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  1. Book ; Online: Make Life Visible

    Toyama, Yoshiaki / Miyawaki, Atsushi / Nakamura, Masaya / Jinzaki, Masahiro

    2020  

    Keywords Immunology ; Neurosciences ; Cellular biology (cytology) ; Medicine ; Cell biology
    Size 1 electronic resource (292 pages)
    Publisher Springer Nature
    Publishing place Singapore
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021030068
    ISBN 978-981-13-7908-6 ; 981-13-7908-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Make Life Visible

    Toyama, Yoshiaki / Miyawaki, Atsushi / Nakamura, Masaya / Jinzaki, Masahiro

    2020  

    Author's details edited by Yoshiaki Toyama, Atsushi Miyawaki, Masaya Nakamura, Masahiro Jinzaki
    Keywords Neurosciences ; Immunology ; Cell biology ; Molekül ; Molekülstruktur ; Visualisierung ; Computergrafik
    Subject Computergraphik ; Digitalgraphik ; Digitalgrafik ; Graphische Datenverarbeitung ; Sichtbarmachung ; Datenvisualisierung ; Visuelle Darstellung ; Molekülbau ; Molekularstruktur ; Molekülgeometrie ; Molekulare Geometrie ; Moleküle
    Subject code 612.8
    Language English
    Size 1 Online-Ressource (IX, 292 p. 137 illus., 106 illus. in color)
    Edition 1st ed. 2020
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online
    HBZ-ID HT020260941
    ISBN 978-981-13-7908-6 ; 9789811379079 ; 9789811379093 ; 9789811379109 ; 981-13-7908-4 ; 9811379076 ; 9811379092 ; 9811379106
    DOI 10.1007/978-981-13-7908-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Full-time Work Rates of Physicians With Physician Spouses vs Nonphysician Spouses in Japan.

    Miyawaki, Atsushi

    JAMA network open

    2022  Volume 5, Issue 11, Page(s) e2242143

    MeSH term(s) Humans ; Spouses ; Japan ; Physicians ; Employment
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.42143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Real-world effectiveness and safety of nemolizumab for the treatment of atopic dermatitis in Japanese patients: a single-centre retrospective study.

    Miyawaki, Kayo / Nakashima, Chisa / Otsuka, Atsushi

    European journal of dermatology : EJD

    2024  Volume 33, Issue 6, Page(s) 691–692

    MeSH term(s) Humans ; Dermatitis, Atopic/drug therapy ; Retrospective Studies ; Japan ; Antibodies, Monoclonal, Humanized/adverse effects ; Pruritus ; Treatment Outcome ; Severity of Illness Index
    Chemical Substances nemolizumab (GN465U8B72) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-03-11
    Publishing country France
    Document type Journal Article
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2023.4551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Casting Light on Life.

    Miyawaki, Atsushi

    The Keio journal of medicine

    2020  Volume 69, Issue 4, Page(s) 105

    Abstract: The behavior of biochemical molecules moving around in cells makes me think of a school of whales wandering in the ocean, captured by the Argus system on the artificial satellite. When bringing a whale back into the sea --- with a transmitter on its ... ...

    Abstract The behavior of biochemical molecules moving around in cells makes me think of a school of whales wandering in the ocean, captured by the Argus system on the artificial satellite. When bringing a whale back into the sea --- with a transmitter on its dorsal fin, every staff member hopes that it will return safely to a school of its species. A transmitter is now minute in size, but it was not this way before. There used to be some concern that a whale fitted with a transmitter could be given the cold shoulder and thus ostracized by other whales for "wearing something annoying." How is whale's wandering related to the tide or a shoal of small fish? What kind of interaction is there among different species of whales? We human beings have attempted to fully understand this fellow creature in the sea both during and since the age of whale fishing.In a live cell imaging experiment, a luminescent probe replaces a transmitter. We put a luminescent probe on a specific region of a biological molecule and bring it back into a cell. We can then visualize how the molecule behaves in response to external stimulation. Since luminescence is a physical phenomenon, we can extract various kinds of information by making full use of its characteristics.Cruising inside cells in a supermicro corps, gliding down in a microtubule like a roller coaster, pushing our ways through a jungle of chromatin while hoisting a flag of nuclear localization signal --- we are reminded to retain a playful and adventurous perspective at all times. What matters is mobilizing all capabilities of science and giving full play to our imagination. We believe that such serendipitous findings can arise out of such a sportive mind, a frame of mind that prevails when enjoying whale-watching.
    MeSH term(s) Animals ; Behavior, Animal ; Biology/methods ; Cell Movement ; Humans ; Luminescence ; Luminescent Agents ; Microtubules/physiology ; Movement ; Whales
    Chemical Substances Luminescent Agents
    Language English
    Publishing date 2020-12-30
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390981-5
    ISSN 1880-1293 ; 0022-9717
    ISSN (online) 1880-1293
    ISSN 0022-9717
    DOI 10.2302/kjm.69-001-ABST
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Sulconazole induces pyroptosis promoted by interferon-γ in monocyte/macrophage lineage cells.

