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Article: [Research on the mechanism of Miao ethnicity medicine formula of Oxalis corniculata against chronic non-bacterial prostatitis].

Lai, Yu-Qi / Yu, Yi / Liu, Peng-Fei / Zhan, Ming-Wei / Ma, Meng-Fei / Wang, Lei / Lou, Qiang / Shang, Xue-Jun

Zhonghua nan ke xue = National journal of andrology

2024 Volume 29, Issue 9, Page(s) 783–789

Abstract: Objective： To explore the mechanism of Miao ethnicity medicine formula of Oxalis corniculata ...

Abstract	Objective： To explore the mechanism of Miao ethnicity medicine formula of Oxalis corniculata against chronic non-bacterial prostatitis. Methods: The rat model of chronic abacterial prostatitis was induced by stimulation with 2% sterile carrageenan solution. After modeling, the rats were randomly divided into two groups, Model control group (Model group) and oxalis group. Another normal control group was set up. The rats in the Model group and the normal control group were given 0.01ml/g normal saline by gavage, and the rats in the oxalis alis group were given 1ml/100g (1 g/kg) of Oxalis corniculata L warm water decoction by gavage once a day for 28 days. Twenty-four hours after the last administration, 10ml blood was collected from the abdominal aorta of the rats, and prostate tissue samples were collected from the rats. hematoxylin-eosin (HE) staining was used to observe the morphological structure of the prostate in normal and prostatitis rats. ELISA was used to detect the levels of serum and prostate cytokines. The protein expressions of 4-HNE , ALDH2 and FGF2 were detected by Western blot. Results: Compared with the blank group, the model group showed obvious hyperplasia of fibrous tissue in the interstitium of the prostate tissue, disordered glandular structure, papillary hyperplasia of epithelial cells in the acini, infiltration of a small amount of lymphocytes, monocytes and other inflammatory cells in the acini, and increased pathological scores. The protein expressions of 4-HNE , ALDH2 , MCP-1 and FGF2 in prostate tissue were significantly increased. Compared with the model group, the prostate tissue of the oxalis group was slightly damaged, with a small amount of fibrous hyperplasia and inflammatory cell infiltration. The protein expressions of 4-HNE , ALDH2 , MCP-1 and FGF2 were decreased in prostate tissue. Conclusion： Oxalis corniculata L can effectively repair the pathological morphology of prostate tissue in rats with CNP, and its mechanism may be related to activating 4-HNE protein and reducing oxidative stress injury of prostate tissue in rats.
MeSH term(s)	Male ; Humans ; Rats ; Animals ; Prostatitis/pathology ; Hyperplasia ; Oxalidaceae ; Ethnicity ; Fibroblast Growth Factor 2 ; Aldehyde Dehydrogenase, Mitochondrial
Chemical Substances	Fibroblast Growth Factor 2 (103107-01-3) ; ALDH2 protein, human (EC 1.2.1.3) ; Aldehyde Dehydrogenase, Mitochondrial (EC 1.2.1.3)
Language	Chinese
Publishing date	2024-04-19
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Zs.A 6577: Show issues

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Article ; Online: Study of the mechanism underlying the anti-inflammatory effect of Miao medicine comprising raw and processed Radix Wikstroemia indica using the "sweat soaking method".

Song, Xueli / Feng, Guo / Ren, Chenchen / Li, Wei / Liu, Wen / Liu, Gang / Zhang, Ju / Lei, Yan / He, Zhengyan / Han, Caiyao / Liu, Tingting / Ma, Kexin / Hou, Jinxin

Journal of ethnopharmacology

2024 Volume 324, Page(s) 117770

Abstract: ... mechanisms of the Miao medicine, both raw and after processing, using the "sweat soaking method" of Radix ... in the anti-inflammatory efficacy and mechanism of action before and after the processing of the Miao medicine (RWI) using ...

