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  1. Article ; Online: Functional plasticity of glutamatergic neurons of medullary reticular nuclei after spinal cord injury in mice.

    Lemieux, Maxime / Karimi, Narges / Bretzner, Frederic

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1542

    Abstract: Spinal cord injury disrupts the descending command from the brain and causes a range of motor deficits. Here, we use optogenetic tools to investigate the functional plasticity of the glutamatergic reticulospinal drive of the medullary reticular formation ...

    Abstract Spinal cord injury disrupts the descending command from the brain and causes a range of motor deficits. Here, we use optogenetic tools to investigate the functional plasticity of the glutamatergic reticulospinal drive of the medullary reticular formation after a lateral thoracic hemisection in female mice. Sites evoking stronger excitatory descending drive in intact conditions are the most impaired after injury, whereas those associated with a weaker drive are potentiated. After lesion, pro- and anti-locomotor activities (that is, initiation/acceleration versus stop/deceleration) are overall preserved. Activating the descending reticulospinal drive improves stepping ability on a flat surface of chronically impaired injured mice, and its priming enhances recovery of skilled locomotion on a horizontal ladder. This study highlights the resilience and capacity for reorganization of the glutamatergic reticulospinal command after injury, along with its suitability as a therapeutical target to promote functional recovery.
    MeSH term(s) Mice ; Animals ; Female ; Neurons/physiology ; Spinal Cord Injuries ; Medulla Oblongata ; Reticular Formation ; Brain/pathology ; Spinal Cord/pathology ; Locomotion/physiology
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45300-4
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  2. Article ; Online: Efficacy of topical curcumin on mild to moderate carpal tunnel syndrome: a randomized double-blind, placebo-controlled clinical trial.

    Sharifi Razavi, Athena / Mohajerani, Fatemeh / Niksolat, Fatemeh / Karimi, Narges

    Pain medicine (Malden, Mass.)

    2024  Volume 25, Issue 5, Page(s) 327–333

    Abstract: Objectives: Recently, there has been a renewed interest in traditional medicine for carpal tunnel syndrome (CTS). Curcumin has been reported as an agent with antioxidant, anti-inflammatory, analgesic, and neuroprotective attributes. This study is one of ...

    Abstract Objectives: Recently, there has been a renewed interest in traditional medicine for carpal tunnel syndrome (CTS). Curcumin has been reported as an agent with antioxidant, anti-inflammatory, analgesic, and neuroprotective attributes. This study is one of the first investigations to assess the effect of curcumin gel on CTS.
    Methods: This study is a prospective, 8-week, randomized, placebo-controlled, parallel-group clinical trial. A total of 70 patients with CTS were analyzed. The intervention group (n = 35) received a topical curcumin gel and a night wrist splint and the control group (n = 35) received a placebo gel and a night wrist splint for 8 weeks. The primary outcome was the assessment of the symptom severity scale (SSS) and functional status scale (FSS) of the participants using the Boston Carpal Tunnel Questionnaire (BCTQ) after 8 weeks. In addition, all participants were evaluated by electrodiagnostic (EDX) test at baseline and after 8 weeks.
    Results: The mean scores of SSS demonstrated a significant decrease in the curcumin group compared to the placebo group; P-value= 0.021. The mean change score of SSS after the intervention was 12.45 ± 8.18 in curcumin and 3.28 ± 7.06 in the placebo group; P-value = 0.0001 and the mean change score of FSS were 6.24 ± 4.91 and 2.31 ± 4.95 in curcumin and placebo groups, respectively; P-value = 0.002. However, the EDX study showed no significant changes in both groups.
    Conclusions: It seems that curcumin gel could be effective in the improvement of the symptom severity and daily activity of patients with CTS.
    MeSH term(s) Humans ; Carpal Tunnel Syndrome/drug therapy ; Curcumin/therapeutic use ; Curcumin/administration & dosage ; Double-Blind Method ; Female ; Male ; Middle Aged ; Adult ; Treatment Outcome ; Administration, Topical ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Prospective Studies ; Aged ; Severity of Illness Index
    Chemical Substances Curcumin (IT942ZTH98) ; Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnae001
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  3. Article ; Online: Adult Abdominal Pain; A Rare Cause of Migraine Disorders

    Narges Karimi

    Case Reports in Clinical Practice, Vol 1, Iss

    2017  Volume 4

    Abstract: Abdominal migraine (AM) is one of the variants of migraine and is rare in the adults. This case report describes a 45- year- old woman with diagnosis of adult abdominal migraine. The patient had improved with anti-migraine drugs. This disorder should be ... ...

