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Book: Ap-nal-ui gang-seong-jo-seon-eul tteo-bad-deu-neun gi-dung-i doela

Kim, Jeong-eun

Jo-seon-so-nyeon-dan-chang-lib 66dols-gyeong-chug jo-seon-so-nyeon-dan jeon-gug-lyeon-hab-dan-che dae-hoe-e-seo han yeon-seol ju-che 101 (2012)nyeon 6-wol 6-il

2013

Title variant	Amnarŭi kangsŏng Chosŏnŭl ttŏbattŭnŭn kidungi toera : Chosŏn sonyŏndan ch'angnip 66tol kyŏngch'uk Chosŏn sonyŏndan chŏn'gunk nyŏnhap tanch'e taehoeesŏ han yŏnsŏl chuch'e 101 (2012)nyŏn 6wŏl 6il
Author's details	Gim Jeong-eun
Language	Korean
Size	7 S.
Publisher	Jo-seon-lo-dong-dang-chul-pan-sa
Publishing place	Pyeong-yang
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Separation of bimodal fMRI responses in mouse somatosensory areas into V1 and non-V1 contributions.

Dinh, Thi Ngoc Anh / Moon, Hyun Seok / Kim, Seong-Gi

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6302

Abstract: Multisensory integration is necessary for the animal to survive in the real world. While conventional methods have been extensively used to investigate the multisensory integration process in various brain areas, its long-range interactions remain less ... ...

Abstract	Multisensory integration is necessary for the animal to survive in the real world. While conventional methods have been extensively used to investigate the multisensory integration process in various brain areas, its long-range interactions remain less explored. In this study, our goal was to investigate interactions between visual and somatosensory networks on a whole-brain scale using 15.2-T BOLD fMRI. We compared unimodal to bimodal BOLD fMRI responses and dissected potential cross-modal pathways with silencing of primary visual cortex (V1) by optogenetic stimulation of local GABAergic neurons. Our data showed that the influence of visual stimulus on whisker activity is higher than the influence of whisker stimulus on visual activity. Optogenetic silencing of V1 revealed that visual information is conveyed to whisker processing via both V1 and non-V1 pathways. The first-order ventral posteromedial thalamic nucleus (VPM) was functionally affected by non-V1 sources, while the higher-order posterior medial thalamic nucleus (POm) was predominantly modulated by V1 but not non-V1 inputs. The primary somatosensory barrel field (S1BF) was influenced by both V1 and non-V1 inputs. These observations provide valuable insights for into the integration of whisker and visual sensory information.
MeSH term(s)	Mice ; Animals ; Magnetic Resonance Imaging ; Thalamus/physiology ; Somatosensory Cortex/diagnostic imaging ; Somatosensory Cortex/physiology ; Vibrissae/physiology
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56305-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biophysics of BOLD fMRI investigated with animal models.

Kim, Seong-Gi

Journal of magnetic resonance (San Diego, Calif. : 1997)

2018 Volume 292, Page(s) 82–89

Abstract: The widely-used BOLD fMRI signal depends on various anatomical, physiological, and imaging parameters. Thus, it is important to examine its biophysical and physiological source in order to optimize, model and accurately interpret fMRI. Animal models have ...

Abstract	The widely-used BOLD fMRI signal depends on various anatomical, physiological, and imaging parameters. Thus, it is important to examine its biophysical and physiological source in order to optimize, model and accurately interpret fMRI. Animal models have been used to investigate these issues to take systematic measurements and combine with conventional invasive approaches. Here, we reviewed and discussed multiple issues, including the echo time-dependent intravascular contribution and extravascular contributions, gradient-echo vs. spin-echo fMRI, the physiological source of BOLD fMRI, arterial vs. venous cerebral blood volume change, cerebral oxygen consumption change, and arterial oxygen saturation change. We then discuss future directions of animal fMRI and translation to human fMRI. Systematic biophysical BOLD fMRI studies provide insight into the modeling and interpretation of BOLD fMRI in animals and humans.
MeSH term(s)	Animals ; Biophysics ; Brain Mapping ; Humans ; Magnetic Resonance Imaging/methods ; Models, Animal ; Oxygen/blood ; Oxygen Consumption ; Regional Blood Flow
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2018-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1469665-4
ISSN	1096-0856 ; 1557-8968 ; 1090-7807 ; 0022-2364
ISSN (online)	1096-0856 ; 1557-8968
ISSN	1090-7807 ; 0022-2364
DOI	10.1016/j.jmr.2018.04.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Theory of chemical exchange saturation transfer MRI in the context of different magnetic fields.