Abstract	Ethnopharmacological relevance: To explore the differences in the anti-inflammatory efficacy and mechanisms of the Miao medicine, both raw and after processing, using the "sweat soaking method" of Radix Wikstroemia indica (RWI). Aim of the study: The purpose of this study was to explore the differences in the anti-inflammatory efficacy and mechanism of action before and after the processing of the Miao medicine (RWI) using the "sweat soaking method." Materials and methods: Network pharmacology technology was used to construct the "drug-component target-pathway-disease" network, and the main anti-inflammatory pathways of RWI were identified. Rat models of collagen-induced arthritis were established. The changes in body weight, swelling rate of the foot pad and ankle joint, arthritis index, thymus index, spleen index, pathological changes of the ankle joint, and the content of inflammatory cytokines (IL-1β, IL-2, IL-6, IL-10, TNF-α, and NO) were used as indices to evaluate the effect of RWI on rats with collagen-induced arthritis before and after its processing. Plasma and urine samples were collected from the rats, and the potential biomarkers of, and metabolic pathways underlying the anti-inflammatory effects of RWI before and after processing were identified using Results: Eleven key anti-inflammatory targets of IL6, IL-1β, TNF, ALB, AKT1, IFNG, INS, STAT3, EGFR, TP53, and SRC were identified by network pharmacology. The PI3K-Akt signaling pathway, steroid hormone biosynthesis, arginine biosynthesis, arginine and proline metabolism, tryptophan metabolism, and other pathways were mainly involved in these effects. Pharmacodynamic studies found that both raw and processed RWI products downregulated inflammatory factors in rats with collagen-induced arthritis and alleviated the pathological changes. A total of 41 potential pathways for the anti-inflammatory effects of raw RWI products and 36 potential pathways for the anti-inflammatory effects of processed RWI products were identified by plasma and urine metabolomics. The common pathways of network pharmacology and metabolomics were steroid hormone biosynthesis, arginine biosynthesis, arginine and proline metabolism, and tryptophan metabolism. Conclusions: The anti-inflammatory effect of RWI was mainly related to the regulation of steroid hormone biosynthesis, arginine biosynthesis, arginine and proline metabolism, and tryptophan metabolism. Finally, the "sweat soaking method" enhanced the anti-inflammatory effect of RWI.
MeSH term(s)	Rats ; Animals ; Wikstroemia ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/pathology ; Sweat/chemistry ; Phosphatidylinositol 3-Kinases ; Tryptophan ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Drugs, Chinese Herbal/analysis ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Arginine ; Steroids ; Hormones ; Proline
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Tryptophan (8DUH1N11BX) ; Drugs, Chinese Herbal ; Anti-Inflammatory Agents ; Arginine (94ZLA3W45F) ; Steroids ; Hormones ; Proline (9DLQ4CIU6V)
Language	English
Publishing date	2024-01-14
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117770
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Zs.A 1494: Show issues

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Article ; Online: Analysis of Chemical Constituents of Miao Ethnomedicine Heiguteng Zhuifeng Huoluo Capsule (HZFC) and the Discovery of Active Substances in the Treatment of Rheumatoid Arthritis.

Mu, Kai-Lang / Li, Lei / Chen, Yun / Zhang, Min-Jie / He, Tian-Lin / Li, Kai-Min / Liu, Yu-Chen / Liu, Gang

ACS omega

2024 Volume 9, Issue 9, Page(s) 10860–10874

Abstract: In this study, the chemical substances of Heiguteng Zhuifeng Huoluo Capsule (HZFC) and its potential active ingredients for the treatment of rheumatoid arthritis (RA) were characterized and analyzed by medicinal chemistry combined with bioinformatics ... ...

