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  1. Article ; Online: Quantitative Tumor Location Methods.

    Sanz-Santos, José / Martínez-Palau, Mireia / Rami-Porta, Ramón / Barreiro, Bienvenido

    Chest

    2024  Volume 161, Issue 5, Page(s) e328–e329

    MeSH term(s) Humans ; Neoplasms/therapy ; Retrospective Studies
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.12.666
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  2. Article ; Online: Systematic or targeted sampling during endobronchial ultrasound for mediastinal staging in patients with lung cancer and abnormal mediastinum.

    Sanz-Santos, José / Serra, Pere / Rosell, Antoni

    JTCVS open

    2022  Volume 11, Page(s) 346–347

    Language English
    Publishing date 2022-04-11
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-2736
    ISSN (online) 2666-2736
    DOI 10.1016/j.xjon.2022.01.030
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  3. Article ; Online: Preoperative staging of the mediastinum is an essential and multidisciplinary task.

    Sanz-Santos, José / Call, Sergi

    Respirology (Carlton, Vic.)

    2020  Volume 25 Suppl 2, Page(s) 37–48

    Abstract: Mediastinal staging is a crucial step in the management of patients with NSCLC. With the recent development of novel techniques, mediastinal staging has evolved from an activity of interest mainly for thoracic surgeons to a joint effort carried out by ... ...

    Abstract Mediastinal staging is a crucial step in the management of patients with NSCLC. With the recent development of novel techniques, mediastinal staging has evolved from an activity of interest mainly for thoracic surgeons to a joint effort carried out by many specialists. In this regard, the debate of cases in MDT sessions is crucial for optimal management of patients. Current evidence-based clinical guidelines for preoperative NSCLC staging recommend that mediastinal staging should be performed with increasing invasiveness. Image-based techniques are the first approach, although they have limited accuracy and findings must be confirmed by pathology in almost all cases. In this setting, the advent of radiomics is promising. Invasive staging depends on procedural factors rather than diagnostic performance. The choice between endoscopy-based or surgical procedures should depend on the local expertise of each centre. As the extension of mediastinal disease in terms of number of involved lymph nodes and nodal stations affects prognosis and the choice of treatment, systematic samplings are preferred over random targeted samplings. Following this approach, a diagnosis of single mediastinal nodal involvement can be unreliable if all reachable mediastinal nodal stations have not been assessed. The performance of confirmatory mediastinoscopy after a negative endoscopy-based procedure is controversial but currently recommended. Current indications of invasive staging in patients with radiologically normal mediastinum have to be re-evaluated, especially for central tumour location.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/secondary ; Carcinoma, Non-Small-Cell Lung/surgery ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Mediastinoscopy ; Mediastinum ; Neoplasm Staging ; Patient Care Team ; Preoperative Period ; Prognosis
    Language English
    Publishing date 2020-07-12
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13901
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    Zs.A 4957: Show issues Location:
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  4. Article ; Online: Inner margin ratio for the prediction of occult nodal metastases.

    Martínez-Palau, Mireia / Sanz-Santos, José / Barreiro, Bienvenido / Rami-Porta, Ramón

    The Journal of thoracic and cardiovascular surgery

    2023  Volume 167, Issue 4, Page(s) e101–e102

    MeSH term(s) Humans ; Carcinoma, Squamous Cell/pathology ; Lymphatic Metastasis ; Neoplasm Staging ; Retrospective Studies
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Letter
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2023.09.037
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  5. Article ; Online: Quantitative geometrical measurement of tumour location.

    Sanz-Santos, José / Martínez-Palau, Mireia / Jaen, Àngels / Rami-Porta, Ramón

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2023  Volume 63, Issue 3

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/surgery ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology
    Language English
    Publishing date 2023-01-31
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezad082
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  6. Article ; Online: Impact of COVID-19 infection on cognition and its association with neurological symptoms.

    Almeria, Marta / Cejudo, Juan Carlos / Sanz-Santos, Jose / Deus, Joan / Krupinski, Jerzy

    Brain and behavior

    2023  Volume 13, Issue 4, Page(s) e2902

    Abstract: Objective: To characterize the cognitive profile following COVID-19 infection and its possible association to clinical symptoms, emotional disturbance, biomarkers, and disease severity.: Methods: This was a single-center cross-sectional cohort study. ...

    Abstract Objective: To characterize the cognitive profile following COVID-19 infection and its possible association to clinical symptoms, emotional disturbance, biomarkers, and disease severity.
    Methods: This was a single-center cross-sectional cohort study. Subjects between 20- and 60-year old with confirmed COVID-19 infection were included. Evaluation was performed between April 2020 and July 2021. Patients with previous cognitive impairment and other neurological or severe psychiatric disorders were excluded. Demographic and laboratory data were extracted from the medical records.
    Results: Altogether 200 patients were included, 85 subjects were female (42.3%), and mean age was 49.12 years (SD: 7.84). Patients were classified into four groups: nonhospitalized (NH, n = 21), hospitalized without intensive care unit (ICU) nor oxygen therapy (HOSP, n = 42), hospitalized without ICU but with oxygen therapy (OXY, n = 107), and ICU (ICU, n = 31) patients. NH group was younger (p = .026). No significant differences were found in any test performed attending severity of illness (p > .05). A total of 55 patients reported subjective cognitive complaints (SCC). Subjects with neurological symptoms (NS) performed worse in trail making test B (p = .013), digits backwards (p = .006), letter&numbers (p = .002), symbol digit modalities test (p = .016), and Stroop color (p = .010) tests.
    Conclusions: OXY patients and females referred more SCC associated with symptoms of anxiety and depression. Objective cognitive performance was unrelated to SCC. No cognitive impairment was found regarding the severity of COVID-19 infection. Results suggest that NS such as headache, anosmia, and dysgeusia during infection were a risk factor for later cognitive deficits. Tests assessing attention, processing speed, and executive function were the most sensitive in detecting cognitive changes in these patients.
    MeSH term(s) Humans ; Female ; Middle Aged ; Young Adult ; Adult ; Male ; Cross-Sectional Studies ; COVID-19/complications ; Cognition ; Cognition Disorders/etiology ; Neuropsychological Tests ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2623587-0
    ISSN 2162-3279 ; 2162-3279
    ISSN (online) 2162-3279
    ISSN 2162-3279
    DOI 10.1002/brb3.2902
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  7. Article ; Online: [Pulmonary

