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  1. Book ; Online ; E-Book: Evidence-based practice of palliative medicine

    Goldstein, Nathan E. / Woodrell, Christopher D. / Morrison, R. Sean

    2023  

    Author's details Nathan E. Goldstein, Christopher D. Woodrell, R. Sean Morrison
    Keywords Palliative treatment ; Evidence-based medicine ; Terminal care
    Subject code 616.029
    Language English
    Size 1 Online-Ressource (1732 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030399090
    ISBN 978-0-323-84703-2 ; 9780323847025 ; 0-323-84703-X ; 0323847021
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Hepatic interoception in health and disease.

    Berthoud, Hans-Rudolf / Münzberg, Heike / Morrison, Christopher D / Neuhuber, Winfried L

    Autonomic neuroscience : basic & clinical

    2024  Volume 253, Page(s) 103174

    Abstract: The liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. ...

    Abstract The liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific sensory and motor components of both vagal and spinal access pathways to the hepatic parenchyma is missing. Lack of progress largely owes to controversies regarding selectivity of vagal access pathways and extent of hepatocyte innervation. In contrast, there is considerable evidence for glucose sensors in the wall of the hepatic portal vein and their importance for glucose handling by the liver and the brain and the systemic response to hypoglycemia. As liver diseases are on the rise globally, and there are intriguing associations between liver diseases and mental illnesses, it will be important to further dissect and identify both neural and humoral pathways that mediate hepatocyte-specific signals to relevant brain areas. The question of whether and how sensations from the liver contribute to interoceptive self-awareness has not yet been explored.
    Language English
    Publishing date 2024-03-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2020105-9
    ISSN 1872-7484 ; 1566-0702
    ISSN (online) 1872-7484
    ISSN 1566-0702
    DOI 10.1016/j.autneu.2024.103174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Protein Leverage Hypothesis: A 2019 Update for Obesity.

    Hill, Cristal M / Morrison, Christopher D

    Obesity (Silver Spring, Md.)

    2019  Volume 27, Issue 8, Page(s) 1221

    MeSH term(s) Dietary Proteins ; Epidemics ; Humans ; Obesity/epidemiology
    Chemical Substances Dietary Proteins
    Language English
    Publishing date 2019-07-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.22568
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    Zs.A 4061: Show issues Location:
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  4. Article ; Online: Moving beyond response times with accessible measures of manual dynamics.

    Smith, Katie Ann / Morrison, Samara / Henderson, Annette M E / Erb, Christopher D

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 19065

    Abstract: Button-press measures of response time (RT) and accuracy have long served a central role in psychological research. However, RT and accuracy provide limited insight into how cognitive processes unfold over time. To address this limitation, researchers ... ...

    Abstract Button-press measures of response time (RT) and accuracy have long served a central role in psychological research. However, RT and accuracy provide limited insight into how cognitive processes unfold over time. To address this limitation, researchers have used hand-tracking techniques to investigate how cognitive processes unfold over the course of a response, are modulated by recent experience, and function across the lifespan. Despite the efficacy of these techniques for investigating a wide range of psychological phenomena, widespread adoption of hand-tracking techniques within the field is hindered by a range of factors, including equipment costs and the use of specialized software. Here, we demonstrate that the behavioral dynamics previously observed with specialized motion-tracking equipment in an Eriksen flanker task can be captured with an affordable, portable, and easy-to-assemble response box. Six-to-eight-year-olds and adults (N = 90) completed a computerized version of the flanker task by pressing and holding a central button until a stimulus array appeared. Participants then responded by releasing the central button and reaching to press one of two response buttons. This method allowed RT to be separated into initiation time (when the central button was released) and movement time (time elapsed between initiation and completion of the response). Consistent with previous research using motion-tracking techniques, initiation times and movement times revealed distinct patterns of effects across trials and between age groups, indicating that the method used in the current study presents a simple solution for researchers from across the psychological and brain sciences looking to move beyond RTs.
    MeSH term(s) Adult ; Humans ; Reaction Time/physiology ; Movement/physiology ; Cognition/physiology ; Brain ; Motion
    Language English
    Publishing date 2022-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-20579-9
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  5. Article: The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model.

