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  1. Article ; Online: A rare vascular injury in a blood donor after whole blood donation.

    Scuracchio, Patricia / Achkar, Ruth / Dias, Lara / Oliveira, Melina / Casella, Ivan / Presti, Calogero / Fachini, Roberta / Wendel, Silvano

    Transfusion

    2024  Volume 64, Issue 3, Page(s) 546–549

    Abstract: Background: Blood donation is a safe process though reactions may still occur. We describe a rare vascular complication in a frequent donor, with improvements in the collection process aimed at avoiding future events.: Methods: A 63-year-old woman ... ...

    Abstract Background: Blood donation is a safe process though reactions may still occur. We describe a rare vascular complication in a frequent donor, with improvements in the collection process aimed at avoiding future events.
    Methods: A 63-year-old woman presented with local pain and an apparent collection in the left arm 8 days after donation. Duplex ultrasound identified a superficial liquid collection and signs of arteriovenous fistula (AVF) between the cubital vein and an arterial branch. A computed tomography (CT)-angio performed 1 day after ultrasound did not identify signs of AVF, followed by a new duplex which confirmed CT-angio findings. It was assumed that a traumatic AVF evolved with spontaneous thrombosis. In the early follow-up (18 days), a progressive regression of hematoma was observed without any sequelae.
    Results: Investigation showed a faster whole blood bag collection time (3 min; normal: 5-9 min), and the processed packed red blood cell had a brighter red color than usual. The donor reported local bleeding after needle withdrawal, not observed in previous donations and a bruise forming on the same day. No arterial puncture (AP) was noticed by the collection staff during the procedure. The staff was retrained and actions were taken focusing on more active surveillance of late reactions, highlighting the importance of post-donation information by the donors, regardless of any adverse reaction observed, to detect late complications.
    Conclusion: We described an uncommon AP in a donor that was not identified, leading to an AVF that spontaneously thrombosed.
    MeSH term(s) Female ; Humans ; Middle Aged ; Blood Donors ; Blood Donation ; Vascular System Injuries ; Blood Component Removal ; Punctures
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Case Reports
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Filariasis and transfusion-associated risk: a literature review.

    Drews, Steven J / Spencer, Bryan R / Wendel, Silvano / Bloch, Evan M

    Vox sanguinis

    2021  Volume 116, Issue 7, Page(s) 741–754

    Abstract: Background and objectives: Filariae are parasitic worms that include the pathogens Loa loa, Onchocerca volvulus, Wuchereria bancrofti, Brugia spp. and Mansonella spp. which are endemic in parts of Africa, Asia, Asia-Pacific, South and Central America. ... ...

    Abstract Background and objectives: Filariae are parasitic worms that include the pathogens Loa loa, Onchocerca volvulus, Wuchereria bancrofti, Brugia spp. and Mansonella spp. which are endemic in parts of Africa, Asia, Asia-Pacific, South and Central America. Filariae have a wide clinical spectrum spanning asymptomatic infection to chronic debilitating disease including blindness and lymphedema. Despite successful eradication programmes, filarial infections remain an important -albeit neglected - source of morbidity. We sought to characterize the risk of transfusion transmission of microfilaria with a view to guide mitigation practices in both endemic and non-endemic countries.
    Materials and methods: A scoping review of scientific publications as well as grey literature was carried out by a group of domain experts in microbiology, transfusion medicine and infectious diseases, representing the parasite subgroup of the International Society of Blood Transfusion.
    Results: Cases of transfusion-transmitted filariasis are rare and confined to case reports of variable quality. Transfusion-associated adverse events related to microfilariae are confined to isolated reports of transfusion reactions. Serious outcomes have not been reported. No known strategies have been implemented, specifically, to mitigate transfusion-transmitted filariasis yet routine blood donor screening for other transfusion-transmissible infections (e.g. hepatitis B, malaria) may indirectly defer donors with microfilaremia in endemic areas.
    Conclusion: Rare examples of transfusion-transmitted filariasis, without serious clinical effect, suggest that filariasis poses low transfusion risk. Dedicated mitigation strategies against filarial transfusion transmission are not recommended. Given endemicity in low-resource regions, priority should be on the control of filariasis with public health measures.
    MeSH term(s) Animals ; Blood Transfusion ; Filariasis/epidemiology ; Filariasis/prevention & control ; Loa ; Transfusion Reaction ; Wuchereria bancrofti
    Language English
    Publishing date 2021-01-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A review and analysis of outcomes in randomized clinical trials of plasma transfusion in patients with bleeding or for the prevention of bleeding: The BEST collaborative study.

