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Article ; Online: Adaptor protein HIP-55 promotes macrophage M1 polarization through promoting AP-1 complex activation.

Bian, Jingwei / Zhu, Yuzhong / Tian, Panhui / Yang, Qiqi / Li, Zijian

2024 Volume 117, Page(s) 111124

Abstract: Overwhelming macrophage M1 polarization induced by malfunction of the renin-angiotensin-aldosterone system (RAAS) initiates inflammatory responses, which play a crucial role in various cardiovascular diseases. However, the underlying regulatory mechanism ...

Abstract	Overwhelming macrophage M1 polarization induced by malfunction of the renin-angiotensin-aldosterone system (RAAS) initiates inflammatory responses, which play a crucial role in various cardiovascular diseases. However, the underlying regulatory mechanism remains elusive. Here, we identified adaptor protein HIP-55 as a critical regulator of macrophage M1 polarization. The expression of HIP-55 was upregulated in M1 macrophage induced by Ang II. Overexpression of HIP-55 significantly promoted Ang II-induced macrophage M1 polarization, whereas genetic deletion of HIP-55 inhibited the Ang II-induced macrophage M1 polarization. Mechanistically, HIP-55 facilitated activator protein-1 (AP-1) complex activation induced by Ang II via promoting ERK1/2 and JNK phosphorylation. Moreover, blocking AP-1 complex activation can attenuate the function of HIP-55 in macrophage polarization. Collectively, our results reveal the role of HIP-55 in macrophage polarization and provide potential therapeutic insights for cardiovascular diseases associated with RAAS dysfunction.
MeSH term(s)	Humans ; Adaptor Proteins, Signal Transducing/metabolism ; Angiotensin II/pharmacology ; Angiotensin II/metabolism ; Cardiovascular Diseases/metabolism ; Macrophages/metabolism ; Signal Transduction ; Transcription Factor AP-1 ; Animals ; Mice ; Microfilament Proteins/metabolism ; src Homology Domains
Chemical Substances	Adaptor Proteins, Signal Transducing ; Angiotensin II (11128-99-7) ; Transcription Factor AP-1 ; Microfilament Proteins
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2024.111124
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Zs.A 2579: Show issues

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Article: Exploration and validation of the hub genes involved in hypoxia-induced endothelial-mesenchymal transition of systemic sclerosis.

Li, Kai / Wang, Qian / Bian, Bo / Xu, Jingwei / Bian, Hua

Clinical and experimental rheumatology

2023 Volume 41, Issue 8, Page(s) 1618–1631

Abstract: Objectives: During the development of systemic sclerosis (SSc), endothelial-mesenchymal transition (EndoMT) has been shown to be one of the mechanisms leading to pulmonary fibrosis. However, the correlation between hypoxia and EndoMT was mostly unknown.! ...

Abstract	Objectives: During the development of systemic sclerosis (SSc), endothelial-mesenchymal transition (EndoMT) has been shown to be one of the mechanisms leading to pulmonary fibrosis. However, the correlation between hypoxia and EndoMT was mostly unknown. Methods: R software was used to analyse differentially expressed genes (DEGs) in vascular endothelial cells under hypoxic conditions, and fibroblasts derived from SSc-related pulmonary fibrotic tissues, respectively. Using a web-based online Venn diagram tool, we analysed overlapping genes of DEGs between endothelial cells and fibroblasts. Finally, the protein-protein interaction network of EndoMT hub genes were constructed using the STRING database. The hub genes were knockdown by transfection of siRNAs in the hypoxia model of HULEC-5a cells constructed by liquid paraffin closure and then used to detect the effect on EndoMT-related biomarkers by western blot. Results: In this study, we found that INHBA, DUSP1, NOX4, PLOD2, BHLHE40 were upregulated in SSc fibroblasts and hypoxic-treated endothelial cells, while VCAM1, RND3, CCL2, and TXNIP were downregulated. In the hypoxia model of HULEC-5a cells, the expression of these 9 hub genes was confirmed by western blot. In addition, through Spearman's correlation analysis and Western blot, we confirmed that these hub genes were closely related to the EndoMT-related markers. The mechanisms of these hypoxia-induced EndoMT hub genes may be related to TGF-β, Notch, Wnt, NF-κ B, TNF and mTOR signalling pathways. Conclusions: Our study provides new insights into the occurrence and development of SSc-related pulmonary fibrosis resulting from hypoxia-induced EndoMT.
MeSH term(s)	Humans ; Endothelial Cells/metabolism ; Pulmonary Fibrosis/metabolism ; Pulmonary Fibrosis/pathology ; Epithelial-Mesenchymal Transition/genetics ; Scleroderma, Systemic/pathology ; Hypoxia/genetics ; Hypoxia/metabolism ; Hypoxia/pathology
Language	English
Publishing date	2023-05-25
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/j7ema8
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Zs.A 2002: Show issues

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Article ; Online: Posttranslational modifications in GPCR internalization.