Abstract	In this study, the chemical substances of Heiguteng Zhuifeng Huoluo Capsule (HZFC) and its potential active ingredients for the treatment of rheumatoid arthritis (RA) were characterized and analyzed by medicinal chemistry combined with bioinformatics methods. Also, the potential active ingredients of HZFC against RA were verified by lipopolysaccharide (LPS)-induced macrophage activation model. The results showed that 79 chemical constituents were successfully identified, mainly including phenylpropanoids, flavonoids, and alkaloids. Among them, 13 active components were closely related to the nine core targets (FASN, ALOX5, EGFR, MMP1, CYP2D6, CNR1, AR, MAOA, and FKBP5) of HZFC in the treatment of RA. Molecular docking further proved that 13 active components had strong docking activity with 9 core targets. In the verification experiment of the LPS-induced RAW 264.7 macrophage model, the verified components (magnoflorine,
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c09788
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Article ; Online: Exploring the effect of Er miao San-containing serum on macrophage polarization through miR-33/NLRP3 pathway.

Liu, Min / Wang, Jin / Chen, Simeng / Meng, Xiangwen / Cheng, Zhiluo / Wang, Jiayu / Tan, Yanan / Su, Wenrui / Lu, Zhiyuan / Zhang, Min / Jia, Xiaoyi

Journal of ethnopharmacology

2023 Volume 307, Page(s) 116178

Abstract: ... autoimmune disease. Er miao San (EMS) has been shown to have good anti-inflammatory effects and is widely used ...

Abstract	Headings ethnopharmacological relevance: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Er miao San (EMS) has been shown to have good anti-inflammatory effects and is widely used in the clinical treatment of RA. However, the exact mechanism is not completely understood. Aim of the study: The aim of this study was to explore that EMS-containing serum affects M1/M2 polarization of macrophages and may be mediated through the microRNA (miRNA)-33/NLRP3 pathway, thereby elucidating the molecular mechanism of EMS treatment of RA. Materials and methods: We screened for safe concentrations of EMS-containing serum by using CCK-8 measurement. RAW264.7 cells were cultured with lipopolysaccharide (LPS) (100 ng/mL) and interferon-γ (20 ng/mL) for 24 h to induce M1-type macrophages. Adenosine triphosphate (ATP) (5 mM) was added in the last 30 min to activate NLRP3. The content of miR-33 was detected by RT‒qPCR after transfection of the miRNA-33 mimic. The protein expression levels of NLRP3, ASC, caspase-1, Inducible Nitric Oxide Synthase (iNOS) and Arginase-1 (Arg-1) were detected by Western blot. The contents of IL-1β, IL-10, TNF-α, TGF-β and IL-18 in serum and cell supernatant were determined by ELISA. The fluorescence intensity of CD86 and CD206 was detected by immunofluorescence. Results: The results showed that EMS-containing serum promoted the protein expression level of Arg-1 and the secretion levels of TGF-β and IL-10, inhibited the levels of iNOS, IL-1β and TNF-α, and regulated the balance of pro-inflammatory factors and anti-inflammatory factors. RT‒qPCR results showed that EMS-containing serum could reduce the level of miRNA-33. EMS-containing serum could reduce the expression of NLRP3 inflammasome-related proteins and downregulate the expression levels of IL-1β and IL-18. These results suggest that EMS exerts its effect on macrophage polarization through the miRNA-33/NLRP3 pathway. Conclusion: EMS-containing serum inhibits the activation of the NLRP3 inflammasome by downregulating miRNA-33, thus preventing the polarization of M1-type macrophages.
MeSH term(s)	Humans ; Arthritis, Rheumatoid/metabolism ; Inflammasomes/metabolism ; Interleukin-10/metabolism ; Interleukin-18/metabolism ; Interleukin-18/pharmacology ; Lipopolysaccharides/pharmacology ; Macrophages ; MicroRNAs/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Transforming Growth Factor beta/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Drugs, Chinese Herbal
Chemical Substances	Inflammasomes ; Interleukin-10 (130068-27-8) ; Interleukin-18 ; Lipopolysaccharides ; MicroRNAs ; NLR Family, Pyrin Domain-Containing 3 Protein ; Transforming Growth Factor beta ; Tumor Necrosis Factor-alpha ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-01-26
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116178
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Zs.A 1494: Show issues

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Article ; Online: Correction for Miao et al., "Long-Term Compost Amendment Spurs Cellulose Decomposition by Driving Shifts in Fungal Community Composition and Promoting Fungal Diversity and Phylogenetic Relatedness".

