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  1. Article ; Online: Exclusively genital psoriasis successfully treated with Risankizumab.

    Ceccarelli, Gabriele / Simonacci, Marco

    Dermatologic therapy

    2022  Volume 35, Issue 8, Page(s) e15591

    MeSH term(s) Antibodies, Monoclonal ; Genitalia ; Humans ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal ; risankizumab (90ZX3Q3FR7)
    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.15591
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5181: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: 3D bioprinting and Rigenera

    Aliberti, Flaminia / Paolin, Elisa / Benedetti, Laura / Cusella, Gabriella / Ceccarelli, Gabriele

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 937709

    Abstract: Plant and animal life forms have progressively developed mechanisms for perceiving and responding to gravity on Earth, where homeostatic mechanisms require feedback. Lack of gravity, as in the International Space Station (ISS), induces acute intra- ... ...

    Abstract Plant and animal life forms have progressively developed mechanisms for perceiving and responding to gravity on Earth, where homeostatic mechanisms require feedback. Lack of gravity, as in the International Space Station (ISS), induces acute intra-generational changes in the quality of life. These include reduced bone calcium levels and muscle tone, provoking skin deterioration. All these problems reduce the work efficiency and quality of life of humans not only during exposure to microgravity (µG) but also after returning to Earth. This article discusses forthcoming experiments required under gravity and µG conditions to ensure effective and successful medical treatments for astronauts during long-term space missions, where healthcare is difficult and not guaranteed.
    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.937709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exercise-induced modulation of Interferon-signature: a therapeutic route toward management of Systemic Lupus Erythematosus.

    Spinelli, Francesca Romana / Berti, Riccardo / Farina, Gabriele / Ceccarelli, Fulvia / Conti, Fabrizio / Crescioli, Clara

    Autoimmunity reviews

    2023  Volume 22, Issue 10, Page(s) 103412

    Abstract: Systemic Lupus Erythematosus (SLE) is a multisystemic autoimmune disorder characterized by flares-ups/remissions with a complex clinical picture related to disease severity and organ/tissue injury, which, if left untreated, may result in permanent damage. ...

    Abstract Systemic Lupus Erythematosus (SLE) is a multisystemic autoimmune disorder characterized by flares-ups/remissions with a complex clinical picture related to disease severity and organ/tissue injury, which, if left untreated, may result in permanent damage. Enhanced fatigue and pain perception, worsened quality of life (QoL) and outcome are constant, albeit symptoms may differ. An aberrant SLE immunoprofiling, note as "interferon (IFN)α-signature", is acknowledged to break immunotolerance. Recently, a deregulated "IFNγ-signature" is suggested to silently precede/trigger IFNα profile before clinical manifestations. IFNα- and IFNγ-over-signaling merge in cytokine/chemokine overexpression exacerbating autoimmunity. Remission achievement and QoL improvement are the main goals. The current therapy (i.e., corticosteroids, immunosuppressants) aims to downregulate immune over-response. Exercise could be a safe treatment due to its ever-emerging ability to shape and re-balance immune system without harmful side-effects; in addition, it improves cardiorespiratory capacity and musculoskeletal strength/power, usually impaired in SLE. Nevertheless, exercise is not yet included in SLE care plans. Furthermore, due to the fear to worsening pain/fatigue, SLE subjects experience kinesiophobia and sedentary lifestyle, worsening physical health. Training SLE patients to exercise is mandatory to fight inactive behavior and ameliorate health. This review aims to focus the attention on the role of exercise as a non-pharmacological therapy in SLE, considering its ability to mitigate IFN-signature and rebalance (auto)immune response. To this purpose, the significance of IFNα- and IFNγ-signaling in SLE etiopathogenesis will be addressed first and discussed thereafter as biotarget of exercise. Comments are addressed on the need to make aware all SLE care professional figures to promote exercise for health patients.
    MeSH term(s) Humans ; Quality of Life ; Interferon-alpha/therapeutic use ; Cytokines/therapeutic use ; Lupus Erythematosus, Systemic/drug therapy ; Autoimmunity
    Chemical Substances Interferon-alpha ; Cytokines
    Language English
    Publishing date 2023-08-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2023.103412
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5913: Show issues Location:
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  4. Article ; Online: Occupational health surveillance of healthcare workers during COVID 19 pandemic: a narrative review.

