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  1. Article ; Online: In Reply to the Letter to the Editor Regarding "Improving Surgeon Well-Being: Ergonomics in Neurosurgery".

    Schupper, Alexander J / Hadjipanayis, Constantinos G

    World neurosurgery

    2023  Volume 179, Page(s) 253

    MeSH term(s) Humans ; Neurosurgery ; Neurosurgical Procedures ; Ergonomics ; Surgeons
    Language English
    Publishing date 2023-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.08.119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1159: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Novel approaches to targeting gliomas at the leading/cutting edge.

    Schupper, Alexander J / Hadjipanayis, Constantinos G

    Journal of neurosurgery

    2023  Volume 139, Issue 3, Page(s) 760–768

    Abstract: Despite decades of clinical trials and surgical advances, the most common high-grade glioma, glioblastoma (GBM), remains an incurable disease with a dismal prognosis. Because of its infiltrative nature, GBM almost always recurs at the margin, or leading ... ...

    Abstract Despite decades of clinical trials and surgical advances, the most common high-grade glioma, glioblastoma (GBM), remains an incurable disease with a dismal prognosis. Because of its infiltrative nature, GBM almost always recurs at the margin, or leading edge, where tumor cells invade the surrounding brain parenchyma. This region of GBMs is unique, or heterogeneous, with its own microenvironment that is different from the tumor bulk or core. The GBM microenvironment at the margin contains immunosuppressive constituents as well as invasive and therapy-resistant tumor cells that are difficult to treat. In addition, the blood-brain barrier remains essentially intact at the infiltrative margin of tumors; further limiting the effectiveness of therapies. The invasive margin creates the greatest challenge for neurosurgeons when managing these tumors. The current paradigm of resection of GBM tumors mainly focuses on resection of the contrast-enhancing component of tumors, while GBMs extend well beyond the contrast enhancement. The infiltrative margin represents a unique challenge and opportunity for solutions that may overcome current limitations in tumor treatments. In this review of the current literature, the authors discuss the current and developing advances focused on the detection and treatment of GBM at the infiltrative margin and how this could impact patient outcomes.
    MeSH term(s) Humans ; Brain Neoplasms/surgery ; Brain Neoplasms/drug therapy ; Neoplasm Recurrence, Local/pathology ; Glioma/surgery ; Glioma/pathology ; Glioblastoma/surgery ; Glioblastoma/drug therapy ; Brain/pathology ; Tumor Microenvironment
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2023.1.JNS221798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Letter to the Editor: Coronavirus Disease 2019 (COVID-19): A New York City Intern's Perspective.

    Schupper, Alexander J

    World neurosurgery

    2020  Volume 140, Page(s) 489–490

    MeSH term(s) Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections ; Humans ; Internship and Residency ; Neurosurgery ; New York City ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country United States
    Document type Letter
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.06.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Neuromonitoring During Condylar Screw Placement.

    Schupper, Alexander J / Gologorsky, Yakov

    World neurosurgery

    2022  

    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Letter
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2022.09.116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Bone Morphogenic Protein in Anterior Cervical Diskectomy and Fusion: Time for a Fresh Look?

    Schupper, Alexander J / Lin D, James / Gologorsky, Yakov

    World neurosurgery

    2023  Volume 175, Page(s) 157

    MeSH term(s) Humans ; Diskectomy ; Bone Morphogenetic Proteins ; Spinal Fusion ; Cervical Vertebrae/surgery ; Treatment Outcome ; Bone Plates
    Chemical Substances Bone Morphogenetic Proteins
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Letter
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.03.142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Letter to the Editor: Sustaining the Life Force: The Importance of Resident Wellness in Neurosurgical Training.

    Schupper, Alexander J / Asfaw, Zerubabbel K / Shrivastava, Raj K

    World neurosurgery

    2023  Volume 175, Page(s) 159–160

    MeSH term(s) Humans ; Internship and Residency ; Burnout, Professional
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.04.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Is Cervical Disk Arthroplasty a Suitable Alternative to Treat Degenerative Cervical Myelopathy?

    Schupper, Alexander J / Boylan, Arianne J / Houten, John K

    Clinical spine surgery

    2023  Volume 36, Issue 9, Page(s) 356–362

    Abstract: Study design: Systemic review.: Objective: To understand the role of cervical disk arthroplasty in the treatment of cervical myelopathy.: Summary of background data: The surgical management of degenerative cervical myelopathy (DCM) most frequently ...

