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  1. Article ; Online: Identifying and managing refractory migraine: barriers and opportunities?

    D'Antona, Linda / Matharu, Manjit

    The journal of headache and pain

    2019  Volume 20, Issue 1, Page(s) 89

    Abstract: The term refractory migraine has been used to describe persistent headache that is difficult to treat or fails to respond to standard and/or aggressive treatments. This subgroup of migraine patients are generally highly disabled and experience impaired ... ...

    Abstract The term refractory migraine has been used to describe persistent headache that is difficult to treat or fails to respond to standard and/or aggressive treatments. This subgroup of migraine patients are generally highly disabled and experience impaired quality of life, despite optimal treatments. Several definitions and criteria for refractory migraine have been published, but as yet, an accepted or established definition is not available. This article reviews the published criteria and proposes a new set of criteria. The epidemiology, pathophysiology and management options are also reviewed.
    MeSH term(s) Humans ; Migraine Disorders/classification ; Migraine Disorders/diagnosis ; Migraine Disorders/physiopathology ; Migraine Disorders/therapy ; Quality of Life
    Language English
    Publishing date 2019-08-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036768-5
    ISSN 1129-2377 ; 1129-2369
    ISSN (online) 1129-2377
    ISSN 1129-2369
    DOI 10.1186/s10194-019-1040-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Using the Postoperative Morbidity Survey to Measure Morbidity After Cranial Neurosurgery.

    Luoma, Astri M V / Douglas, Deborah R / D'Antona, Linda / Toma, Ahmed K / Smith, Martin

    Journal of neurosurgical anesthesiology

    2022  Volume 34, Issue 2, Page(s) 201–208

    Abstract: ... month period. Postsurgical morbidity was quantified on postoperative days (D) 1, 3, 5, 8, and 15 using ...

    Abstract Background: The incidence of morbidity after cranial neurosurgery is significant, reported in up to a quarter of patients depending on methodology used. The Postoperative Morbidity Survey (POMS) is a reliable method for identifying clinically relevant postsurgical morbidity using 9 organ system domains. The primary aim of this study was to quantify early morbidity after cranial neurosurgery using POMS. The secondary aims were to identify non-POMS-defined morbidity and association of POMS with postoperative hospital length of stay (LOS).
    Materials and methods: A retrospective electronic health care record review was conducted for all patients who underwent elective or expedited major cranial surgery over a 3-month period. Postsurgical morbidity was quantified on postoperative days (D) 1, 3, 5, 8, and 15 using POMS. A Poisson regression model was used to test the correlation between LOS and total POMS scores on D1, 3 and 5. A further regression model was used to test the association of LOS with specific POMS domains.
    Results: A total of 246 patients were included. POMS-defined morbidity was 40%, 30%, and 33% on D1, D3, and D8, respectively. The presence of POMS morbidity on these days was associated with longer median (range) LOS: D1 6 (1 to 49) versus 4 (2 to 45) days; D3 8 (4 to 89) versus 6 (4 to 35) days; D5 14 (5 to 49) versus 8.5 (6 to 32) days; D8 18 (9 to 49) versus 12.5 (9 to 32) days (P<0.05). Total POMS score correlated with overall LOS on D1 (P<0.001), D3 (P<0.001), and D5 (P<0.001). A positive response to the "infectious" (D1, 3), "pulmonary" (D1), and "renal" POMS items (D1) were associated with longer LOS.
    Conclusion: Although our data suggests that POMS is a useful tool for measuring morbidity after cranial neurosurgery, some important morbidity items that impact on LOS are missed. A neurosurgery specific tool would be of value.
    MeSH term(s) Humans ; Length of Stay ; Morbidity ; Neurosurgery ; Neurosurgical Procedures/adverse effects ; Postoperative Complications/epidemiology ; Retrospective Studies ; Skull
    Language English
    Publishing date 2022-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1018119-2
    ISSN 1537-1921 ; 0898-4921
    ISSN (online) 1537-1921
    ISSN 0898-4921
    DOI 10.1097/ANA.0000000000000756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Identifying and managing refractory migraine

    Linda D’Antona / Manjit Matharu

    The Journal of Headache and Pain, Vol 20, Iss 1, Pp 1-

    barriers and opportunities?

