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  1. Article: The 8

    Lancia, Andrea / Merizzoli, Elisa / Filippi, Andrea Riccardo

    Annals of translational medicine

    2019  Volume 7, Issue Suppl 6, Page(s) S205

    Language English
    Publishing date 2019-09-05
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2019.07.02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immunonutrition in head and neck cancer patients undergoing chemoradiotherapy: an alternative approach for overcoming potential bias.

    Caccialanza, Riccardo / Cereda, Emanuele / Orlandi, Ester / Filippi, Andrea Riccardo / Comoli, Patrizia / Alberti, Andrea / Imarisio, Ilaria / Pedrazzoli, Paolo / Bossi, Paolo

    The American journal of clinical nutrition

    2021  Volume 113, Issue 4, Page(s) 1053–1054

    MeSH term(s) Chemoradiotherapy, Adjuvant ; Double-Blind Method ; Food, Formulated ; Head and Neck Neoplasms/therapy ; Humans
    Language English
    Publishing date 2021-04-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.1093/ajcn/nqaa421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Future perspectives of radiation therapy for Hodgkin Lymphoma: Risk-adapted, response-adapted, and safer than before.

    Saddi, Jessica / Barcellini, Amelia / Gotti, Manuel / Mazzacane, Alessandro / Tolva, Alessandra / Lazic, Tanja / Arcaini, Luca / Zecca, Marco / Orlandi, Ester / Filippi, Andrea Riccardo

    Hematological oncology

    2024  Volume 42, Issue 3, Page(s) e3269

    Abstract: Classical Hodgkin lymphoma is a lymphoproliferative disease with a good prognosis mainly seen in young people. Nevertheless secondary malignancy, cardiac disease and infertility may affect the long survivors with significant impact on quality of life, ... ...

    Abstract Classical Hodgkin lymphoma is a lymphoproliferative disease with a good prognosis mainly seen in young people. Nevertheless secondary malignancy, cardiac disease and infertility may affect the long survivors with significant impact on quality of life, morbidity and overall survival. In the last decades several treatment strategies were evaluated to reduce the toxicity of first line treatment such as avoiding radiotherapy or its reduction in terms of dosage and extension. Many trials including interim Positron Emission Tomography evaluation fail to compare efficacy between combined modality treatment versus chemotherapy alone in particular in early stage disease. In this review we analyze which subset of patients could take advantage from proton therapy in terms of toxicity and cost effectiveness.
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.3269
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  4. Article: Shoulder Rehabilitation Exercises With Kinematic Biofeedback After Arthroscopic Rotator Cuff Repair: Protocol for a New Integrated Rehabilitation Program.

    Parel, Ilaria / Candoli, Valeria / Filippi, Maria Vittoria / Padolino, Antonio / Merolla, Giovanni / Sanniti, Stefano / Galassi, Riccardo / Paladini, Paolo / Cutti, Andrea Giovanni

    JMIR research protocols

    2023  Volume 12, Page(s) e35757

    Abstract: Background: The recovery of scapular and humeral physiological kinematic parameters, as well as the sensorimotor control of movement, plays a primary role in the rehabilitation process after arthroscopic rotator cuff repair. A highly customized ... ...

