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Article: Zinc-Boron Complex-Based Dietary Supplements for Longevity and Healthy Life.

Biţă, Andrei / Scorei, Ion Romulus / Bălşeanu, Tudor Adrian / Rău, Gabriela / Ciocîlteu, Maria Viorica / Mogoşanu, George Dan

Current health sciences journal

2023 Volume 49, Issue 3, Page(s) 381–387

Abstract: The nutritional role of zinc (Zn) and boron (B) in the plant-animal-human food chain is highly topical worldwide research. Our data indicated that Zn-B complex (ZBC)-based dietary supplements can be used as stable non-toxic formulations, with high ... ...

Abstract	The nutritional role of zinc (Zn) and boron (B) in the plant-animal-human food chain is highly topical worldwide research. Our data indicated that Zn-B complex (ZBC)-based dietary supplements can be used as stable non-toxic formulations, with high intestinal absorption rate, inducing alpha2-macroglobulin (A2M) expression for longevity and healthy life. ZBC is metabolized by hydrolysis, mainly at the absorption site (intestinal level), and most of it is excreted in the urine. Within seven hours from the administration in mice, almost the entire amount of orally absorbed ZBC is eliminated in a metabolized form. The highest amount of A2M protein in mouse liver was determined by immunoabsorbance assay in the chronic experiment (1000mg/kg of ZBC), followed by the subchronic experiment (at the same dose of ZBC), and by the acute experiment (5000mg/kg of ZBC).
Language	English
Publishing date	2023-09-30
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2708703-7
ISSN	2069-4032 ; 2067-0656
ISSN (online)	2069-4032
ISSN	2067-0656
DOI	10.12865/CHSJ.49.03.10
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Article ; Online: Letter to the Editor: Boron enhances the antiviral activity of the curcumin against SARS-CoV-2.

Scorei, Ion Romulus / Biţă, Andrei / Mogoşanu, George Dan

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2021 Volume 61, Issue 3, Page(s) 967–970

MeSH term(s)	Antiviral Agents/administration & dosage ; Antiviral Agents/pharmacology ; Boron/administration & dosage ; Boron/pharmacology ; Boron Compounds/administration & dosage ; Boron Compounds/pharmacology ; COVID-19/blood ; COVID-19/epidemiology ; COVID-19/virology ; Curcumin/administration & dosage ; Curcumin/pharmacology ; Drug Synergism ; Gene Frequency ; Hemin/pharmacology ; Heterozygote ; Humans ; Iron/blood ; Oxidative Stress/drug effects ; Phytotherapy/methods ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; beta-Thalassemia/blood ; beta-Thalassemia/epidemiology ; beta-Thalassemia/genetics ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; Boron Compounds ; Hemin (743LRP9S7N) ; Iron (E1UOL152H7) ; Curcumin (IT942ZTH98) ; Boron (N9E3X5056Q)
Language	English
Publishing date	2021-03-30
Publishing country	Romania
Document type	Journal Article
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
DOI	10.47162/RJME.61.3.39
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Article ; Online: The role of boron in the functioning of the osteoarticular system

Maria-Victoria Racu / Ion Romulus Scorei / Iurie Pinzaru

The Moldovan Medical Journal, Vol 64, Iss 5, Pp 76-

2021 Volume 80

Abstract: Background: Boron was classified by the World Health Organization as ‘possible essential elements for human health’. It can be found in different forms in the environment, has beneficial effects on bones and its deprivation can impair calcium and ... ...

Abstract	Background: Boron was classified by the World Health Organization as ‘possible essential elements for human health’. It can be found in different forms in the environment, has beneficial effects on bones and its deprivation can impair calcium and magnesium metabolism and bone development, their health and maintenance. Dietary boron supplementation can help prevent and manage degenerative and inflammatory bones and articular diseases, such as arthritis, osteoarthritis, rheumatoid arthritis and osteoporosis. Relevant articles were identified in PubMed, Google Scholar, ProQuest, and Scopus databases published until June 2021, describing the role of boron in the functioning of the osteoarticular system. Conclusions: From organic and inorganic boron forms that can enter the human body, organic plant based boron compounds are highly bioavailable. In the functioning of the osteoarticular system boron acts by regulation of calcium and magnesium metabolism, enhancing the vitamin D activation process and influencing serum steroid hormone levels. A boron intake equal to or higher than 3 mg per day can help prevent/or correct arthritis, osteoporosis and osteoarthritis. Calcium fructoborate can reduce pain, joint discomfort and increase endogenous vitamin D level in patients with osteoarthritis. Boron may play a role in pathophysiology of rheumatoid arthritis and its severity and a supplementation with boron element may be useful.
Keywords	boron ; boron containing compounds ; osteoarticular system ; osteoarthritis ; rheumatoid arthritis ; Medicine ; R
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Scientific Medical Association of Moldova
Document type	Article ; Online
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Article ; Online: The role of boron in prevention of osteoarticular diseases and its distribution in the Republic of Moldova

