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Article ; Online: Insufficient Cardiovascular Research & Development Funding.

Garcia-Dorado, David

2017 Volume 38, Issue 1, Page(s) 10–11

Language	English
Publishing date	2017-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehw587
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Pre-clinical studies in remote ischaemic conditioning: a solid foundation for on-going clinical research?

Garcia-Dorado, David

Cardiovascular research

2017 Volume 113, Issue 3, Page(s) 251–253

MeSH term(s)	Animals ; Ischemia ; Ischemic Preconditioning, Myocardial ; Myocardial Reperfusion Injury
Language	English
Publishing date	2017-04-10
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1093/cvr/cvw241
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Article ; Online: Dual or triple therapy in patients with atrial fibrillation and drug-eluting stents?

Sambola, Antonia / García-Dorado, David

Coronary artery disease

2015 Volume 26, Issue 5, Page(s) 367–368

MeSH term(s)	Anticoagulants/therapeutic use ; Aspirin/therapeutic use ; Atrial Fibrillation/drug therapy ; Coronary Artery Disease/therapy ; Female ; Fibrinolytic Agents/therapeutic use ; Humans ; Male ; Percutaneous Coronary Intervention/instrumentation ; Platelet Aggregation Inhibitors/therapeutic use ; Pyridines/therapeutic use ; Stents ; Warfarin/therapeutic use
Chemical Substances	Anticoagulants ; Fibrinolytic Agents ; Platelet Aggregation Inhibitors ; Pyridines ; Warfarin (5Q7ZVV76EI) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2015-08
Publishing country	England
Document type	Comment ; Editorial
ZDB-ID	1047268-x
ISSN	1473-5830 ; 0954-6928
ISSN (online)	1473-5830
ISSN	0954-6928
DOI	10.1097/MCA.0000000000000257
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Zs.A 3039: Show issues

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Article ; Online: The cGMP/PKG pathway as a common mediator of cardioprotection: translatability and mechanism.

Inserte, Javier / Garcia-Dorado, David

British journal of pharmacology

2015 Volume 172, Issue 8, Page(s) 1996–2009

Abstract: Cardiomyocyte cell death occurring during myocardial reperfusion (reperfusion injury) contributes to final infarct size after transient coronary occlusion. Different interrelated mechanisms of reperfusion injury have been identified, including ... ...

Abstract	Cardiomyocyte cell death occurring during myocardial reperfusion (reperfusion injury) contributes to final infarct size after transient coronary occlusion. Different interrelated mechanisms of reperfusion injury have been identified, including alterations in cytosolic Ca(2+) handling, sarcoplasmic reticulum-mediated Ca(2+) oscillations and hypercontracture, proteolysis secondary to calpain activation and mitochondrial permeability transition. All these mechanisms occur during the initial minutes of reperfusion and are inhibited by intracellular acidosis. The cGMP/PKG pathway modulates the rate of recovery of intracellular pH, but has also direct effect on Ca(2+) oscillations and mitochondrial permeability transition. The cGMP/PKG pathway is depressed in cardiomyocytes by ischaemia/reperfusion and preserved by ischaemic postconditioning, which importantly contributes to postconditioning protection. The present article reviews the mechanisms and consequences of the effect of ischaemic postconditioning on the cGMP/PKG pathway, the different pharmacological strategies aimed to stimulate it during myocardial reperfusion and the evidence, limitations and promise of translation of these strategies to the clinical practice. Overall, the preclinical and clinical evidence suggests that modulation of the cGMP/PKG pathway may be a therapeutic target in the context of myocardial infarction.
MeSH term(s)	Animals ; Cardiotonic Agents/pharmacology ; Cardiotonic Agents/therapeutic use ; Cyclic GMP/metabolism ; Cyclic GMP-Dependent Protein Kinases/metabolism ; Humans ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/prevention & control ; Signal Transduction/drug effects
Chemical Substances	Cardiotonic Agents ; Cyclic GMP-Dependent Protein Kinases (EC 2.7.11.12) ; Cyclic GMP (H2D2X058MU)
Language	English
Publishing date	2015-03-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.12959
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Article ; Online: Optimal opportunistic screening of atrial fibrillation using pulse palpation in cardiology outpatient clinics: Who and how.

Bañeras, Jordi / Pariggiano, Ivana / Ródenas-Alesina, Eduard / Oristrell, Gerard / Escalona, Roxana / Miranda, Berta / Rello, Pau / Soriano, Toni / Gordon, Blanca / Belahnech, Yassin / Calabrò, Paolo / García-Dorado, David / Ferreira-González, Ignacio / Radua, Joaquim

PloS one

2022 Volume 17, Issue 4, Page(s) e0266955

Abstract: Background: Atrial fibrillation (AF) remain a prevalent undiagnosed condition frequently encountered in primary care.: Objective: We aimed to find the parameters that optimize the diagnostic accuracy of pulse palpation to detect AF. We also aimed to ... ...

