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Article ; Online: Trends in workplace homicides in the U.S., 1994-2021: An end to years of decline.

Hendricks, Scott A / Hendricks, Kitty J / Tiesman, Hope M / Gomes, Harold L / Collins, James W / Hartley, Dan

2024

Abstract: Workplace and non-workplace homicides in the United States (U.S.) have declined for over 30 years ... Joinpoint and autoregressive models were used to assess trends of U.S. workplace and non-workplace homicides ... p < 0.0001). U.S. workplace and non-workplace homicide rates declined from the 1990s ...

Abstract	Workplace and non-workplace homicides in the United States (U.S.) have declined for over 30 years until recently. This study was conducted to address the change in trends for both workplace and non-workplace homicides and to evaluate the homogeneity of the change in workplace homicides by specified categories. Joinpoint and autoregressive models were used to assess trends of U.S. workplace and non-workplace homicides utilizing surveillance data collected by the Bureau of Labor Statistics and the Federal Bureau of Investigation from 1994 through 2021. Both workplace and non-workplace homicides decreased significantly from 1994 through 2014. Workplace homicides showed no significant trend from 2014 through 2021 (p = 0.79), while non-workplace homicides showed a significant average annual increase of 4.1% from 2014 through 2020 (p = 0.0013). The large decreases in the trend of workplace homicides occurring during a criminal act, such as robbery, leveled off and started to increase by the end of the study period (p < 0.0001). Declines in workplace homicides due to shootings also leveled off and started to increase by the end of the study period (p < 0.0001). U.S. workplace and non-workplace homicide rates declined from the 1990s until around 2014. Trends in workplace homicides varied by the types of the homicide committed and by the type of employee that was the victim. Criminal-intent-related events, such as robbery, appear to be the largest contributor to changes in workplace homicides. Researchers and industry leaders could develop and evaluate interventions that further address criminal-intent-related workplace homicides.
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	604538-8
ISSN	1097-0274 ; 0271-3586
ISSN (online)	1097-0274
ISSN	0271-3586
DOI	10.1002/ajim.23584
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Article ; Online: Implementation of a hotline ("S-T-I-C-K") to expedite management of occupational bloodborne pathogen exposures at an academic medical center: A Process Improvement Initiative.

Kenne, Lynnette / Hinman, Ashley / Holley, Stephanie / Healy, Sarah / Sebolt, Tamara / Edmond, Michael / Nelson, David L / Valley, Kenneth / Mueller, Rashmi N / Schuessler, Barbara / Hanna, Beth / Kobayashi, Takaaki / Hartley, Patrick

American journal of infection control

2024 Volume 52, Issue 5, Page(s) 618–620

Abstract: ... the "S-T-I-C-K" program where health care personnel were evaluated immediately after exposure by a nurse ...

Abstract	Previously, blood and body fluid exposures were managed by a visit to the University Employee Health Clinic during normal business hours and the Emergency Department after hours. We implemented the "S-T-I-C-K" program where health care personnel were evaluated immediately after exposure by a nurse-driven 24/7 hotline. Increasing accessibility to care and a simplified process for exposure management led to a significant decrease in Emergency Department utilization and time between the exposure and receipt of post-exposure prophylaxis.
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2024.01.002
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Zs.A 1773: Show issues

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Article ; Online: Research priorities for children’s cancer

Nigel J Hall / David Weller / Bob Phillips / Faith Gibson / Susie Aldiss / Rachel Dommett / Jessica Elizabeth Morgan / Alex Brownsdon / Helen Morris / Julia Chisholm / Sonia Malik / Jonathan Gower / Andy Stewart / Dan Saunders / Ashley Ball-Gamble / Helen Hartley / Rachel Hollis / Scott Crowther / Jenni Hatton /

Louise Henry / Loveday Langton / Kirsty Maddock / Keeley McEvoy / Simon Parke / Sue Picton / Rosa Reed-Berendt / Wendy Tarplee-Morris / Amy Walsh / Anna Watkins

BMJ Open, Vol 13, Iss

a James Lind Alliance Priority Setting Partnership in the UK

2023 Volume 12

Abstract: ... survey. Seventy-one children submitted questions in the children’s surveys, eight children attended ... We have identified research priorities for children’s cancer from the perspectives of children, survivors ...

