese Gdf15-null and control mice. To explore the anatomical co-localization of neurons in the hindbrain responding to GLP-1 and/or GDF15 we used GLP-1R reporter mice treated with GDF15, as well as naïve mouse brain and human brain stained by ISH and IHC, respectively, for GLP-1R and GFRAL. Lastly we performed a series of food intake experiments where we treated mice with targeted genetic disruption of either Gdf15 or Gfral with liraglutide; Glp1r-null mice with GDF15; or combined liraglutide and GDF15 treatment in wild-type mice. Results: We found that GDF15 treatment significantly lowered the preference for fat intake in mice, whereas no changes in fat intake were observed after genetic deletion of Gdf15 or Gfral. In addition, deletion of Gdf15 did not alter the food intake or bodyweight after sleeve gastrectomy. Lack of GDF15 or GFRAL signaling did not alter the ability of the GLP-1R agonist liraglutide to reduce food intake. Similarly lack of GLP-1R signaling did not reduce GDF15's anorexic effect. Interestingly, there was a significant synergistic effect on weight loss when treating wild-type mice with both GDF15 and liraglutide. Conclusion: These data suggest that while GDF15 does ...
Keywords	Internal medicine ; RC31-1245
Subject code	616
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The VA National TeleNeurology Program implementation: a mixed-methods evaluation guided by RE-AIM framework.

Damush, Teresa M / Wilkinson, Jayne R / Martin, Holly / Miech, Edward J / Tang, Qing / Taylor, Stanley / Daggy, Joanne K / Bastin, Grace / Islam, Robin / Myers, Laura J / Penney, Lauren S / Narechania, Aditi / Schreiber, Steve S / Williams, Linda S

Frontiers in health services

2023 Volume 3, Page(s) 1210197

Abstract: Introduction: The Veteran Affairs (VA) Office of Rural Health (ORH) funded the Veterans Health Administration (VHA) National TeleNeurology Program (NTNP) as an Enterprise-Wide Initiative (EWI). NTNP is an innovative healthcare delivery model designed to ...

Abstract	Introduction: The Veteran Affairs (VA) Office of Rural Health (ORH) funded the Veterans Health Administration (VHA) National TeleNeurology Program (NTNP) as an Enterprise-Wide Initiative (EWI). NTNP is an innovative healthcare delivery model designed to fill the patient access gap for outpatient neurological care especially for Veterans residing in rural communities. The specific aim was to apply the RE-AIM framework in a pragmatic evaluation of NTNP services. Materials and methods: We conducted a prospective implementation evaluation. Guided by the pragmatic application of the RE-AIM framework, we conceptualized a mixed-methods evaluation for key metrics: (1) reach into the Veteran patient population assessed as total NTNP new patient consult volume and total NTNP clinical encounters (new and return); (2) effectiveness through configurational analysis of conditions leading to high Veteran satisfaction and referring providers perceived effectiveness; (3) adoption and implementation by VA sites through site staff and NTNP interviews; (4) implementation success through perceived management, implementation barriers, facilitators, and adaptations and through rapid qualitative analysis of multiple stakeholders' assessments; and (5) maintenance of NTNP through monitoring quarterly TeleNeurology consultation volume. Results: NTNP was successfully implemented in 13 VA Medical Centers over 2 years. The total NTNP new patient consult volume in fiscal year 2021 (FY21) was 836 (58% rurally residing); this increased to 1,706 in fiscal year 2022 (FY22) (55% rurally residing). Total (new and follow-up) NTNP clinical encounters were 1,306 in FY21 and 3,730 in FY22. Overall, the sites reported positive experiences with program implementation and perceived that the program was serving Veterans with little access to neurological care. Veterans also reported high satisfaction with the NTNP program. We identified the patient level of perceived excellent teleneurologist-patient communications, reduced need to drive to get care, and that NTNP provided care that the Veteran otherwise could not access as key factors related to high Veteran satisfaction. Conclusions: The VA NTNP demonstrated substantial reach, adoption, effectiveness, implementation success, and maintenance over the first 2 years of the program. The NTNP was highly acceptable to both the clinical providers making the referrals and the Veterans receiving the referred video care. The pragmatic application of the RE-AIM framework to guide implementation evaluations is appropriate, comprehensive, and recommended for future applications.
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article
ISSN	2813-0146
ISSN (online)	2813-0146
DOI	10.3389/frhs.2023.1210197
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hypothalamic and Cell-Specific Transcriptomes Unravel a Dynamic Neuropil Remodeling in Leptin-Induced and Typical Pubertal Transition in Female Mice