Maria-Victoria RACU / Ion Romulus SCOREI / Iurie PINZARU

One Health & Risk Management, Vol 2, Iss 4, Pp 54-

2021 Volume 64

Abstract: Introduction. Boron is a trace mineral that is supposed to be essential for human health. Organic plant based boron compounds are highly bioavailable for humans and can positively influence minerals such as calcium, phosphorus, magnesium and act in ... ...

Abstract	Introduction. Boron is a trace mineral that is supposed to be essential for human health. Organic plant based boron compounds are highly bioavailable for humans and can positively influence minerals such as calcium, phosphorus, magnesium and act in synergy with vitamin D, which are beneficial for osteoarticular health. Material and methods. We made an analysis of 126 bibliographic sources and mapped the Republic of Moldova to the content of boron in deep water and to the adults’ prevalence of rheumatoid arthritis and inflammatory polyarthropathy. Results. Boron is important for osteogenesis and its deficiency can lead to impaired growth and abnormal bones development. It supports bone health in postmenopausal women by reducing urinary loss of the minerals such as calcium, magnesium and phosphorus, which are essential for bone building. In countries where soil was depleted of boron and daily intake of this mineral was 1 mg or lower, the incidence of arthritis was between 20 and 70%. In Moldova, in the regions where boron concentration in deep drinking water were low (0.28 mg/L in well water and 0.51 mg/L in artesian well water) in Soroca in 2019, the prevalence with the rheumatoid arthritis and inflammatory polyarthropathy were high (51.6 per 10000 inhabitants) with one exception, UTA Gagauzia (35.1 per 10000 inhabitants), where we found a high boron concentration in deep drinking water (2.05 mg/L in well water and 2.2 mg/L in artesian well water) in 2015. Conclusions. Boron can affect bone metabolism. In regions where boron concentration in deep drinking water is low, the osteoarticular morbidity can be higher with the exception of UTA Gagauzia, where we suppose that dietary pattern can be a cause of these results. In the future we will study eating habits in this region and a clearer conclusion will be made.
Keywords	osteoarticular diseases ; boron ; boron compounds ; Medicine ; R ; Science ; Q
Subject code	500
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Asociatia de Biosiguranta si Biosecuritate
Document type	Article ; Online
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Article ; Online: The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology.

Grams, R Justin / Santos, Webster L / Scorei, Ion Romulus / Abad-García, Antonio / Rosenblum, Carol Ann / Bita, Andrei / Cerecetto, Hugo / Viñas, Clara / Soriano-Ursúa, Marvin A

Chemical reviews

2024 Volume 124, Issue 5, Page(s) 2441–2511

Abstract: Boron-containing compounds (BCC) have emerged as important pharmacophores. To date, five BCC drugs (including boronic acids and boroles) have been approved by the FDA for the treatment of cancer, infections, and atopic dermatitis, while some natural BCC ... ...

Abstract	Boron-containing compounds (BCC) have emerged as important pharmacophores. To date, five BCC drugs (including boronic acids and boroles) have been approved by the FDA for the treatment of cancer, infections, and atopic dermatitis, while some natural BCC are included in dietary supplements. Boron's Lewis acidity facilitates a mechanism of action via formation of reversible covalent bonds within the active site of target proteins. Boron has also been employed in the development of fluorophores, such as BODIPY for imaging, and in carboranes that are potential neutron capture therapy agents as well as novel agents in diagnostics and therapy. The utility of natural and synthetic BCC has become multifaceted, and the breadth of their applications continues to expand. This review covers the many uses and targets of boron in medicinal chemistry.
MeSH term(s)	Humans ; Boron/chemistry ; Chemistry, Pharmaceutical ; Boron Compounds/chemistry ; Neoplasms/drug therapy ; Boronic Acids ; Boranes ; Boron Neutron Capture Therapy/methods
Chemical Substances	Boron (N9E3X5056Q) ; Boron Compounds ; Boronic Acids ; Boranes
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	207949-5
ISSN	1520-6890 ; 0009-2665
ISSN (online)	1520-6890
ISSN	0009-2665
DOI	10.1021/acs.chemrev.3c00663
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Article ; Online: THE INFLUENCE OF BORON-CONTAINING COMPOUNDS ON CARDIOVASCULAR HEALTH

Maria-Victoria Racu / Ion Romulus Scorei / Iurie Pînzaru

Arta Medica, Vol 77, Iss

2020 Volume 4

Abstract: Objectives. Boron is a biological trace element which can be find in different natural compounds, but there is substantial and growing support for it to be classified as an essential nutrient for animals and humans. Previous studies suggest an active ... ...