    Spann, Redin A / Morrison, Christopher D / den Hartigh, Laura J

    Frontiers in endocrinology

    2022  Volume 12, Page(s) 802541

    Abstract: Fibroblast growth factor 21 (FGF21) is a hormone that is involved in the regulation of lipid, glucose, and energy metabolism. Pharmacological FGF21 administration promotes weight loss and improves insulin sensitivity in rodents, non-human primates, and ... ...

    Abstract Fibroblast growth factor 21 (FGF21) is a hormone that is involved in the regulation of lipid, glucose, and energy metabolism. Pharmacological FGF21 administration promotes weight loss and improves insulin sensitivity in rodents, non-human primates, and humans. However, pharmacologic effects of FGF21 likely differ from its physiological effects. Endogenous FGF21 is produced by many cell types, including hepatocytes, white and brown adipocytes, skeletal and cardiac myocytes, and pancreatic beta cells, and acts on a diverse array of effector tissues such as the brain, white and brown adipose tissue, heart, and skeletal muscle. Different receptor expression patterns dictate FGF21 function in these target tissues, with the primary effect to coordinate responses to nutritional stress. Moreover, different nutritional stimuli tend to promote FGF21 expression from different tissues; i.e., fasting induces hepatic-derived FGF21, while feeding promotes white adipocyte-derived FGF21. Target tissue effects of FGF21 also depend on its capacity to enter the systemic circulation, which varies widely from known FGF21 tissue sources in response to various stimuli. Due to its association with obesity and non-alcoholic fatty liver disease, the metabolic effects of endogenously produced FGF21 during the pathogenesis of these conditions are not well known. In this review, we will highlight what is known about endogenous tissue-specific FGF21 expression and organ cross-talk that dictate its diverse physiological functions, with particular attention given to FGF21 responses to nutritional stress. The importance of the particular experimental design, cellular and animal models, and nutritional status in deciphering the diverse metabolic functions of endogenous FGF21 cannot be overstated.
    MeSH term(s) Adipocytes/metabolism ; Animals ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/metabolism ; Gene Editing ; Gene Expression ; Humans ; Liver/metabolism ; Metabolic Diseases/metabolism ; Metabolic Diseases/therapy ; Models, Animal ; Muscle, Skeletal/metabolism ; Pancreas/metabolism ; Stress, Physiological
    Chemical Substances fibroblast growth factor 21 ; Fibroblast Growth Factors (62031-54-3)
    Language English
    Publishing date 2022-01-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2021.802541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Caveats in reporting of national vaccine uptake.

    Millington, Tristan / Morrison, Kirsty / Jeffrey, Karen / Sullivan, Christopher / Kurdi, Amanj / Fagbamigbe, Adeniyi Francis / Swallow, Ben / Shi, Ting / Shah, Syed Ahmar / Kerr, Steven / Simpson, Colin R / Ritchie, Lewis D / Robertson, Chris / Sheikh, Aziz / Rudan, Igor

    Journal of global health

    2024  Volume 14, Page(s) 3006

    MeSH term(s) Humans ; Influenza Vaccines ; Influenza, Human/prevention & control
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2024-02-09
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2986
    ISSN (online) 2047-2986
    ISSN 2047-2986
    DOI 10.7189/jogh.14.03006
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  7. Article ; Online: Dietary branched chain amino acids and metabolic health: when less is more.

    Hill, Cristal M / Morrison, Christopher D

    The Journal of physiology

    2018  Volume 596, Issue 4, Page(s) 555–556

    MeSH term(s) Amino Acids, Branched-Chain ; Blood Glucose ; Insulin
    Chemical Substances Amino Acids, Branched-Chain ; Blood Glucose ; Insulin
    Language English
    Publishing date 2018-01-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP275613
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
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  8. Article ; Online: Maternal tadalafil treatment does not increase uterine artery blood flow or oxygen delivery in the pregnant ewe.

