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  1. Article ; Online: Früherkennung des Prostatakarzinoms.

    Rodler, Severin / Stief, Christian G

    MMW Fortschritte der Medizin

    2023  Volume 165, Issue 8, Page(s) 50–52

    Title translation Early detection of prostate cancer.
    MeSH term(s) Male ; Humans ; Early Detection of Cancer ; Prostatic Neoplasms/diagnosis ; Prostate-Specific Antigen
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language German
    Publishing date 2023-04-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1478211-x
    ISSN 1613-3560 ; 1438-3276
    ISSN (online) 1613-3560
    ISSN 1438-3276
    DOI 10.1007/s15006-023-2521-z
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  2. Article: Nierenzellkarzinom und Urothelkarzinom. Berichterstattung zu den Highlights vom ESMO-Kongress 2020

    Rodler, Severin

    TZM-News

    2020  Volume 22, Issue 4, Page(s) 4

    Language German
    Document type Article
    ZDB-ID 1497189-6
    ISSN 1437-8019
    Database Current Contents Medicine

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  3. Book ; Online ; Thesis: Implementierung und Analyse des experimentellen Einsatzes von digitalen Technologien in der Diagnostik und Therapie uro-onkologischer Patienten

    Rodler, Severin [Verfasser]

    2021  

    Author's details Severin Rodler
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article: The Vanishing Clinical Value of PD-L1 Status as a Predictive Biomarker in the First-Line Treatment of Urothelial Carcinoma of the Bladder.

    Tamalunas, Alexander / Aydogdu, Can / Unterrainer, Lena M / Schott, Melanie / Rodler, Severin / Ledderose, Stephan / Schulz, Gerald B / Stief, Christian G / Casuscelli, Jozefina

    Cancers

    2024  Volume 16, Issue 8

    Abstract: Background: Our study endeavors to elucidate the clinical implications of PD-L1 positivity in individuals afflicted with advanced urothelial carcinoma of the bladder (UCB).: Methods: Patients with advanced UCB were prospectively enrolled following a ... ...

    Abstract Background: Our study endeavors to elucidate the clinical implications of PD-L1 positivity in individuals afflicted with advanced urothelial carcinoma of the bladder (UCB).
    Methods: Patients with advanced UCB were prospectively enrolled following a radical cystectomy (RC) performed within January 2017 to December 2022 at our tertiary referral center. The clinical outcome, defined as the progression-free survival (PFS) and overall survival (OS) on systemic treatment, was analyzed using an χ
    Results: A total of 648 patients were included following an RC performed within January 2017 to December 2022. Their PD-L1 status was analyzed with the primary PD-L1-specific antibody (clone SP263, Ventana) and defined both by the CPS and IC-score in 282 patients (43.5%) with a high risk (pT3-pT4 and/or lymph node involvement) or metastatic UCB. While the median PFS was significantly prolonged 5-fold in PD-L1+ patients, we found no difference in OS, regardless of PD-L1 status, or treatment regimen.
    Conclusions: While PD-L1 positivity indicates prolonged PFS, the presence of PD-L1 does not influence OS rates, suggesting its limited usefulness as a prognostic biomarker in bladder cancer. However, the positive correlation between an PD-L1 status and a sustained response to ICI treatments indicates its potential role as a predictive biomarker. Further research is required to understand how the predictive value of PD-L1 positivity may extend to the use of ICIs in combination with antibody-drug conjugates.
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16081536
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  5. Article ; Online: [No title information]

    Witzsch, Ulrich K Fr / Borkowetz, Angelika / Enzmann, Thomas / Rodler, Severin / Leyh-Bannurah, Sami-Ramzi / Loch, Tillmann / Borgmann, Hendrik / Steidle, Oliver

    Urologie (Heidelberg, Germany)

    2023  Volume 62, Issue 10, Page(s) 1094

    Title translation Publisher Erratum zu: Digitalisierung in der Urologie – Herausforderung und Chance.
    Language German
    Publishing date 2023-08-29
    Publishing country Germany
    Document type Published Erratum
    ISSN 2731-7072
    ISSN (online) 2731-7072
    DOI 10.1007/s00120-023-02196-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Tumor-infiltrating lymphocytes predict survival in ≥ pT2 urothelial bladder cancer.

