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  1. Article ; Online: NTRK

    Theik, Nyein Wint Yee / Muminovic, Meri / Alvarez-Pinzon, Andres M / Shoreibah, Ahmed / Hussein, Atif M / Raez, Luis E

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Neurotrophic tyrosine receptor kinase ( ...

    Abstract Neurotrophic tyrosine receptor kinase (
    MeSH term(s) Humans ; Receptor, trkA/metabolism ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Medical Oncology ; Signal Transduction ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Oncogene Proteins, Fusion/metabolism
    Chemical Substances Receptor, trkA (EC 2.7.10.1) ; Protein Kinase Inhibitors ; Oncogene Proteins, Fusion
    Language English
    Publishing date 2024-02-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042366
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  2. Article: 5-Aminolevulinic Acid-A Biomarker for Worse Prognosis in IDH-Wildtype II Tumors? Evolution of a Fluorescence-Positive Diffuse Astrocytoma: A Case Report.

    Valerio, Jose E / Ochoa, Sebastian / Alvarez, Sandra / Borro, Matteo / Alvarez-Pinzon, Andres M

    Journal of neurological surgery reports

    2022  Volume 83, Issue 3, Page(s) e95–e99

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2022-08-25
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2653397-2
    ISSN 2193-6366 ; 2193-6358
    ISSN (online) 2193-6366
    ISSN 2193-6358
    DOI 10.1055/a-1858-7628
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  3. Article ; Online: Frame navigation guided percutaneous balloon compression for intractable trigeminal neuralgia secondary to multiple sclerosis.

    Valerio Pascua, Jose E / Mantilla Farfan, Penelope / Fernandez, Maria Paula / Santiago Rea, Noe / Borro, Matteo / Alvarez-Pinzon, Andres M

    Brain & spine

    2024  Volume 4, Page(s) 102798

    Abstract: Background: Patients with multiple sclerosis (MS) are more likely to develop trigeminal neuralgia (TN) compared to the regular population, due to scarring of the nerve and development of a demyelination plaque. Despite treatment, approximately 10% of MS ...

    Abstract Background: Patients with multiple sclerosis (MS) are more likely to develop trigeminal neuralgia (TN) compared to the regular population, due to scarring of the nerve and development of a demyelination plaque. Despite treatment, approximately 10% of MS patients treated for TN experience symptom recurrence, including the development of MS-like symptoms such as optic neuritis and bilateral facial pain.
    Methods: A computed tomography (CT) scan was performed preoperatively on two patients diagnosed with multiple sclerosis (MS) who experienced secondary trigeminal neuralgia (TN). A precise reference frame was strapped firmly to the patient's forehead during the intraoperative procedure. Preliminary CT images were registered using the navigation system and the bony landmarks were set.
    Case description: Two patients diagnosed with multiple sclerosis (MS) who experienced refractory trigeminal neuralgia (TN) underwent percutaneous balloon compression. Initial conservative treatment and one dosage of Gamma Knife Radiosurgery (GKR) resulted in symptom control for a few weeks. Both patients had an acute recurrence of pain; thus, percutaneous retrogasserian balloon compression was performed. During follow-up, the patients reported a 70% decrease in pain after the procedure, with minimal recurrence of shooting episodes.
    Conclusion: Management of trigeminal neuralgia secondary to drug-resistant multiple sclerosis presents a persistent challenge. The percutaneous technique for retrogasserian balloon compression may offer a solution for some patients, but it presents unique challenges for neurosurgeons. Given the complexity of the pathogenesis, target identification, and the potential absence of neurovascular conflict, microvascular decompression remains a debated approach for this patient population. While stereotactic radiosurgery may be a promising alternative.
    Language English
    Publishing date 2024-04-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-5294
    ISSN (online) 2772-5294
    DOI 10.1016/j.bas.2024.102798
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  4. Article: 5-Aminolevulinic Acid—A Biomarker for Worse Prognosis in IDH-Wildtype II Tumors? Evolution of a Fluorescence-Positive Diffuse Astrocytoma: A Case Report

    Valerio, Jose E. / Ochoa, Sebastian / Alvarez, Sandra / Borro, Matteo / Alvarez-Pinzon, Andres M.

    Journal of Neurological Surgery Reports

    2022  Volume 83, Issue 03, Page(s) e95–e99

    Abstract: Introduction: In 2017, the U.S. Food and Drug Administration (FDA) approved 5-aminolevulinic acid (5-ALA) as an intraoperative optical imaging agent in patients with suspected high-grade gliomas (HGGs). However, the application of 5-ALA for low-grade ... ...