Abstract	Background: Atrial fibrillation (AF) remain a prevalent undiagnosed condition frequently encountered in primary care. Objective: We aimed to find the parameters that optimize the diagnostic accuracy of pulse palpation to detect AF. We also aimed to create a simple algorithm for selecting which individuals would benefit from pulse palpation and, if positive, receive an ECG to detect AF. Methods: Nurses from four Cardiology outpatient clinics palpated 7,844 pulses according to a randomized list of arterial territories and durations of measure and immediately followed by a 12-lead ECG, which we used as the reference standard. We calculated the sensitivity and specificity of the palpation parameters. We also assessed whether diagnostic accuracy depended on the nurse's experience or on a list of clinical factors of the patients. With this information, we estimated the positive predictive values and false omission rates according to very few clinical factors readily available in primary care (age, sex, and diagnosis of heart failure) and used them to create the algorithm. Results: The parameters associated with the highest diagnostic accuracy were palpation of the radial artery and classifying as irregular those palpations in which the nurse was uncertain about pulse regularity or unable to palpate pulse (sensitivity = 79%; specificity = 86%). Specificity decreased with age. Neither the nurse's experience nor any investigated clinical factor influenced diagnostic accuracy. We provide the algorithm to select the ≥40 years old individuals that would benefit from a pulse palpation screening: a) do nothing in <60 years old individuals without heart failure; b) do ECG in ≥70 years old individuals with heart failure; c) do radial pulse palpation in the remaining individuals and do ECG if the pulse is irregular or you are uncertain about its regularity or unable to palpate it. Conclusions: Opportunistic screening for AF using optimal pulse palpation in candidate individuals according to a simple algorithm may have high effectiveness in detecting AF in primary care.
MeSH term(s)	Adult ; Aged ; Ambulatory Care Facilities ; Atrial Fibrillation/diagnosis ; Cardiology ; Electrocardiography ; Heart Failure ; Humans ; Mass Screening ; Middle Aged ; Palpation ; Pulse
Language	English
Publishing date	2022-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0266955
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Article ; Online: Shining the spotlight on cardioprotection: beyond the cardiomyocyte.

Davidson, Sean M / Andreadou, Ioanna / Garcia-Dorado, David / Hausenloy, Derek J

Cardiovascular research

2019 Volume 115, Issue 7, Page(s) 1115–1116

MeSH term(s)	Animals ; Cardiovascular Agents/adverse effects ; Cardiovascular Agents/therapeutic use ; Extracellular Vesicles/metabolism ; Extracellular Vesicles/transplantation ; Humans ; Ischemic Preconditioning/adverse effects ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Myocardial Infarction/therapy ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/physiopathology ; Myocardial Reperfusion Injury/prevention & control ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Paracrine Communication ; Platelet Activation/drug effects ; Signal Transduction ; Treatment Outcome ; Ventricular Function, Left/drug effects ; Ventricular Remodeling/drug effects
Chemical Substances	Cardiovascular Agents
Language	English
Publishing date	2019-02-05
Publishing country	England
Document type	Editorial ; Introductory Journal Article
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1093/cvr/cvz072
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Article ; Online: Postural Orthostatic Tachycardia Syndrome and Vasospastic Angina: Therapeutic Approach to a Previously Unreported Association.

Casas, Guillem / Rivas-Gándara, Nuria / Francisco-Pascual, Jaume / Moya-Mitjans, Àngel / García-Dorado, David

Revista espanola de cardiologia (English ed.)

2018 Volume 72, Issue 6, Page(s) 509–510

MeSH term(s)	Adrenergic beta-Antagonists/therapeutic use ; Angina Pectoris, Variant/diagnosis ; Angina Pectoris, Variant/drug therapy ; Angina Pectoris, Variant/etiology ; Anti-Inflammatory Agents/therapeutic use ; Cardiovascular Agents/therapeutic use ; Coronary Angiography ; Drug Therapy, Combination ; Electrocardiography ; Female ; Fludrocortisone/therapeutic use ; Humans ; Ivabradine/therapeutic use ; Middle Aged ; Postural Orthostatic Tachycardia Syndrome/complications ; Postural Orthostatic Tachycardia Syndrome/diagnosis ; Postural Orthostatic Tachycardia Syndrome/drug therapy ; Propranolol/therapeutic use ; Tilt-Table Test
Chemical Substances	Adrenergic beta-Antagonists ; Anti-Inflammatory Agents ; Cardiovascular Agents ; Ivabradine (3H48L0LPZQ) ; Propranolol (9Y8NXQ24VQ) ; Fludrocortisone (U0476M545B)
Language	Spanish
Publishing date	2018-10-12
Publishing country	Spain
Document type	Case Reports ; Journal Article
ISSN	1885-5857
ISSN (online)	1885-5857
DOI	10.1016/j.rec.2018.05.043
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Article ; Online: Metabolomics and Heart Diseases: From Basic to Clinical Approach.