    D'Ettorre, Gabriele / Pellicani, Vincenza / Muratore, Massimo / Ceccarelli, Giancarlo

    Acta bio-medica : Atenei Parmensis

    2022  Volume 93, Issue 1, Page(s) e2022007

    Abstract: Background and aims: Current literature has increasingly highlighted the risk of spreading the SARS-COV-2 infection in healthcare settings and showed the need for occupational health surveillance of HCWs during the current epidemiological emergency from ...

    Abstract Background and aims: Current literature has increasingly highlighted the risk of spreading the SARS-COV-2 infection in healthcare settings and showed the need for occupational health surveillance of HCWs during the current epidemiological emergency from COVID-19, as a preventive measure to minimize the spread of the infection. The purpose of this narrative review was to evaluate the literature and discover what the latest developments are about the management of the occupational health surveillance of healthcare workers (HCWs) during COVID-19 pandemic.
    Methods: We searched for publications in MEDLINE, Pubmed and Google Scholar using selected keywords. Each article was reviewed and categorized into one or more of the following three categories based on its subject matter: early diagnosis of COVID-19 in HCWs, detection of worker susceptibility to severe COVID-19, medical examination of HCWs returning to work after COVID-19.
    Results: Selected articles showed the RT-PCR test for Sars-CoV-2 as the gold standard to enable rapid identification of infected HCWs; an effective schedule of occupational health surveillance allows the identification of the susceptibility of the workers to severe Covid-19 and protect HCWs returning to work from the disease.
    Conclusions: The findings of the present narrative review show the need to strenghten the occupational health surveillance of HCWs during the current COVID-19 pandemic, with the aim not only to contain the spread of the infection in healthcare settings, but also to protect HCWs coming back to work after the disease.
    MeSH term(s) COVID-19 ; Health Personnel ; Humans ; Occupational Health ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-03-14
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v93i1.10277
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    Zs.B 925: Show issues Location:
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  5. Article ; Online: Discovery and Structure-Activity Relationships of Novel

    Ceccarelli, Giada / Goracci, Laura / Carotti, Andrea / Paccoia, Federico / Passeri, Daniela / Cipolloni, Marco / Di Bona, Stefano / Cruciani, Gabriele / Pellicciari, Roberto / Gioiello, Antimo

    Journal of medicinal chemistry

    2024  Volume 67, Issue 5, Page(s) 4150–4169

    Abstract: The nuclear ... ...

    Abstract The nuclear receptor
    MeSH term(s) Animals ; Humans ; Strongyloidiasis/drug therapy ; Strongyloidiasis/parasitology ; Strongyloides stercoralis/metabolism ; Steroids/therapeutic use ; Life Cycle Stages ; Structure-Activity Relationship
    Chemical Substances Steroids
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c02421
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    Zs.B 151: Show issues Location:
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  6. Article ; Online: SARS-CoV-2 pandemic, influenza, and influenza-like illness epidemics: Allies or enemies?

    Ceccarelli, Giancarlo / d'Ettorre, Gabriele / Russo, Alessandro / Fabris, Silvia / Ciccozzi, Massimo / d'Ettorre, Gabriella

    Journal of medical virology

    2022  Volume 95, Issue 1, Page(s) e28148

    MeSH term(s) Humans ; SARS-CoV-2 ; Influenza, Human/epidemiology ; Pandemics ; COVID-19/epidemiology ; Virus Diseases ; Epidemics
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28148
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Letter to the Editor in response to the article "Could IL-17 represent a new therapeutic target for the treatment and/or management of COVID-19-related respiratory syndrome?"

    Ceccarelli, Gabriele / Nardi, Katiuscia / Marchesani, Francesca

    Pharmacological research

    2020  Volume 158, Page(s) 104933

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Interleukin-17 ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Interleukin-17
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2020.104933
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
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  8. Article ; Online: 3D bioprinting and Rigenera® micrografting technology

    Flaminia Aliberti / Elisa Paolin / Laura Benedetti / Gabriella Cusella / Gabriele Ceccarelli

    Frontiers in Bioengineering and Biotechnology, Vol

    A possible countermeasure for wound healing in spaceflight

    2022  Volume 10

    Abstract: Plant and animal life forms have progressively developed mechanisms for perceiving and responding to gravity on Earth, where homeostatic mechanisms require feedback. Lack of gravity, as in the International Space Station (ISS), induces acute intra- ... ...

