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Article ; Online: Experimental Evidence of 2,3,7,8-Tetrachlordibenzo-p-Dioxin (TCDD) Transgenerational Effects on Reproductive Health.

Gaspari, Laura / Paris, Françoise / Kalfa, Nicolas / Soyer-Gobillard, Marie-Odile / Sultan, Charles / Hamamah, Samir

International journal of molecular sciences

2021 Volume 22, Issue 16

Abstract: ... the transgenerational inheritance of disease susceptibility. Among the many existing EDs, 2,3,7,8-tetrachlordibenzo-p ...

Abstract	Previous studies have demonstrated that endocrine disruptors (EDs) can promote the transgenerational inheritance of disease susceptibility. Among the many existing EDs, 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) affects reproductive health, including in humans, following direct occupational exposure or environmental disasters, for instance the Agent Orange sprayed during the Vietnam War. Conversely, few studies have focused on TCDD multigenerational and transgenerational effects on human reproductive health, despite the high amount of evidence in animal models of such effects on male and female reproductive health that mimic human reproductive system disorders. Importantly, these studies show that paternal ancestral TCDD exposure substantially contributes to pregnancy outcome and fetal health, although pregnancy outcome is considered tightly related to the woman's health. In this work, we conducted a systematic review of the literature and a knowledge synthesis in order (i) to describe the findings obtained in rodent models concerning TCDD transgenerational effects on reproductive health and (ii) to discuss the epigenetic molecular alterations that might be involved in this process. As ancestral toxicant exposure cannot be changed in humans, identifying the crucial reproductive functions that are negatively affected by such exposure may help clinicians to preserve male and female fertility and to avoid adverse pregnancy outcomes.
MeSH term(s)	Animals ; Environmental Exposure/adverse effects ; Hazardous Substances/adverse effects ; Humans ; Polychlorinated Dibenzodioxins/adverse effects ; Reproduction/drug effects ; Reproductive Health
Chemical Substances	Hazardous Substances ; Polychlorinated Dibenzodioxins
Language	English
Publishing date	2021-08-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22169091
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Comparison of the Blood-Brain Barrier Transport and Vulnerability to P-Glycoprotein-Mediated Drug-Drug Interaction of Domperidone versus Metoclopramide Assessed Using In Vitro Assay and PET Imaging.

Breuil, Louise / Goutal, Sébastien / Marie, Solène / Del Vecchio, Antonio / Audisio, Davide / Soyer, Amélie / Goislard, Maud / Saba, Wadad / Tournier, Nicolas / Caillé, Fabien

Pharmaceutics

2022 Volume 14, Issue 8

Abstract: ... side effects. The impact of P-glycoprotein (P-gp)-mediated efflux at the blood−brain barrier (BBB) on brain ... imaging in rats with the radiolabeled analogs [11C]domperidone and [11C]metoclopramide. In P ... gp-overexpressing cells, the IC50 of tariquidar, a potent P-gp inhibitor, was drastically different using [11C ...

Abstract	Domperidone and metoclopramide are widely prescribed antiemetic drugs with distinct neurological side effects. The impact of P-glycoprotein (P-gp)-mediated efflux at the blood−brain barrier (BBB) on brain exposure and BBB permeation was compared in vitro and in vivo using positron emission tomography (PET) imaging in rats with the radiolabeled analogs [11C]domperidone and [11C]metoclopramide. In P-gp-overexpressing cells, the IC50 of tariquidar, a potent P-gp inhibitor, was drastically different using [11C]domperidone (221 nM [198−248 nM]) or [11C]metoclopramide (4 nM [2−8 nM]) as the substrate. Complete P-gp inhibition led to a 1.8-fold higher increase in the cellular uptake of [11C]domperidone compared with [11C]metoclopramide (p < 0.0001). Brain PET imaging revealed that the baseline brain exposure (AUCbrain) of [11C]metoclopramide was 2.4-fold higher compared with [11C]domperidone (p < 0.001), consistent with a 1.8-fold higher BBB penetration (AUCbrain/AUCplasma). The maximal increase in the brain exposure (2.9-fold, p < 0.0001) and BBB penetration (2.9-fold, p < 0.0001) of [11C]metoclopramide was achieved using 8 mg/kg of tariquidar. In comparison, neither 8 nor 15 mg/kg of tariquidar increased the brain exposure of [11C]domperidone (p > 0.05). Domperidone is an avid P-gp substrate that was in vitro compared with metoclopramide. Domperidone benefits from a lower brain exposure and a limited risk for P-gp-mediated drug−drug interaction involving P-gp inhibition at the BBB.
Language	English
Publishing date	2022-08-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14081658
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Article ; Online: Experimental Evidence of 2,3,7,8-Tetrachlordibenzo-p-Dioxin (TCDD) Transgenerational Effects on Reproductive Health