    Abstract Abdominal migraine (AM) is one of the variants of migraine and is rare in the adults. This case report describes a 45- year- old woman with diagnosis of adult abdominal migraine. The patient had improved with anti-migraine drugs. This disorder should be considered in the adult patients with abdominal pain who be normal complete gastrointestinal work up.
    Keywords adult ; abdominal pain ; migraine ; case report ; Medicine ; R
    Language English
    Publishing date 2017-06-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Paroxysmal Tonic Spasm in a Patient with the Sudden Zolpidem Withdrawal: A Case Report.

    Keighobadi, Masoud / Karimi, Narges

    Clinical neuropsychiatry

    2021  Volume 17, Issue 5, Page(s) 314–316

    Abstract: Zolpidem is an imidazopyridine derivative and a non-benzodiazepine hypnotic drug. There are several case reports of zolpidem abuse or dependence and zolpidem withdrawal. This study reports a case of paroxysmal tonic spasm (PTS) after abrupt withdrawal of ...

    Abstract Zolpidem is an imidazopyridine derivative and a non-benzodiazepine hypnotic drug. There are several case reports of zolpidem abuse or dependence and zolpidem withdrawal. This study reports a case of paroxysmal tonic spasm (PTS) after abrupt withdrawal of high dose zolpidem. The case was a 21-year- old male patient with complaints of acute involuntary and painful spasms of all extremities after the sudden withdrawal of taking supratherapeutic zolpidem. In his medical records, He had the history of insomnia and psychiatric disorder . The patient's symptoms improved with intravenous injection of 10 mg diazepam slowly and zolpidem was tapered gradually. This case report indicates that zolpidem has a dependency and abusage properties. To the best of our knowledge , this is the first report of zolpidem withdrawal with PTS.
    Language English
    Publishing date 2021-11-10
    Publishing country Italy
    Document type Case Reports
    ISSN 2385-0787
    ISSN (online) 2385-0787
    DOI 10.36131/cnfioritieditore20200507
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  5. Article ; Online: A retrospective study of the safety and efficacy of rituximab in Iranian patients with myasthenia gravis: A single-center experience.

    Ziaadini, Bentolhoda / Karimi, Narges / Panahi, Akram / Okhovat, Ali Asghar / Fatehi, Farzad / Nafissi, Shahriar

    Current journal of neurology

    2023  Volume 21, Issue 2, Page(s) 91–97

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-11-27
    Publishing country Iran
    Document type Journal Article
    ISSN 2717-011X
    ISSN (online) 2717-011X
    DOI 10.18502/cjn.v21i2.10492
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  6. Article ; Online: Reversible Cerebral Vasoconstriction Syndromes

    Narges Karimi

    Advances in Bioscience and Clinical Medicine, Vol 0, Iss

    2017  

    Abstract: Reversible cerebral vasoconstriction syndromes (RCVS) show reversible multifocal narrowing of the cerebral arteries with clinical manifestations that characteristically include thunderclap headache and less commonly focal neurologic deficits related to ... ...

    Abstract Reversible cerebral vasoconstriction syndromes (RCVS) show reversible multifocal narrowing of the cerebral arteries with clinical manifestations that characteristically include thunderclap headache and less commonly focal neurologic deficits related to brain edema, stroke, or seizure. RCVS predominantly affects women (female to male ratio 2:1 to 10:1, depending on the case series). The mean age across published studies is 42 to 44 years. RCVS has been associated with a multiplicity of conditions including pregnancy, migraine ,use of vasoconstrictive drugs and other medications, neurosurgical procedures, hypercalcemia, unruptured saccular aneurysms, cervical artery dissection, cerebral venous thrombosis, and others. Between 30 and 70 percent of patients with RCVS have no abnormality on initial brain scans, despite having widespread cerebral vasoconstriction. However, approximately 75 percent of admitted patients eventually develop parenchymal lesions. The most frequent lesions are ischemic stroke and cortical surface (nonaneurysmal or convexal) subarachnoid hemorrhage, followed by reversible vasogenic brain edema and parenchymal hemorrhage. Infarcts are often bilateral and symmetrical, located in arterial "watershed" regions of the cerebral hemispheres or in the cortical-subcortical junction. Larger infarcts are often wedge-shaped. Cerebral angiographic abnormalities are dynamic and progress proximally, resulting in a "sausage on a string" appearance of the circle of Willis arteries and their branches. There is no proven therapy for RCVS. Supportive care is directed towards managing blood pressure, severe headaches, and other complications such as seizures. Oral calcium channel blockers are often administered to treat vasoconstriction but the supporting evidence for this strategy is weak.
    Keywords RCVS ; stroke ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2017-02-01T00:00:00Z
    Publisher Australian International Academic Centre PTY.LTD.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Predictors of health behavior compliance for the prevention of Covid-19 based on the extended parallel process model in pregnant women in Iran.

