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  1. Book: Basics Arbeitstechniken Chirurgie

    Koeppen, Piet / Sterk, Peter J. W.

    (Basics)

    2009  

    Title variant Arbeitstechniken Chirurgie
    Author's details P. Koeppen ; P. Sterk
    Series title Basics
    Keywords Operationstechnik
    Subject Operative Technik ; Chirurgisches Verfahren ; Operationsverfahren
    Language German
    Size VII, 135 S. : Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher Elsevier, Urban & Fischer
    Publishing place München
    Publishing country Germany
    Document type Book
    HBZ-ID HT015903945
    ISBN 978-3-437-42431-1 ; 3-437-42431-9
    Database Catalogue ZB MED Medicine, Health

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  2. Book: An atlas of induced sputum

    Djukanović, Ratko / Sterk, Peter J. W.

    an aid for research and diagnosis

    (The encyclopedia of visual medicine series)

    2004  

    Title variant Induced sputum
    Author's details Ratko Djukanovíc and Peter Sterk
    Series title The encyclopedia of visual medicine series
    Keywords Sputum / cytology ; Lung Diseases / diagnosis ; Sputum/Examination ; Sputum ; Atlas
    Subject Weltatlas ; Bildatlas ; Topographischer Atlas ; Topografischer Atlas ; Atlanten ; Auswurf
    Subject code 612.313
    Language English
    Size 135 S. : Ill., graph. Darst.
    Publisher Parthenon Publ. Group
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013818201
    ISBN 1-84214-005-1 ; 978-1-84214-005-5
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Thesis: The carrot extracellular lipid transfer protein EP2

    Sterk, Peter J. W.

    1994  

    Author's details Peter Sterk
    Keywords Kartoffel ; Pflanzenvermehrung ; Somatische Embryogenese ; Extrazellulärraum ; Pflanzliche Proteine
    Subject Extrazellularraum ; EZR ; Extrazelluläres Vorkommen ; Embryoidbildung ; Erdapfel ; Solanum tuberosum ; Kartoffelpflanze ; Kartoffeln ; Erdäpfel ; Erdbirne ; Grundbirne ; Bramburi
    Size 117 S. : Ill., graph. Darst.
    Publishing country Netherlands
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Wageningen, Landbouwuniv., Diss., 1994
    Note Zsfassung in niederländ. Sprache
    Remark AY 17141 ; Abt. Nussallee/Bereichsbibl. ZBMed: AY 17141
    HBZ-ID HT006550596
    ISBN 90-5485-329-8 ; 978-90-5485-329-9
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  4. Book ; Thesis: SCE-Rate in stimulierten B- und T-Lymphozyten der Maus als Ausdruck der Toxizität des Benzols

    Sterk, Peter J. W.

    1990  

    Author's details vorgelegt von Peter J. W. Sterk
    Size 2 Mikrofiches : 24x
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Ulm, Univ., Diss., 1990
    Note Mikroreprod. e. Ms.: 77 Bl. : Ill., graph. Darst.
    HBZ-ID HT004196965
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Lead Optimization of the 5-Phenylpyrazolopyrimidinone NPD-2975 toward Compounds with Improved Antitrypanosomal Efficacy.

    Zheng, Yang / van den Kerkhof, Magali / Ibrahim, Mohamed / De Esch, Iwan J P / Maes, Louis / Sterk, Geert Jan / Caljon, Guy / Leurs, Rob

    Journal of medicinal chemistry

    2024  Volume 67, Issue 4, Page(s) 2849–2863

    Abstract: Human African trypanosomiasis (HAT) still faces few therapeutic options and emerging drug resistance, stressing an urgency for novel antitrypanosomal drug discovery. Here, we describe lead optimization efforts aiming at improving antitrypanosomal ... ...

    Abstract Human African trypanosomiasis (HAT) still faces few therapeutic options and emerging drug resistance, stressing an urgency for novel antitrypanosomal drug discovery. Here, we describe lead optimization efforts aiming at improving antitrypanosomal efficacy and better physicochemical properties based on our previously reported optimized hit NPD-2975 (pIC
    MeSH term(s) Animals ; Mice ; Humans ; Trypanocidal Agents/pharmacology ; Trypanocidal Agents/therapeutic use ; Trypanosomiasis, African/drug therapy ; Antiprotozoal Agents/therapeutic use ; Trypanosoma brucei brucei ; Drug Development
    Chemical Substances Trypanocidal Agents ; Antiprotozoal Agents
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c01976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: From lab to field

    Sterk, Guido / Hanegraaf, Janna / Persigehl, Markus / Rossbach, Andrea / Kolokytha, Paraskevi

    a solid methodology for Bombus terrestris dalmatinus side effect studies

    2023  

    Abstract: A solid methodology for trials testing the side effects of PPPs on the large earth bumblebee, Bombus terrestris dalmatinus, from the laboratory to large-scale field studies is presented with a stepwise approach. The study designs may serve various ... ...

