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  1. Book: Radiosurgery of the skull base

    Noureldine, Mohammad Hassan A. / Agazzi, Siviero / Berk, Lawrence B.

    a case-based approach

    2024  

    Author's details edited by Siviero Agazzi, Mohammad Hassan A. Noureldine, Lawrence B. Berk
    Language English
    Size xv, 266 Seiten, Illustrationen
    Edition First edition
    Publisher Elsevier
    Publishing place Philadelphia
    Publishing country United States
    Document type Book
    Accompanying material Zugang zur Online-Ausgabe über Code
    HBZ-ID HT030698341
    ISBN 978-0-323-87437-3 ; 0-323-87437-1
    Database Catalogue ZB MED Medicine, Health

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    2024 A 391 available for loan (reading room) Lesesaal EG
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  2. Book ; Online ; E-Book: Brainstem Tumors

    Jallo, George I. / Noureldine, Mohammad Hassan A. / Shimony, Nir

    Diagnosis and Management

    2020  

    Abstract: This illuminating and comprehensive work offers readers a thorough and detailed perspective of brainstem surgery as well as state-of-the-art discussion on the diagnosis and management of related pathologies. Hailing from around the globe and currently ... ...

    Author's details edited by George I. Jallo, Mohammad Hassan A. Noureldine, Nir Shimony
    Abstract This illuminating and comprehensive work offers readers a thorough and detailed perspective of brainstem surgery as well as state-of-the-art discussion on the diagnosis and management of related pathologies. Hailing from around the globe and currently practicing in various countries in Asia, Europe, and North America, the expert authors of this work represent a wide range of disciplines and experiences, providing a comprehensive, interdisciplinary overview of brainstem surgery. Indeed, brainstem pathologies remain the most challenging to manage surgically due to the high eloquence and the deep and hidden location of the brainstem, turning surgical treatment of brainstem pathologies into one of the most complex and demanding fields in neurosurgery. This vital book guides readers through this very complex anatomical territory in which any pathology leads to grave consequences. Taking readers through the depth of the complex architecture of the brainstem in the clinical context, and emphasizing the evidence-based treatment of different brainstem pathologies while also reviewing what the future holds for the management of these pathologies, the book presents a review of state-of-the-art preoperative assessment modalities and surgical. The book covers brainstem-related pathologies from infancy to adulthood, and the text is enriched with diagnostic and surgical images that cover almost all types of brainstem lesions. The book is written in a way that neurosurgery specialists and fellows will feel comfortable navigating throughout its contents, and the enthusiastic neurosurgery resident will find this book to be a valuable guide. A major contribution to the clinical literature, Brainstem Tumors: Diagnosis and Management will also serve as a reference for anyone involved in the treatment of patients suffering from brainstem pathologies, including medical team members such as adult and pediatric neurosurgeons, neurologists, neurooncologists, residents and fellows, clinical neuropsychologists, electrophysiologists, neuroradiologists, and medical students who have a passion to learn about the assessment and surgical management of patients with brainstem diseases.
    Keywords Neurosurgery ; Neurology  ; Neurology
    Subject code 612.826
    Language English
    Size 1 online resource (XXI, 400 p. 152 illus., 98 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-38774-7 ; 3-030-38773-9 ; 978-3-030-38774-7 ; 978-3-030-38773-0
    DOI 10.1007/978-3-030-38774-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Benign Spinal Tumors.

    Noureldine, Mohammad Hassan A / Shimony, Nir / Jallo, George I

    Advances in experimental medicine and biology

    2023  Volume 1405, Page(s) 583–606

    Abstract: Benign spinal intradural tumors are relatively rare and include intramedullary tumors with a favorable histology such as low-grade astrocytomas and ependymomas, as well as intradural extramedullary tumors such as meningiomas and schwannomas. The effect ... ...

