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  1. Article: Insulin Resistance and the Brain-Novel Insights Combining Metabolic Research and Neuroscience.

    Ekblad, Laura / Rebelos, Eleni

    Metabolites

    2022  Volume 12, Issue 9

    Abstract: In the last decades, we have been facing an epidemic of obesity and type 2 diabetes (T2D) [ ... ]. ...

    Abstract In the last decades, we have been facing an epidemic of obesity and type 2 diabetes (T2D) [...].
    Language English
    Publishing date 2022-08-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12090780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Complementary actions of finerenone and SGLT2-i on renal outcomes?: An urgent need for more information.

    Rebelos, Eleni / Tentolouris, Nikolaos

    Nephrology (Carlton, Vic.)

    2022  Volume 27, Issue 12, Page(s) 915–916

    MeSH term(s) Humans ; Sodium-Glucose Transporter 2 ; Naphthyridines ; Kidney ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Mineralocorticoid Receptor Antagonists ; Renal Insufficiency, Chronic
    Chemical Substances finerenone ; Sodium-Glucose Transporter 2 ; Naphthyridines ; Mineralocorticoid Receptor Antagonists
    Language English
    Publishing date 2022-10-22
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.14124
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4822: Show issues Location:
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  3. Article ; Online: Bariatric surgery to treat hypertension.

    Moriconi, Diego / Nannipieri, Monica / Rebelos, Eleni

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 5, Page(s) 1341–1343

    MeSH term(s) Humans ; Gastric Bypass ; Prospective Studies ; Bariatric Surgery ; Hypertension/drug therapy ; Hypertension/surgery ; Hypertension/physiopathology ; Gastrectomy ; Recurrence
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01227-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
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  4. Article ; Online: The Role of Vitamin D in Health and Disease: A Narrative Review on the Mechanisms Linking Vitamin D with Disease and the Effects of Supplementation.

    Rebelos, Eleni / Tentolouris, Nikolaos / Jude, Edward

    Drugs

    2023  Volume 83, Issue 8, Page(s) 665–685

    Abstract: Vitamin D insufficiency or deficiency (VDD) is a very prevalent condition in the general population. Vitamin D is necessary for optimal bone mineralization, but apart from the bone effects, preclinical and observational studies have suggested that ... ...

    Abstract Vitamin D insufficiency or deficiency (VDD) is a very prevalent condition in the general population. Vitamin D is necessary for optimal bone mineralization, but apart from the bone effects, preclinical and observational studies have suggested that vitamin D may have pleiotropic actions, whereas VDD has been linked to several diseases and higher all-cause mortality. Thus, supplementing vitamin D has been considered a safe and inexpensive approach to generate better health outcomes-and especially so in frail populations. Whereas it is generally accepted that prescribing of vitamin D in VDD subjects has demonstrable health benefits, most randomized clinical trials, although with design constraints, assessing the effects of vitamin D supplementation on a variety of diseases have failed to demonstrate any positive effects of vitamin D supplementation. In this narrative review, we first describe mechanisms through which vitamin D may exert an important role in the pathophysiology of the discussed disorder, and then provide studies that have addressed the impact of VDD and of vitamin D supplementation on each disorder, focusing especially on randomized clinical trials and meta-analyses. Despite there already being vast literature on the pleiotropic actions of vitamin D, future research approaches that consider and circumvent the inherent difficulties in studying the effects of vitamin D supplementation on health outcomes are needed to assess the potential beneficial effects of vitamin D. The evaluation of the whole vitamin D endocrine system, rather than only of 25-hydroxyvitamin D levels before and after treatment, use of adequate and physiologic vitamin D dosing, grouping based on the achieved vitamin D levels rather than the amount of vitamin D supplementation subjects may receive, and sufficiently long follow-up are some of the aspects that need to be carefully considered in future studies.
    MeSH term(s) Humans ; Vitamin D Deficiency/drug therapy ; Vitamin D/therapeutic use ; Vitamins/pharmacology ; Vitamins/therapeutic use ; Dietary Supplements
    Chemical Substances Vitamin D (1406-16-2) ; Vitamins
    Language English
    Publishing date 2023-05-06
    Publishing country New Zealand
    Document type Review ; Journal Article
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.1007/s40265-023-01875-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 762: Show issues Location:
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  5. Article: Kinetic Modeling of Brain [

    Bucci, Marco / Rebelos, Eleni / Oikonen, Vesa / Rinne, Juha / Nummenmaa, Lauri / Iozzo, Patricia / Nuutila, Pirjo

    Metabolites

    2024  Volume 14, Issue 2

    Abstract: Accurate positron emission tomography (PET) data quantification relies on high-quality input plasma curves, but venous blood sampling may yield poor-quality data, jeopardizing modeling outcomes. In this study, we aimed to recover sub-optimal input ... ...