Miao, Yuncai / Li, Junjie / Li, Ye / Niu, Yuhui / He, Tiehu / Liu, Deyan / Ding, Weixin

mBio

2022 Volume 13, Issue 6, Page(s) e0295622

Language	English
Publishing date	2022-11-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.02956-22
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Article: Miao sour soup influences serum lipid via regulation of high-fat diet-induced intestinal flora in obese rats.

Zhou, Qianqian / Qu, Zihan / Wang, Nanlan / Liu, Huijuan / Yang, Hongmei / Wang, Huiqun

Food science & nutrition

2022 Volume 11, Issue 5, Page(s) 2232–2242

Abstract: ... disturbances. Our previous studies have demonstrated that Miao sour soup (SS) contains abundant ...

Abstract	Obesity is associated with the gut microbiota and has been shown to cause gut microbiota disturbances. Our previous studies have demonstrated that Miao sour soup (SS) contains abundant short-chain fatty acids (SCFAs) which can be used as energy substrates of intestinal flora to selectively stimulate their growth and reproduction. Therefore, we explored whether the intestinal microbiota of rats with high-fat diet-induced obesity could be restored to normal by SS intervention. Male obese rats were divided into five groups randomly after successful modeling of obese rats: normal diet, high-fat diet (HDF), HFD + SS, HFD with antibiotic, and HFD with antibiotic + SS. After 12 weeks of intervention, the weight and serum lipid of obese rats decreased. Furthermore, 16S rRNA analysis showed an imbalance and a decrease in the abundance and diversity of intestinal flora in obese rats, which improved after SS intervention. At the phylum level, Firmicutes increased while Proteobacteria decreased. The composition of the intestinal flora recovered at the genus level, inhibiting the reproduction of pathogenic bacteria, while the levels of SCFA-producing bacteria such as
Language	English
Publishing date	2022-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.3136
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Article: [Genetic Analysis of Thalassemia in 22 940 Pregnant Women in Xiangxi Tujia and Miao Autonomous Prefecture].

Yu, Hui / Yang, Qing-Xiang / Liu, Chun / Peng, La-Ying / Zhou, Xiao-Bo / Shao, Lu / Huang, Nan

Zhongguo shi yan xue ye xue za zhi

2022 Volume 30, Issue 1, Page(s) 206–210

Abstract: Objective: To investigate the incidence and types of thalassemia in Xiangxi Tujia and Miao ... ethnicity, 2 821 cases of Miao ethnicity, and 2 233 cases of Han ethnicity included, whose ethnicity were ...

Abstract	Objective: To investigate the incidence and types of thalassemia in Xiangxi Tujia and Miao Autonomous Prefecture. Methods: Automatic capillary electrophoresis was used to screen the thalassemia phenotypes of 22 940 blood samples of pregnant women and puerperants collected in our hospital and some other medical institutions in the prefecture during 2017-2019, among which there were 3 356 cases of Tujia ethnicity, 2 821 cases of Miao ethnicity, and 2 233 cases of Han ethnicity included, whose ethnicity were indicated. The samples with positive result would undergo further genetic testing. Results: There were 2 314 cases of suspicious thalassemia were screened from 22 940 cases by the electrophoresis, thus the positive rate was 10.1% (hematological phenotypes from some other institutions were not included). Specifically, there were 1 706 cases with HBA Conclusion: The positive rate of thalassemia screening in Xiangxi Autonomous Prefecture is roughly the same as that in other regions of Hunan. The positive predictive value of β-thalassemia screening is as high as 86%. Compared with the missed screening data, it is recommended to use hematology (MCV, MCH) method combined with capillary hemoglobin electrophoresis for thalassemia screening.
MeSH term(s)	Ethnicity ; Female ; Genetic Testing ; Hemoglobin A2/analysis ; Humans ; Pregnancy ; Pregnant Women ; alpha-Thalassemia/genetics ; beta-Thalassemia/genetics
Chemical Substances	Hemoglobin A2 (9034-53-1)
Language	Chinese
Publishing date	2022-02-05
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2022.01.034
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Zs.A 6603: Show issues