    Abstract Benign spinal intradural tumors are relatively rare and include intramedullary tumors with a favorable histology such as low-grade astrocytomas and ependymomas, as well as intradural extramedullary tumors such as meningiomas and schwannomas. The effect on the neural tissue is usually a combination of mass effect and neuronal involvement in cases of infiltrative tumors. The new understanding of molecular profiling of different tumors allowed us to better define central nervous system tumors and tailor treatment accordingly. The mainstay of management of many intradural spinal tumors is maximal safe surgical resection. This goal is more achievable with intradural extramedullary tumors; yet, with a meticulous surgical approach, many of the intramedullary tumors are amenable for safe gross-total or near-total resection. The nature of these tumors is benign; hence, a different way to measure outcome success is pursued and usually depends on functional rather than oncological or survival outcomes.
    MeSH term(s) Humans ; Spinal Neoplasms/pathology ; Spinal Neoplasms/surgery ; Spinal Cord Neoplasms/genetics ; Spinal Cord Neoplasms/pathology ; Meningioma/genetics ; Meningioma/surgery ; Neurilemmoma/genetics ; Neurilemmoma/surgery ; Meningeal Neoplasms
    Language English
    Publishing date 2023-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-3-031-23705-8_23
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  4. Article: Malignant Spinal Tumors.

    Noureldine, Mohammad Hassan A / Shimony, Nir / Jallo, George I

    Advances in experimental medicine and biology

    2023  Volume 1405, Page(s) 565–581

    Abstract: Malignant spinal tumors constitute around 22% of all primary spinal tumors. The most common location of metastases to the spinal region is the extradural compartment. The molecular and genetic characterization of these tumors was the basis for the ... ...

    Abstract Malignant spinal tumors constitute around 22% of all primary spinal tumors. The most common location of metastases to the spinal region is the extradural compartment. The molecular and genetic characterization of these tumors was the basis for the updated WHO classification of CNS tumors in 2016, where many CNS tumors are now diagnosed according to their genetic profile rather than relying solely on the histopathological appearance. Magnetic resonance imaging (MRI) is the current gold standard for the initial evaluation and subsequent follow-up on intradural spinal cord tumors, and the imaging sequences must include T2-weighted images (WI), short time inversion recovery (STIR), and pre- and post-contrast T1-WI in the axial, sagittal, and coronal planes. The clinical presentation is highly variable and depends on the tumor size, growth rate, type, infiltrative, necrotic and hemorrhagic potential as well as the exact location within the spinal compartment. Surgical intervention remains the mainstay of management of symptomatic and radiographically enlarging spinal tumors, where the goal is to achieve maximal safe resection. Tumor recurrences are managed with repeat surgical resection (preferred whenever possible and safe), radiotherapy, chemotherapy, or any combination of these therapies.
    MeSH term(s) Humans ; Spinal Neoplasms/diagnostic imaging ; Spinal Neoplasms/genetics ; Spinal Neoplasms/therapy ; Neoplasm Recurrence, Local ; Spinal Cord Neoplasms/diagnostic imaging ; Spinal Cord Neoplasms/genetics ; Spine ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2023-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-3-031-23705-8_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Role of Oxidative Stress in the Progression of Secondary Brain Injury Following Germinal Matrix Hemorrhage.

    Nour Eldine, Mariam / Alhousseini, Maryam / Nour-Eldine, Wared / Noureldine, Hussein / Vakharia, Kunal V / Krafft, Paul R / Noureldine, Mohammad Hassan A

    Translational stroke research

    2023  

    Abstract: Germinal matrix hemorrhage (GMH) can be a fatal condition responsible for the death of 1.7% of all neonates in the USA. The majority of GMH survivors develop long-term sequalae with debilitating comorbidities. Higher grade GMH is associated with higher ... ...