    Darby, Jack R T / Flouri, Dimitra / Cho, Steven K S / Williams, Georgia K / Holman, Stacey L / Meakin, Ashley S / Wiese, Michael D / David, Anna L / Macgowan, Christopher K / Seed, Mike / Melbourne, Andrew / Morrison, Janna L

    Experimental physiology

    2024  

    Abstract: Increasing placental perfusion (PP) could improve outcomes of growth-restricted fetuses. One way of increasing PP may be by using phosphodiesterase (PDE)-5 inhibitors, which induce vasodilatation of vascular beds. We used a combination of clinically ... ...

    Abstract Increasing placental perfusion (PP) could improve outcomes of growth-restricted fetuses. One way of increasing PP may be by using phosphodiesterase (PDE)-5 inhibitors, which induce vasodilatation of vascular beds. We used a combination of clinically relevant magnetic resonance imaging (MRI) techniques to characterize the impact that tadalafil infusion has on maternal, placental and fetal circulations. At 116-117 days' gestational age (dGA; term, 150 days), pregnant ewes (n = 6) underwent fetal catheterization surgery. At 120-123 dGA ewes were anaesthetized and MRI scans were performed during three acquisition windows: a basal state and then ∼15-75 min (TAD 1) and ∼75-135 min (TAD 2) post maternal administration (24 mg; intravenous bolus) of tadalafil. Phase contrast MRI and T
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP091593
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    Uc I Zs.102: Show issues Location:
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  9. Article ; Online: The obesity epidemic in the face of homeostatic body weight regulation: What went wrong and how can it be fixed?

    Berthoud, Hans-Rudolf / Morrison, Christopher D / Münzberg, Heike

    Physiology & behavior

    2020  Volume 222, Page(s) 112959

    Abstract: Ever since the pioneering discoveries in the mid nineteen hundreds, the hypothalamus was recognized as a crucial component of the neural system controlling appetite and energy balance. The new wave of neuron-specific research tools has confirmed this key ...

    Abstract Ever since the pioneering discoveries in the mid nineteen hundreds, the hypothalamus was recognized as a crucial component of the neural system controlling appetite and energy balance. The new wave of neuron-specific research tools has confirmed this key role of the hypothalamus and has delineated many other brain areas to be part of an expanded neural system sub serving these crucial functions. However, despite significant progress in defining this complex neural circuitry, many questions remain. One of the key questions is why the sophisticated body weight regulatory system is unable to prevent the rampant obesity epidemic we are experiencing. Why are pathologically obese body weight levels defended, and what can we do about it? Here we try to find answers to these questions by 1) reminding the reader that the neural controls of ingestive behavior have evolved in a demanding, restrictive environment and encompass much of the brain's major functions, far beyond the hypothalamus and brainstem, 2) hypothesizing that the current obesogenic environment impinges mainly on a critical pathway linking hypothalamic areas with the motivational and reward systems to produce uncompensated hyperphagia, and 3) proposing adequate strategies for prevention and treatment.
    MeSH term(s) Body Weight ; Eating ; Energy Metabolism ; Epidemics ; Homeostasis ; Humans ; Hypothalamus ; Obesity/epidemiology
    Language English
    Publishing date 2020-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3907-x
    ISSN 1873-507X ; 0031-9384
    ISSN (online) 1873-507X
    ISSN 0031-9384
    DOI 10.1016/j.physbeh.2020.112959
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  10. Article ; Online: MFP1/MSD-1 and MFP2/NSPH-2 co-localize with MSP during

    Morrison, Kayleigh N / Uyehara, Christopher M / Ragle, James Matthew / Ward, Jordan D / Shakes, Diane C

    microPublication biology

    2021  Volume 2021

    Abstract: Until recently, the only verified component of Fibrous Bodies (FBs) ... ...

    Abstract Until recently, the only verified component of Fibrous Bodies (FBs) within
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000427
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