    2019  Volume 11

    Abstract: Abstract The term refractory migraine has been used to describe persistent headache that is difficult to treat or fails to respond to standard and/or aggressive treatments. This subgroup of migraine patients are generally highly disabled and experience ... ...

    Abstract Abstract The term refractory migraine has been used to describe persistent headache that is difficult to treat or fails to respond to standard and/or aggressive treatments. This subgroup of migraine patients are generally highly disabled and experience impaired quality of life, despite optimal treatments. Several definitions and criteria for refractory migraine have been published, but as yet, an accepted or established definition is not available. This article reviews the published criteria and proposes a new set of criteria. The epidemiology, pathophysiology and management options are also reviewed.
    Keywords Migraine ; Refractory ; Medication overuse ; Preventive ; Abortive ; Disability ; Medicine ; R
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Ambulatory intracranial pressure in humans: ICP increases during movement between body positions.

    Moncur, Eleanor M / D'Antona, Linda / Peters, Amy L / Favarato, Graziella / Thompson, Simon / Vicedo, Celine / Thorne, Lewis / Watkins, Laurence D / Day, Brian L / Toma, Ahmed K / Bancroft, Matthew J

    Brain & spine

    2024  Volume 4, Page(s) 102771

    Abstract: Introduction: Positional changes in intracranial pressure (ICP) have been described in humans when measured over minutes or hours in a static posture, with ICP higher when lying supine than when sitting or standing upright. However, humans are often ... ...

    Abstract Introduction: Positional changes in intracranial pressure (ICP) have been described in humans when measured over minutes or hours in a static posture, with ICP higher when lying supine than when sitting or standing upright. However, humans are often ambulant with frequent changes in position self-generated by active movement.
    Research question: We explored how ICP changes during movement between body positions.
    Material and methods: Sixty-two patients undergoing clinical ICP monitoring were recruited. Patients were relatively well, ambulatory and of mixed age, body habitus and pathology. We instructed patients to move back and forth between sitting and standing or lying and sitting positions at 20 s intervals after an initial 60s at rest. We simultaneously measured body position kinematics from inertial measurement units and ICP from an intraparenchymal probe at 100 Hz.
    Results: ICP increased transiently during movements beyond the level expected by body position alone. The amplitude of the increase varied between participants but was on average ∼5 mmHg during sit-to-stand, stand-to-sit and sit-to-lie movements and 10.8 mmHg [95%CI: 9.3,12.4] during lie-to-sit movements. The amplitude increased slightly with age, was greater in males, and increased with median 24-h ICP. For lie-to-sit and sit-to-lie movements, higher BMI was associated with greater mid-movement increase (β = 0.99 [0.78,1.20]; β = 0.49 [0.34,0.64], respectively).
    Discussion and conclusion: ICP increases during movement between body positions. The amplitude of the increase in ICP varies with type of movement, age, sex, and BMI. This could be a marker of disturbed ICP dynamics and may be particularly relevant for patients with CSF-diverting shunts in situ.
    Language English
    Publishing date 2024-02-29
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-5294
    ISSN (online) 2772-5294
    DOI 10.1016/j.bas.2024.102771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Spontaneous Venous Pulsations Detected With Infrared Videography: Response.

    McHugh, James A / D'Antona, Linda / Toma, Ahmed K / Bremner, Fion D

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2021  Volume 43, Issue 3, Page(s) e94–e95

    Language English
    Publishing date 2021-12-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000001256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A case of recurrent flight-induced cerebrospinal fluid shunt overdrainage.

    D'Antona, Linda / Craven, Claudia Louise / Haq, Huzaifah / Thorne, Lewis / Matharu, Manjit Singh / Toma, Ahmed Kassem / Watkins, Laurence Dale

    British journal of neurosurgery

    2022  Volume 37, Issue 1, Page(s) 112–115

    Abstract: Shunted patients often complain of headaches after flights. The effect of air travel on shunt systems is unknown. We describe the case of a patient with longstanding hydrocephalus, who suffered flight-induced clinical deterioration and shunt overdrainage ...