    Miyawaki, Shiori / Sawamoto, Atsushi / Okuyama, Satoshi / Nakajima, Mitsunari

    Journal of pharmacological sciences

    2024  Volume 154, Issue 3, Page(s) 166–174

    Abstract: Imidazole derivatives are commonly used as antifungal agents. Here, we aimed to investigate the functions of imidazole derivatives on macrophage lineage cells. We assessed the expression levels of inflammatory cytokines in mouse monocyte/macrophage ... ...

    Abstract Imidazole derivatives are commonly used as antifungal agents. Here, we aimed to investigate the functions of imidazole derivatives on macrophage lineage cells. We assessed the expression levels of inflammatory cytokines in mouse monocyte/macrophage lineage (RAW264.7) cells. All six imidazole derivatives examined, namely ketoconazole, sulconazole, isoconazole, luliconazole, clotrimazole, and bifonazole, reduced the expression levels of inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α, after induction by lipopolysaccharide (LPS) in RAW264.7 cells. These imidazole derivatives also induced cell death in RAW264.7 cells, regardless of the presence or absence of LPS. Since the cell death was characteristic in morphology, we investigated the mode of the cell death. An imidazole derivative, sulconazole, induced gasdermin D degradation together with caspase-11 activation, namely, pyroptosis in RAW264.7 cells and peritoneal macrophages. Furthermore, priming with interferon-γ promoted sulconazole-induced pyroptosis in RAW264.7 cells and macrophages and reduced the secretion of the inflammatory cytokine, IL-1β, from sulconazole-treated macrophages. Our results suggest that imidazole derivatives suppress inflammation by inducing macrophage pyroptosis, highlighting their modulatory potential for inflammatory diseases.
    MeSH term(s) Mice ; Animals ; Pyroptosis ; Interferon-gamma/metabolism ; Monocytes/metabolism ; Lipopolysaccharides/pharmacology ; Macrophages/metabolism ; Imidazoles/pharmacology ; Imidazoles/metabolism ; Cytokines/metabolism
    Chemical Substances Interferon-gamma (82115-62-6) ; sulconazole (5D9HAA5Q5S) ; Lipopolysaccharides ; Imidazoles ; Cytokines
    Language English
    Publishing date 2024-01-24
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2104264-0
    ISSN 1347-8648 ; 1347-8613
    ISSN (online) 1347-8648
    ISSN 1347-8613
    DOI 10.1016/j.jphs.2024.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 237: Show issues Location:
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  7. Article ; Online: Physician characteristics associated with antiviral prescriptions for older adults with COVID-19 in Japan: an observational study.

    Miyawaki, Atsushi / Kitajima, Kei / Iwata, Akihiro / Sato, Daichi / Tsugawa, Yusuke

    BMJ open

    2024  Volume 14, Issue 3, Page(s) e083342

    Abstract: Objectives: Although guidelines recommend antiviral therapy for outpatients with COVID-19 who are at high risk of progressing to severe conditions, such as older adults, many patients do not receive appropriate treatment. Little is known, however, about ...