Tang, Xueqing / Bian, Jingwei / Li, Zijian

American journal of physiology. Cell physiology

2022 Volume 323, Issue 1, Page(s) C84–C94

Abstract: G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve as the most important drug targets. Classically, GPCR internalization has been considered to lead to receptor desensitization. However, many studies over the past ...

Abstract	G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve as the most important drug targets. Classically, GPCR internalization has been considered to lead to receptor desensitization. However, many studies over the past decade have reported that internalized membrane receptors can trigger distinct signal activation. The "internalized activation" provides a completely new understanding for the receptor internalization, the mechanism of physiology/pathology and novel drug targets for precision medicine. GPCR internalization undergoes a series of strict regulations, especially by posttranslational modifications (PTMs). Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in GPCR internalization dynamics, internalization routes, postinternalization fates, and related diseases, which will offer new insights into the regulatory mechanism of GPCR signaling and novel drug targets for precision medicine.
MeSH term(s)	Protein Processing, Post-Translational ; Receptors, G-Protein-Coupled/metabolism
Chemical Substances	Receptors, G-Protein-Coupled
Language	English
Publishing date	2022-05-25
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	392098-7
ISSN	1522-1563 ; 0363-6143
ISSN (online)	1522-1563
ISSN	0363-6143
DOI	10.1152/ajpcell.00015.2022
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Uc I Zs.89: Show issues

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Article ; Online: Internalized Activation of Membrane Receptors: From Phenomenon to Theory.

Wang, Wenjing / Bian, Jingwei / Li, Zijian

Trends in cell biology

2021 Volume 31, Issue 6, Page(s) 428–431

Abstract: Many studies over the past decade have reported that internalized membrane receptors can trigger distinct signal activation, rather than being desensitized inside the cell. Here, we propose the concept of 'internalized activation' as a distinctive ... ...

Abstract	Many studies over the past decade have reported that internalized membrane receptors can trigger distinct signal activation, rather than being desensitized inside the cell. Here, we propose the concept of 'internalized activation' as a distinctive component of the receptor theory framework and exhibit its significance and role in diseases.
Language	English
Publishing date	2021-04-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	30122-x
ISSN	1879-3088 ; 0962-8924
ISSN (online)	1879-3088
ISSN	0962-8924
DOI	10.1016/j.tcb.2021.03.008
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Zs.A 3410: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)

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Article: Letter to the editor: Anti-RAS drugs and SARS-CoV-2 infection.

Bian, Jingwei / Zhao, Rongsheng / Zhai, Suodi / Li, Zijian

Acta pharmaceutica Sinica. B

2020 Volume 10, Issue 7, Page(s) 1251–1252

Keywords	covid19
Language	English
Publishing date	2020-04-28
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-3835
ISSN	2211-3835
DOI	10.1016/j.apsb.2020.04.013
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Article: Angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS modulator.

Bian, Jingwei / Li, Zijian

Acta pharmaceutica Sinica. B

2020 Volume 11, Issue 1, Page(s) 1–12

Abstract: The coronavirus disease 2019 (COVID-19) outbreak is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Angiotensin-converting enzyme 2 (ACE2) was rapidly identified as the critical functional receptor for SARS-CoV-2. ACE2 is well- ... ...

Abstract	The coronavirus disease 2019 (COVID-19) outbreak is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Angiotensin-converting enzyme 2 (ACE2) was rapidly identified as the critical functional receptor for SARS-CoV-2. ACE2 is well-known as a counter-regulator of the renin-angiotensin system (RAS) and plays a key role in the cardiovascular system. Given that ACE2 functions as both a SARS-CoV-2 receptor and a RAS modulator, the treatment for COVID-19 presents a dilemma of how to limit virus entry but protect ACE2 physiological functions. Thus, an in-depth summary of the recent progress of ACE2 research and its relationship to the virus is urgently needed to provide possible solution to the dilemma. Here, we summarize the complexity and interplay between the coronavirus, ACE2 and RAS (including anti-RAS drugs). We propose five novel working modes for functional receptor for SARS-CoV-2 infection and the routes of ACE2-mediated virus entering host cells, as well as its regulatory mechanism. For the controversy of anti-RAS drugs application, we also give theoretical analysis and discussed for drug application. These will contribute to a deeper understanding of the complex mechanisms of underlying the relationship between the virus and ACE2, and provide guidance for virus intervention strategies.
Keywords	covid19
Language	English
Publishing date	2020-10-13
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2211-3835
ISSN	2211-3835
DOI	10.1016/j.apsb.2020.10.006
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Article ; Online: Nanoparticles Internalization through HIP-55-Dependent Clathrin Endocytosis Pathway.

Guan, Kaihang / Liu, Kai / Jiang, Yunqi / Bian, Jingwei / Gao, Yang / Dong, Erdan / Li, Zijian

Nano letters

2023 Volume 23, Issue 24, Page(s) 11477–11484

Abstract: Nanoparticles are promising tools for biomedicine. Many nanoparticles are internalized to function. Clathrin-mediated endocytosis is one of the most important mechanisms for nanoparticle internalization. However, the regulatory mechanism of clathrin- ... ...