    Abstract Accurate positron emission tomography (PET) data quantification relies on high-quality input plasma curves, but venous blood sampling may yield poor-quality data, jeopardizing modeling outcomes. In this study, we aimed to recover sub-optimal input functions by using information from the tail (5th-100th min) of curves obtained through the frequent sampling protocol and an input recovery (IR) model trained with reference curves of optimal shape. Initially, we included 170 plasma input curves from eight published studies with clamp [
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo14020114
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  6. Article ; Online: What is New on Diabetic Neuropathy? Insights from the 2023 ADA and EASD Conferences.

    Rebelos, Eleni / Anastasiou, Ioanna A / Tentolouris, Anastasios / Papanas, Nikolaos / Jude, Edward

    The international journal of lower extremity wounds

    2024  , Page(s) 15347346241233938

    Abstract: Diabetic neuropathy is a common complication of diabetes; yet its pathophysiology is still incompletely understood and until today, there is no specific treatment against it. In the two 2023 large congresses on diabetes (American Diabetes Association, ... ...

    Abstract Diabetic neuropathy is a common complication of diabetes; yet its pathophysiology is still incompletely understood and until today, there is no specific treatment against it. In the two 2023 large congresses on diabetes (American Diabetes Association, ADA, European Association for the Study of Diabetes, EASD), several high-level studies have been presented. They have attempted to delineate the pathophysiology of DN, the characteristics of affected patients, and future potential treatments. We herein review the presented studies on diabetic neuropathy at these diabetes congresses and discuss the needs for future research on this topic.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2171119-7
    ISSN 1552-6941 ; 1534-7346
    ISSN (online) 1552-6941
    ISSN 1534-7346
    DOI 10.1177/15347346241233938
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6003: Show issues Location:
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  7. Article: Hepatic Positron Emission Tomography: Applications in Metabolism, Haemodynamics and Cancer.

    Honka, Miikka-Juhani / Rebelos, Eleni / Malaspina, Simona / Nuutila, Pirjo

    Metabolites

    2022  Volume 12, Issue 4

    Abstract: Evaluating in vivo the metabolic rates of the human liver has been a challenge due to its unique perfusion system. Positron emission tomography (PET) represents the current gold standard for assessing non-invasively tissue metabolic rates in vivo. Here, ... ...

    Abstract Evaluating in vivo the metabolic rates of the human liver has been a challenge due to its unique perfusion system. Positron emission tomography (PET) represents the current gold standard for assessing non-invasively tissue metabolic rates in vivo. Here, we review the existing literature on the assessment of hepatic metabolism, haemodynamics and cancer with PET. The tracer mainly used in metabolic studies has been [
    Language English
    Publishing date 2022-04-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12040321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Near-Infrared Spectroscopy: A Free-Living Neuroscience Tool to Better Understand Diabetes and Obesity.

    Rebelos, Eleni / Malloggi, Eleonora / Parenti, Martina / Dardano, Angela / Tura, Andrea / Daniele, Giuseppe

    Metabolites

    2023  Volume 13, Issue 7

    Abstract: The human brain is the least accessible of all organs and attempts to study it in vivo rely predominantly on neuroimaging. Functional near-infrared spectroscopy (fNIRS) allows for the study of cortical neural activity in a non-invasive manner that may ... ...