    Abstract A solid methodology for trials testing the side effects of PPPs on the large earth bumblebee, Bombus terrestris dalmatinus, from the laboratory to large-scale field studies is presented with a stepwise approach. The study designs may serve various purposes, such as practical help regarding commercial pollination, safeguarding biodiversity or for risk assessments in the registration process under GLP. In order to achieve high uniformity between bumblebee colonies, specially standardized R&D colonies (IPM Impact-Koppert) are used and adapted to the different test designs. The initial step is the study under laboratory conditions, through simulating the three possible means of bumblebee exposure to the compound: acute contact, oral by sugar water and/or by pollen. The products are mainly tested according to the maximum field recommended concentration (MFRC), but a sequential dilution testing scheme may be applied to the oral sugar water exposure, if triggered. In the next step, simulating a more field-realistic but still controlled exposure scenario, R&D colonies can be tested under semi-field conditions in a tunnel set-up. The test design can be customised according to the specific requirements. The final step, if needed, is to monitor bumblebees in a field study where colonies are exposed to the product in a common agricultural landscape. In all study types, the following assessment parameters are recorded at regular intervals during the experimental phase: the presence/vitality of the mother queen, colony strength, colony weight, brood volume, the number of queen-brood cells, and the number of newly-formed queens (gynes). In a final assessment of the colonies, the reproduction rate of the control and treated colonies expressed as number of newly formed queens and, if possible, drones and the colony strength as the number of worker bees is compared at the end of the experiment. In conclusion, an extrapolation of study results to commercial colonies used in practice for pollination and/or to natural ...
    Keywords Text ; abstract_or_summary ; ddc:630 ; Bombus terrestris dalmatinus -- methodology -- laboratory studies -- semi-field studies -- largescale studies
    Subject code 600
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book: Chirurgisches 1x1

    Kirk, Raymond M. / Koeppen, Piet / Sterk, Peter J. W.

    Arbeitstechniken für die operativen Fachgebiete

    2006  

    Title translation Basic surgical techniques
    Author's details P. Koeppen ; P. Sterk. Nach der englischen Vorlage von R. M. Kirk
    Keywords Operationstechnik
    Subject Operative Technik ; Chirurgisches Verfahren ; Operationsverfahren
    Language German
    Size VIII, 260 S. : zahlr. Ill., 240 mm x 170 mm
    Edition 1. Aufl.
    Publisher Elsevier, Urban & Fischer
    Publishing place München u.a.
    Publishing country Germany
    Document type Book
    Note Aus dem Engl. übers. ; Ausg. der engl. Vorl.: 5. ed., 2002
    HBZ-ID HT014496905
    ISBN 3-437-41142-X ; 978-3-437-41142-7
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: Desertification—Scientific Versus Political Realities

    Geert Sterk / Jetse J. Stoorvogel

    Land, Vol 9, Iss 156, p

    2020  Volume 156

    Abstract: Desertification is defined as land degradation occurring in the global drylands. It is one of the global problems targeted under the Sustainable Development Goals (SDG 15). The aim of this article is to review the history of desertification and to ... ...

    Abstract Desertification is defined as land degradation occurring in the global drylands. It is one of the global problems targeted under the Sustainable Development Goals (SDG 15). The aim of this article is to review the history of desertification and to evaluate the scientific evidence for desertification spread and severity. First quantitative estimates of the global extent and severity of desertification were dramatic and resulted in the establishment of the UN Convention to Combat Desertification (UNCCD) in 1994. UNCCD’s task is to mitigate the negative impacts of desertification in drylands. Since the late 1990s, science has become increasingly critical towards the role of desertification in sustainable land use and food production. Many of the dramatic global assessments of desertification in the 1970s and 1980s were heavily criticized by scientists working in drylands. The used methodologies and the lack of ground-based evidence gave rise to critical reflections on desertification. Some even called desertification a myth. Later desertification assessments relied on remote sensing imagery and mapped vegetation changes in drylands. No examples of large areas completely degraded were found in the scientific literature. In science, desertification is now perceived as a local feature that certainly exists but is not as devastating as was earlier believed. However, the policy arena continues to stress the severity of the problem. Claims that millions of hectares of once productive land are annually lost due to desertification are regularly made. This highlights the disconnection between science and policy, and there is an urgent need for better dialogue in order to achieve SDG 15.
    Keywords desertification ; land degradation ; global assessment ; drylands ; Sahel ; Agriculture ; S
    Subject code 710
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: 4-acetaminophen (Paracetamol) levels in treated and untreated veal calves, an update