Zaiss, Moritz / Jin, Tao / Kim, Seong-Gi / Gochberg, Daniel F

NMR in biomedicine

2023 Volume 36, Issue 6, Page(s) e4961

Abstract: The article from this special issue was previously published in NMR In Biomedicine , Volume 35, Issue 11, 2022. For completeness we are including the title page of the article below. The full text of the article can be read in Issue 35:11 on Wiley Online ...

Abstract	The article from this special issue was previously published in NMR In Biomedicine , Volume 35, Issue 11, 2022. For completeness we are including the title page of the article below. The full text of the article can be read in Issue 35:11 on Wiley Online Library: https://doi.org/10.1002/nbm.4789.
MeSH term(s)	Magnetic Fields ; Magnetic Resonance Imaging/methods ; Algorithms ; Protons ; Radio Waves ; Water/chemistry
Chemical Substances	Protons ; Water (059QF0KO0R)
Language	English
Publishing date	2023-05-19
Publishing country	England
Document type	Duplicate Publication ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Corrected and Republished Article
ZDB-ID	1000976-0
ISSN	1099-1492 ; 0952-3480
ISSN (online)	1099-1492
ISSN	0952-3480
DOI	10.1002/nbm.4961
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Article ; Online: Role of chemical exchange on the relayed nuclear Overhauser enhancement signal in saturation transfer MRI.

Jin, Tao / Kim, Seong-Gi

Magnetic resonance in medicine

2021 Volume 87, Issue 1, Page(s) 365–376

Abstract: Purpose: The pH sensitivity of chemical exchange-relayed nuclear Overhauser enhancement (rNOE) signal in a saturation transfer experiment is not fully understood and needs further investigation.: Methods: A three-pool-exchange model was simulated ... ...

Abstract	Purpose: The pH sensitivity of chemical exchange-relayed nuclear Overhauser enhancement (rNOE) signal in a saturation transfer experiment is not fully understood and needs further investigation. Methods: A three-pool-exchange model was simulated assuming that the magnetization transfer between an NOE pool and water is relayed by a chemical exchange (CE) pool. The saturation transfer signals from bovine serum albumin (BSA) and egg white albumin (EWA) phantoms were measured with different pH or different D Results: Simulation results showed that the rNOE signal is independent of the Larmor frequency of the CE pool, indicating any CE pool can effectively relay NOE magnetization. The rNOE signal is sensitive to a change of the CE pool size and/or exchange rate only if the CE becomes a rate-limiting step in the relay process. The rNOE signal from BSA phantoms showed larger pH-dependence at -3.0 ppm than those at -1.9 and -4.0 ppm. However, rNOE signals from aliphatic protons have much weaker pH-dependence than the CEST signal, suggesting that CE is unlikely the rate-limiting step and the rNOE signals in BSA are mainly relayed by fast exchanging protons. The existence of aromatic NOE was confirmed by proton spectroscopy. Conclusion: The pH-sensitivity of the rNOE signal is determined by whether the CE process is a rate-limiting step in the relay. The rNOE signal has much weaker pH-sensitivity than the CEST signal in BSA proteins, which can explain the weak pH sensitivity of rNOE in vivo.
MeSH term(s)	Algorithms ; Brain ; Magnetic Resonance Imaging ; Phantoms, Imaging ; Proteins ; Protons
Chemical Substances	Proteins ; Protons
Language	English
Publishing date	2021-08-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.28961
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Article ; Online: Mapping cerebral perfusion in mice under various anesthesia levels using highly sensitive BOLD MRI with transient hypoxia.