Abstract	Objectives. Boron is a biological trace element which can be find in different natural compounds, but there is substantial and growing support for it to be classified as an essential nutrient for animals and humans. Previous studies suggest an active involvement of boron-containing compounds in the mediation of several biological reactions in the body, as inflammation and oxidative stress, which can influence occurrence of cardiovascular diseases and can amplify the risk factor impact. Although, the exact role of boron-containing compounds on human body has not yet been established, this work aims to study existing results with a special focus on cardiovascular health. The aim of this study was to review the literature and to detect the possible influence of boron compounds on cardiovascular health. Materials and methods. We made an analysis of more than 150 bibliographic sources that highlighted the boron and its compounds functions, and their impact on cardiovascular risk factors. Results. We found out that the most important compounds for human health are boron esters which can be taken from plant-based food and can be used directly in human cellular metabolism. These compounds have the ability to modulate a response to cardiovascular risk factors, such as oxidative stress and inflammation, but also can influence dyslipidemia, type II diabetes, smoking and obesity. Conclusions. Current studies suggest that a rich boron plant-based diet can have a potential cardioprotective effect and can be involved in reducing of risk factors for cardiovascular diseases.
Keywords	cardiovascular diseases ; boron ; boron compounds ; Medicine ; R ; Surgery ; RD1-811
Subject code	500
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	Association of Surgeons of the Republic of Moldova
Document type	Article ; Online
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Article ; Online: Zinc-Boron-PLGA biocomposite material: preparation, structural characterization, and in vitro assessment.

Ciocîlteu, Maria Viorica / Scorei, Ion Romulus / Rău, Gabriela / Nicolicescu, Claudiu / Biţă, Andrei / Ene, Vladimir Lucian / Simionescu, Andreea / Turcu-Ştiolică, Adina / Dinescu, Venera Cristina / Neamţu, Johny / Mogoantă, Laurenţiu / Mogoşanu, George Dan

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2024 Volume 64, Issue 4, Page(s) 567–577

Abstract: Nowadays, the state-of-the-art discoveries in the field of delivery systems for therapeutic purposes have redefined the importance of biocompatible and biodegradable poly(lactic-co-glycolic acid (PLGA) nanocomposites. The study aimed to obtain a ... ...

Abstract	Nowadays, the state-of-the-art discoveries in the field of delivery systems for therapeutic purposes have redefined the importance of biocompatible and biodegradable poly(lactic-co-glycolic acid (PLGA) nanocomposites. The study aimed to obtain a biocomposite material, with improved properties of its constituents [zinc-boron (Zn-B) complex and PLGA], by a simple, cost-effective method. The water∕oil∕water double emulsion technique allowed the adjustment of the synthesis parameters, to maximize the degree of Zn-B complex encapsulation. The morphological aspects of the samples were established by scanning electron microscopy (SEM). Particle size distribution was determined by dynamic light scattering (DLS). Morphology was typical for PLGA, spherical one. Depending on the synthesis conditions, the obtained particles have diameters between 10-450 nm. Zeta potential (ZP) showed that the particles have electronegative surface charge, offering a favorable perspective on aggregation, flocculation, and dispersion phenomena. It was observed, applying the design of experiments, that the particles size increased with increasing amounts of PLGA and polyvinyl alcohol (PVA), while ZP increased with higher PLGA and smaller PVA amounts in the formulation. The encapsulation efficiency was determined by ultra-high performance liquid chromatography∕mass spectrometry (UHPLC∕MS). The in vitro assessment was performed using Vero CCL-81 epithelial cell line and the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test. Zn-B-PLGA biocomposite has promising characteristics and can be used for future biomedical applications.
MeSH term(s)	Humans ; Boron ; Glycols ; Liquid Chromatography-Mass Spectrometry ; Microscopy, Electron, Scanning ; Zinc ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry
Chemical Substances	Boron (N9E3X5056Q) ; Glycols ; Zinc (J41CSQ7QDS) ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS)
Language	English
Publishing date	2024-01-07
Publishing country	Romania
Document type	Journal Article
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
DOI	10.47162/RJME.64.4.14
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Article ; Online: Nicotinamide Riboside, a Promising Vitamin B

Biţă, Andrei / Scorei, Ion Romulus / Ciocîlteu, Maria Viorica / Nicolaescu, Oana Elena / Pîrvu, Andreea Silvia / Bejenaru, Ludovic Everard / Rău, Gabriela / Bejenaru, Cornelia / Radu, Antonia / Neamţu, Johny / Mogoşanu, George Dan / Benner, Steven A

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 16

Abstract: Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide ( ... ...

