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  1. Book ; Conference proceedings: Symposium in Honor of the Memory of Francis P. Tally, MD

    Snydman, David R.

    held at Tufts Medical Center and Tufts University School of Medicine, 11 June 2007 [Boston, MA]

    (Clinical infectious diseases ; 50, Suppl. 1)

    2010  

    Event/congress Symposium in Honor of the Memory of Francis P. Tally, MD (2007, BostonMass.)
    Author's details guest ed.: David R. Snydman
    Series title Clinical infectious diseases ; 50, Suppl. 1
    Collection
    Language English
    Size S33 : Ill.
    Publisher Univ. of Chicago Press
    Publishing place Chicago, IL
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT016260781
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1505 -50,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Article: Comparative Effectiveness of Fidaxomicin vs Vancomycin in Populations With Immunocompromising Conditions for the Treatment of

    Alsoubani, Majd / Chow, Jennifer K / Rodday, Angie Mae / Kent, David / Snydman, David R

    Open forum infectious diseases

    2023  Volume 11, Issue 1, Page(s) ofad622

    Abstract: Background: Clostridioides difficile: Methods: This single-center retrospective study evaluated patients with CDI between 2011 and 2021. The primary outcome was a composite of clinical failure, relapse at 30 days, or CDI-related death. A ... ...

    Abstract Background: Clostridioides difficile
    Methods: This single-center retrospective study evaluated patients with CDI between 2011 and 2021. The primary outcome was a composite of clinical failure, relapse at 30 days, or CDI-related death. A multivariable cause-specific Cox proportional hazards model was used to test the relationship between treatment and the composite outcome, adjusting for confounders and treating death from other causes as a competing risk.
    Results: This study analyzed 238 patients who were immunocompromised and treated for CDI with oral fidaxomicin (n = 38) or vancomycin (n = 200). There were 42 composite outcomes: 4 (10.5%) in the fidaxomicin arm and 38 (19.0%) in the vancomycin arm. After adjustment for sex, number of antecedent antibiotics, CDI severity and type of immunosuppression, fidaxomicin use significantly decreased the risk of the composite outcome as compared with vancomycin (10.5% vs 19.0%; hazard ratio, 0.28; 95% CI, .08-.93). Furthermore, fidaxomicin was associated with 70% reduction in the combined risk of 30- and 90-day relapse following adjustment (hazard ratio, 0.27; 95% CI, .08-.91).
    Conclusions: The findings of this study suggest that the use of fidaxomicin for treatment of CDI reduces poor outcomes in patients who are immunocompromised.
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A Clinical Model to Predict the Occurrence of Select High-risk Infections in the First Year Following Heart Transplantation.

    Perry, Whitney A / Chow, Jennifer K / Nelson, Jason / Kent, David M / Snydman, David R

    Transplantation direct

    2023  Volume 9, Issue 12, Page(s) e1542

    Abstract: Background: Invasive infection remains a dangerous complication of heart transplantation (HT). No objectively defined set of clinical risk factors has been established to reliably predict infection in HT. The aim of this study was to develop a clinical ... ...

    Abstract Background: Invasive infection remains a dangerous complication of heart transplantation (HT). No objectively defined set of clinical risk factors has been established to reliably predict infection in HT. The aim of this study was to develop a clinical prediction model for use at 1 mo post-HT to predict serious infection by 1 y.
    Methods: A retrospective cohort study of HT recipients (2000-2018) was performed. The composite endpoint included cytomegalovirus (CMV), herpes simplex or varicella zoster virus infection, blood stream infection, invasive fungal, or nocardial infection occurring 1 mo to 1 y post-HT. A least absolute shrinkage and selection operator regression model was constructed using 10 candidate variables. A concordance statistic, calibration curve, and mean calibration error were calculated. A scoring system was derived for ease of clinical application.
    Results: Three hundred seventy-five patients were analyzed; 93 patients experienced an outcome event. All variables remained in the final model: aged 55 y or above, history of diabetes, need for renal replacement therapy in first month, CMV risk derived from donor and recipient serology, use of induction and/or early lymphodepleting therapy in the first month, use of trimethoprim-sulfamethoxazole prophylaxis at 1 mo, lymphocyte count under 0.75 × 10
    Conclusion: This model synthesizes multiple highly relevant clinical parameters, available at 1 mo post-HT, into a unified, objective, and clinically useful prediction tool for occurrence of serious infection by 1 y post-HT.
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000001542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Transplant infections

    Bowden, Raleigh A. / Ljungman, Per / Snydman, David R.