Le, Thuy Thi / Im, Geun Ho / Lee, Chan Hee / Choi, Sang Han / Kim, Seong-Gi

Science advances

2024 Volume 10, Issue 9, Page(s) eadm7605

Abstract: Cerebral perfusion is critical for the early detection of neurological diseases and for effectively monitoring disease progression and treatment responses. Mouse models are widely used in brain research, often under anesthesia, which can affect vascular ... ...

Abstract	Cerebral perfusion is critical for the early detection of neurological diseases and for effectively monitoring disease progression and treatment responses. Mouse models are widely used in brain research, often under anesthesia, which can affect vascular physiology. However, the impact of anesthesia on regional cerebral blood volume and flow in mice has not been thoroughly investigated. In this study, we have developed a whole-brain perfusion MRI approach by using a 5-second nitrogen gas stimulus under inhalational anesthetics to induce transient BOLD dynamic susceptibility contrast (DSC). This method proved to be highly sensitive, repeatable within each imaging session, and across four weekly sessions. Relative cerebral blood volumes measured by BOLD DSC agree well with those by contrast agents. Quantitative cerebral blood volume and flow metrics were successfully measured in mice under dexmedetomidine and various isoflurane doses using both total vasculature-sensitive gradient-echo and microvasculature-sensitive spin-echo BOLD MRI. Dexmedetomidine reduces cerebral perfusion, while isoflurane increases cerebral perfusion in a dose-dependent manner.
MeSH term(s)	Animals ; Mice ; Isoflurane/pharmacology ; Dexmedetomidine/pharmacology ; Magnetic Resonance Imaging/methods ; Hypoxia ; Brain/blood supply ; Anesthesia ; Perfusion ; Cerebrovascular Circulation/physiology
Chemical Substances	Isoflurane (CYS9AKD70P) ; Dexmedetomidine (67VB76HONO)
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adm7605
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Article ; Online: Characterization of brain-wide somatosensory BOLD fMRI in mice under dexmedetomidine/isoflurane and ketamine/xylazine

Taeyi You / Geun Ho Im / Seong-Gi Kim

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 13

Abstract: Abstract Mouse fMRI under anesthesia has become increasingly popular due to improvement in obtaining brain-wide BOLD response. Medetomidine with isoflurane has become well-accepted for resting-state fMRI, but whether this combination allows for stable, ... ...

Abstract	Abstract Mouse fMRI under anesthesia has become increasingly popular due to improvement in obtaining brain-wide BOLD response. Medetomidine with isoflurane has become well-accepted for resting-state fMRI, but whether this combination allows for stable, expected, and robust brain-wide evoked response in mice has yet to be validated. We thus utilized intravenous infusion of dexmedetomidine with inhaled isoflurane and intravenous infusion of ketamine/xylazine to elucidate whether stable mouse physiology and BOLD response are obtainable in response to simultaneous forepaw and whisker-pad stimulation throughout 8 h. We found both anesthetics result in hypercapnia with depressed heart rate and respiration due to self-breathing, but these values were stable throughout 8 h. Regardless of the mouse condition, brain-wide, robust, and stable BOLD response throughout the somatosensory axis was observed with differences in sensitivity and dynamics. Dexmedetomidine/isoflurane resulted in fast, boxcar-like, BOLD response with consistent hemodynamic shapes throughout the brain. Ketamine/xylazine response showed higher sensitivity, prolonged BOLD response, and evidence for cortical disinhibition as significant bilateral cortical response was observed. In addition, differing hemodynamic shapes were observed between cortical and subcortical areas. Overall, we found both anesthetics are applicable for evoked mouse fMRI studies.
Keywords	Medicine ; R ; Science ; Q
Subject code	150
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neural mechanisms of pain relief through paying attention to painful stimuli.

Kim, Dongho / Woo, Choong-Wan / Kim, Seong-Gi

Pain

2021 Volume 163, Issue 6, Page(s) 1130–1138

Abstract: Abstract: A commonly held belief suggests that turning one's attention away from pain reduces it, whereas paying attention to pain increases it. However, some attention-based therapeutic strategies for pain, such as mindfulness-based interventions, ... ...