    Abstract Background: The recovery of scapular and humeral physiological kinematic parameters, as well as the sensorimotor control of movement, plays a primary role in the rehabilitation process after arthroscopic rotator cuff repair. A highly customized rehabilitation approach is required to achieve this aim. Biofeedback can be a useful tool, but there is poor evidence of its application in the rehabilitation after arthroscopic rotator cuff tear repair.
    Objective: The aim of this paper is to outline an innovative exercise-based rehabilitation program exploiting visual biofeedback for the recovery of patients arthroscopically treated for rotator cuff repair.
    Methods: For establishment of the innovative program, a multidisciplinary team involving experts in shoulder surgery, rehabilitation medicine, physical therapy, and biomedical and clinical engineering was formed. Starting from a conventional rehabilitation program, the team selected a set of exercises to be integrated with a biofeedback tool, named the INAIL (National Institute for Insurance against Accidents at Work) Shoulder and Elbow Outpatient program (ISEO program). ISEO is a motion analysis system based on inertial wearable sensors positioned over the thorax, scapula, humerus, and forearm. ISEO can return a visual biofeedback of humerus and scapula angles over time or of the scapula-humeral coordination, with possible overlap of patient-specific or asymptomatic reference values. A set of 12 progressive exercises was defined, divided into four groups based on humerus and scapula movements. Each group comprises 2-4 of the 12 exercises with an increasing level of complexity. Exercises can require the use of a ball, stick, rubber band, and/or towel. For each exercise, we present the starting position of the patient, the modality of execution, and the target position, together with notes about the critical factors to observe. The type of visual biofeedback to adopt is specified, such as the coordination between angles or the variation of a single angle over time. To guide the therapist in customizing the patient's rehabilitation program, a list of operative guidelines is provided.
    Results: We describe various applications of the ISEO exercise program in terms of frequency and intensity.
    Conclusions: An innovative rehabilitation program to restore scapular and humeral kinematics after rotator cuff repair based on kinematic biofeedback is presented. Biofeedback is expected to increase patient awareness and self-correction under therapist supervision. Randomized controlled trials are needed to investigate the potential effect of the exercise-based biofeedback in comparison with conventional rehabilitation programs.
    International registered report identifier (irrid): DERR1-10.2196/35757.
    Language English
    Publishing date 2023-03-22
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2719222-2
    ISSN 1929-0748
    ISSN 1929-0748
    DOI 10.2196/35757
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  5. Article: Intrathoracic core needle biopsy and repeat biopsy for PD-L1 evaluation in non-small cell lung cancer.

    Stella, Giulia Maria / Bortolotto, Chandra / Filippi, Andrea Riccardo

    Journal of thoracic disease

    2018  Volume 10, Issue Suppl 33, Page(s) S4031–S4033

    Language English
    Publishing date 2018-10-22
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.09.92
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Letter from Italy: First practical indications for radiation therapy departments during COVID-19 outbreak.

    Filippi, Andrea Riccardo / Russi, Elvio / Magrini, Stefano Maria / Corvò, Renzo

    International journal of radiation oncology, biology, physics

    2020  Volume 107, Issue 3, Page(s) 597–599

    MeSH term(s) COVID-19 ; Caregivers ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Disease Outbreaks ; Hospital Departments ; Humans ; Italy/epidemiology ; Neoplasms/radiotherapy ; Pandemics/prevention & control ; Patient Safety ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Radiotherapy
    Keywords covid19
    Language English
    Publishing date 2020-03-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2020.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Unmet needs in the management of unresectable stage III non-small cell lung cancer: a review after the 'radio talk' webinars.

    Borghetti, Paolo / Guerini, Andrea Emanuele / Sangalli, Claudia / Piperno, Gaia / Franceschini, Davide / La Mattina, Salvatore / Arcangeli, Stefano / Filippi, Andrea Riccardo

    Expert review of anticancer therapy

    2022  Volume 22, Issue 5, Page(s) 549–559

    Abstract: Introduction: Stage III non-small cell lung cancer (NSCLC) is a variable entity, encompassing bulky primary tumors, nodal involvement, or both. Multidisciplinary evaluation is essential to discuss multiple treatment options, to outline optimal ... ...

    Abstract Introduction: Stage III non-small cell lung cancer (NSCLC) is a variable entity, encompassing bulky primary tumors, nodal involvement, or both. Multidisciplinary evaluation is essential to discuss multiple treatment options, to outline optimal management, and to examine the main debated topics and critical issues not addressed by current trials and guidelines that influence daily clinical practice.
    Areas covered: From March to 5 May 2021 ,meetings were scheduled in a webinar format titled 'Radio Talk' due to the COVID-19 pandemic; the faculty was composed of 6 radiation oncologists from 6 different Institutions of Italy, all of them were the referring radiation oncologist for lung cancer treatment at their respective departments and were or had been members of AIRO (Italian Association of Radiation Oncology) Thoracic Oncology Study Group. The topics covered included: pulmonary toxicity, cardiac toxicity, radiotherapy dose, fractionation and volumes, unfit/elderly patients, multidisciplinary management.
    Expert opinion: The debate was focused on the unmet needs triggered by case reports, personal experiences and questions; the answers were often not univocal; however, the exchange of opinion and the contribution of different centers confirmed the role of multidisciplinary management and the necessity that the most critical issues should be investigated in clinical trials.
    MeSH term(s) Aged ; COVID-19 ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/radiotherapy ; Neoplasm Staging ; Pandemics ; Radiation Oncologists
    Language English
    Publishing date 2022-04-25
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2022.2069098
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  8. Article ; Online: In Reply to Scarpelli et al.