    2010  

    Author's details editors, Raleigh A. Bowden, Per Ljungman, David R. Snydman
    Keywords Transplants - adverse effects ; Bacterial infections - etiology ; Mycoses - etiology ; Virus diseases - etiology
    Language English
    Size 1 Online-Ressource
    Edition 3rd ed.
    Publisher Wolters Kluwer Health/Lippincott Williams & Wilkins
    Publishing place Philadelphia
    Document type Book ; Online
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-1-582-55820-2 ; 1-582-55820-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: In Vitro

    Snydman, David R / McDermott, Laura

    Microbiology spectrum

    2021  Volume 9, Issue 3, Page(s) e0190821

    Abstract: Aztreonam-avibactam is under clinical development for multidrug-resistant Gram-negative infections. We ... ...

    Abstract Aztreonam-avibactam is under clinical development for multidrug-resistant Gram-negative infections. We evaluated
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Azabicyclo Compounds/pharmacology ; Aztreonam/pharmacology ; Bacteria, Anaerobic/classification ; Bacteria, Anaerobic/drug effects ; Bacteria, Anaerobic/genetics ; Bacteria, Anaerobic/isolation & purification ; Bacterial Infections/microbiology ; Drug Evaluation, Preclinical ; Humans ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents ; Azabicyclo Compounds ; avibactam (7352665165) ; Aztreonam (G2B4VE5GH8)
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/Spectrum.01908-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Transplant infections

    Ljungman, Per / Snydman, David R. / Bowden, Raleigh A.

    2010  

    Author's details ed. Raleigh A. Bowden ; Per Ljungman ; David R. Snydman
    Keywords Transplants / adverse effects ; Virus Diseases / etiology ; Bacterial Infections / etiology ; Mycoses / etiology ; Communicable diseases ; Transplantation of organs, tissues, etc./Complications ; Nosocomial infections ; Transplantation ; Infektion
    Subject Ansteckung ; Erstinfektion ; Infektionen ; Verpflanzung ; Organtransplantation ; Organ ; Organverpflanzung
    Subject code 617.95
    Language English
    Size XII, 788 S. : Ill., graph. Darst.
    Edition 3. ed.
    Publisher Wolters Kluwer Lippincott Williams & Wilkins
    Publishing place Philadelphia, Pa. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016441627
    ISBN 978-1-58255-820-2 ; 1-58255-820-5
    Database Catalogue ZB MED Medicine, Health

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    2010 A 3636 order for loan Magazin

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  7. Article ; Online: Difference in absolute lymphocyte count among male and female heart transplant recipients.

    Perry, Whitney A / Chow, Jennifer K / Snydman, David R

    Clinical transplantation

    2021  Volume 35, Issue 9, Page(s) e14412

    Abstract: The impact of sex on immune composition in the setting of solid organ transplantation is unknown. Immunocompetent men and women have quantitative differences in multiple markers of immunity, including lymphocyte subsets. Lymphocytes are of particular ... ...

    Abstract The impact of sex on immune composition in the setting of solid organ transplantation is unknown. Immunocompetent men and women have quantitative differences in multiple markers of immunity, including lymphocyte subsets. Lymphocytes are of particular interest given the routine use of medications targeted at cell-mediated immunity. The objective of this retrospective cohort study was to compare absolute lymphocyte count (ALC) measurements of male and female heart recipients immediately before, and 1 month after, transplantation. Data was collected on 375 adult recipients (104 female and 271 male) from 2000 to 2018 at a single center. Mean ALC was compared using Student's t-test. Women had higher mean ALC both at baseline (female 1.6 × 10
    MeSH term(s) Female ; Heart Transplantation ; Humans ; Lymphocyte Count ; Lymphocytes ; Male ; Organ Transplantation ; Retrospective Studies
    Language English
    Publishing date 2021-07-19
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.14412
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    Zs.A 2204: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Sex- and age-based comparison of serum immunoglobulins following liver transplantation.