    Ledderose, Stephan / Rodler, Severin / Eismann, Lennert / Ledderose, Georg / Ledderose, Carola

    Pathology, research and practice

    2022  Volume 237, Page(s) 154037

    Abstract: Tumor-infiltrating lymphocytes (TILs) are associated with improved survival in several types of cancers, including genitourinary cancers. However, multiple different scoring methods used to assess TILs complicate the comparison of different studies and ... ...

    Abstract Tumor-infiltrating lymphocytes (TILs) are associated with improved survival in several types of cancers, including genitourinary cancers. However, multiple different scoring methods used to assess TILs complicate the comparison of different studies and are not always suitable for daily practice. In 2014, the International TILs Working Group (ITWG) proposed a simple and robust assessment method for a more standardized evaluation of TILs. Here, we validated this system in muscle-invasive urinary bladder cancer (MIBC). Patient history and histologic specimens from 203 patients with MIBC were retrospectively analyzed. The stromal TIL (sTIL) score was determined using the ITWG system and 3 groups were defined according to the degree of stromal lymphocytic infiltration: low (0-10%), intermediate (10-55%) and high (55-100%). Associations between sTIL score, clinicopathological variables, tumor-specific survival (TSS), overall survival (OS), and disease-free survival (DFS) were analyzed. High stromal lymphocytic infiltration was associated with significantly higher OS, TSS and DFS when compared to low grade sTILs. The survival benefit remained statistically significant in multivariate analyses, confirming that sTILs are a strong independent positive prognostic factor in patients with MIBC. In summary, the degree of sTILs as defined by the ITWG robustly predicts survival in MIBC patients. Prospective studies with larger case numbers are needed to determine whether sTILs should be included in staging guidelines and how they could aid in therapeutic decision making.
    MeSH term(s) Humans ; Lymphocytes, Tumor-Infiltrating/pathology ; Urinary Bladder Neoplasms/pathology ; Prognosis ; Retrospective Studies ; Prospective Studies ; Carcinoma, Transitional Cell/pathology
    Language English
    Publishing date 2022-07-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2022.154037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Systemtherapie des Nierenzellkarzinoms und Management von Nebenwirkungen.

    Berg, Elena K / Aydogdu, Can / Götz, Melanie / Rodler, Severin / Tamalunas, Alexander / Stief, Christian G / Casuscelli, Jozefina

    MMW Fortschritte der Medizin

    2023  Volume 165, Issue 13, Page(s) 39–41

    Title translation Systemic treatment of renal cancer and management of immunotherapy related toxicity.
    MeSH term(s) Humans ; Carcinoma, Renal Cell/drug therapy ; Kidney Neoplasms/drug therapy ; Immunotherapy/adverse effects ; Retrospective Studies
    Language German
    Publishing date 2023-06-20
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1478211-x
    ISSN 1613-3560 ; 1438-3276
    ISSN (online) 1613-3560
    ISSN 1438-3276
    DOI 10.1007/s15006-023-2751-0
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  8. Article ; Online: Digitalisierung in der Urologie – Herausforderung und Chance.

    Witzsch, Ulrich K Fr / Borkowetz, Angelika / Enzmann, Thomas / Rodler, Severin / Leyh-Bannurah, Sami-Ramzi / Loch, Tillmann / Borgmann, Hendrik / Steidle, Oliver

    Urologie (Heidelberg, Germany)

    2023  Volume 62, Issue 9, Page(s) 913–928

    Abstract: Digitalization is changing medicine. In Germany these changes are not highly accepted yet. Medical pathways should be supported and become safer by digital transformation. Furthermore, artificial intelligence (AI) applications are increasingly used in ... ...