    Apelseth, Torunn O / Raza, Sheharyar / Callum, Jeannie / Ipe, Tina / Blackwood, Bronagh / Akhtar, Adeel / Hess, John R / Marks, Denese C / Brown, Bethany / Delaney, Meghan / Wendel, Silvano / Stanworth, Simon J

    Transfusion

    2024  

    Abstract: Background: Previous systematic reviews have revealed an inconsistency of outcome definitions as a major barrier in providing evidence-based guidance for the use of plasma transfusion to prevent or treat bleeding. We reviewed and analyzed outcomes in ... ...

    Abstract Background: Previous systematic reviews have revealed an inconsistency of outcome definitions as a major barrier in providing evidence-based guidance for the use of plasma transfusion to prevent or treat bleeding. We reviewed and analyzed outcomes in randomized controlled trials (RCTs) to provide a methodology for describing and classifying outcomes.
    Study design and methods: RCTs involving transfusion of plasma published after 2000 were identified from a prior review (Yang 2012) and combined with an updated systematic literature search of multiple databases (July 1, 2011 to January 17, 2023). Inclusion of publications, data extraction, and risk of bias assessments were performed in duplicate. (PROSPERO registration number is: CRD42020158581).
    Results: In total, 5579 citations were identified in the new systematic search and 22 were included. Six additional trials were identified from the previous review, resulting in a total of 28 trials: 23 therapeutic and five prophylactic studies. An increasing number of studies in the setting of major bleeding such as in cardiovascular surgery and trauma were identified. Eighty-seven outcomes were reported with a mean of 11 (min-max. 4-32) per study. There was substantial variation in outcomes used with a preponderance of surrogate measures for clinical effect such as laboratory parameters and blood usage.
    Conclusion: There is an expanding literature on plasma transfusion to inform guidelines. However, considerable heterogeneity of reported outcomes constrains comparisons. A core outcome set should be developed for plasma transfusion studies. Standardization of outcomes will motivate better study design, facilitate comparison, and improve clinical relevance for future trials of plasma transfusion.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Advances in transfusion safety.

    Wendel, Silvano

    Biologicals : journal of the International Association of Biological Standardization

    2009  Volume 37, Issue 2, Page(s) 61

    MeSH term(s) Blood Transfusion/standards ; Blood Transfusion/trends ; Humans ; Peer Review, Research/trends ; Safety ; Transfusion Reaction
    Language English
    Publishing date 2009-04
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1017370-5
    ISSN 1095-8320 ; 1045-1056
    ISSN (online) 1095-8320
    ISSN 1045-1056
    DOI 10.1016/j.biologicals.2009.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Plasma-based COVID-19 treatments in low-and middle-income countries and the risk of transfusion-transmitted infections.

    Epstein, Jay / Martin Smid, W / Wendel, Silvano / Somuah, Daniel / Burnouf, Thierry

    NPJ vaccines

    2020  Volume 5, Issue 1, Page(s) 103

    Language English
    Publishing date 2020-11-03
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-020-00256-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Use of COVID-19 convalescent plasma in low- and middle-income countries: a call for ethical principles and the assurance of quality and safety.

    Epstein, Jay / Smid, W Martin / Wendel, Silvano / Somuah, Daniel / Burnouf, Thierry

    Vox sanguinis

    2020  Volume 116, Issue 1, Page(s) 13–14

    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.12964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Transfusion transmitted Chagas disease: is it really under control?

    Wendel, Silvano

    Acta tropica

    2010  Volume 115, Issue 1-2, Page(s) 28–34

    Abstract: Transfusion transmitted Chagas disease was recognized as a medical problem more than 50 years ago. However, little attention was paid to it by Transfusion Medicine, medical authorities or regulatory agencies as a major problem and threat (especially ... ...