Laura Gaspari / Françoise Paris / Nicolas Kalfa / Marie-Odile Soyer-Gobillard / Charles Sultan / Samir Hamamah

International Journal of Molecular Sciences, Vol 22, Iss 9091, p

2021 Volume 9091

Abstract: ... the transgenerational inheritance of disease susceptibility. Among the many existing EDs, 2,3,7,8-tetrachlordibenzo-p ...

Abstract	Previous studies have demonstrated that endocrine disruptors (EDs) can promote the transgenerational inheritance of disease susceptibility. Among the many existing EDs, 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) affects reproductive health, including in humans, following direct occupational exposure or environmental disasters, for instance the Agent Orange sprayed during the Vietnam War. Conversely, few studies have focused on TCDD multigenerational and transgenerational effects on human reproductive health, despite the high amount of evidence in animal models of such effects on male and female reproductive health that mimic human reproductive system disorders. Importantly, these studies show that paternal ancestral TCDD exposure substantially contributes to pregnancy outcome and fetal health, although pregnancy outcome is considered tightly related to the woman’s health. In this work, we conducted a systematic review of the literature and a knowledge synthesis in order (i) to describe the findings obtained in rodent models concerning TCDD transgenerational effects on reproductive health and (ii) to discuss the epigenetic molecular alterations that might be involved in this process. As ancestral toxicant exposure cannot be changed in humans, identifying the crucial reproductive functions that are negatively affected by such exposure may help clinicians to preserve male and female fertility and to avoid adverse pregnancy outcomes.
Keywords	dioxin (TCDD) ; multigenerational transmission ; endocrine disruptors (EDs) ; epigenetic ; murine models ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cinematic Rendering: A New Look at Pancreatic Neuroendocrine Tumour Imaging.

Soyer, Philippe

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes

2024 , Page(s) 8465371241247800

Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Editorial
ZDB-ID	418190-6
ISSN	1488-2361 ; 0846-5371 ; 0008-2902
ISSN (online)	1488-2361
ISSN	0846-5371 ; 0008-2902
DOI	10.1177/08465371241247800
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Article ; Online: Serving as a reviewer.

Soyer, Philippe

Diagnostic and interventional imaging

2023 Volume 104, Issue 2, Page(s) 49–50

MeSH term(s)	Humans ; Peer Review, Research ; Publishing
Language	English
Publishing date	2023-01-02
Publishing country	France
Document type	Editorial ; Comment
ZDB-ID	2648283-6
ISSN	2211-5684 ; 2211-5684
ISSN (online)	2211-5684
ISSN	2211-5684
DOI	10.1016/j.diii.2022.11.008
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Article ; Online: Reviewer: Not an easy role.

Soyer, Philippe

Diagnostic and interventional imaging

2023 Volume 105, Issue 1, Page(s) 1–2

MeSH term(s)	Humans ; Peer Review, Research ; Publishing
Language	English
Publishing date	2023-11-30
Publishing country	France
Document type	Editorial
ZDB-ID	2648283-6
ISSN	2211-5684 ; 2211-5684
ISSN (online)	2211-5684
ISSN	2211-5684
DOI	10.1016/j.diii.2023.11.003
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Book ; Online: Actinic Keratosis

Soyer, H.P.

(Current Problems in Dermatology ; Vol.46)

2015

Series title	Current Problems in Dermatology ; Vol.46
Keywords	Dermatology ; Oncology
Language	English
Size	1 Online-Ressource (VIII + 154 S.)
Publisher	S. Karger
Publishing place	Basel
Document type	Book ; Online
Note	Extraordinary insights into an ordinary pathology
HBZ-ID	HT019543269
ISBN	978-3-318-02763-1 ; 3-318-02763-4
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Peer review and peer reviewers.