Abstract	Objectives To engage children who have experienced cancer, childhood cancer survivors, their families and professionals to systematically identify and prioritise research questions about childhood cancer to inform the future research agenda.Design James Lind Alliance Priority Setting Partnership.Setting UK health service and community.Methods A steering group oversaw the initiative. Potential research questions were collected in an online survey, then checked to ensure they were unanswered. Shortlisting via a second online survey identified the highest priority questions. A parallel process with children was undertaken. A final consensus workshop was held to determine the Top 10 priorities.Participants Children and survivors of childhood cancer, diagnosed before age 16, their families, friends and professionals who work with this population.Results Four hundred and eighty-eight people submitted 1299 potential questions. These were refined into 108 unique questions; 4 were already answered and 3 were under active study, therefore, removed. Three hundred and twenty-seven respondents completed the shortlisting survey. Seventy-one children submitted questions in the children’s surveys, eight children attended a workshop to prioritise these questions. The Top 5 questions from children were taken to the final workshop where 23 questions in total were discussed by 25 participants (young adults, carers and professionals). The top priority was ‘can we find effective and kinder (less burdensome, more tolerable, with fewer short and long-term effects) treatments for children with cancer, including relapsed cancer?’Conclusions We have identified research priorities for children’s cancer from the perspectives of children, survivors, their families and the professionals who care for them. Questions reflect the breadth of the cancer experience, including diagnosis, relapse, hospital experience, support during/after treatment and the long-term impact of cancer. These should inform funding of future research as they are the ...
Keywords	Medicine ; R
Subject code	360
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Friedman’s plucking model: New international evidence from Maddison Project data

Hartley, Jonathan S

Economics letters. 2021 Feb., v. 199

2021

Abstract: Milton Friedman’s plucking model of business cycles hypothesizes that deeper recessions forecast ...

Abstract	Milton Friedman’s plucking model of business cycles hypothesizes that deeper recessions forecast larger booms while stronger booms do not necessarily forecast deeper recessions. While most previous past empirical work is limited to post-war data in the US, this paper tests the plucking model using Maddison Project growth data for 169 countries across several centuries. We find that the plucking property is broadly evident across time and countries. Plucking is particularly strong in advanced economies in East Asia (Japan), Europe (Western Europe) and North America (US and Canada) while to a lesser extent elsewhere in emerging economies. The overall strength of the plucking property globally also appears to have increased during the 20th century with the rise of widespread industrialized economies.
Keywords	Japan ; business cycles ; industrialization ; models ; paper ; testing ; Canada ; Europe ; Western European region
Language	English
Dates of publication	2021-02
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light
ISSN	0165-1765
DOI	10.1016/j.econlet.2021.109724
Database	NAL-Catalogue (AGRICOLA)

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Article: Gene Drives in the U.K., U.S., and Australian Press (2015-2019): How a New Focus on Responsibility Is Shaping Science Communication.

Stelmach, Aleksandra / Nerlich, Brigitte / Hartley, Sarah

Science communication

2022 Volume 44, Issue 2, Page(s) 143–168

Abstract: ... to explore how responsibility is reflected in the coverage of this technology in the U.S., U.K., and ...

Abstract	Gene drive is a controversial biotechnology for pest control. Despite a commitment from gene drive researchers to responsibility and the key role of the media in debates about science and technology, little research has been conducted on media reporting of gene drive. We employ metaphor and discourse analysis to explore how responsibility is reflected in the coverage of this technology in the U.S., U.K., and Australian press. The findings reveal a rhetorical strategy of trust-building by evoking the moral attributes of gene drive researchers. We discuss the implications of these findings for the communication of new technologies.
Language	English
Publishing date	2022-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2014915-3
ISSN	1552-8545 ; 1075-5470
ISSN (online)	1552-8545
ISSN	1075-5470
DOI	10.1177/10755470211072245
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bacterial catabolism of s-triazine herbicides: biochemistry, evolution and application.

Esquirol, Lygie / Peat, Thomas S / Sugrue, Elena / Balotra, Sahil / Rottet, Sarah / Warden, Andrew C / Wilding, Matthew / Hartley, Carol J / Jackson, Colin J / Newman, Janet / Scott, Colin

Advances in microbial physiology

2020 Volume 76, Page(s) 129–186

Abstract: The synthetic s-triazines are abundant, nitrogen-rich, heteroaromatic compounds used in a multitude ... of these anthropogenic chemicals as a nitrogen source that supports growth. Herbicidal s-triazines have been used ... catabolism of the herbicidal s-triazines has been studied extensively. Pseudomonas sp. strain ADP, which was ...