    Abstract Introduction: In 2017, the U.S. Food and Drug Administration (FDA) approved 5-aminolevulinic acid (5-ALA) as an intraoperative optical imaging agent in patients with suspected high-grade gliomas (HGGs). However, the application of 5-ALA for low-grade gliomas is still less accepted. Astrocytoma, isocitrate dehydrogenase (IDH) mutant tumors are diffuse infiltrating astrocytic tumors where there is no identifiable border between the tumor and normal brain tissue, even though the borders may appear relatively well-marginated on imaging. Generally, it is considered that 5-ALA cannot pass through a normal blood–brain barrier (BBB). Thus, 5-ALA fluorescence may mean disruption of BBB in grade II glioma.
    Case Report: A 74-year-old male patient was diagnosed with a right parietal lesion suggestive of a low-grade brain tumor in a surgical resection using 5-ALA, which led to the detection of tiny fluorescence spots during the surgery. The frozen section was consistent with diffuse astrocytoma, IDH-wildtype (World Health Organization [WHO] grade II). The patient's postoperative magnetic resonance imaging (MRI) showed complete resection. Eight months after surgery, he began experiencing symptoms again and was admitted with a brain MRI finding consistent with recurrent infiltrating astrocytomas. This required reoperation of the brain tumor resection with 5-ALA. Unlike the first surgery, they observed a high fluorescence intensity; the pathological finding was glioblastoma, IDH-wildtype (WHO grade IV). Postsurgical brain MRI showed total resection of the tumor. The patient was discharged 4 weeks after surgery and continued with specialized clinical follow-up.
    Conclusion: The use of 5-ALA continues to be a great contributor to the improvement in complete resection of primary brain tumors, especially HGG. Besides, fluorescence is increasingly approaching its use as a prognostic tool for aggressive clinical course, regardless of the initial grade of the tumor. This case report is an effort to expand knowledge for potentially using 5-ALA to help prognosticate brain tumors. Nevertheless, more clinical prospective studies must be conducted.
    Keywords brain tumor ; 5-ALA ; diffuse astrocytoma
    Language English
    Publishing date 2022-05-22
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2653397-2
    ISSN 2193-6366 ; 2193-6358
    ISSN (online) 2193-6366
    ISSN 2193-6358
    DOI 10.1055/a-1858-7628
    Database Thieme publisher's database

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  5. Article ; Online: Letter to the Editor Regarding Effects of the COVID-19 Outbreak in Northern Italy: Perspectives from the Bergamo Neurosurgery Department, and the Role of Radiosurgery as a Minimally Invasive Procedure for Primary Central Nervous System Lymphoma in the Pandemic Outbreak.

    Alvarez Pinzon, Andres M / Wolf, Aizik L / Delgado, Victor / Valerio, Jose E / González, Arturo / Alonso, José Ramón

    World neurosurgery

    2020  Volume 139, Page(s) 264–265

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Disease Outbreaks ; Humans ; Italy ; Lymphoma ; Nervous System ; Neurosurgery ; Pandemics ; Pneumonia, Viral ; Radiosurgery ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.04.209
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  6. Article ; Online: Can food allergy be cured? What are the future prospects?

    Sampath, Vanitha / Sindher, Sayantani B / Alvarez Pinzon, Andres M / Nadeau, Kari C

    Allergy

    2019  Volume 75, Issue 6, Page(s) 1316–1326

    Abstract: Food allergies have become a significant heath burden as prevalence continues to rise, affecting 6%-13% of the global population. In the absence of drugs approved by regulatory agencies, the current standard of care remains avoidance of allergenic foods ... ...

    Abstract Food allergies have become a significant heath burden as prevalence continues to rise, affecting 6%-13% of the global population. In the absence of drugs approved by regulatory agencies, the current standard of care remains avoidance of allergenic foods and management of acute allergic reactions with antihistamines and epinephrine autoinjectors. Allergen immunotherapy has been shown to increase the threshold of reactivity in the majority of food-allergic individuals. However, challenges include long treatment periods, high rates of adverse reactions, and lack of permanence of desensitization and established protocols. To address these limitations, adjunctive allergen-specific immunotherapy, vaccines, and non-allergen-specific therapies (eg, monoclonal antibodies) are being explored. The future of food allergy treatment is promising with a number of clinical trials in progress. Currently, although desensitization can be achieved for the majority of individuals with food allergy through immunotherapy, continued ingestion of allergen is needed for most individuals to maintain desensitization. Further understanding of the mechanisms of food allergy and identification of biomarkers to distinguish between temporary and permanent resolution of allergies is needed before a cure, where reactivity to the allergen is permanently lost enabling the individual to consume the allergen in any amount at any time, can be envisioned.
    MeSH term(s) Allergens ; Antibodies, Monoclonal ; Desensitization, Immunologic ; Food ; Food Hypersensitivity/therapy ; Humans
    Chemical Substances Allergens ; Antibodies, Monoclonal
    Language English
    Publishing date 2019-12-03
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14116
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    Uh III Zs.150: Show issues Location:
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  7. Article ; Online: Gamma knife stereotactic radiosurgery as an effective tool in primary CNS lymphoma: Evaluation of stereotactic radiosurgery and methotrexate treatment in a prospective and observational clinical research study.