Barba, Ignasi / Andrés, Mireia / Garcia-Dorado, David

Current medicinal chemistry

2017 Volume 26, Issue 1, Page(s) 46–59

Abstract: Background: The field of metabolomics has been steadily increasing in size for the last 15 years. Advances in analytical and statistical methods have allowed metabolomics to flourish in various areas of medicine. Cardiovascular diseases are some of the ... ...

Abstract	Background: The field of metabolomics has been steadily increasing in size for the last 15 years. Advances in analytical and statistical methods have allowed metabolomics to flourish in various areas of medicine. Cardiovascular diseases are some of the main research targets in metabolomics, due to their social and medical relevance, and also to the important role metabolic alterations play in their pathogenesis and evolution. Metabolomics has been applied to the full spectrum of cardiovascular diseases: from patient risk stratification to myocardial infarction and heart failure. However - despite the many proof-ofconcept studies describing the applicability of metabolomics in the diagnosis, prognosis and treatment evaluation in cardiovascular diseases - it is not yet used in routine clinical practice. Recently, large phenome centers have been established in clinical environments, and it is expected that they will provide definitive proof of the applicability of metabolomics in clinical practice. But there is also room for small and medium size centers to work on uncommon pathologies or to resolve specific but relevant clinical questions. Objectives: In this review, we will introduce metabolomics, cover the metabolomic work done so far in the area of cardiovascular diseases. Conclusion: The cardiovascular field has been at the forefront of metabolomics application and it should lead the transfer to the clinic in the not so distant future.
MeSH term(s)	Heart Diseases/diagnosis ; Heart Diseases/metabolism ; Humans ; Metabolomics
Language	English
Publishing date	2017-10-09
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867324666171006151408
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Article ; Online: On the Stability of Stable Coronary Artery Disease.

Barrabés, José A / García Del Blanco, Bruno / Garcia-Dorado, David

Journal of the American College of Cardiology

2017 Volume 69, Issue 17, Page(s) 2157–2159

MeSH term(s)	Coronary Artery Disease ; Humans ; Myocardial Infarction ; Outpatients ; Stents ; Thrombosis
Language	English
Publishing date	2017-04-23
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2017.03.535
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Article ; Online: Safe and Efficacious Use of 1-Month Triple Therapy in Patients with Atrial Fibrillation and High Bleeding Risk Undergoing PCI.

Sambola, Antonia / Bueno, Héctor / Miranda, Berta / Hernandez, Adrian V / Limeres, Javier / Del Blanco, Bruno García / García-Dorado, David

Cardiovascular drugs and therapy

2019 Volume 33, Issue 4, Page(s) 425–433

Abstract: Background: The impact of short or prolonged use of triple therapy (TT) on outcomes in patients with atrial fibrillation (AF) and high risk of bleeding undergoing percutaneous coronary intervention (PCI) is unclear. We compared clinical outcomes ... ...

Abstract	Background: The impact of short or prolonged use of triple therapy (TT) on outcomes in patients with atrial fibrillation (AF) and high risk of bleeding undergoing percutaneous coronary intervention (PCI) is unclear. We compared clinical outcomes according to the duration of TT in patients with AF and HAS-BLED ≥ 3 at 1 year of follow-up. Methods: A prospective observational cohort enrolled 735 patients with AF between 2010 and 2015. Of these, 521 (70.9%) had HAS-BLED ≥ 3 and 380 (72.9%) were discharged on TT. TT was prescribed for 1 month in 233 patients (61.3%). The primary endpoint was the incidence of Bleeding Academic Research Consortium (BARC ≥ 3). The secondary endpoint was the occurrence of ischemic events (cardiac death, MI, stroke, or stent thrombosis). Results: Patients on 1-month TT had a higher median HAS-BLED. Intracraneal hemorrhage was twofold more frequently in patients on > 1-month TT but without statistical significance (0.9% vs 2.1%, p = 0.20). Rates of the primary endpoint (bleeding BARC ≥ 3) were 8.2% vs 10.9% and did not differ between groups, while secondary endpoint did not occur more frequently in the 1-month TT group compared with the > 1-month TT group (26.6% vs 23.1%). In adjusted multivariate analyses, patients receiving 1-month TT had a similar risk of the primary endpoint compared to those with > 1-month TT (HR 1.47; 95% CI 0.48-4.47, p = 0.50). No difference was found in the secondary ischemic endpoint (HR 1.24; 95% CI 0.77-2.00, p = 0.38). Conclusions: In patients with AF undergoing PCI at lower ischemic risk and higher bleeding risk, 1 month of TT seems safe and efficacious. Further studies are warranted in patients at high ischemic risk.
MeSH term(s)	Aged ; Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/etiology ; Female ; Hemorrhage/chemically induced ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Percutaneous Coronary Intervention/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Prospective Studies ; Risk Factors
Chemical Substances	Anticoagulants ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2019-07-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	639068-7
ISSN	1573-7241 ; 0920-3206
ISSN (online)	1573-7241
ISSN	0920-3206
DOI	10.1007/s10557-019-06889-7
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