    Abstract Transfusion transmitted Chagas disease was recognized as a medical problem more than 50 years ago. However, little attention was paid to it by Transfusion Medicine, medical authorities or regulatory agencies as a major problem and threat (especially after the advent of HIV/AIDS); perhaps because it was mainly restricted to tropical regions, usually in less developed countries. With the intense human migratory movement from developing to developed countries, it became more common and evident. The scope of this review is to cover the main transfusional aspects of American trypanosomiasis (Chagas disease), including the main strategies to prevent it through donor questionnaires, specific serological testing and alternative methods such as leukofiltration and pathogen reduction procedures, in order to increase the blood safety in both developing and developed countries.
    MeSH term(s) Blood/parasitology ; Chagas Disease/diagnosis ; Chagas Disease/epidemiology ; Chagas Disease/transmission ; Communicable Disease Control/methods ; Developed Countries ; Emigration and Immigration ; Humans ; Mass Screening/methods ; Serologic Tests ; Surveys and Questionnaires ; Transfusion Reaction
    Language English
    Publishing date 2010-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 210415-5
    ISSN 1873-6254 ; 0001-706X
    ISSN (online) 1873-6254
    ISSN 0001-706X
    DOI 10.1016/j.actatropica.2009.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Climate change and parasitic risk to the blood supply.

    Drews, Steven J / Wendel, Silvano / Leiby, David A / Tonnetti, Laura / Ushiro-Lumb, Ines / O'Brien, Sheila F / Lieshout-Krikke, Ryanne W / Bloch, Evan M

    Transfusion

    2022  Volume 63, Issue 3, Page(s) 638–645

    MeSH term(s) Animals ; Humans ; Climate Change ; Parasites
    Language English
    Publishing date 2022-12-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian Hospital.

    Fachini, Roberta Maria / Fontão-Wendel, Rita / Achkar, Ruth / Scuracchio, Patrícia / Brito, Mayra / Amaral, Marcelo / Wendel, Silvano

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 11

    Abstract: 1) Background: We reviewed the logistics of the implementation of pathogen reduction (PR) using the INTERCEPT Blood System™ for platelets and the experience with routine use and clinical outcomes in the patient population at the Sírio-Libanês Hospital ... ...

    Abstract (1) Background: We reviewed the logistics of the implementation of pathogen reduction (PR) using the INTERCEPT Blood System™ for platelets and the experience with routine use and clinical outcomes in the patient population at the Sírio-Libanês Hospital of São Paulo, Brazil. (2) Methods: Platelet concentrate (PC), including pathogen reduced (PR-PC) production, inventory management, discard rates, blood utilization, and clinical outcomes were analyzed over the 40 months before and after PR implementation. Age distribution and wastage rates were compared over the 10 months before and after approval for PR-PC to be stored for up to seven days. (3) Results: A 100% PR-PC inventory was achieved by increasing double apheresis collections and production of double doses using pools of two single apheresis units. Discard rates decreased from 6% to 3% after PR implementation and further decreased to 1.2% after seven-day storage extension for PR-PCs. The blood utilization remained stable, with no increase in component utilization. A significant decrease in adverse transfusion events was observed after the PR implementation. (4) Conclusion: Our experience demonstrates the feasibility for Brazilian blood centers to achieve a 100% PR-PC inventory. All patients at our hospital received PR-PC and showed no increase in blood component utilization and decreased rates of adverse transfusion reactions.
    Language English
    Publishing date 2021-11-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10111499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Plasma-based COVID-19 treatments in low-and middle-income countries and the risk of transfusion-transmitted infections

    Jay Epstein / W. Martin Smid / Silvano Wendel / Daniel Somuah / Thierry Burnouf

    npj Vaccines, Vol 5, Iss 1, Pp 1-

    2020  Volume 2

    Abstract: Ethical principles should prevail in the collection, testing and use of COVID-19 convalescent plasma (CCP) for human research in low- and middle- income countries. To appropriately guarantee safety, only blood establishments that comply with recognized ... ...

    Abstract Ethical principles should prevail in the collection, testing and use of COVID-19 convalescent plasma (CCP) for human research in low- and middle- income countries. To appropriately guarantee safety, only blood establishments that comply with recognized quality standards should collect CCP.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; covid19
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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