    Abstract Germinal matrix hemorrhage (GMH) can be a fatal condition responsible for the death of 1.7% of all neonates in the USA. The majority of GMH survivors develop long-term sequalae with debilitating comorbidities. Higher grade GMH is associated with higher mortality rates and higher prevalence of comorbidities. The pathophysiology of GMH can be broken down into two main titles: faulty hemodynamic autoregulation and structural weakness at the level of tissues and cells. Prematurity is the most significant risk factor for GMH, and it predisposes to both major pathophysiological mechanisms of the condition. Secondary brain injury is an important determinant of survival and comorbidities following GMH. Mechanisms of brain injury secondary to GMH include apoptosis, necrosis, neuroinflammation, and oxidative stress. This review will have a special focus on the mechanisms of oxidative stress following GMH, including but not limited to inflammation, mitochondrial reactive oxygen species, glutamate toxicity, and hemoglobin metabolic products. In addition, this review will explore treatment options of GMH, especially targeted therapy.
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2541897-X
    ISSN 1868-601X ; 1868-4483
    ISSN (online) 1868-601X
    ISSN 1868-4483
    DOI 10.1007/s12975-023-01147-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pelvic Incidence as a Predictor of Proximal Junctional Failure in Patients Undergoing Anterior Column Realignment with Anterior Longitudinal Ligament Release to Restore Lordosis in Adult Spinal Deformity: A Retrospective Cohort Study.

    Noureldine, Mohammad Hassan A / McBride, Paul / Liaw, Deborah / Coughlin, Emily / Mhaskar, Rahul / Alikhani, Puya

    World neurosurgery

    2023  Volume 182, Page(s) e772–e779

    Abstract: Objective: To identify variables that may contribute to the development of proximal junctional failure (PJF) in patients with long lumbo-sacral and thoraco-lumbo-pelvic constructs undergoing anterior column realignment (ACR) with anterior longitudinal ... ...

    Abstract Objective: To identify variables that may contribute to the development of proximal junctional failure (PJF) in patients with long lumbo-sacral and thoraco-lumbo-pelvic constructs undergoing anterior column realignment (ACR) with anterior longitudinal ligament release (ALLR).
    Methods: Data of patients with adult spinal deformity who underwent ACR with ALLR at L3-4 were collected retrospectively from medical records and a prospectively maintained spine research database between 2016 and 2022.
    Results: Eleven (41%) developed PJF at a mean of 24 ± 21 months from the index surgery. The cohort was then divided into 2 groups for analysis, 13 subjects in the high pelvic incidence (PI) group (defined as PI ≥ 55°) and 14 subjects in the low PI group (defined as PI < 55°). Visual Analog Scale for back pain and Oswestry Disability Index decreased from 9.5 to 2.1 and 61 to 10 in the high PI group, and from 8.9 to 2.4 and 60.9 to 10.3 in the low PI group, respectively. PI (P = 0.004), sacral slope (P = 0.005), and postoperative PI-lumbar lordosis mismatch (P = 0.02) were found to be significant predictors of PJF. The receiver operator curve revealed a cutoff PI value ≤ 53° (95% confidence interval: 52°-64°), below which the risk of PJF becomes significantly higher in patients undergoing ACR with ALLR at L3-4.
    Conclusions: PI may be a predictor of PJF and highly correlates with ACR-ALLR levels. In patients undergoing L3-4 ACR-ALLR, a PI value of ≤53° is associated with a significantly elevated risk of PJF. Preoperative planning of ACR-ALLR level based on normal sagittal alignment in otherwise healthy individuals may mitigate the risk of PJF development in patients with adult spinal deformity treated with ACR-ALLR.
    MeSH term(s) Adult ; Humans ; Lordosis/diagnostic imaging ; Lordosis/surgery ; Lordosis/etiology ; Retrospective Studies ; Longitudinal Ligaments/surgery ; Spinal Fusion/adverse effects ; Sacrum ; Kyphosis/surgery ; Postoperative Complications/epidemiology ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.12.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Biochemical Markers of Early Renal Dysfunction in Patients with β-thalassemia Major: A Systematic Review and Meta-analysis.

    Arian, Mahdieh / Oghazian, Mohammad Bagher / Noureldine, Mohammad Hassan A / Valinejad, Ali / Badiee, Zahra / Soleimani, Mohsen / Sahebkar, Amirhossein

    Current medicinal chemistry

    2023  

    Abstract: Background: Early diagnosis of renal dysfunction in β-thalassemia major (β- TM) may help take specific measures to delay irreversible damage and renal failure. Therefore, the present meta-analysis aimed to compare biochemical markers of premature renal ... ...