Soyer, Philippe

Diagnostic and interventional imaging

2022 Volume 103, Issue 1, Page(s) 1–2

MeSH term(s)	Humans ; Peer Review, Research
Language	English
Publishing date	2022-01-10
Publishing country	France
Document type	Editorial
ZDB-ID	2648283-6
ISSN	2211-5684 ; 2211-5684
ISSN (online)	2211-5684
ISSN	2211-5684
DOI	10.1016/j.diii.2021.12.001
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Article ; Online: Effect of P/E-selectin blockage on antisperm antibody development and histopathological alterations in experimental orchitis.

Cesur, Özkan / Aslan, Mustafa Kemal / Ayva, Sebnem Kupana / Fedakar-Şenyücel, Mine / Soyer, Tutku / Kısa, Üçler / Çakmak, Murat

Journal of pediatric surgery

2013 Volume 48, Issue 10, Page(s) 2164–2170

Abstract: Aim: This study aimed to evaluate the effect of P/E-selectin blockage on antisperm antibody (ASA ... groups (n = 6) including control (CG), sham (SG), orchitis (OG), antimicrobial treatment (AG), P/E ... selectin blockage (PESG), and both antimicrobial and P/E-selectin treatment (TG) groups. In CG, serum ...

Abstract	Aim: This study aimed to evaluate the effect of P/E-selectin blockage on antisperm antibody (ASA) development and histopathological alterations in experimental orchitis. Materials and methods: Thirty-six Wistar albino-type male rats weighing 100-150 g were included in the study. Rats were allocated into six groups (n = 6) including control (CG), sham (SG), orchitis (OG), antimicrobial treatment (AG), P/E-selectin blockage (PESG), and both antimicrobial and P/E-selectin treatment (TG) groups. In CG, serum samples were taken from the tail vein prior to the procedure and followed by extraction of both testes. In SG, 1 ml of saline solution was injected in testicular parenchyma. OG was obtained by injecting 0.1 ml 106 cfu/ml Escherichia coli (0:6 strain) and 1 ml saline solution into the right testes. AG received ciprofloxacin (50 mg/kg/day) twice a day through gastrogavage 24 hours after generating orchitis. In PESG, P/E-selectin antibody (100 μg) was administered intravenously via the tail vein 24 hours after the induction of orchitis. Finally, both ciprofloxacin and P/E-selectin antibody were administered in TG 24 hours after the induction of orchitis for 14 days. At the end of treatment, 1 ml of serum sample was obtained to evaluate the ASA, P-selectin and E-selectin levels. In order to evaluate spermatogenesis (Johnsen score) and testicular injury (Cosentino score), both testes were extracted at the end of the 14th day. Results: In orchitis-induced groups (OG, ATG, PSEG, TG), ASA levels were significantly increased at the 14th day when compared to SG (p < 0.05). In TG, ASA levels were decreased when compared to AG. However, similar alteration in ASA levels was not detected in PSEG (p > 0.05). In OG and AG, P-selectin levels were decreased at the 14th day when compared to levels observed on 0 day (p < 0.05). E-selectin levels on 0 day showed that each group had higher levels of E-selectin when compared to CG (p > 0.05). There was no significant difference regarding E-selectin when compared to CG (p > 0.05). No significant differences regarding E-selectin levels were detected on the 0th and 14th days between AG and CG (p > 0.05). When the Cosentino and Johnsen scores were compared among groups, TG and PSEG has decreased scores of Cosentino than OG on the right testicle (p < 0.05). In contrast, an increased Johnsen score was detected in TG and PSEG when compared to OG (p < 0/05). No significant difference was detected for both Cosentino and Johnsen scores on the left testicle (p > 0.05). There was no difference with regard to the right and left testicular injury in TG. In P/E-blocked groups, decreased histopathological alterations were observed in the contralateral testis. Conclusion: P/E-selectin blockage may reduce ASA production after orchitis when combined with antimicrobial treatment. P/E-selectin blockage not only has a protective effect on blood-testis barrier but also decreases the histopathological alterations in both the affected and contralateral testis. Histopathological parameters of spermatogenesis may also be prevented by P/E-selectin blockage in experimental orchitis.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Autoantibodies/blood ; Autoantibodies/pharmacology ; Autoantibodies/therapeutic use ; Ciprofloxacin/pharmacology ; Ciprofloxacin/therapeutic use ; Drug Administration Schedule ; Drug Therapy, Combination ; E-Selectin/blood ; E-Selectin/immunology ; Escherichia coli Infections/blood ; Escherichia coli Infections/drug therapy ; Male ; Orchitis/blood ; Orchitis/drug therapy ; P-Selectin/blood ; P-Selectin/immunology ; Rats ; Rats, Wistar ; Spermatogenesis/drug effects ; Testis/drug effects ; Testis/pathology
Chemical Substances	Anti-Bacterial Agents ; Autoantibodies ; E-Selectin ; P-Selectin ; Ciprofloxacin (5E8K9I0O4U)
Language	English
Publishing date	2013-10
Publishing country	United States
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2013.06.030
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Article ; Online: Evaluation of omental inflammatory response with P-/E-selectin levels and histopathologic findings in experimental model.