Xingfa Han / Laura L. Burger / David Garcia-Galiano / Seokmin Sim / Susan J. Allen / David P. Olson / Martin G. Myers, Jr. / Carol F. Elias

iScience, Vol 23, Iss 10, Pp 101563- (2020)

2020

Abstract: Summary: Epidemiological and genome-wide association studies (GWAS) have shown high correlation between childhood obesity and advance in puberty. Early age at menarche is associated with a series of morbidities, including breast cancer, cardiovascular ... ...

Abstract	Summary: Epidemiological and genome-wide association studies (GWAS) have shown high correlation between childhood obesity and advance in puberty. Early age at menarche is associated with a series of morbidities, including breast cancer, cardiovascular diseases, type 2 diabetes, and obesity. The adipocyte hormone leptin signals the amount of fat stores to the neuroendocrine reproductive axis via direct actions in the brain. Using mouse genetics, we and others have identified the hypothalamic ventral premammillary nucleus (PMv) and the agouti-related protein (AgRP) neurons in the arcuate nucleus (Arc) as primary targets of leptin action in pubertal maturation. However, the molecular mechanisms underlying leptin's effects remain unknown. Here we assessed changes in the PMv and Arc transcriptional program during leptin-stimulated and typical pubertal development using overlapping analysis of bulk RNA sequecing, TRAP sequencing, and the published database. Our findings demonstrate that dynamic somatodendritic remodeling and extracellular space organization underlie leptin-induced and typical pubertal maturation in female mice.
Keywords	Neuroscience ; Computational Bioinformatics ; Transcriptomics ; Science ; Q
Subject code	630 ; 616
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of the leptin receptor sequences crucial for the STAT3-Independent control of metabolism

Tammy M. Barnes / Kimi Shah / Margaret B. Allison / Gabrielle K. Steinl / Desiree Gordian / Paul V. Sabatini / Abigail J. Tomlinson / Wenwen Cheng / Justin C. Jones / Qing Zhu / Chelsea Faber / Martin G. Myers, Jr.

Molecular Metabolism, Vol 32, Iss , Pp 168-

2020 Volume 175

Abstract: Background: Leptin acts via its receptor, LepRb, on specialized neurons in the brain to modulate energy balance and glucose homeostasis. LepRb→STAT3 signaling plays a crucial role in leptin action, but LepRb also mediates an additional as-yet- ... ...

Abstract	Background: Leptin acts via its receptor, LepRb, on specialized neurons in the brain to modulate energy balance and glucose homeostasis. LepRb→STAT3 signaling plays a crucial role in leptin action, but LepRb also mediates an additional as-yet-unidentified signal (Signal 2) that is important for leptin action. Signal 2 requires LepRb regions in addition to those required for JAK2 activation but operates independently of STAT3 and LepRb phosphorylation sites. Methods: To identify LepRb sequences that mediate Signal 2, we used CRISPR/Cas9 to generate five novel mouse lines containing COOH-terminal truncation mutants of LepRb. We analyzed the metabolic phenotype and measures of hypothalamic function for these mouse lines. Results: We found that deletion of LepRb sequences between residues 921 and 960 dramatically worsens metabolic control and alters hypothalamic function relative to smaller truncations. We also found that deletion of the regions including residues 1013–1053 and 960–1013 each decreased obesity compared to deletions that included additional COOH-terminal residues. Conclusions: LepRb sequences between residues 921 and 960 mediate the STAT3 and LepRb phosphorylation-independent second signal that contributes to the control of energy balance and metabolism by leptin/LepRb. In addition to confirming the inhibitory role of the region (residues 961–1013) containing Tyr985, we also identified the region containing residues 1013–1053 (which contains no Tyr residues) as a second potential mediator of LepRb inhibition. Thus, the intracellular domain of LepRb mediates multiple Tyr-independent signals. Keywords: Leptin receptor, STAT3, Truncation mutant, Obesity, Diabetes
Keywords	Internal medicine ; RC31-1245
Subject code	570
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: A global database of dissolved organic matter (DOM) measurements in coastal waters (CoastDOM v1)