    Groot, M.J. / van Dijk, A. / van Baak, M.J. / Boshuis, P. / van de Braak, A.E. / Zuidema, T. / Sterk, S.S.

    Food Control

    2023  Volume 147

    Abstract: Recently, residues of 4-acetaminophen (paracetamol) have been found in urine of slaughter animals. To investigate its possible origin, a 7 week animal experiment was performed with 5 groups of 4 calves fed different amounts of roughage, and treated or ... ...

    Abstract Recently, residues of 4-acetaminophen (paracetamol) have been found in urine of slaughter animals. To investigate its possible origin, a 7 week animal experiment was performed with 5 groups of 4 calves fed different amounts of roughage, and treated or not with 4-acetaminophen. Group 1 (control): new-born calves were fed, after the first days of colostrum, solely dairy based calf milk replacer (CMR). The animals from the other groups were 2–3 weeks of age at the start of the experiment and were fed the same CMR. Group 2 was administered oral Pracetam® 30 mg acetaminophen/kg Body Weight (BW) in the CMR, 5 days a week at alternate weeks, with maximum roughage. Group 3 was fed legal minimum roughage. Group 4 received the maximum roughage. Group 5 was administered human paracetamol pills 30 mg/kg BW once a week at weeks 2–6 with maximum roughage. The animals were housed in separate pens on slatted rubber floors without bedding. The controls were housed in a different room than the other animals. Urine was sampled once in the acclimatization period and for 5 days after treatment. At week 2, 4 and 6 at respectively 1, 2 and 3 days after treatment, one animal from groups 2 and 5 was sacrificed. An additional animal from group 4 was sacrificed at week 4, the rest of the animals at day 43. Urine, muscle, liver and kidney were analysed for residues of 4-acetaminophen and its metabolites. It appeared that controls and the low and high roughage animals had almost no 4-acetaminophen (<3 μg/L) in the urine and low levels of metabolites, whereas high roughage had at slaughter higher levels of metabolites than low roughage. Pracetam® treated animals showed high levels 4-acetaminophen (up to 130.000 μg/L) and metabolites during treatment, and lower levels (2800 μg/L) at slaughter. In the paracetamol treated animals 4-acetaminophen and metabolites were detectable during treatment (up to 130.000 μg/L) and until 7 days after treatment (110 μg/L). 4-Acetaminophen and metabolites were only present in tissues of treated animals, ...
    Keywords Life Science
    Subject code 630
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 1027805-9
    ISSN 0956-7135
    ISSN 0956-7135
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Online: Bovine Teeth

    Lasaroms, J.J.P. / van Dam, M.D. / Linders, R.F. / Sterk, S.S.

    A new Forensic Matrix for the detection of Regulated and Banned Substances

    2022  

    Abstract: To investigate illicit administration of regulated and banned substances used for growth-promoting purposes in cattle breeding, it is common to analyse the usual matrices like urine, feed, animal tissue, and hair samples nowadays.We wondered if there is ... ...

    Abstract To investigate illicit administration of regulated and banned substances used for growth-promoting purposes in cattle breeding, it is common to analyse the usual matrices like urine, feed, animal tissue, and hair samples nowadays.We wondered if there is a different type of sample material available that could overcome these disadvantages? A requirement is that the samples should be traceable to the animals and be easy to collect, for example, at slaughterhouses. Possible 'offal’? The question arised if bovine teeth could be the ‘new’ matrix.Therefore, we set to develop and validate a liquid chromatography tandem-mass spectrometry (UHPLC-MS/MS) method to detect different class of compounds (beta-agonists, NSAID’s and a selection of veterinary drugs (tetracyclines, quinolines, macrolides and sulfonamides) in bovine teeth.
    Keywords Life Science
    Language English
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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