Abstract	Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide (NAD
MeSH term(s)	Humans ; Longevity ; Healthy Aging ; NAD ; Borates ; Vitamins
Chemical Substances	nicotinamide-beta-riboside (0I8H2M0L7N) ; NAD (0U46U6E8UK) ; Borates ; Vitamins
Language	English
Publishing date	2023-08-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28166078
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Article ; Online: Natural and semisynthetic candidate molecules for COVID-19 prophylaxis and treatment.

Biţă, Andrei / Scorei, Ion Romulus / Mogoantă, Laurenţiu / Bejenaru, Cornelia / Mogoşanu, George Dan / Bejenaru, Ludovic Everard

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2021 Volume 61, Issue 2, Page(s) 321–334

Abstract: Coronaviruses (CoVs) represent a family of viruses that have numerous animal hosts, and they cause severe respiratory, as well as systemic and enteric infections, in humans. Currently, there are limited antiviral strategies for treating patients infected ...

Abstract	Coronaviruses (CoVs) represent a family of viruses that have numerous animal hosts, and they cause severe respiratory, as well as systemic and enteric infections, in humans. Currently, there are limited antiviral strategies for treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The lack of specific antiviral medicines and SARS-CoV-2 vaccines continues to aggravate the situation. Natural product-based antiviral drugs have been used in the two previous CoV outbreaks: Middle East respiratory syndrome coronavirus (MERS-CoV) and the first SARS-CoV. This review emphasizes the role of natural and semisynthetic candidate molecules for coronavirus disease 2019 (COVID-19) prophylaxis and treatment. The experimental evidence suggests that nature could offer huge possibilities for treatment of the COVID-19 pandemic.
MeSH term(s)	Animals ; Antiviral Agents/pharmacology ; COVID-19/epidemiology ; COVID-19/prevention & control ; Humans ; Pandemics ; SARS-CoV-2/isolation & purification ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-02-05
Publishing country	Romania
Document type	Journal Article ; Review
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
DOI	10.47162/RJME.61.2.02
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Article ; Online: Calcium fructoborate: plant-based dietary boron as potential medicine for cancer therapy.

Scorei, Ion Romulus

Frontiers in bioscience (Scholar edition)

2011 Volume 3, Issue 1, Page(s) 205–215

Abstract: It was predicted that more B-containing molecules will be discovered that will prove useful in applications involving cell surface signaling, but insufficient progress was made in this general direction. The main objective of this review is to reveal ... ...

Abstract	It was predicted that more B-containing molecules will be discovered that will prove useful in applications involving cell surface signaling, but insufficient progress was made in this general direction. The main objective of this review is to reveal other promising research directions for B-chemoprevention and chemotherapy using Calcium Fructoborate (CF). Targets include breast cancer, prostate cancer, lung cancer and cervical cancer. CF has been identified as Ca ( (C6H10O6)2B)2o4H2O and is a natural product from plants (can be produced by chemical synthesis as well), and is efficient in the prevention and treatments (as adjuvant) of osteoporosis and osteoarthritis. CF showed inhibitory effects on MDA-MB-231 breast cancer cells as well, and enters the cell (most likely) by a co-transport mechanism via a sugar transporter. Inside cells CF acts as an antioxidant and induces the overexpression of apoptosis-related proteins and eventually apoptosis.
MeSH term(s)	Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Apoptosis/drug effects ; Borates/chemistry ; Borates/pharmacology ; Borates/therapeutic use ; Boron Neutron Capture Therapy/methods ; Female ; Fructose/analogs & derivatives ; Fructose/chemistry ; Fructose/pharmacology ; Fructose/therapeutic use ; Humans ; Male ; Neoplasms/drug therapy ; Neoplasms/prevention & control ; Neoplasms/radiotherapy ; Oxidative Stress
Chemical Substances	Antioxidants ; Borates ; calcium fructoborate ; Fructose (30237-26-4)
Language	English
Publishing date	2011-01-01
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2565100-6
ISSN	1945-0524 ; 1945-0516
ISSN (online)	1945-0524
ISSN	1945-0516
DOI	10.2741/s145
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