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Article: Understanding of Diabetes in Tibetan, Mongolian, Miao, Dai, Uygur, and Yi Medicine and Collation of Prevention and Cure Medicines.

Shi, Yi / Zhou, Banghua / Yu, Liqiong / Liu, Yaqin / Han, Yunfeng / Tang, Xi / Lai, Xianrong

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 9308598

Abstract: ... and treatment of diabetes of Tibetan, Mongolian, Miao, Dai, Uygur, and Yi people by searching ...

Abstract	Diabetes seriously endangers human health and causes a huge economic burden. With the improvement of people's living standard, the prevalence of diabetes is getting higher and higher, and age is becoming younger. It is an increasingly serious global problem. Therefore, it is imperative to find the drugs to treat diabetes. Ethnic medicine is an important part of the world's medicinal treasure house and has its own unique system. This study systematically combined the theoretical understanding of the prevention and treatment of diabetes of Tibetan, Mongolian, Miao, Dai, Uygur, and Yi people by searching the existing literature studies published until 2021, library collection resources (related ethnic monographs, medical books, standards of medicinal materials, etc.), CNKI, PubMed, and other databases and collected and sorted the relevant medicines. A total of 112 kinds of ethnic medicines for the prevention and treatment of diabetes have been discovered, including plant medicines (105 kinds), animal medicines (6 kinds), and fungal medicines (1 kind). The composition of family and genus, medicinal parts, and life forms of medicinal plants were analyzed, and the number of drugs used in the prevention and treatment of diabetes in each ethnic group was statistically analyzed. The results showed that Rosaceae was at the top of the list, and the drugs used in underground parts accounted for 33.90% of the total, and the medicinal plants were mainly herbaceous, and the Mongolians have the largest number of diabetes medicines. In addition, CNKI, PubMed, and other databases selected "medicinal materials name," "diabetes," and "hypoglycemia" as keywords, the top 30 medicinal materials reported in existing literature were listed, and their Chinese name, the Latin name of the original plant, family and genus, nationality used, medicinal parts, and active ingredients related to the prevention and treatment of diabetes were introduced in detail. Among the 30 medicines, Astragalus membranaceus, Pueraria lobata, and Coptis chinensis are the most commonly used. Through literature research, this study summarized the existing theories of ethnic medicine for the prevention and treatment of diabetes, collected and sorted out ethnic medicine, clarified the potential mechanism of ethnic medicine, and provided effective data compilation. Ethnic medicine has a long history of treating diabetes, and there are abundant medicinal materials, to provide a new idea and basis for treating diabetes.
Language	English
Publishing date	2022-03-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9308598
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Zs.A 5995: Show issues

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Article ; Online: Effect of Er Miao San on peritoneal macrophage polarisation through the miRNA-33/NLRP3 signalling pathway in a rat model of adjuvant arthritis.

Liu, Min / Meng, Xiangwen / Xuan, Zihua / Chen, Simeng / Wang, Jin / Chen, Zhiluo / Wang, Jiayu / Jia, Xiaoyi

Pharmaceutical biology

2022 Volume 60, Issue 1, Page(s) 846–853

Abstract: Context: Er Miao San (EMS) is a formulation that contains : Objective: We investigated ...

