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  1. Book ; Online ; E-Book: Mitochondrial medicine

    Prasun, Pankaj

    a primer for health care providers and translational researchers

    2019  

    Author's details Pankaj Prasun
    Keywords Mitochondrial pathology
    Subject code 616.042
    Language English
    Size 1 Online-Ressource (xvi, 122 Seiten), Illustrationen
    Publisher Elsevier AP Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020153267
    ISBN 978-0-12-817007-6 ; 9780128170069 ; 0-12-817007-7 ; 0128170069
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: NCOR2 Is a Candidate Gene for Neurodevelopmental Disorders.

    Prasun, Pankaj

    Pediatric neurology

    2024  Volume 156, Page(s) 1–3

    Language English
    Publishing date 2024-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2024.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2260: Show issues Location:
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  3. Article ; Online: COVID-19: A Mitochondrial Perspective.

    Prasun, Pankaj

    DNA and cell biology

    2021  Volume 40, Issue 6, Page(s) 713–719

    Abstract: Coronavirus disease 2019 (COVID-19) is the worst public health crisis of the century. Although we have made tremendous progress in understanding the pathogenesis of this disease, a lot more remains to be learned. Mitochondria appear to be important in ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is the worst public health crisis of the century. Although we have made tremendous progress in understanding the pathogenesis of this disease, a lot more remains to be learned. Mitochondria appear to be important in COVID-19 pathogenesis because of its role in innate antiviral immunity, as well as inflammation. This article examines pathogenesis of COVID-19 from a mitochondrial perspective and tries to answer some perplexing questions such as why the prognosis is so poor in those with obesity, metabolic syndrome, or type 2 diabetes. Although effective vaccines and antiviral drugs will be the ultimate solution to this crisis, a better understanding of disease mechanisms will open novel avenues for treatment and prevention.
    MeSH term(s) COVID-19/drug therapy ; COVID-19/epidemiology ; COVID-19/immunology ; Humans ; Immunity, Innate ; Inflammation/immunology ; Mitochondria/immunology ; Pandemics ; Prognosis ; SARS-CoV-2/immunology
    Language English
    Publishing date 2021-04-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1024454-2
    ISSN 1557-7430 ; 0198-0238 ; 1044-5498
    ISSN (online) 1557-7430
    ISSN 0198-0238 ; 1044-5498
    DOI 10.1089/dna.2020.6453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2061: Show issues Location:
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  4. Article: Dystonic cerebral palsy like presentation caused by a novel TCF20 variant.

    Prasun, Pankaj / Vermeire, Kylie / Ferimer, Stephanie

    Journal of movement disorders

    2024  

    Language English
    Publishing date 2024-04-26
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3021788-X
    ISSN 2093-4939 ; 2005-940X
    ISSN (online) 2093-4939
    ISSN 2005-940X
    DOI 10.14802/jmd.24007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Letter to the Editor:

    Prasun, Pankaj

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2020  Volume 40, Issue 9, Page(s) 466–467

    MeSH term(s) Betacoronavirus/drug effects ; Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/pathology ; Humans ; Interferon Type I/therapeutic use ; Interferon-gamma/therapeutic use ; Mitochondria/pathology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/pathology ; SARS Virus/drug effects ; SARS Virus/immunology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/drug therapy
    Chemical Substances IFNG protein, human ; Interferon Type I ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2020-07-28
    Publishing country United States
    Document type Letter
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2020.0112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1748: Show issues Location:
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  6. Article ; Online: Cockayne syndrome: A pediatric neurodegenerative disorder linking mitochondria to aging.

    Hatch, Mary Kate / Donnelly, Colleen / Prasun, Pankaj

    Journal of the neurological sciences

    2024  Volume 457, Page(s) 122863

    MeSH term(s) Humans ; Child ; Cockayne Syndrome/complications ; Cockayne Syndrome/genetics ; Aging ; DNA Damage ; Mitochondria ; DNA Repair Enzymes/genetics
    Chemical Substances DNA Repair Enzymes (EC 6.5.1.-)
    Language English
    Publishing date 2024-01-03
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2023.122863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 308: Show issues Location:
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  7. Article: Role of mitochondria in pathogenesis of type 2 diabetes mellitus.