    Abstract Shunted patients often complain of headaches after flights. The effect of air travel on shunt systems is unknown. We describe the case of a patient with longstanding hydrocephalus, who suffered flight-induced clinical deterioration and shunt overdrainage in two independent occasions. The patient, clinically stable for 1.5 and 5 years before each episode, reported severe headaches starting during the descent stages of the air travel. On both occasions, brain MRI imaging demonstrated pronounced ventricular size reduction. This case suggests that flight-induced shunt overdrainage can occur and should be suspected in patients with prolonged headaches and/or clinical deterioration triggered by air travel.
    MeSH term(s) Humans ; Clinical Deterioration ; Cerebrospinal Fluid Shunts/adverse effects ; Hydrocephalus/etiology ; Headache/etiology ; Magnetic Resonance Imaging ; Ventriculoperitoneal Shunt/adverse effects
    Language English
    Publishing date 2022-05-13
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2022.2066629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Regional Scalp Blockade for Painless Removal ofIntracranial Pressure Bolts: Technical Note and Patient-Reported Outcomes.

    Goel, Aimee / Asif, Hasan / Craven, Claudia / D'Antona, Linda / Das, Pranoy / Thorne, Lewis / Toma, Ahmed

    World neurosurgery

    2022  Volume 162, Page(s) 43–46

    Abstract: Objective: Elective insertion of intracranial pressure (ICP) monitoring bolts is useful for the diagnosis and treatment of disorders of cerebrospinal fluid dynamics. Patients typically report severe discomfort on bolt removal, which negatively impacts ... ...

    Abstract Objective: Elective insertion of intracranial pressure (ICP) monitoring bolts is useful for the diagnosis and treatment of disorders of cerebrospinal fluid dynamics. Patients typically report severe discomfort on bolt removal, which negatively impacts overall patient satisfaction of ICP monitoring. We assessed the efficacy and safety of using supratrochlear and supraorbital nerve block-a commonly used form of scalp anesthesia-alongside oral analgesia before bolt removal.
    Methods: We compared the efficacy and safety of regional scalp block anesthesia alongside oral analgesia versus oral analgesia alone in a cohort of 85 patients undergoing removal of diagnostic ICP bolts between June 2017 and April 2019 using retrospective patient questionnaires, as well as electronic admission documentation.
    Results: We found that scalp block alongside oral analgesia improved bolt removal experience (4/5 vs. 3/5 on a 1-5 point Likert scale) and that a majority (70.6%) of patients would have preferred local anesthetic before removal in the oral analgesia-only group. Only 2 patients experienced mild and localized side effects: mild bruising and temporary facial and eyelid swelling following regional scalp block.
    Conclusions: We conclude that regional supraorbital and supratrochlear nerve block is a simple, safe, and effective adjunct to minimizing discomfort during bolt removal and improving overall patient satisfaction of ICP monitoring.
    MeSH term(s) Anesthesia, Conduction ; Anesthetics, Local ; Humans ; Pain, Postoperative ; Patient Reported Outcome Measures ; Retrospective Studies ; Scalp
    Chemical Substances Anesthetics, Local
    Language English
    Publishing date 2022-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2022.03.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Letter: Thirty-Day Hospital Readmission and Surgical Complication Rates for Shunting in Normal Pressure Hydrocephalus: A Large National Database Analysis.

    D'Antona, Linda / Thompson, Simon David / Thorne, Lewis / Watkins, Laurence Dale / Toma, Ahmed Kassem

    Neurosurgery

    2020  Volume 87, Issue 6, Page(s) E707–E708

    MeSH term(s) Databases, Factual ; Humans ; Hydrocephalus, Normal Pressure/epidemiology ; Hydrocephalus, Normal Pressure/surgery ; Neurosurgical Procedures ; Patient Readmission ; Ventriculoperitoneal Shunt/adverse effects
    Language English
    Publishing date 2020-09-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyaa386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: External ventricular drain management in subarachnoid haemorrhage: a systematic review and meta-analysis.

    Palasz, Joanna / D'Antona, Linda / Farrell, Sarah / Elborady, Mohamed A / Watkins, Laurence D / Toma, Ahmed K

    Neurosurgical review

    2021  Volume 45, Issue 1, Page(s) 365–373

    Abstract: External ventricular drainage (EVD) is one of the most commonly performed neurosurgical procedures. Despite this, the optimal drainage and weaning strategies are still unknown. This PRISMA-compliant systematic review and meta-analysis analysed the ... ...