Abstract	Context: Er Miao San (EMS) is a formulation that contains Objective: We investigated the mechanism of action and effects of EMS on peritoneal macrophage differentiation in a rat model of adjuvant arthritis (AA). Materials and methods: EMS (3, 1.5 and 0.75 g/kg; once daily) and methotrexate (0.5 mg/kg; once every 3 days) were administered orally from days 21 to 35 after immunisation. Paw swelling and arthritis index were measured; pathological changes in the ankle joint were observed using x-ray and haematoxylin eosin staining. The ratio of CD86/CD206 in macrophages was detected by flow cytometry. Examination of the miRNA-33/NLRP3 signalling pathway was examined by RT-qPCR and western blotting. The levels of cytokines in the serum and cell supernatants were tested by ELISA. Results: EMS significantly reduced the AA index in rats (from 11.0 to 9.3) and pathological changes in the ankle joint (from 3.8 to 1.4). The ratio of CD86/CD206 was reduced, and polarisation to M1 improved (from 0.9 to 0.6) in macrophages of EMS-treated rats. EMS downregulated the miRNA-33/NLRP3 pathway. Furthermore, EMS treatment increased IL-10 and TGF-β levels in the serum and supernatant of macrophages of AA rats and simultaneously decreased the levels of IL-1β and TNF-α. Discussion and conclusions: Our results suggest that EMS may reduce macrophage polarisation to the M1 inflammatory phenotype by downregulating the miRNA-33/NLRP3 pathway in AA rats. These findings may provide new insights into the treatment of RA.
MeSH term(s)	Animals ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/pathology ; Arthritis, Rheumatoid/pathology ; Macrophage Activation ; Macrophages, Peritoneal/metabolism ; MicroRNAs/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Rats
Chemical Substances	MIRN33 microRNA, rat ; MicroRNAs ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, rat
Language	English
Publishing date	2022-05-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2022.2066700
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Article ; Online: Evaluation of anthropometric indices as a predictor of diabetes in Dong and Miao ethnicities in China

Qianyuan Yang / Yalan Liu / Zhaofeng Jin / Leilei Liu / Zhiping Yuan / Degan Xu / Feng Hong

PLoS ONE, Vol 17, Iss

A cross-sectional analysis of China Multi-Ethnic Cohort Study

2022 Volume 3

Abstract: ... for predicting diabetes. Method In total, 11,035 Dong and Miao ethnic participants (age: 30–79 years ... Among Chinese Dong men and women and Miao men, WHR had the largest AUC (0.654/0.719/0.651). Among Miao women ... VAI had the largest AUC(0.701). The best cut-off values of WHR for Dong men and women and Miao men ...

Abstract	Background Although it is known that obesity is inseparable from diabetes, many anthropometric indices are used for determining obesity. At the same time, research on the predictive indices of diabetes in Chinese minority populations is lacking. Therefore, this study determines the relationship between different anthropometric indices and diabetes, and identifies the best index and best cut-off values for predicting diabetes. Method In total, 11,035 Dong and Miao ethnic participants (age: 30–79 years) from the China Multi-Ethnic Cohort study were included. The logistic regression model was used to examine the relationship between the different anthropometric indices and diabetes risk. The receiver operating characteristic curve and the area under the curve (AUC) were used to identify the best predictor of diabetes. Results In multivariate adjusted logistic regression models, body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), a body shape index (ABSI), body roundness index (BRI), and visceral adiposity index (VAI) were positively correlated with diabetes risk. Among Chinese Dong men and women and Miao men, WHR had the largest AUC (0.654/0.719/0.651). Among Miao women, VAI had the largest AUC(0.701). The best cut-off values of WHR for Dong men and women and Miao men were 0.94, 0.92, and 0.91, respectively. The best cut-off value of VAI for Miao women was 2.20. Conclusion Obesity indicators better predict diabetes in women than men. WHR may be the best predictor of diabetes risk in both sex of Dong ethnicity and Miao men, and VAI may be the best predictor of diabetes risk in Miao women.
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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