    Abstract Objectives: Although guidelines recommend antiviral therapy for outpatients with COVID-19 who are at high risk of progressing to severe conditions, such as older adults, many patients do not receive appropriate treatment. Little is known, however, about the physician factors associated with the prescription of guideline-recommended antiviral therapy for patients with COVID-19.
    Design: A cross-sectional study.
    Setting: Data including outpatient visits in primary care clinics in Japan from April to August 2023.
    Participants: We analysed 30 953 outpatients aged ≥65 years treated with COVID-19 (mean (SD) age, 75.0 (7.6) years; 17 652 women (57.0%)) in 1394 primary care clinics.
    Outcome measures: The primary outcome was the prescription of guideline-recommended antivirals (ie, nirmatrelvir-ritonavir or molnupiravir), adjusted for patient characteristics, months of visits and regions.
    Results: Antiviral prescriptions were concentrated among a small proportion of physicians; for example, the top 10% of physicians that had the largest number of nirmatrelvir-ritonavir prescriptions accounted for 92.4% of all nirmatrelvir-ritonavir prescriptions. After adjusting for potential confounders, physicians with higher patient volumes were more likely to prescribe guideline-recommended antivirals to their patients (adjusted OR (aOR) for high vs low volume, 1.76; 95% CI 1.31 to 2.38; adjusted p<0.001). We found no evidence that the likelihood of guideline-recommended antiviral prescription differed based on physicians' gender (aOR for women vs men, 1.24; 95% CI 0.88 to 1.74; adjusted p=0.48) or age (aOR for 45-59 vs <45 years, 1.16; 95% CI 0.87 to 1.54; adjusted p=0.48; aOR for ≥60 vs <45 years, 0.88; 95% CI 0.66 to 1.16; adjusted p=0.48). These patterns were similar when examining nirmatrelvir-ritonavir and molnupiravir separately.
    Conclusions: Our findings suggest that provider-level factors, such as the clinical experience of treating the patients with COVID-19, play an important role in the appropriate prescription of antiviral medications for COVID-19 in the primary care setting.
    MeSH term(s) Male ; Humans ; Female ; Aged ; COVID-19 ; Japan/epidemiology ; Cross-Sectional Studies ; Ritonavir/therapeutic use ; Antiviral Agents/therapeutic use ; Hydroxylamines ; Cytidine/analogs & derivatives ; Nitriles ; Lactams ; Proline ; Leucine
    Chemical Substances molnupiravir (YA84KI1VEW) ; nirmatrelvir (7R9A5P7H32) ; Ritonavir (O3J8G9O825) ; Antiviral Agents ; Hydroxylamines ; Cytidine (5CSZ8459RP) ; Nitriles ; Lactams ; Proline (9DLQ4CIU6V) ; Leucine (GMW67QNF9C)
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-083342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comparison of Hospital Mortality and Readmission Rates by Physician and Patient Sex.

    Miyawaki, Atsushi / Jena, Anupam B / Rotenstein, Lisa S / Tsugawa, Yusuke

    Annals of internal medicine

    2024  

    Abstract: Background: Little is known as to whether the effects of physician sex on patients' clinical outcomes vary by patient sex.: Objective: To examine whether the association between physician sex and hospital outcomes varied between female and male ... ...

    Abstract Background: Little is known as to whether the effects of physician sex on patients' clinical outcomes vary by patient sex.
    Objective: To examine whether the association between physician sex and hospital outcomes varied between female and male patients hospitalized with medical conditions.
    Design: Retrospective observational study.
    Setting: Medicare claims data.
    Patients: 20% random sample of Medicare fee-for-service beneficiaries hospitalized with medical conditions during 2016 to 2019 and treated by hospitalists.
    Measurements: The primary outcomes were patients' 30-day mortality and readmission rates, adjusted for patient and physician characteristics and hospital-level averages of exposures (effectively comparing physicians within the same hospital).
    Results: Of 458 108 female and 318 819 male patients, 142 465 (31.1%) and 97 500 (30.6%) were treated by female physicians, respectively. Both female and male patients had a lower patient mortality when treated by female physicians; however, the benefit of receiving care from female physicians was larger for female patients than for male patients (difference-in-differences, -0.16 percentage points [pp] [95% CI, -0.42 to 0.10 pp]). For female patients, the difference between female and male physicians was large and clinically meaningful (adjusted mortality rates, 8.15% vs. 8.38%; average marginal effect [AME], -0.24 pp [CI, -0.41 to -0.07 pp]). For male patients, an important difference between female and male physicians could be ruled out (10.15% vs. 10.23%; AME, -0.08 pp [CI, -0.29 to 0.14 pp]). The pattern was similar for patients' readmission rates.
    Limitation: The findings may not be generalizable to younger populations.
    Conclusion: The findings indicate that patients have lower mortality and readmission rates when treated by female physicians, and the benefit of receiving treatments from female physicians is larger for female patients than for male patients.
    Primary funding source: Gregory Annenberg Weingarten, GRoW @ Annenberg.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M23-3163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Why do homeless women in New York state experience fewer hospital revisits after childbirth than housed women?

    Miyawaki, Atsushi / Tsugawa, Yusuke

    BMJ quality & safety

    2021  Volume 31, Issue 4, Page(s) 243–246

    MeSH term(s) Delivery, Obstetric ; Female ; Homeless Persons ; Hospitals ; Humans ; New York ; Pregnancy
    Language English
    Publishing date 2021-08-13
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592909-4
    ISSN 2044-5423 ; 2044-5415
    ISSN (online) 2044-5423
    ISSN 2044-5415
    DOI 10.1136/bmjqs-2021-013746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3754: Show issues Location:
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  10. Article ; Online: Antibiotic Prescription for Outpatients With COVID-19 in Primary Care Settings in Japan.

    Miyawaki, Atsushi / Kitajima, Kei / Iwata, Akihiro / Sato, Daichi / Tsugawa, Yusuke

    JAMA network open

    2023  Volume 6, Issue 7, Page(s) e2325212

    MeSH term(s) Humans ; Japan ; Outpatients ; COVID-19 ; Primary Health Care
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.25212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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