Lønborg, Christian / Carreira, Cátia / Abril, Gwenaël / Agustí, Susana / Amaral, Valentina / Andersson, Agneta / Arístegui, Javier / Bhadury, Punyasloke / Bernardi Bif, Mariana / Borges, Alberto V. / Bouillon, Steven / Ll. Calleja, Maria / Cotovicz Jr., Luiz C. / Cozzi, Stefano / Doval, Maryló / Duarte, Carlos M. / Eyre, Bradley / Fichot, Cédric G. / García-Martín, E. Elena /

Garzon-Garcia, Alexandra / Giani, Michele / Gonçalves-Araujo, Rafael / Gruber, Renee / A. Hansell, Dennis / Hashihama, Fuminori / He, Ding / Holding, Johnna M. / Hunter, William R. / Ibánhez, J. Severino P. / Ibello, Valeria / Jiang, Shan / Kim, Guebuem / Klun, Katja / Kowalczuk, Piotr / Kubo, Atsushi / Weng Lee, Choon / Lopes, Cláudia B. / Maggioni, Federica / Magni, Paolo / Marrase, Celia / Martin, Patrick / McCallister, S. Leigh / McCallum, Roisin / Medeiros, Patricia M. / Morán, Xosé Anxelu G. / Muller-Karger, Frank / Myers-Pigg, Allison / Norli, Marit / Oakes, Joanne M. / Osterholz, Helena / Park, Hyekyung / Lund Paulsen, Maria / Rosentreter, Judith A. / Rueda-Roa, Digna / Santinelli, Chiara / Shen, Yuan / Teira, Eva / Tinta, Tinkara / Uher, Guenther / Wakita, Masahide / Ward, Nicholas / Watanabe, Kenta / Xin, Yu / Yamashita, Youhei / Yang, Liyang / Yeo, Jacob / Yuan, Huamao / Zheng, Qiang / Álvarez-Salgado, Xosé Antón

eISSN: 1866-3516

2023

Abstract: ... such as temperature and salinity and, to the extent possible, other biogeochemical variables (e.g., Chlorophyll ... a , inorganic nutrients) and the inorganic carbon system (e.g., dissolved inorganic carbon and total alkalinity ...

Abstract	The measurements of dissolved organic carbon (DOC), nitrogen (DON), and phosphorus (DOP) are used to characterize the dissolved organic matter (DOM) pool and are important components of biogeochemical cycling in the coastal ocean. Here, we present the first edition of a global database (CoastDOM v1; available at https://figshare.com/s/512289eb43c4f8e8eaef ) compiling previously published and unpublished measurements of DOC, DON, and DOP collected in coastal waters. These data are complemented by hydrographic data such as temperature and salinity and, to the extent possible, other biogeochemical variables (e.g., Chlorophyll- a , inorganic nutrients) and the inorganic carbon system (e.g., dissolved inorganic carbon and total alkalinity). Overall, CoastDOM v1 includes observations from all continents however, most data were collected in the Northern Hemisphere, with a clear gap in coastal water DOM measurements from the Southern Hemisphere. The data included were collected from 1978 to 2022 and consist of 62339 data points for DOC, 20360 for DON and 13440 for DOP. The number of measurements decreases progressively in the sequence DOC > DON > DOP, reflecting both differences in the maturity of the analytical methods and the greater focus on carbon cycling by the aquatic science community. The global database shows that the average DOC concentration in coastal waters (average (standard deviation; SD): 182 (314) µmol C L −1 median: 103 µmol C L −1 ), is 13-fold greater than the average coastal DON concentrations (average (SD): 13.6 (30.4) µmol N L −1 median: 8.0 µmol N L −1 ), which was itself 39-fold greater than the average coastal DOP concentrations (average (SD): 0.34 ± 1.11 µmol P L −1 median: 0.18 µmol P L −1 ). This dataset will be useful to identify global spatial and temporal patterns in DOM and to facilitate reuse of DOC, DON and DOP data in studies aimed at better characterising local biogeochemical processes, closing nutrient budgets, estimating carbon, nitrogen and phosphorous pools, as well ...
Subject code	333
Language	English
Publishing date	2023-09-27
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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