    Barreiro López, Bienvenido / Martinez Palau, Mireia / Luizaga, Luis / Sanz-Santos, Jose

    Open respiratory archives

    2022  Volume 4, Issue 2, Page(s) 100159

    Title translation Infección pulmonar por
    Language Spanish
    Publishing date 2022-01-19
    Publishing country Spain
    Document type Case Reports
    ISSN 2659-6636
    ISSN (online) 2659-6636
    DOI 10.1016/j.opresp.2022.100159
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  8. Article ; Online: Lessons Already Learnt From the Coronavirus Disease 2019 Pandemic.

    Sanz-Santos, José / Rami-Porta, Ramón / Call, Sergi

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2020  Volume 15, Issue 7, Page(s) e107–e108

    MeSH term(s) COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Coronavirus Infections/transmission ; Hospitalization/statistics & numerical data ; Humans ; Lung Neoplasms/surgery ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/transmission ; Spain/epidemiology ; Thoracic Surgical Procedures/statistics & numerical data
    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Letter
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2020.04.012
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    Zs.A 6664: Show issues Location:
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  9. Article ; Online: N3 Hilar Nodes Approach When Performing Systematic EBUS-TBNA for Mediastinal Staging in Patients With Negative PET/CT Scans.

    Serra, Pere / Sanz-Santos, Jose / Rosell, Antoni / Andreo, Felipe

    Chest

    2021  Volume 160, Issue 3, Page(s) e328

    MeSH term(s) Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Humans ; Mediastinum/diagnostic imaging ; Positron Emission Tomography Computed Tomography
    Language English
    Publishing date 2021-09-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.05.045
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  10. Article ; Online: Video-assisted mediastinoscopic lymphadenectomy (VAMLA): Mature results for staging non-small cell lung cancer with normal mediastinum.

    Call, Sergi / Reig-Oussedik, Nina / Obiols, Carme / Sanz-Santos, José / Ochoa-Alba, Juan Manuel / Cabanillas, Lucía Reyes / Serra-Mitjans, Mireia / Rami-Porta, Ramón

    The Journal of thoracic and cardiovascular surgery

    2024  

    Abstract: Objectives: The aim of this study is to analyze the accuracy of video-assisted mediastinoscopic lymphadenectomy (VAMLA) and the unsuspected (u) N2/3 rates in patients with non-small cell lung cancer (NSCLC) and normal mediastinum by integrated positron ... ...

    Abstract Objectives: The aim of this study is to analyze the accuracy of video-assisted mediastinoscopic lymphadenectomy (VAMLA) and the unsuspected (u) N2/3 rates in patients with non-small cell lung cancer (NSCLC) and normal mediastinum by integrated positron emission tomography-computed tomography.
    Methods: Prospective observational single-center study of 603 consecutive VAMLAs from 2010 to 2022.
    Exclusion criteria: other indications (n = 32), tumors different from NSCLC (n = 91), and clinical (c) N2/3 tumors by positron emission tomography-computed tomography (n = 46). Systematic nodal dissection was the gold standard to validate negative VAMLAs. Those patients with negative VAMLA and missing reference standard test were excluded. uN2/3 rates were analyzed in the global series and in the subgroups of tumors according to their clinical nodal and tumor categories. Pathologic findings were reviewed, and staging values were calculated.
    Results: Three hundred eighty-three patients with cN0/1 NSCLC underwent VAMLA. Staging values of VAMLA were: sensitivity, 0.98 (95% CI, 0.92-0.99); negative predictive value, 0.99 (95% CI, 0.98-1); and diagnostic accuracy, 0.99 (95% CI, 0.98-1). The uN2/3 rate for the whole series (N = 383) was 18.8%. The uN2/3 rates according to presurgical nodal and tumor categories determined by positron emission tomography computed tomography were: 3.6% (4 out of 111) in cT1N0; 16.3% (18 out of 110) in cT2N0; 10.25% (4 out of 39) in cT3N0; and 32% (7 out of 22) in cT4N0. Forty-two percent (39 out of 93) in cN1; complication rate was 7%.
    Conclusions: This series of NSCLC with normal mediastinum staged by VAMLA demonstrates a high accuracy of this technique and a high rate of uN2/3 disease (specially in cN1 and cT4N0). VAMLA could be considered the reference staging procedure for staging cN0/1 NSCLC.
    Language English
    Publishing date 2024-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2024.01.040
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