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  1. Article ; Online: Letter: Ethical concerns and scientific communication on neuralink device.

    Armocida, Daniele / Garbossa, Diego / Cofano, Fabio

    Neurosurgical review

    2024  Volume 47, Issue 1, Page(s) 194

    MeSH term(s) Humans
    Language English
    Publishing date 2024-04-26
    Publishing country Germany
    Document type Letter
    ZDB-ID 6907-3
    ISSN 1437-2320 ; 0344-5607
    ISSN (online) 1437-2320
    ISSN 0344-5607
    DOI 10.1007/s10143-024-02432-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1445: Show issues Location:
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  2. Article ; Online: Letter to the editor regarding: "Malpractice litigation in elective lumbar spinal fusion: a comprehensive review of reported legal claims in the US in the past 50 years" by Zhang et al. Highlight the question in Europe.

    Tartara, Fulvio / Armocida, Daniele / Cofano, Fabio / Garbossa, Diego

    The spine journal : official journal of the North American Spine Society

    2023  Volume 23, Issue 5, Page(s) 786–787

    MeSH term(s) Humans ; Spinal Fusion ; Malpractice ; Europe
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Review ; Letter ; Comment
    ZDB-ID 2037072-6
    ISSN 1878-1632 ; 1529-9430
    ISSN (online) 1878-1632
    ISSN 1529-9430
    DOI 10.1016/j.spinee.2023.01.020
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5898: Show issues Location:
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  3. Article ; Online: A case-based review on the neuroendoscopic management of intraventricular and subarachnoid basal neurocysticercosis.

    De Marco, Raffaele / Lacatena, Filippo / Cofano, Fabio / Garbossa, Diego / Fiumefreddo, Alessandro

    Clinical neurology and neurosurgery

    2024  Volume 240, Page(s) 108268

    Abstract: Objective: Extraparenchymal localization of neurocysticercosis (NCC) is rare in non-endemic areas. A case of mixed (intraventricular, IV, and subarachnoid basal, SAB) NCC was surgically treated using the neuroendoscope and a systematic review of the ... ...

    Abstract Objective: Extraparenchymal localization of neurocysticercosis (NCC) is rare in non-endemic areas. A case of mixed (intraventricular, IV, and subarachnoid basal, SAB) NCC was surgically treated using the neuroendoscope and a systematic review of the literature was performed with the aim to analyze the use of this instrument in the management of the extraparenchymal forms of the parasitic disease.
    Materials and methods: Medline and Embase databases were searched for studies where the neuroendoscope was used for the management of IV/SAB NCC cysts, either for the cerebrospinal fluid diversion or cyst removal. Cyst location, complete removal, cyst breakage during removal, intraoperative and postoperative complications, administration of antihelmintic therapy, outcome and follow-up period were extracted from the articles.
    Results: 281 patients were treated by means of the neuroendoscope. 254 patients who were described in retrospective cohort studies, came all from endemic areas, with no significant difference between sexes. Mean age at surgery was 30.7 years. Of all cysts reported in retrospective studies, 37.9% were located in the fourth ventricle. An attempt of cyst removal was described in the 84.6% of cases and an endoscopic third ventriculostomy was performed in another 76.4%. A small number of complications were reported intraoperatively (9.1%) obtaining, but a good recovery was achieved at follow-up. Only 17 ventriculoperitoneal shunts were placed after the first procedure, defining a low risk of postoperative hydrocephalus even in case of partial cyst removal.
    Conclusion: Neuroendoscopic removal of an extraparenchymal NCC cyst is a safe procedure that should be preferred for lateral and third ventricle localization and, in a specialized centre, even for a localization in the fourth ventricle if feasible. It is also efficient because of the possibility of performing an internal CSF diversion concomitantly to cyst removal, avoiding the complication registered with VPS. The need for cysticidal treatment after surgery should be addressed in a prospective study.
    Language English
    Publishing date 2024-03-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2024.108268
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  4. Article: Spinal dural and epidural arteriovenous fistula: Recurrence rate after surgical and endovascular treatment.