    Abstract Study design: Systemic review.
    Objective: To understand the role of cervical disk arthroplasty in the treatment of cervical myelopathy.
    Summary of background data: The surgical management of degenerative cervical myelopathy (DCM) most frequently involves decompression and fusion, but stiffness introduced by the fusion and adjacent segment degeneration remain problems that can result in significant morbidity. Cervical disk arthroplasty (CDA) is a newer procedure that has been demonstrated to be safe and effective for the management of cervical spine degenerative disk disease, but it has not been traditionally considered as a treatment option for DCM and the use for this indication has not been extensively studied.
    Materials and methods: A systematic review was undertaken using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using a search strategy to query all relevant articles on the use of cervical disk arthroplasty in the setting of cervical myelopathy over a 20-year period (2004-2023). This review examines the literature to assess our current understanding of the appropriateness, safety, and value of CDA in the treatment of DCM.
    Results: A total of 844 patients received CDA across the 14 studies that met inclusion criteria, with an average of 60.3±40.4 patients per study (range: 11-152 subjects). Featured studies included 5 (35.7%) prospective studies, of which 2 were randomized. All studies had primary outcome measures of disability and/or pain scores, with the Japanese Orthopedic Association myelopathy score and neck disability index as the most commonly assessed. Four (26.7%) studies compared arthroplasty with arthrodesis. Safety of CDA for DCM was found in all studies with improvement in clinical outcome measurements.
    Conclusion: Cervical disk arthroplasty appears to be a safe and effective surgical option in the management of degenerative cervical myelopathy. Further study is needed to assess if arthroplasty provides clinical improvement in DCM of comparable magnitude and durability as traditional fusion strategies.
    MeSH term(s) Humans ; Arthroplasty/methods ; Cervical Vertebrae/surgery ; Intervertebral Disc Degeneration/surgery ; Prospective Studies ; Spinal Cord Diseases/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-09-08
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 2849646-2
    ISSN 2380-0194 ; 2380-0186
    ISSN (online) 2380-0194
    ISSN 2380-0186
    DOI 10.1097/BSD.0000000000001528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2427: Show issues Location:
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  8. Article ; Online: Vertebral Column Shortening for Recurrent Tethered Cord Syndrome.

    Schupper, Alexander J / Gologorsky, Yakov

    World neurosurgery

    2021  Volume 157, Page(s) 240–241

    MeSH term(s) Humans ; Neural Tube Defects ; Spine
    Language English
    Publishing date 2021-12-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2021.09.129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1159: Show issues Location:
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  9. Article ; Online: The 100 Top-Cited Articles on Robotic Neurosurgery: A Bibliometric Analysis.

    Ezzat, Bahie / Schüpper, Alexander J / Asfaw, Zerubabbel K / Patel, Shrey / Yuk, Frank J / Choudhri, Tanvir

    World neurosurgery

    2023  

    Abstract: Background: Robotic neurosurgery is a rapidly advancing field with numerous applications in various subspecialties, including spine, functional, skull base, and cerebrovascular. This study aims to provide a comprehensive analysis of the most-cited ... ...

    Abstract Background: Robotic neurosurgery is a rapidly advancing field with numerous applications in various subspecialties, including spine, functional, skull base, and cerebrovascular. This study aims to provide a comprehensive analysis of the most-cited articles on robotic neurosurgery.
    Methods: The Web of Science database was used to collect data, and bibliometric analysis was performed using VOSviewer and RStudio. Network analysis techniques such as co-occurrence, coauthorship, bibliographic coupling, and thematic mapping analyses were used to identify the top 100 most cited articles, major contributors, emerging trends, and noteworthy themes in the field.
    Results: The results showed that there has been a steady increase in the number of publications on robotic neurosurgery since 1991, with an exponential growth in the number of citations. The United States was the most common country of origin for articles, followed by Canada. The most productive authors in this field were Burton S.A. and Gerszten P.C., while the University of Pittsburgh was the most productive institution, and Neurosurgery was the most productive journal. Themes such as robotics, back pain, and prostate cancer, as well as trends in developing new technologies and improving the precision of surgical procedures, were identified.
    Conclusions: This study provides a comprehensive analysis of the most-cited articles on robotic neurosurgery. The broad range of topics and techniques explored emphasize the importance of continued innovation and investigation. Ultimately, the study's findings provide valuable guidance for future research and contribute to advancing our understanding of this critical area of study.
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.06.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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