Abstract	Nanoparticles are promising tools for biomedicine. Many nanoparticles are internalized to function. Clathrin-mediated endocytosis is one of the most important mechanisms for nanoparticle internalization. However, the regulatory mechanism of clathrin-mediated nanoparticle endocytosis is still unclear. Here, we report that the adapter protein HIP-55 regulates clathrin-mediated nanoparticle endocytosis. CdSe/ZnS quantum dots (QDs), a typical nanoparticle, enter cells through the HIP-55-dependent clathrin endocytosis pathway. Both pharmacological inhibitor and genetic intervention demonstrate that QDs enter cells through clathrin-mediated endocytosis. HIP-55 can interact with clathrin and promote clathrin-mediated QDs endocytosis. Furthermore, HIP-55 ΔADF which is defective in F-actin binding fails to promote QDs endocytosis, indicating HIP-55 promotes clathrin-mediated QDs endocytosis depending on interaction with F-actin.
MeSH term(s)	Clathrin/metabolism ; Actins ; Nanoparticles ; Endocytosis ; Quantum Dots
Chemical Substances	Clathrin ; Actins
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.3c03074
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Article ; Online: Effects of two celery fibers on the structural properties and digestibility of glutinous rice starch: A comparative study.

Yu, Yiyang / Hao, Zongwei / Wang, Baixue / Deng, Changyue / Hu, Jingwei / Bian, Yiran / Wang, Taosuo / Zheng, Mingming / Yu, Zhenyu / Zhou, Yibin

International journal of biological macromolecules

2024 Volume 264, Issue Pt 2, Page(s) 130776

Abstract: The present study focused on the extraction of water-soluble dietary fiber (CSDF) and water-insoluble dietary fiber (CIDF) from celery. It investigated their effects on glutinous rice starch's (GRS) physicochemical, structural, and digestive properties. ... ...

Abstract	The present study focused on the extraction of water-soluble dietary fiber (CSDF) and water-insoluble dietary fiber (CIDF) from celery. It investigated their effects on glutinous rice starch's (GRS) physicochemical, structural, and digestive properties. The results showed that as the addition of the two dietary fibers increased, they compounded with GRS to varying degrees, with the complexing index reaching 69.41 % and 60.81 %, respectively. The rheological results indicated that the two dietary fibers reduced the viscosity of GRS during pasting and inhibited the short-term regrowth of starch. The FTIR and XRD results revealed that the two fibers interacted with GRS through hydrogen bonding, effectively inhibiting starch retrogradation. Furthermore, both fibers increased the pasting temperature of GRS, thus delaying its pasting and exhibiting better thermal stability. Regarding digestibility, the starch gels containing dietary fibers exhibited significantly reduced digestibility, with RS significantly increased by 8.15 % and 8.95 %, respectively. This study provides insights into the interaction between two dietary fibers and GRS during processing. It enriches the theoretical model of dietary fiber-starch interaction and provides a reference for the application development of starch-based functional foods.
MeSH term(s)	Oryza/chemistry ; Apium ; Starch/chemistry ; Dietary Fiber ; Viscosity ; Water
Chemical Substances	Starch (9005-25-8) ; Dietary Fiber ; Water (059QF0KO0R)
Language	English
Publishing date	2024-03-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130776
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Zs.B 2374: Show issues

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Article ; Online: The new fate of internalized membrane receptors: Internalized activation.

Wang, Wenjing / Bian, Jingwei / Sun, Yang / Li, Zijian

Pharmacology & therapeutics

2021 Volume 233, Page(s) 108018

Abstract: Classically, the fate of internalized membrane receptors includes receptor degradation and receptor recycling. However, recent findings have begun to challenge these views. Much research demonstrated that many internalized membrane receptors can trigger ... ...

Abstract	Classically, the fate of internalized membrane receptors includes receptor degradation and receptor recycling. However, recent findings have begun to challenge these views. Much research demonstrated that many internalized membrane receptors can trigger distinct signal activation rather than being desensitized inside the cell. Here, we introduce the concept of "internalized activation" which not only represents a new mode of receptor activation, but also endows the new fate for receptor internalization (from death to life). The new activation mode and fate of membrane receptor are ubiquitous and have unique theoretical significance. We systematically put forward the features, process, and regulation of "internalized activation" and its significance in signal transduction and diseases. "Internalized activation" will provide a completely new understanding for the theory of receptor activation, internalization and novel drug targets for precision medicine.
MeSH term(s)	Endocytosis ; Humans ; Signal Transduction
Language	English
Publishing date	2021-10-06
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	194735-7
ISSN	1879-016X ; 0163-7258
ISSN (online)	1879-016X
ISSN	0163-7258
DOI	10.1016/j.pharmthera.2021.108018
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Zs.A 1183: Show issues

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Article ; Online: Letter to the editor

Jingwei Bian / Rongsheng Zhao / Suodi Zhai / Zijian Li

Acta Pharmaceutica Sinica B, Vol 10, Iss 7, Pp 1251-

Anti-RAS drugs and SARS-CoV-2 infection

2020 Volume 1252

Keywords	Therapeutics. Pharmacology ; RM1-950 ; covid19
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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