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  1. Article ; Online: Let COVID-19 expand awareness of disability tech.

    Shew, Ashley

    Nature

    2020  Volume 581, Issue 7806, Page(s) 9

    MeSH term(s) Amputees ; COVID-19 ; Coronavirus Infections/epidemiology ; Disabled Persons/psychology ; Education, Distance/methods ; Efficiency ; Food Supply/methods ; Humans ; Pandemics ; Persons With Hearing Impairments ; Pharmacy/methods ; Pneumonia, Viral/epidemiology ; Research Personnel/psychology ; Restaurants/organization & administration ; Telemedicine/methods ; Videoconferencing
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-01312-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)
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    Zs.MO 244: Show issues

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  2. Article ; Online: Review of Fables and Futures

    Ashley Shew

    Disability Studies Quarterly, Vol 40, Iss

    Biotechnology, Disability, and the Stories We Tell Ourselves by George Estreich

    2020  Volume 1

    Abstract: No abstract available. ...

    Abstract No abstract available.
    Keywords Social Sciences ; H
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher The Ohio State University Libraries
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Let COVID-19 expand awareness of disability tech

    Shew, Ashley

    Nature

    2020  Volume 581, Issue 7806, Page(s) 9–9

    Keywords Multidisciplinary ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-01312-w
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  5. Article ; Online: From a figment of your imagination

    Shew, Ashley

    Human Affairs

    Disabled marginal cases and underthought experiments

    2020  Volume 30, Issue 4, Page(s) 608–616

    Abstract: Abstract Philosophers often enroll disabled bodies and minds as objects of thought in their arguments from marginal cases and in thought experiments: for example, arguments for animal ethics use cognitively disabled people as a contrast case, and Merleau- ...

    Abstract Abstract Philosophers often enroll disabled bodies and minds as objects of thought in their arguments from marginal cases and in thought experiments: for example, arguments for animal ethics use cognitively disabled people as a contrast case, and Merleau-Ponty uses a blind man with a cane as an exemplar of the relationship of technology to the human, of how technology mediates. However, these philosophers enroll disabled people without engaging significantly in any way with disabled people themselves. Instead, disabled people are treated in philosophy as literal objects—and in many cases, as less than human. (This sense of a categorical difference between disabled and nondisabled people is becoming especially clear during the Covid-19 pandemic, as I write this article.) Philosophical reflection thus makes assumptions—often wrong—about disabled people’s lives, experiences, and relationships to technology. Outside of philosophy as well as in, disabled people are not regarded as experts about our own experiences and lives; our testimony is paternalistically written over. We need better consideration of disabled people as people as we consider the future. Lack of disabled people’s points of view in philosophy colors—and sometimes invalidates—views of technological change.
    Keywords Philosophy ; Sociology and Political Science ; Law ; covid19
    Publisher Walter de Gruyter GmbH
    Publishing country de
    Document type Article ; Online
    ZDB-ID 2172795-8
    ISSN 1337-401X ; 1210-3055
    ISSN (online) 1337-401X
    ISSN 1210-3055
    DOI 10.1515/humaff-2020-0054
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Single-cell strand sequencing of a macaque genome reveals multiple nested inversions and breakpoint reuse during primate evolution.

    Maggiolini, Flavia Angela Maria / Sanders, Ashley D / Shew, Colin James / Sulovari, Arvis / Mao, Yafei / Puig, Marta / Catacchio, Claudia Rita / Dellino, Maria / Palmisano, Donato / Mercuri, Ludovica / Bitonto, Miriana / Porubský, David / Cáceres, Mario / Eichler, Evan E / Ventura, Mario / Dennis, Megan Y / Korbel, Jan O / Antonacci, Francesca

    Genome research

    2020  Volume 30, Issue 11, Page(s) 1680–1693

    Abstract: Rhesus macaque is an Old World monkey that shared a common ancestor with human ∼25 Myr ago and is an important animal model for human disease studies. A deep understanding of its genetics is therefore required for both biomedical and evolutionary studies. ...

    Abstract Rhesus macaque is an Old World monkey that shared a common ancestor with human ∼25 Myr ago and is an important animal model for human disease studies. A deep understanding of its genetics is therefore required for both biomedical and evolutionary studies. Among structural variants, inversions represent a driving force in speciation and play an important role in disease predisposition. Here we generated a genome-wide map of inversions between human and macaque, combining single-cell strand sequencing with cytogenetics. We identified 375 total inversions between 859 bp and 92 Mbp, increasing by eightfold the number of previously reported inversions. Among these, 19 inversions flanked by segmental duplications overlap with recurrent copy number variants associated with neurocognitive disorders. Evolutionary analyses show that in 17 out of 19 cases, the Hominidae orientation of these disease-associated regions is always derived. This suggests that duplicated sequences likely played a fundamental role in generating inversions in humans and great apes, creating architectures that nowadays predispose these regions to disease-associated genetic instability. Finally, we identified 861 genes mapping at 156 inversions breakpoints, with some showing evidence of differential expression in human and macaque cell lines, thus highlighting candidates that might have contributed to the evolution of species-specific features. This study depicts the most accurate fine-scale map of inversions between human and macaque using a two-pronged integrative approach, such as single-cell strand sequencing and cytogenetics, and represents a valuable resource toward understanding of the biology and evolution of primate species.
    MeSH term(s) Animals ; Chromosome Breakpoints ; Chromosome Inversion ; Disease/genetics ; Evolution, Molecular ; Gene Expression Regulation ; Genome ; Genomics ; Heterozygote ; Humans ; In Situ Hybridization, Fluorescence ; Macaca mulatta/genetics ; Recombination, Genetic ; Sequence Analysis, DNA ; Single-Cell Analysis
    Language English
    Publishing date 2020-10-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1284872-4
    ISSN 1549-5469 ; 1088-9051 ; 1054-9803
    ISSN (online) 1549-5469
    ISSN 1088-9051 ; 1054-9803
    DOI 10.1101/gr.265322.120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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