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  1. Book ; Online ; E-Book: Drug disposition and pharmacokinetics

    Curry, Stephen H. / Whelpton, Robin

    principles and applications for medicine, toxicology and biotechnology

    2022  

    Author's details Stephen H. Curry and Robin Whelpton
    Keywords Pharmacokinetics ; Biopharmaceutics ; Drugs/Metabolism
    Subject code 615.7
    Language English
    Size 1 online resource (480 pages)
    Edition Second edition.
    Publisher John Wiley & Sons
    Publishing place Hoboken, New Jersey
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-119-58918-5 ; 1-119-58919-3 ; 9781119588436 ; 978-1-119-58918-1 ; 978-1-119-58919-8 ; 111958843X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book: Drug Disposition and Pharmacokinetics

    Whelpton, Robin / Curry, Stephen H.

    Principles and Applications for Medicine, Toxicology and Biotechnology

    2022  

    Author's details Stephen H. Curry, PhD, D.Sc. (Med.), has held professorial positions in Pharmacology, Physiology and Pharmaceutical Sciences at the Universities of London, Florida, and Rochester, as well as posts in the pharmaceutical industry. He is a Fellow of the Royal Pharmaceutical Society, and currently works in the field of technology transfer and translational science with a primary interest in aiding university scientists with commercialization of patented medically-significant discoveries. He is based in Rochester, New York. Robin Whelpton, PhD, has taught undergraduate and postgraduate students of medicine, dentistry, pharmacology, analytical toxicology, pharmaceutical chemistry, and biomedical sciences at Queen Mary, University of London
    Size 480 p.
    Publisher John Wiley & Sons Ltd
    Document type Book
    Note PDA Manuell_18
    Format 260 x 208 x 35
    ISBN 9781119588436 ; 111958843X
    Database PDA

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  3. Article ; Online: Let's move beyond the rhetoric: it's time to change how we judge research.

    Curry, Stephen

    Nature

    2020  Volume 554, Issue 7691, Page(s) 147

    Language English
    Publishing date 2020-02-24
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-018-01642-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Let's move beyond the rhetoric: it's time to change how we judge research.

    Curry, Stephen

    Nature

    2018  Volume 554, Issue 7691, Page(s) 147

    MeSH term(s) Bibliometrics ; Journal Impact Factor ; Reproducibility of Results ; Research/standards ; Research Personnel/standards ; Reward
    Language English
    Publishing date 2018--08
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-018-01642-w
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  5. Article ; Online: Guest Editorial: Open Access: Principles, Practice, and Potential.

    Curry, Stephen

    ACS omega

    2017  Volume 2, Issue 6, Page(s) 2803–2804

    Language English
    Publishing date 2017-06-19
    Publishing country United States
    Document type Editorial
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.7b00707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Narrative Literature Review of the Established Safety of Human Serum Albumin Use as a Stabilizer in Aesthetic Botulinum Toxin Formulations Compared to Alternatives.

    Sattler, Sonja / Gollomp, Stephen / Curry, Andrew

    Toxins

    2023  Volume 15, Issue 10

    Abstract: Despite more than 80 years of use in a number of conditions, including in critically ill patients, comments have recently arisen regarding the safety and efficacy of human serum albumin (HSA) as a therapeutic product and stabilizer/excipient in botulinum ...

    Abstract Despite more than 80 years of use in a number of conditions, including in critically ill patients, comments have recently arisen regarding the safety and efficacy of human serum albumin (HSA) as a therapeutic product and stabilizer/excipient in botulinum neurotoxins. This review summarizes the literature on the safety of HSA. Beyond decades of safe use, the largest clinical dataset of HSA safety is a large meta-analysis of HSA supplier data, which found only an extremely remote risk of serious adverse events across millions of doses of therapeutic concentrations of HSA. There is a paucity of literature identifying HSA-specific adverse events when used as a stabilizer/excipient; however, studies of HSA-containing botulinum neurotoxins (BoNTs) suggest that adverse events are not related to HSA. Polysorbates, which are synthetically produced and not physiologically inert, are contained in pending or new-to-market BoNT formulations. In contrast to HSA, evidence exists to suggest that polysorbates (particularly PS20/PS80) can cause serious adverse events (e.g., hypersensitivity, anaphylaxis, and immunogenicity).
    MeSH term(s) Humans ; Botulinum Toxins/adverse effects ; Serum Albumin, Human/adverse effects ; Excipients ; Polysorbates ; Botulinum Toxins, Type A/adverse effects
    Chemical Substances Botulinum Toxins (EC 3.4.24.69) ; Serum Albumin, Human (ZIF514RVZR) ; Excipients ; Polysorbates ; Botulinum Toxins, Type A (EC 3.4.24.69)
    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Meta-Analysis ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins15100619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: What is the meaning of Brexit?