Aslan, Mustafa Kemal / Boybeyi, Ozlem / Soyer, Tutku / Senyücel, Mine Fedakar / Ayva, Sebnem / Kısa, Ucler / Cesur, Ozkan / Cakmak, Murat

Journal of pediatric surgery

2012 Volume 47, Issue 11, Page(s) 2050–2054

Abstract: ... to evaluate the inflammatory response of omentum in different abdominal events with omental P-/E-selectin ... of vessels in sections, polymorphic nuclear leukocytes [PMLs], lymphocytes). The mean P-/E-selectin levels ... in other groups. P-selectin and E-selectin levels and number of PML were significantly increased in the CLP group ...

Abstract	Aim: The omentum plays a crucial role in abdominal defense mechanism by adhering to sites of inflammation and absorbing bacteria and debris from the peritoneal cavity. An experimental study was conducted to evaluate the inflammatory response of omentum in different abdominal events with omental P-/E-selectin levels and histopathologic findings. Materials and methods: Thirty Wistar rats were placed into 5 groups (n = 6), including a control group (CG), sham group (SG), bladder perforation (BP) group, splenic laceration (SL) group, and cecal ligation and puncture (CLP) group. Omental samples were obtained in CG after median laparotomy. In accordance with described models, BP, SL, and CLP were performed in experimental groups. Twenty-four hours after the first laparotomy, localization of the omental pad was noted, and omental samples were obtained for biochemical analysis of levels and histopathologic findings (no. of vessels in sections, polymorphic nuclear leukocytes [PMLs], lymphocytes). The mean P-/E-selectin levels and histopathologic findings of inflammation were compared between groups. Results: Although omentum was adhered to the cecum in all subjects after CLP, similar findings were not detected in other groups. P-selectin and E-selectin levels and number of PML were significantly increased in the CLP group when compared with other groups (P < .05). The number of vessels in sections was significantly increased in CLP group when compared with SG and BP groups (P < .05), and the BP group had a decreased number of vessels than CG (P < .05). The number of PML was significantly increased in SG and SL and BP groups with respect to CG (P < .05). Conclusion: Among different experimental intraabdominal catastrophes, only CLP caused an inflammatory response and increased levels of adhesion molecules in the omentum. These findings suggest that the nature of the inflammation is the main determining factor for the omental function in intraabdominal events.
MeSH term(s)	Animals ; Biomarkers/metabolism ; Cecum/surgery ; E-Selectin/metabolism ; Female ; Inflammation/etiology ; Inflammation/metabolism ; Inflammation/pathology ; Ligation ; Male ; Neutrophils/metabolism ; Omentum/blood supply ; Omentum/metabolism ; Omentum/pathology ; P-Selectin/metabolism ; Postoperative Complications/etiology ; Postoperative Complications/metabolism ; Postoperative Complications/pathology ; Random Allocation ; Rats ; Rats, Wistar ; Spleen/injuries ; Tissue Adhesions/etiology ; Tissue Adhesions/metabolism ; Tissue Adhesions/pathology ; Urinary Bladder/injuries
Chemical Substances	Biomarkers ; E-Selectin ; P-Selectin
Language	English
Publishing date	2012-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2012.06.024
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