    Prasun, Pankaj

    Journal of diabetes and metabolic disorders

    2020  Volume 19, Issue 2, Page(s) 2017–2022

    Abstract: Type 2 diabetes mellitus (T2DM) is global health problem. An estimated 425 million people in the world had diabetes in 2017. It is a major cause of morbidity and mortality worldwide. Although, pathogenesis of T2DM and its complications have been focus of ...

    Abstract Type 2 diabetes mellitus (T2DM) is global health problem. An estimated 425 million people in the world had diabetes in 2017. It is a major cause of morbidity and mortality worldwide. Although, pathogenesis of T2DM and its complications have been focus of medical research for long, much remains to be learned. A better understanding of molecular pathogenesis is essential for more effective preventive and therapeutic interventions. Role of mitochondria in pathogenesis of metabolic problems such as obesity, metabolic syndrome, and T2DM is the focus of many recent research studies. Mitochondrial dysfunction contributes to the oxidative stress and systemic inflammation leading to insulin resistance (IR). Mitochondria are also essential for pancreatic beta cell insulin secretion. Hence, mitochondria are important players in the pathogenesis of T2DM. In this article, pathogenesis of T2DM is examined from a mitochondrial perspective.
    Language English
    Publishing date 2020-11-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2680289-2
    ISSN 2251-6581
    ISSN 2251-6581
    DOI 10.1007/s40200-020-00679-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Mitochondrial dysfunction in metabolic syndrome.

    Prasun, Pankaj

    Biochimica et biophysica acta. Molecular basis of disease

    2020  Volume 1866, Issue 10, Page(s) 165838

    Abstract: Metabolic syndrome is co-occurrence of obesity, insulin resistance, atherogenic dyslipidemia (high triglyceride, low high density lipoprotein cholesterol), and hypertension. It is a global health problem. An estimated 20%-30% of adults of the world have ... ...

    Abstract Metabolic syndrome is co-occurrence of obesity, insulin resistance, atherogenic dyslipidemia (high triglyceride, low high density lipoprotein cholesterol), and hypertension. It is a global health problem. An estimated 20%-30% of adults of the world have metabolic syndrome. Metabolic syndrome is associated with increased risk of type 2 diabetes mellitus, nonalcoholic fatty liver disease, myocardial infarction, and stroke. Thus, it is a major cause of morbidity and mortality worldwide. However, molecular pathogenesis of metabolic syndrome is not well known. Recently, there has been interest in the role of mitochondria in pathogenesis of metabolic problems such as obesity, metabolic syndrome, and type 2 diabetes mellitus. Mitochondrial dysfunction contributes to the oxidative stress and systemic inflammation seen in metabolic syndrome. Role of mitochondria in the pathogenesis of metabolic syndrome is intriguing but far from completely understood. However, a better understanding will be very rewarding as it may lead to novel approaches to control this major public health problem. This brief review explores pathogenesis of metabolic syndrome from a mitochondrial perspective.
    MeSH term(s) Atherosclerosis/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Dyslipidemias/metabolism ; Humans ; Inflammation/metabolism ; Insulin Resistance ; Metabolic Syndrome/metabolism ; Metabolic Syndrome/therapy ; Mitochondria/metabolism ; Mitochondrial Diseases/metabolism ; Mitochondrial Diseases/therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; Obesity/metabolism ; Organelle Biogenesis ; Oxidative Stress ; Triglycerides/metabolism
    Chemical Substances Triglycerides
    Language English
    Publishing date 2020-05-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2020.165838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Triheptanoin in Pyruvate Dehydrogenase Deficiency

    Prasun, Pankaj

    Journal of Pediatric Neurology

    2020  Volume 19, Issue 01, Page(s) 65–68

    Language English
    Publishing date 2020-08-05
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 1875-9041 ; 1304-2580
    ISSN (online) 1875-9041
    ISSN 1304-2580
    DOI 10.1055/s-0040-1714069
    Database Thieme publisher's database

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  10. Article ; Online: Letter to the Editor

    Prasun, Pankaj

    Journal of Interferon & Cytokine Research

    COVID-19, Mitochondria, and Interferon

    2020  Volume 40, Issue 9, Page(s) 466–467

    Keywords Immunology ; Cell Biology ; Virology ; covid19
    Language English
    Publisher Mary Ann Liebert Inc
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2020.0112
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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