    Curry, Stephen

    EMBO reports

    2016  Volume 17, Issue 9, Page(s) 1239–1240

    MeSH term(s) European Union ; Research ; Research Personnel ; Research Support as Topic/economics ; United Kingdom
    Language English
    Publishing date 2016-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.201643113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5433: Show issues Location:
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  8. Article ; Online: Effect of Composition and Size on Surface Properties of Anti-Cancer Nanoparticles.

    Mishra, Ina / Garrett, Meredith / Curry, Stephen / Jameson, Jeffrey / Kastellorizios, Michail

    International journal of molecular sciences

    2023  Volume 24, Issue 17

    Abstract: Liposomal formulations offer significant advantages as anticancer drug carriers for targeted drug delivery; however, due to their complexity, clinical translation has been challenging. In addition, liposomal product manufacturing has been interrupted in ... ...

    Abstract Liposomal formulations offer significant advantages as anticancer drug carriers for targeted drug delivery; however, due to their complexity, clinical translation has been challenging. In addition, liposomal product manufacturing has been interrupted in the past, as was the case for Doxil
    MeSH term(s) Humans ; Liposomes ; Surface Properties ; Neoplasms ; Surface-Active Agents ; Pulmonary Surfactants ; Nanoparticles
    Chemical Substances Liposomes ; liposomal doxorubicin ; Surface-Active Agents ; Pulmonary Surfactants
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241713417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Guest Editorial

    Stephen Curry

    ACS Omega, Vol 2, Iss 6, Pp 2803-

    Open Access: Principles, Practice, and Potential

    2017  Volume 2804

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2017-06-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Platelet transfusion and anticoagulation in hematological cancer-associated thrombosis and thrombocytopenia: The CAVEaT multicenter prospective cohort.

    Booth, Stephen / Desborough, Michael / Curry, Nicola / Stanworth, Simon

    Journal of thrombosis and haemostasis : JTH

    2022  Volume 20, Issue 8, Page(s) 1830–1838

    Abstract: Background: Venous thromboembolism (VTE) in patients with thrombocytopenia represents a complex management challenge.: Objectives: To describe practice, document outcomes, and compare management to national guidelines.: Methods: We present a ... ...

    Abstract Background: Venous thromboembolism (VTE) in patients with thrombocytopenia represents a complex management challenge.
    Objectives: To describe practice, document outcomes, and compare management to national guidelines.
    Methods: We present a prospective multicenter cohort of 105 patients with hematological cancer, VTE within 28 days, and platelets <50 × 10
    Results: Median age was 64 and median initial platelet count 28 × 10
    Conclusions: This data set demonstrates the heterogeneity of approaches used in patients presenting with severe thrombocytopenia and acute thrombosis and confirms the high rates of bleeding in this cohort with thrombosis progression rates similar to the wider cancer-associated thrombosis population. Randomized data is required to inform the optimal management.
    MeSH term(s) Anticoagulants/adverse effects ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/therapy ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Humans ; Middle Aged ; Neoplasm Recurrence, Local/chemically induced ; Platelet Transfusion ; Prospective Studies ; Pulmonary Embolism ; Thrombocytopenia/chemically induced ; Thrombocytopenia/diagnosis ; Thrombocytopenia/therapy ; Thrombosis/chemically induced ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/etiology ; Venous Thromboembolism/therapy
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-05-23
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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