Abstract	The synthetic s-triazines are abundant, nitrogen-rich, heteroaromatic compounds used in a multitude of applications including, herbicides, plastics and polymers, and explosives. Their presence in the environment has led to the evolution of bacterial catabolic pathways in bacteria that allow use of these anthropogenic chemicals as a nitrogen source that supports growth. Herbicidal s-triazines have been used since the mid-twentieth century and are among the most heavily used herbicides in the world, despite being withdrawn from use in some areas due to concern about their safety and environmental impact. Bacterial catabolism of the herbicidal s-triazines has been studied extensively. Pseudomonas sp. strain ADP, which was isolated more than thirty years after the introduction of the s-triazine herbicides, has been the model system for most of these studies; however, several alternative catabolic pathways have also been identified. Over the last five years, considerable detail about the molecular mode of action of the s-triazine catabolic enzymes has been uncovered through acquisition of their atomic structures. These structural studies have also revealed insights into the evolutionary origins of this newly acquired metabolic capability. In addition, s-triazine-catabolizing bacteria and enzymes have been used in a range of applications, including bioremediation of herbicides and cyanuric acid, introducing metabolic resistance to plants, and as a novel selectable marker in fermentation organisms. In this review, we cover the discovery and characterization of bacterial strains, metabolic pathways and enzymes that catabolize the s-triazines. We also consider the evolution of these new enzymes and pathways and discuss the practical applications that have been considered for these bacteria and enzymes. One Sentence Summary: A detailed understanding of bacterial herbicide catabolic enzymes and pathways offer new evolutionary insights and novel applied tools.
MeSH term(s)	Bacteria/enzymology ; Bacteria/genetics ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biodegradation, Environmental ; Evolution, Molecular ; Gene Expression Regulation, Bacterial ; Herbicides/chemistry ; Herbicides/metabolism ; Metabolic Networks and Pathways ; Models, Biological ; Protein Conformation ; Pseudomonas/enzymology ; Pseudomonas/genetics ; Pseudomonas/metabolism ; Triazines/chemistry ; Triazines/metabolism
Chemical Substances	Bacterial Proteins ; Herbicides ; Triazines
Language	English
Publishing date	2020-02-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	174-0
ISSN	2162-5468 ; 0065-2911
ISSN (online)	2162-5468
ISSN	0065-2911
DOI	10.1016/bs.ampbs.2020.01.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 366: Show issues

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Article ; Online: Corrigendum to "Spatial distribution of toxic metal(loid)s at an abandoned zinc smelting site, Southern China."

Zeng, Jiaqing / Luo, Xinghua / Cheng, Yizhi / Ke, Wenshun / Hartley, William / Li, Chuxuan / Jiang, Jun / Zhu, Feng / Xue, Shengguo

Journal of hazardous materials

2021 Volume 427, Page(s) 128110

Language	English
Publishing date	2021-12-30
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.128110
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Article ; Online: Spatial distribution of toxic metal(loid)s at an abandoned zinc smelting site, Southern China.

Zeng, Jiaqing / Luo, Xinghua / Cheng, Yizhi / Ke, Wenshun / Hartley, William / Li, Chuxuan / Jiang, Jun / Zhu, Feng / Xue, Shengguo

Journal of hazardous materials

2021 Volume 425, Page(s) 127970

Abstract: Toxic metal(loid) (TM) soil pollution at large-scale non-ferrous metal smelting contaminated sites is of great concern in China, but there are no detailed reports relating to them. A comprehensive study was conducted to determine contamination ... ...