    Abstract Background: Early diagnosis of renal dysfunction in β-thalassemia major (β- TM) may help take specific measures to delay irreversible damage and renal failure. Therefore, the present meta-analysis aimed to compare biochemical markers of premature renal dysfunction between β-TM and healthy subjects and identify renal issues' prevalence in patients with β-TM.
    Methods: We searched PubMed, Cumulative Index of Nursing and Allied Health Literature (CINAHL), Medline, Scopus, Web of Science, ScienceDirect, ProQuest, Google Scholar, and State Inpatient Databases (SIDs) without any language constraints for all relevant articles published up to April 2019.
    Results: Out of 1458 articles published up to April 2019, 24 case-control and 22 crosssectional studies were investigated. The investigated levels of serum phosphorus, uric acid (UA), cystatin C, and ferritin were significantly different between β-TM patients and controls. The albumin/creatinine ratio (ACR), N-acetyl-β-D-glucosaminidase/creatinine (NAG/Cr) ratio, urinary and serum β2 microglobulin (β2MG), and serum ferritin levels were significantly higher in β-TM patients than in healthy individuals. However, glomerular filtration rate, creatinine clearance, and pretransfusion hemoglobin indicated a significantly lower rate. The general prevalence of renal glomerular and/or tubular defects in patients with β-TM was 50.22%.
    Conclusion: Urinary NAG, β2MG, ACR, and Scys-C may be early markers of renal dysfunction in patients with β-thalassemia major. An observation of elevated levels of these markers despite normal levels of other markers of renal dysfunction may indicate primary, subclinical injury to the renal tubules and glomeruli.
    Language English
    Publishing date 2023-10-26
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0109298673250805230922054406
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  8. Article ; Online: Simultaneous Sacroiliac Joint Fusion in Patients with Long Lumbosacral Constructs: Case Report and Operative Technique.

    Noureldine, Mohammad Hassan A / Freeman, Thomas B / Alikhani, Puya

    World neurosurgery

    2020  Volume 139, Page(s) 434–439

    Abstract: Background: Literature data on the frequency and pathogenesis of sacroiliac joint (SIJ) pain and arthropathy following lumbosacral fusion with long constructs combined with sacroiliac fixation remains scarce. From clinical experience, we noticed that ... ...

    Abstract Background: Literature data on the frequency and pathogenesis of sacroiliac joint (SIJ) pain and arthropathy following lumbosacral fusion with long constructs combined with sacroiliac fixation remains scarce. From clinical experience, we noticed that many patients undergoing these surgeries develop SIJ disease postoperatively.
    Case description: We report a clinical observation of no occurrence or remission of SIJ pain following simultaneous SIJ fusion in cases of long-construct lumbosacral fusion and sacropelvic fixation with S2-alar-iliac screws. An illustrative case and description of the simultaneous SIJ fusion technique are discussed as well.
    Conclusions: Based on our experience, we believe that fusing the SIJ simultaneously during sacropelvic fixation in the context of a long lumbosacral fusion surgery may lead to a decline in the incidence of SIJ disease, as well as remission of SIJ pain in patients requiring revision surgeries. Future, multicenter prospective studies are needed to test and validate this observation.
    MeSH term(s) Aged ; Bone Screws ; Humans ; Joint Diseases/surgery ; Male ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Reoperation ; Sacroiliac Joint/surgery ; Spinal Fusion/adverse effects ; Spinal Fusion/methods
    Language English
    Publishing date 2020-05-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.04.188
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  9. Article ; Online: Vein of Galen Malformations in adults.