    Title translation Digitalization in urology-challenge and opportunity.
    Abstract Digitalization is changing medicine. In Germany these changes are not highly accepted yet. Medical pathways should be supported and become safer by digital transformation. Furthermore, artificial intelligence (AI) applications are increasingly used in medicine. Only time will tell whether these will decrease the workload and make patient treatment easier, while increasing precision and individualization.. Urology must accept the upcoming new challenges. This can best be done by participating in the development.
    MeSH term(s) Humans ; Urology ; Artificial Intelligence ; Medicine ; Germany ; Workload
    Language German
    Publishing date 2023-08-22
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7072
    ISSN (online) 2731-7072
    DOI 10.1007/s00120-023-02154-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Generative artificial intelligence in surgery.

    Rodler, Severin / Ganjavi, Conner / De Backer, Pieter / Magoulianitis, Vasileios / Ramacciotti, Lorenzo Storino / De Castro Abreu, Andre Luis / Gill, Inderbir S / Cacciamani, Giovanni E

    Surgery

    2024  

    Abstract: Generative artificial intelligence is able to collect, extract, digest, and generate information in an understandable way for humans. As the first surgical applications of generative artificial intelligence are applied, this perspective paper aims to ... ...

    Abstract Generative artificial intelligence is able to collect, extract, digest, and generate information in an understandable way for humans. As the first surgical applications of generative artificial intelligence are applied, this perspective paper aims to provide a comprehensive overview of current applications and future perspectives for the application of generative artificial intelligence in surgery, from preoperative planning to training. Generative artificial intelligence can be used before surgery for planning and decision support by extracting patient information and providing patients with information and simulation regarding the procedure. Intraoperatively, generative artificial intelligence can document data that is normally not captured as intraoperative adverse events or provide information to help decision-making. Postoperatively, GAIs can help with patient discharge and follow-up. The ability to provide real-time feedback and store it for later review is an important capability of GAIs. GAI applications are emerging as highly specialized, task-specific tools for tasks such as data extraction, synthesis, presentation, and communication within the realm of surgery. GAIs have the potential to play a pivotal role in facilitating interaction between surgeons and artificial intelligence.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2024.02.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Propensity Score-Matched Analysis of Single Fraction Robotic Radiosurgery Versus Open Partial Nephrectomy in Renal Cell Carcinoma: Oncological Outcomes.

    Staehler, Michael / Schuler, Tina / Spek, Annabel / Rodler, Severin / Tamalunas, Alexander / Fürweger, Christoph / Muacevic, Alexander

    Cureus

    2022  Volume 14, Issue 1, Page(s) e21623

    Abstract: Introduction High-dose local stereotactic robotic radiosurgery (RRS) is a non-invasive alternative to surgery in renal masses and selected patients. We have, so far, limited its use to the elderly and patients at high risk from surgery. In this study, we ...

    Abstract Introduction High-dose local stereotactic robotic radiosurgery (RRS) is a non-invasive alternative to surgery in renal masses and selected patients. We have, so far, limited its use to the elderly and patients at high risk from surgery. In this study, we matched patients with renal tumors who were treated with single fraction RRS to patients who underwent open partial nephrectomy (OPN). Methods Between January 2009 and December 2017, we included 571 consecutive patients undergoing OPN and 99 patients who underwent RRS in this retrospective analysis. Patients had to have a follow-up of at least six months and we were able to match 35 with a propensity score. Matching criteria were Eastern Cooperative Oncology Group (ECOG) status, age, clinical tumor, nodes, and metastases (TNM), and tumor diameter. Tumor response, renal function, survival, and adverse events were evaluated every three months until progression or death. Results Median age was 65 years for RRS (range 58-75) and 71 (range 56-76) for OPN (p=0.131). Median diameter of renal tumors was 2.8 cm (range 2.4-3.9) for RRS and 3.5 cm (2.8-4.5) for OPN, p=0.104. Median follow-up was 28.1 months (range 6.0-78.3 months). Local tumor control nine months after RRS and OPN was 98% (95% CI: 89-99%). Renal function remained stable with a median creatinine clearance (Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)) at baseline of 76.8mlmin/1.73m
    Language English
    Publishing date 2022-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.21623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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