    Specht, Lena / Wong, Jeffrey Y C / Filippi, Andrea Riccardo / Dabaja, Bouthaina Shbib / Yahalom, Joachim

    International journal of radiation oncology, biology, physics

    2020  Volume 108, Issue 5, Page(s) 1396

    MeSH term(s) Humans ; Lymphoma ; Whole-Body Irradiation
    Language English
    Publishing date 2020-11-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2020.07.2315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Role of Native T1 and T2 Mapping Times in Identifying PD-L1 Expression and the Histological Subtype of NSCLCs.

    Bortolotto, Chandra / Messana, Gaia / Lo Tito, Antonio / Stella, Giulia Maria / Pinto, Alessandra / Podrecca, Chiara / Bellazzi, Riccardo / Gerbasi, Alessia / Agustoni, Francesco / Han, Fei / Nickel, Marcel Dominik / Zacà, Domenico / Filippi, Andrea Riccardo / Bottinelli, Olivia Maria / Preda, Lorenzo

    Cancers

    2023  Volume 15, Issue 12

    Abstract: We investigated the association of T1/T2 mapping values with programmed death-ligand 1 protein (PD-L1) expression in lung cancer and their potential in distinguishing between different histological subtypes of non-small cell lung cancers (NSCLCs). Thirty- ...

    Abstract We investigated the association of T1/T2 mapping values with programmed death-ligand 1 protein (PD-L1) expression in lung cancer and their potential in distinguishing between different histological subtypes of non-small cell lung cancers (NSCLCs). Thirty-five patients diagnosed with stage III NSCLC from April 2021 to December 2022 were included. Conventional MRI sequences were acquired with a 1.5 T system. Mean T1 and T2 mapping values were computed for six manually traced ROIs on different areas of the tumor. Data were analyzed through RStudio. Correlation between T1/T2 mapping values and PD-L1 expression was studied with a Wilcoxon-Mann-Whitney test. A Kruskal-Wallis test with a post-hoc Dunn test was used to study the correlation between T1/T2 mapping values and the histological subtypes: squamocellular carcinoma (SCC), adenocarcinoma (ADK), and poorly differentiated NSCLC (PD). There was no statistically significant correlation between T1/T2 mapping values and PD-L1 expression in NSCLC. We found statistically significant differences in T1 mapping values between ADK and SCC for the periphery ROI (
    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15123252
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  10. Article: Malignant Pleural Mesothelioma: Genetic and Microenviromental Heterogeneity as an Unexpected Reading Frame and Therapeutic Challenge.

    Abbott, David Michael / Bortolotto, Chandra / Benvenuti, Silvia / Lancia, Andrea / Filippi, Andrea Riccardo / Stella, Giulia Maria

    Cancers

    2020  Volume 12, Issue 5

    Abstract: Mesothelioma is a malignancy of serosal membranes including the peritoneum, pleura, pericardium and the tunica vaginalis of the testes. Malignant mesothelioma (MM) is a rare disease with a global incidence in countries like Italy of about 1.15 per 100, ... ...

    Abstract Mesothelioma is a malignancy of serosal membranes including the peritoneum, pleura, pericardium and the tunica vaginalis of the testes. Malignant mesothelioma (MM) is a rare disease with a global incidence in countries like Italy of about 1.15 per 100,000 inhabitants. Malignant Pleural Mesothelioma (MPM) is the most common form of mesothelioma, accounting for approximately 80% of disease. Although rare in the global population, mesothelioma is linked to industrial pollutants and mineral fiber exposure, with approximately 80% of cases linked to asbestos. Due to the persistent asbestos exposure in many countries, a worldwide progressive increase in MPM incidence is expected for the current and coming years. The tumor grows in a loco-regional pattern, spreading from the parietal to the visceral pleura and invading the surrounding structures that induce the clinical picture of pleural effusion, pain and dyspnea. Distant spreading and metastasis are rarely observed, and most patients die from the burden of the primary tumor. Currently, there are no effective treatments for MPM, and the prognosis is invariably poor. Some studies average the prognosis to be roughly one-year after diagnosis. The uniquely poor mutational landscape which characterizes MPM appears to derive from a selective pressure operated by the environment; thus, inflammation and immune response emerge as key players in driving MPM progression and represent promising therapeutic targets. Here we recapitulate current knowledge on MPM with focus on the emerging network between genetic asset and inflammatory microenvironment which characterize the disease as amenable target for novel therapeutic approaches.
    Language English
    Publishing date 2020-05-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12051186
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