    Alvarez-Pinzon, Andres M / Wolf, Aizik / Valerio, Jose E / Borro, Matteo / Herrera, Daniela / Alonso, Jose Ramon

    Clinical neurology and neurosurgery

    2020  Volume 201, Page(s) 106457

    Abstract: Objective: The purpose of this study was to compare the progression of Primary Central Nervous System Lymphoma (PCNSL) in patients treated with methotrexate (MTX) versus those treated with a combination of Stereotactic Radiosurgery (SRS) and MTX. ... ...

    Abstract Objective: The purpose of this study was to compare the progression of Primary Central Nervous System Lymphoma (PCNSL) in patients treated with methotrexate (MTX) versus those treated with a combination of Stereotactic Radiosurgery (SRS) and MTX. Progression was measured via brain lesion count and tumor volume.
    Methods: This observational and prospective cohort study evaluated the outcome of SRS treatment of PCNSL in one hundred twenty-eight subjects. We analyzed baseline, prospective, and retrospective data of patients enrolled in the brain tumor registry between June 2010 and August 2017. Seventy-three patients were treated exclusively with MTX while the remaining fifty-five patients received a combination of SRS and MTX. Strict inclusion and exclusion criteria were established.
    Results: Mean survival rate for patients receiving combined SRS and MTX treatment was significantly higher (52.6 months) compared to the MTX group (19.8 months); p = 0.0029. At the 36 months follow-up, patients treated with SRS and MTX also had a lower rate of tumor progression (32.7 %) than the MTX group (95.9 %); p = 0.00192. Local tumor control was achieved in all patients treated with SRS. No clinical toxicity was observed in this group.
    Conclusions: Clinical results obtained from this observational study highlight the potential effectiveness of SRS in the treatment of PCNSL. Although treatment outcomes have improved in the past years, additional evidence in the clinical design of randomized trials is needed to evaluate the strength of this treatment in specific situations.
    MeSH term(s) Adult ; Aged ; Antimetabolites, Antineoplastic/therapeutic use ; Central Nervous System Neoplasms/therapy ; Chemoradiotherapy/methods ; Female ; Humans ; Lymphoma/therapy ; Male ; Methotrexate/therapeutic use ; Middle Aged ; Radiosurgery/methods ; Treatment Outcome
    Chemical Substances Antimetabolites, Antineoplastic ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2020-12-29
    Publishing country Netherlands
    Document type Journal Article ; Observational Study
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2020.106457
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  8. Article: Letter to the Editor Regarding Effects of the COVID-19 Outbreak in Northern Italy: Perspectives from the Bergamo Neurosurgery Department, and the Role of Radiosurgery as a Minimally Invasive Procedure for Primary Central Nervous System Lymphoma in the Pandemic Outbreak

    Alvarez Pinzon, Andres M / Wolf, Aizik L / Delgado, Victor / Valerio, Jose E / González, Arturo / Alonso, José Ramón

    World Neurosurg

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #437603
    Database COVID19

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  9. Book ; Online: Letter to the Editor Regarding Effects of the COVID-19 Outbreak in Northern Italy

    Alvarez Pinzon, Andres M. / Wolf, Aizik L. / Delgado, Victor / Valerio, Jose E. / Gonzalez, Arturo / Alonso, Jose Ramon

    Coronavirus Research at FIU

    Perspectives from the Bergamo Neurosurgery Department, and the Role of Radiosurgery as a Minimally Invasive Procedure for Primary Central Nervous System Lymphoma in the Pandemic Outbreak

    2020  

    Keywords Medicine and Health Sciences ; covid19
    Publishing date 2020-07-01T07:00:00Z
    Publisher FIU Digital Commons
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Letter to the Editor Regarding Effects of the COVID-19 Outbreak in Northern Italy

    Alvarez Pinzon, Andres M. / Wolf, Aizik L. / Delgado, Victor / Valerio, Jose E. / González, Arturo / Alonso, José Ramón

    World Neurosurgery

    Perspectives from the Bergamo Neurosurgery Department, and the Role of Radiosurgery as a Minimally Invasive Procedure for Primary Central Nervous System Lymphoma in the Pandemic Outbreak

    2020  Volume 139, Page(s) 264–265

    Keywords Surgery ; Clinical Neurology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.04.209
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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