Abstract	Abstract: A commonly held belief suggests that turning one's attention away from pain reduces it, whereas paying attention to pain increases it. However, some attention-based therapeutic strategies for pain, such as mindfulness-based interventions, suggest that paying attention to painful stimuli can reduce pain, resulting in seemingly contradictory conclusions regarding attention and pain. Here, we investigated the analgesic effects of attention modulation and provide behavioral and neural evidence that paying attention to pain can reduce pain when attention is directed toward the specific features of painful stimuli. The analgesic effects of paying attention to painful stimuli were mediated by the primary somatosensory cortex and goal-directed attention regions in the prefrontal and parietal cortex. These findings suggest that suppressing early somatosensory processing through top-down modulation is the key mechanism of the analgesic effects of paying attention to painful stimuli, providing evidence that pain itself can be used as a component of pain management.
MeSH term(s)	Analgesics ; Brain Mapping ; Humans ; Pain ; Pain Management ; Pain Measurement ; Parietal Lobe
Chemical Substances	Analgesics
Language	English
Publishing date	2021-08-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	193153-2
ISSN	1872-6623 ; 0304-3959
ISSN (online)	1872-6623
ISSN	0304-3959
DOI	10.1097/j.pain.0000000000002464
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Article ; Online: No replication of direct neuronal activity-related (DIANA) fMRI in anesthetized mice.

Choi, Sang-Han / Im, Geun Ho / Choi, Sangcheon / Yu, Xin / Bandettini, Peter A / Menon, Ravi S / Kim, Seong-Gi

Science advances

2024 Volume 10, Issue 13, Page(s) eadl0999

Abstract: Direct imaging of neuronal activity (DIANA) by functional magnetic resonance imaging (fMRI) could be a revolutionary approach for advancing systems neuroscience research. To independently replicate this observation, we performed fMRI experiments in ... ...

Abstract	Direct imaging of neuronal activity (DIANA) by functional magnetic resonance imaging (fMRI) could be a revolutionary approach for advancing systems neuroscience research. To independently replicate this observation, we performed fMRI experiments in anesthetized mice. The blood oxygenation level-dependent (BOLD) response to whisker stimulation was reliably detected in the primary barrel cortex before and after DIANA experiments; however, no DIANA-like fMRI peak was observed in individual animals' data with the 50 to 300 trials. Extensively averaged data involving 1050 trials in six mice showed a flat baseline and no detectable neuronal activity-like fMRI peak. However, spurious, nonreplicable peaks were found when using a small number of trials, and artifactual peaks were detected when some outlier-like trials were excluded. Further, no detectable DIANA peak was observed in the BOLD-responding thalamus from the selected trials with the neuronal activity-like reference function in the barrel cortex. Thus, we were unable to replicate the previously reported results without data preselection.
MeSH term(s)	Mice ; Animals ; Magnetic Resonance Imaging/methods ; Cerebral Cortex ; Neurons/physiology ; Thalamus/physiology ; Vibrissae/physiology ; Oxygen ; Brain Mapping/methods
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adl0999
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Optogenetic fMRI for Brain-Wide Circuit Analysis of Sensory Processing.

Lee, Jeong-Yun / You, Taeyi / Woo, Choong-Wan / Kim, Seong-Gi

International journal of molecular sciences

2022 Volume 23, Issue 20

Abstract: Sensory processing is a complex neurological process that receives, integrates, and responds to information from one's own body and environment, which is closely related to survival as well as neurological disorders. Brain-wide networks of sensory ... ...

Abstract	Sensory processing is a complex neurological process that receives, integrates, and responds to information from one's own body and environment, which is closely related to survival as well as neurological disorders. Brain-wide networks of sensory processing are difficult to investigate due to their dynamic regulation by multiple brain circuits. Optogenetics, a neuromodulation technique that uses light-sensitive proteins, can be combined with functional magnetic resonance imaging (ofMRI) to measure whole-brain activity. Since ofMRI has increasingly been used for investigating brain circuits underlying sensory processing for over a decade, we systematically reviewed recent ofMRI studies of sensory circuits and discussed the challenges of optogenetic fMRI in rodents.
MeSH term(s)	Optogenetics/methods ; Magnetic Resonance Imaging/methods ; Brain Mapping/methods ; Brain/diagnostic imaging ; Brain/physiology ; Perception
Language	English
Publishing date	2022-10-14
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232012268
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