    Perry, Whitney A / Martino, Audrey E A / Garcia, Marta Rodriguez / Chow, Jennifer K / Snydman, David R

    Transplant immunology

    2023  Volume 78, Page(s) 101826

    Abstract: Background: Over a quarter of organ transplant recipients have low immunoglobulin levels in their early post-transplant course, which is associated with increased risk of infection and mortality. Although immunoglobulin level varies by sex among healthy ...

    Abstract Background: Over a quarter of organ transplant recipients have low immunoglobulin levels in their early post-transplant course, which is associated with increased risk of infection and mortality. Although immunoglobulin level varies by sex among healthy individuals, it is unknown how such differences are affected by transplant-related immunosuppression. This study compared post-liver transplant immunoglobulin G (IgG) between sexes at varying ages.
    Methods: Serum specimens from a prospective cohort of 130 liver transplant recipients were analyzed. IgG was measured at time of transplant and from one-month post-transplant samples. Post-transplant IgG was compared between sexes using multivariable linear regression. Four age and sex categories were created (women<50, women≥50, men<50, men≥50) and the model repeated with this as the explanatory variable. The relationship between sex hormone concentrations and post-transplant IgG was also explored. Infection type and incidence were examined within groups.
    Results: The cohort included 99 men, 31 women (mean age 53). In adjusted linear regression, post-transplant IgG was not significantly different by sex (p = 0.92). However, when broken into four categories by age and sex, the contrast in IgG levels between younger versus older patients was strikingly greater among women than among men. An interaction term including age and sex was statistically significant (p = 0.03). The combined age-sex categorical variable was also significantly associated with post-transplant IgG (p = 0.01). Finally, an association was identified between baseline estradiol level and post-transplant change in IgG (p = 0.04).
    Conclusions: Sex and age have an important relationship with post-transplant IgG with older women demonstrating lowest concentrations. Immunoglobulin levels have previously demonstrated association with post-transplant outcomes.
    MeSH term(s) Male ; Humans ; Female ; Aged ; Middle Aged ; Liver Transplantation ; Prospective Studies ; Immunoglobulin G ; Immunosuppression Therapy
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2023-03-17
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1160846-8
    ISSN 1878-5492 ; 0966-3274
    ISSN (online) 1878-5492
    ISSN 0966-3274
    DOI 10.1016/j.trim.2023.101826
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    Zs.A 3784: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Diagnosis and management of diarrhea in solid-organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

    Angarone, Michael / Snydman, David R

    Clinical transplantation

    2019  Volume 33, Issue 9, Page(s) e13550

    Abstract: These guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of diarrhea in the pre- and post-transplant period. Diarrhea in an organ transplant recipient ... ...

    Abstract These guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of diarrhea in the pre- and post-transplant period. Diarrhea in an organ transplant recipient may result in significant morbidity including dehydration, increased toxicity of medications, and rejection. Transplant recipients are affected by a wide range of etiologies of diarrhea with the most common causes being Clostridioides (formerly Clostridium) difficile infection, cytomegalovirus, and norovirus. Other bacterial, viral, and parasitic causes can result in diarrhea but are far less common. Further, noninfectious causes including medication toxicity, inflammatory bowel disease, post-transplant lymphoproliferative disease, and malignancy can also result in diarrhea in the transplant population. Management of diarrhea in this population is directed at the cause of the diarrhea, instituting therapy where appropriate and maintaining proper hydration. Identification of the cause to the diarrhea needs to be timely and focused.
    MeSH term(s) Communicable Diseases/epidemiology ; Diarrhea/diagnosis ; Diarrhea/etiology ; Diarrhea/therapy ; Humans ; Organ Transplantation/adverse effects ; Practice Guidelines as Topic/standards ; Societies, Medical
    Language English
    Publishing date 2019-04-10
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.13550
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    Zs.A 2204: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Editorial commentary: the complexity of latent cytomegalovirus infection in stem cell donors.

    Snydman, David R

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2014  Volume 59, Issue 4, Page(s) 482–483

    MeSH term(s) Cytomegalovirus Infections/immunology ; Female ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Male ; Tissue Donors ; Transplantation, Homologous/adverse effects
    Language English
    Publishing date 2014-08-15
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciu369
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 480: Show issues

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