    Udine, Matthew / Croci, Davide / Wasserman, Jacob / A Noureldine, Mohammad Hassan / Monsour, Molly / Vakharia, Kunal / Agazzi, Siviero

    Clinical neurology and neurosurgery

    2023  Volume 228, Page(s) 107671

    Abstract: Objective: Vein of Galen Malformations (VoGM) are rare vascular malformations, typically seen in pediatric age groups. Even more rarely, VoGM's may be seen later in adulthood. In this case report and systematic review, we provide a thorough description ... ...

    Abstract Objective: Vein of Galen Malformations (VoGM) are rare vascular malformations, typically seen in pediatric age groups. Even more rarely, VoGM's may be seen later in adulthood. In this case report and systematic review, we provide a thorough description of the current literature as well as provide a case example exploring the diagnosis, imaging, treatment, and management of VoGM in adults.
    Methods: In accordance with PRISMA guidelines, we performed a systematic literature search for all relevant cases and case series of VoGM in adult patients. The reference list of all articles were reviewed for additional relevant cases. Articles were included if they described a VoGM of a patient over the age of 18 years old and published in English. 149 articles were originally identified and 26 described cases met our inclusion criteria.
    Results: In our literature review we found 26 patients that met our inclusion criteria. We found 14 male patients and 12 female patients. The mean age at presentation was 37.2 years (median=34 years, SD= 13.6 years). The most common presenting symptoms of patient were headache (n = 9), seizure (n = 6), and vomiting (n = 4). Of the 12 cases which clearly reported the subtype of VoGM, the choroidal type was more frequently seen (n = 10) compared to the mural type (n = 2). In 3 patients, the VoGM was thrombosed at time of diagnosis. Of the 26 patients, endovascular treatment was performed most frequently (n = 8) but some received microsurgical treatment (n = 4) or were treated conservatively (n = 6). Other treatment modalities included (ventriculoperitoneal shunt, ventriculostomy) (n = 5). In 3 cases treatment was not specified. In comparison to VoGM seen in pediatric or neonatal populations, VoGM in adults generally resulted in more favorable outcomes with only 2 patients reported to have passed away following treatment.
    Conclusion: VoGM remains a rare finding amongst the adult population. Hence, we described the clinical presentation, treatment modalities, and outcomes of the cases described in the English literature. Perhaps due to the rate of thrombosis and the unique angioarchitecture seen in adult VoGM patients, outcomes were generally more favorable than those described in the literature in pediatric or neonate VoGM patients.
    MeSH term(s) Adult ; Child ; Female ; Humans ; Infant, Newborn ; Male ; Middle Aged ; Developmental Disabilities ; Embolization, Therapeutic/methods ; Vein of Galen Malformations/diagnostic imaging ; Vein of Galen Malformations/therapy ; Ventriculoperitoneal Shunt ; Ventriculostomy
    Language English
    Publishing date 2023-03-14
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2023.107671
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  10. Article ; Online: Thalassemia and malignancy: An emerging concern?

    Hodroj, Mohammad Hassan / Bou-Fakhredin, Rayan / Nour-Eldine, Wared / Noureldine, Hussein A / Noureldine, Mohammad Hassan A / Taher, Ali T

    Blood reviews

    2019  Volume 37, Page(s) 100585

    Abstract: The thalassemias constitute a variable group of anemias that result from autosomal recessive inherited defects in the production of hemoglobin. The life expectancy of thalassemia patients has been extended over the last decades as a result of key ... ...

    Abstract The thalassemias constitute a variable group of anemias that result from autosomal recessive inherited defects in the production of hemoglobin. The life expectancy of thalassemia patients has been extended over the last decades as a result of key milestones being achieved in optimizing management with transfusion and iron chelation therapy. Such advances have prolonged the survival of thalassemia patients and improved their overall quality of life. However, this increase in life expectancy has led to the manifestation of several morbidities, including multiple types of solid and hematologic malignancies. In this review we report the different types of solid and hematological malignancies that can develop in thalassemia patients, in addition to the possible predisposing factors and mechanisms behind their development.
    MeSH term(s) Humans ; Neoplasms/etiology ; Thalassemia/complications
    Language English
    Publishing date 2019-06-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2019.06.002
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