Abstract	Toxic metal(loid) (TM) soil pollution at large-scale non-ferrous metal smelting contaminated sites is of great concern in China, but there are no detailed reports relating to them. A comprehensive study was conducted to determine contamination characteristics and horizontal and vertical spatial distribution patterns of soils at an abandoned zinc smelting site in Southern China. The spatial distribution of TMs revealed that soil environmental quality was seriously threatened, with Cd, Zn, As, Pb and Hg being the main contaminants present. The distribution of all TMs showed strong spatial heterogeneity and were expressed as a "patchy aggregation" pattern due to strong anthropogenic and production activities. Vertical migration of TMs indicated that the pollutants were mainly concentrated in the fill layers. Different contaminants had various migration depths, with migration occurring as: Cd > Hg > As > Zn > Pb> Cu> Mn> Sb. Analysis of their spatial variability showed that As, Pb, Cd and Hg had strong regional spatial variability. This research provides a new approach to comprehensively analyze TM pollution characteristics of non-ferrous smelting sites. It provides valuable information for guiding post-remediation strategies at abandoned non-ferrous metal smelting sites.
MeSH term(s)	China ; Environmental Monitoring ; Metalloids ; Metals, Heavy/analysis ; Risk Assessment ; Soil ; Soil Pollutants/analysis ; Zinc/analysis
Chemical Substances	Metalloids ; Metals, Heavy ; Soil ; Soil Pollutants ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2021-12-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.127970
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Article ; Online: Antibody-drug conjugate therapies in multiple myeloma—what’s next on the horizon?

Monique Hartley-Brown / Paul Richardson

Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 1, Pp 1-

2022 Volume 10

Abstract: Targeted immunotherapy has arisen over the past decade to the forefront of cancer care. Notably, targeted therapies such as antibody-drug conjugates (ADCs) are becoming more recognized for a novel approach in cancer treatment. The mechanism of action of ... ...

Abstract	Targeted immunotherapy has arisen over the past decade to the forefront of cancer care. Notably, targeted therapies such as antibody-drug conjugates (ADCs) are becoming more recognized for a novel approach in cancer treatment. The mechanism of action of ADCs incorporates a monoclonal antibody portion directed against the tumor cell antigen and attached to the tumoricidal portion via chemical linkage. The binding of the monoclonal antibody portion allows for tumor cell internalization of the ADC and precise release of the toxic payload within the cancer cell. Multiple myeloma (MM) is an incurable cancer for which belantamab mafodotin was the first-in-class ADC to achieve United States Food and Drug Administration (FDA) approval for treatment of this disease. Clinical trials are currently evaluating other ADCs in the treatment of MM. In this review, a look at the current ADCs being tested in MM clinical trials with a focus on those that are more promising and a potential next-in-line for FDA approval for treatment of MM is discussed.
Keywords	antibody-drug conjugates ; multiple myeloma ; cancer ; immunotherapy ; targeted therapy ; Internal medicine ; RC31-1245
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Open Exploration Publishing Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cryo-EM structure of a monomeric yeast S. cerevisiae complex IV isolated with maltosides: Implications in supercomplex formation.

Ing, Gabriel / Hartley, Andrew M / Pinotsis, Nikos / Maréchal, Amandine

Biochimica et biophysica acta. Bioenergetics

2022 Volume 1863, Issue 7, Page(s) 148591

Abstract: ... with other respiratory complexes. The atomic structure of the yeast S. cerevisiae CIV in a supercomplex (SC) with complex ... the structure of the isolated monomeric CIV from S. cerevisiae stabilised in amphipol A8-35 at 3.9 Å using ...

Abstract	In mitochondria, complex IV (CIV) can be found as a monomer, a dimer or in association with other respiratory complexes. The atomic structure of the yeast S. cerevisiae CIV in a supercomplex (SC) with complex III (CIII) pointed to a region of significant conformational changes compared to the homologous mammalian CIV structures. These changes involved the matrix side domain of Cox5A at the CIII-CIV interface, and it was suggested that it could be required for SC formation. To investigate this, we solved the structure of the isolated monomeric CIV from S. cerevisiae stabilised in amphipol A8-35 at 3.9 Å using cryo-electron microscopy. Only a minor change in flexibility was seen in this Cox5A region, ruling out large CIV conformational shift for interaction with CIII and confirming the different fold of the yeast Cox5A subunit compared to mammalian homologues. Other differences in structure were the absence of two canonical subunits, Cox12 and Cox13, as well as Cox26, which is unique to the yeast CIV. Their absence is most likely due to the protein purification protocol used to isolate CIV from the III-IV SC.
MeSH term(s)	Animals ; Cryoelectron Microscopy/methods ; Electron Transport Complex IV/metabolism ; Mammals/metabolism ; Mitochondrial Membranes/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism
Chemical Substances	Cox26 protein, S cerevisiae ; Saccharomyces cerevisiae Proteins ; Electron Transport Complex IV (EC 1.9.3.1)
Language	English
Publishing date	2022-07-14
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-2650 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2650 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbabio.2022.148591
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