    Abstract Plant and animal life forms have progressively developed mechanisms for perceiving and responding to gravity on Earth, where homeostatic mechanisms require feedback. Lack of gravity, as in the International Space Station (ISS), induces acute intra-generational changes in the quality of life. These include reduced bone calcium levels and muscle tone, provoking skin deterioration. All these problems reduce the work efficiency and quality of life of humans not only during exposure to microgravity (µG) but also after returning to Earth. This article discusses forthcoming experiments required under gravity and µG conditions to ensure effective and successful medical treatments for astronauts during long-term space missions, where healthcare is difficult and not guaranteed.
    Keywords microgravity ; 3D bioprinting ; micrografting ; skin ; regenerative medicine ; wound healing ; Biotechnology ; TP248.13-248.65
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Electrospun Naringin-Loaded Fibers for Preventing Scar Formation during Wound Healing.

    Tottoli, Erika M / Benedetti, Laura / Chiesa, Enrica / Pisani, Silvia / Bruni, Giovanna / Genta, Ida / Conti, Bice / Ceccarelli, Gabriele / Dorati, Rossella

    Pharmaceutics

    2023  Volume 15, Issue 3

    Abstract: Hypertrophic scars (HTSs) are aberrant structures that develop where skin is injured complexly and represent the result of a chronic inflammation as a healing response. To date, there is no satisfactory prevention option for HTSs, which is due to the ... ...

    Abstract Hypertrophic scars (HTSs) are aberrant structures that develop where skin is injured complexly and represent the result of a chronic inflammation as a healing response. To date, there is no satisfactory prevention option for HTSs, which is due to the complexity of multiple mechanisms behind the formation of these structures. The present work aimed to propose Biofiber (Biodegradable fiber), an advanced textured electrospun dressing, as a suitable solution for HTS formation in complex wounds. Biofiber has been designed as a 3-day long-term treatment to protect the healing environment and enhance wound care practices. Its textured matrix consists of homogeneous and well-interconnected Poly-L-lactide-co-poly-ε-caprolactone (PLA-PCL) electrospun fibers (size 3.825 ± 1.12 µm) loaded with Naringin (NG, 2.0%
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15030747
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  10. Article ; Online: Post-traumatic stress disorder symptoms in healthcare workers: a ten-year systematic review.

    D'Ettorre, Gabriele / Pellicani, Vincenza / Ceccarelli, Giancarlo

    Acta bio-medica : Atenei Parmensis

    2020  Volume 91, Issue 12-S, Page(s) e2020009

    Abstract: Background and aims: Healthcare workers (HCWs) employed in hospital settings frequently experience many occupational stressors leading to post-traumatic stress disorder (PTSD) symptoms. Literature has increasingly highlighted PTSD as a major issue that ... ...

    Abstract Background and aims: Healthcare workers (HCWs) employed in hospital settings frequently experience many occupational stressors leading to post-traumatic stress disorder (PTSD) symptoms. Literature has increasingly highlighted PTSD as a major issue that involves both staff and healthcare organizations; the consequences of PTSD may include medication errors and lower standards of care. The current COVID-19 pandemic poses the need for preventing PTSD in HCWs working closely with COVID-19 patients. The purpose of this systematic review was to analyze the latest developments in assessing and managing the occupational risk of PTSD symptoms in hospital HCWs.
    Methods: We searched for publications in MEDLINE/Pubmed using selected keywords. Each article was reviewed and categorized into one or more of the following four categories based on its subject matter: risk assessment, risk management and occurrence rates.
    Results: Our search resulted in a total of 32 publications that matched our inclusion criteria.  Increased years of service, older age, previous year exposure to violence, personality traits (i.e. neuroticism), history of mental disorders, being non-graduates, were found to be workers' pre-trauma factors predicting PTSD symptoms.
    Conclusions: The findings suggest the need to prioritize preventative interventions aimed to anticipate the effects of traumatic exposure by training HCWs in evidence based anticipatory methods of coping with stressful events. With regard to the current COVID-19 pandemic, we found evidence of the need to strength social support and training targeted at psychological skills of medical staff who treated COVID-19 patients.
    MeSH term(s) Age Factors ; Exposure to Violence ; Health Personnel/psychology ; Humans ; Mental Disorders/complications ; Personality ; Risk Factors ; Stress Disorders, Post-Traumatic/etiology
    Language English
    Publishing date 2020-11-30
    Publishing country Italy
    Document type Journal Article ; Systematic Review
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v91i12-S.9459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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