    Abstract External ventricular drainage (EVD) is one of the most commonly performed neurosurgical procedures. Despite this, the optimal drainage and weaning strategies are still unknown. This PRISMA-compliant systematic review and meta-analysis analysed the outcomes of patients undergoing EVD procedures, comparing continuous versus intermittent drainage and rapid versus gradual weaning. Four databases were searched from inception to 01/10/2020. Articles reporting at least 10 patients treated for hydrocephalus secondary to subarachnoid haemorrhage were included. Other inclusion criteria were the description of the EVD drainage and weaning strategies used and a comparison of continuous versus intermittent drainage or rapid versus gradual weaning within the study. Random effect meta-analyses were used to compare functional outcomes, incidence of complications and hospital length of stay. Intermittent external CSF drainage was associated with lower incidence of EVD-related infections (RR = 0.20, 95% CI 0.05-0.72, I-squared = 0%) and EVD blockages compared to continuous CSF drainage (RR = 0.45, 95% CI 0.27-0.74, I-squared = 0%). There was no clear advantage in using gradual EVD weaning strategies compared to rapid EVD weaning; however, patients who underwent rapid EVD weaning had a shorter hospital length of stay (SMD = 0.34, 95% CI 0.22-0.47, I-squared = 0%). Intermittent external CSF drainage after SAH is associated with lower incidence of EVD-related infections and EVD blockages compared to continuous CSF drainage. Patients who underwent rapid EVD weaning had a shorter hospital length of stay and there was no clear clinical advantage in using gradual weaning.
    MeSH term(s) Drainage ; Humans ; Hydrocephalus/surgery ; Neurosurgical Procedures ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/surgery ; Ventriculostomy
    Language English
    Publishing date 2021-08-26
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 6907-3
    ISSN 1437-2320 ; 0344-5607
    ISSN (online) 1437-2320
    ISSN 0344-5607
    DOI 10.1007/s10143-021-01627-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effect of position on intracranial pressure and compliance: a cross-sectional study including 101 patients.

    D'Antona, Linda / Craven, Claudia Louise / Bremner, Fion / Matharu, Manjit Singh / Thorne, Lewis / Watkins, Laurence Dale / Toma, Ahmed Kassem

    Journal of neurosurgery

    2021  Volume 136, Issue 6, Page(s) 1781–1789

    Abstract: Objective: A better understanding of the effect of position on intracranial pressure (ICP) and compliance is important for the development of treatment strategies that can restore normal cerebrospinal fluid (CSF) dynamics. There is limited knowledge on ... ...

    Abstract Objective: A better understanding of the effect of position on intracranial pressure (ICP) and compliance is important for the development of treatment strategies that can restore normal cerebrospinal fluid (CSF) dynamics. There is limited knowledge on the effect of position on intracranial compliance. In this cross-sectional study the authors tested the association of pulse amplitude (PA) with position and the day/night cycle. Additionally, they describe the postural ICP and PA changes of patients with "normal" ICP dynamics.
    Methods: This single-center retrospective study included patients with suspected and/or confirmed CSF dynamics abnormalities who had been examined with elective 24-hour ICP monitoring between October 2017 and September 2019. Patients had been enrolled in a short exercise battery including four positions: supine, lumbar puncture position in the left lateral decubitus position, sitting, and standing. Each position was maintained for 2 minutes, and mean ICP and PA were calculated for each position. The 24-hour day and night median ICP and PA data were also collected. Linear regression models were used to test the correlation of PA with position and day/night cycle. All linear regressions were corrected for confounders. The postural ICP monitoring results of patients without obvious ICP dynamics abnormality were summarized.
    Results: One hundred one patients (24 males and 77 females) with a mean age of 39 ± 13years (mean ± standard deviation) were included in the study. The adjusted linear regression models demonstrated a significant association of ICP with position and day/night cycle, with upright (sitting and standing) and day ICP values lower than supine and night ICP values. The adjusted linear regression model was also significant for the association of PA with position and day/night cycle, with upright and day PA values higher than supine and night PA results. These associations were confirmed for patients with and without shunts. Patients without clear ICP dynamics abnormality had tighter control of their postural ICP changes than the other patients; however, the difference among groups was not statistically significant.
    Conclusions: This is the largest study investigating the effect of postural changes on intracranial compliance. The results of this study suggest that PA, as well as ICP, is significantly associated with posture, increasing in upright positions compared to that while supine. Further studies will be needed to investigate the mechanism behind this association.
    Language English
    Publishing date 2021-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2021.6.JNS203573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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