    Abstract The human brain is the least accessible of all organs and attempts to study it in vivo rely predominantly on neuroimaging. Functional near-infrared spectroscopy (fNIRS) allows for the study of cortical neural activity in a non-invasive manner that may resemble free-living conditions. Moreover, compared to other neuroimaging tools, fNIRS is less expensive, it does not require the use of ionizing radiation, and can be applied to all study populations (patients suffering from claustrophobia, or neonates). In this narrative review, we provide an overview of the available research performed using fNIRS in patients with diabetes and obesity. The few studies conducted to date have presented controversial results regarding patients with diabetes, some reporting a greater hemodynamic response and others reporting a reduced hemodynamic response compared to the controls, with an unclear distinction between types 1 and 2. Subjects with obesity or a binge eating disorder have reduced prefrontal activation in response to inhibitory food or non-food stimuli; however, following an intervention, such as cognitive treatment, prefrontal activation is restored. Moreover, we discuss the potential of future applications of fNIRS for a better understanding of cortical neural activity in the context of metabolic disorders.
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13070814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Long-Term effects of physical activity on weight loss, metabolic parameters and blood pressure in subjects undergoing bariatric surgery: A 5-year follow-up study.

    Moriconi, Diego / Manca, Laura / Rebelos, Eleni / Guidotti, Emanuele / Bonvicini, Linda / Troilo, Antonio / Anselmino, Marco / Nannipieri, Monica

    American journal of surgery

    2024  

    Abstract: Background: bariatric surgery stands as an effective intervention for weight loss and improved metabolic control in obesity, although over time there is a proportion of weight regain and type-2-diabetes (T2D) relapse.: Aims: to explore the role of ... ...

    Abstract Background: bariatric surgery stands as an effective intervention for weight loss and improved metabolic control in obesity, although over time there is a proportion of weight regain and type-2-diabetes (T2D) relapse.
    Aims: to explore the role of physical activity (PA) after surgery and its impact on metabolic parameters during a 5-year follow-up.
    Methods: 148 individuals who underwent bariatric surgery completed scheduled examinations over 5-years. Physical assessments and laboratory tests were conducted pre-surgery and annually thereafter. PA levels were evaluated using the International Physical Activity Questionnaire.
    Results: participants were split into the PA group, who engaged in regular physical activity, and No-PA group, who remained sedentary throughout. In T2D individuals before surgery, PA group showed significant reductions in blood pressure and a lower T2D recurrence (6.7 ​% vs 36 ​%) compared to No-PA group. In normoglycemic individuals, the PA group led to sustained BMI reduction and improved blood pressure control (p ​< ​0.001) compared to No-PA group, for the entire duration of follow-up.
    Conclusions: regular PA demonstrated cardio-metabolic benefits post-bariatric surgery. Integrating PA into post-bariatric care could enhance long-term outcomes.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2024.04.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.42: Show issues Location:
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  10. Article ; Online: Green Tea from the Far East to the Drug Store: Focus on the Beneficial Cardiovascular Effects.

    Landini, Linda / Rebelos, Eleni / Honka, Miikka-Juhani

    Current pharmaceutical design

    2021  Volume 27, Issue 16, Page(s) 1931–1940

    Abstract: Cardiovascular diseases (CVD) are the leading cause of death worldwide. Evidence from observational and randomized controlled studies showing the potential benefits of green tea on lowering CVD risk has been emerging rapidly during the past few decades. ... ...

    Abstract Cardiovascular diseases (CVD) are the leading cause of death worldwide. Evidence from observational and randomized controlled studies showing the potential benefits of green tea on lowering CVD risk has been emerging rapidly during the past few decades. These benefits include reduced risk for major cardiovascular events, lowering of blood pressure, decreased LDL cholesterol levels and weight loss. At the same time, the understanding of the physiological mechanisms behind these alterations is advancing. Consumption of green tea originated from China thousands of years ago, but since then, it expanded all over the world. Recent advances in understanding the role of tea polyphenols, mainly catechins, as mediators of tea's health benefits, have caused the emergence of various types of green tea extracts (GTE) on the market. While taking green tea is generally considered safe, there are concerns about the safety of using tea extracts. The present article reviews the current evidence of green tea consumption leading to reduced CVD risk, its potential biological mechanisms and the safety of using GTE.
    MeSH term(s) Catechin/pharmacology ; China ; Far East ; Humans ; Plant Extracts ; Tea
    Chemical Substances Plant Extracts ; Tea ; Catechin (8R1V1STN48)
    Language English
    Publishing date 2021-01-12
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612826666201102104902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4714: Show issues Location:
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