    Afshar, Mohammad / Ghahramani, Leila / Asadollahi, Abdolrahim / Karimi, Masoud / Mobasheri, Narges

    Health care for women international

    2023  Volume 44, Issue 7-8, Page(s) 1019–1035

    Abstract: Pregnant women are at higher risk of getting severe Covid-19 disease and consequences on the health status of them and their fetuses. Despite vaccination, all preventive behaviors are emphasized. This study aimed to identify the determinants of Covid-19 ... ...

    Abstract Pregnant women are at higher risk of getting severe Covid-19 disease and consequences on the health status of them and their fetuses. Despite vaccination, all preventive behaviors are emphasized. This study aimed to identify the determinants of Covid-19 preventive health behaviors in pregnant women using Extended Parallel Process Model. This cross-sectional study, was conducted on 175pregnant women. The model fit indices were acceptable. Knowledge had indirect effect on adherence to Covid-19 preventive behaviors trough mediating role of self-efficacy and response efficacy. So, it is suggested that, educational interventions should focus on increasing knowledge.
    MeSH term(s) Humans ; Female ; Pregnancy ; COVID-19/prevention & control ; Pregnant Women ; Iran/epidemiology ; Cross-Sectional Studies ; Surveys and Questionnaires ; Health Knowledge, Attitudes, Practice ; Health Behavior
    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632677-8
    ISSN 1096-4665 ; 0739-9332
    ISSN (online) 1096-4665
    ISSN 0739-9332
    DOI 10.1080/07399332.2023.2181349
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    Zs.B 2847: Show issues Location:
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  8. Article ; Online: The Possible Associaton Between Cerebral Venous Thrombosis and COVID-19 Infecton in a Patent WithSickle Cell Disease

    Athena Sharif Razavi / Narges Karimi

    Case Reports in Clinical Practice, Vol 5, Iss Covid-

    A Case Report

    2021  Volume 19

    Abstract: Background: The most common symptom of the novel Coronavirus Disease 2019 (COVID-19) infection is fever and dyspnea that leads to hypoxia in severe cases. Some COVID-19 patients experience neurological symptoms, including ischemic stroke and ... ...

    Abstract Background: The most common symptom of the novel Coronavirus Disease 2019 (COVID-19) infection is fever and dyspnea that leads to hypoxia in severe cases. Some COVID-19 patients experience neurological symptoms, including ischemic stroke and intracerebral hemorrhage. Sickle Cell Disease (SCD) is a hypercoagulable state, however, it has not been approved as a significant cause of Cerebral Venous Thrombosis (CVT). Case presentation: In this case report, we described CVT in an SCD patient who had COVID-19, as well. We reported a 32-year-old man with a history of sickle cell anemia presented with left hemiparesis, headache, and seizure. After evaluation of the patient, CVT accompanied by COVID-19 infection was diagnosed. He was treated with intravenous unsaturated heparin, antiepileptic drugs, and antiviral agents with a favorable outcome. Based on our knowledge, this is the first case study to describe an association between CVT and COVID-19 infection in a patient with SCD. Conclusion: During the recent pandemic, vaso-occlusive attacks in SCD patients can be evaluated for COVID-19 as an etiological factor.
    Keywords COVID-19 ; Coronavirus ; Cerebral venous thrombosis ; Sickle cell disease ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Letter to the editor. Concerning the article entitled ''Guillain Barre syndrome associated with COVID-19 infection: A case report".

    Karimi, Narges / Sedaghat, Zahra

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2020  Volume 79, Page(s) 257–258

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Guillain-Barre Syndrome/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-04
    Publishing country Scotland
    Document type Letter ; Comment
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2020.06.025
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3999: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: Analyzing the impact of energy consumption, the democratic process, and government service delivery on life expectancy: evidence from a global sample.

    Salehnia, Narges / Karimi Alavijeh, Nooshin / Hamidi, Mina

    Environmental science and pollution research international

    2022  Volume 29, Issue 24, Page(s) 36967–36984

    Abstract: Life expectancy is one of the crucial criteria for determining the quality of life in today's societies. As such, the study of factors affecting life expectancy is a key issue for policymakers. This study aims to investigate the impact of energy ... ...

    Abstract Life expectancy is one of the crucial criteria for determining the quality of life in today's societies. As such, the study of factors affecting life expectancy is a key issue for policymakers. This study aims to investigate the impact of energy consumption, the democratic process, and government service delivery on life expectancy in 100 countries during 2000-2018, using panel quantile regression. The impact of these factors on life expectancy has been estimated in quantiles of 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, and 0.95. Also, the impact of GDP, CO
    MeSH term(s) Carbon Dioxide ; Economic Development ; Government ; Life Expectancy ; Quality of Life
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2022-01-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-021-18180-0
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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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