    Vercelli, Giovanni Giulio / Minardi, Massimiliano / Bergui, Mauro / Zenga, Francesco / Garbossa, Diego / Cofano, Fabio

    Frontiers in surgery

    2023  Volume 10, Page(s) 1148968

    Abstract: Introduction: Spinal dural arteriovenous fistula consist of an heterogenous group of vascular malformation often causing severe neurological deficit due to progressive myelopathy. This type of malformation could be associated with subarachnoid or ... ...

    Abstract Introduction: Spinal dural arteriovenous fistula consist of an heterogenous group of vascular malformation often causing severe neurological deficit due to progressive myelopathy. This type of malformation could be associated with subarachnoid or subdural hemorrhage inside the spinal canal. In the English literature surgical treatment is regarded as the best option if compared to endovascular procedure, being the latter associated with an increased risk of relapse despite its less invasiveness.
    Methods: In this study a retrospective analysis of 30 patients with spinal dural and epidural fistula associated with perimedullary venous congestion was undertaken. The radiological and clinical presentation of each patient is analyzed, and the grade of myelopathy is classified through the mJOA score.
    Results: A total number of 31 out of 41 collected procedures (22 surgery vs. 19 endovascular) were dural fistulas while the remaining 10 were classified as epidural. A 46% recurrence rate for endovascular treatment against 0% for surgical (
    Discussion: According to the results, surgical treatment could be considered as first-line treatment for spinal dural arteriovenous fistulas. Endovascular embolization can be proposed in selected cases, as a less invasive technique, for elderly patients or with important comorbidities. In spinal epidural arteriovenous fistulas, in view of the greater invasiveness of the surgical treatment and the non-significant difference in terms of recurrence risk between the two techniques, endovascular treatment could be proposed as a first choice treatment; in the event of a recurrence, a surgical intervention will instead be proposed in a short time.
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1148968
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  5. Article: Porous titanium microsphere kyphoplasty for augmentation treatment of osteoporotic vertebral fractures: Technical report and case series.

    Tartara, Fulvio / Armocida, Daniele / Garbossa, Diego / Meli, Francesco / Costantino, Gabriele / Cofano, Fabio / Francaviglia, Natale

    Frontiers in surgery

    2023  Volume 10, Page(s) 1152995

    Abstract: Background: Vertebral augmentation procedures (VAPs) are used in cases of persistent and unresponsive pain in patients with vertebral compression fractures (VCFs). Although VAPs are considered a safe procedure providing quick pain relief and improved ... ...

    Abstract Background: Vertebral augmentation procedures (VAPs) are used in cases of persistent and unresponsive pain in patients with vertebral compression fractures (VCFs). Although VAPs are considered a safe procedure providing quick pain relief and improved physical function, some postoperative complications can occur, for example, bone cement leakage. The material used in this procedure is almost exclusively polymethyl methacrylate (PMMA), which appears to lack biological activity and osteointegration capabilities. In this study, we introduce a new filling system consisting of cannulas preloaded with titanium microspheres, which stabilizes and consolidates the structure of the vertebral body in treating VCFs after the performance of the kyphoplasty procedure.
    Methods: We report a retrospective case series of six patients affected by osteoporotic vertebral fractures with worsening back pain, neurologic impairment, and failed conservative treatment who underwent the VAP at our institute, for which the SPHEROPLAST [MT ORTHO s.r.l., Aci Sant'Antonio (CT), Italy] system was used.
    Results: The patients had failed an average conservative trial of 3.9 weeks before they presented to us with neurodeficit. There were two men and four women with a mean age of 74.5 years. The average hospital stay was 2 days. There were no reported perioperative complications related to cement injection, such as intraoperative hypoxia, hypotension, pulmonary embolization, myocardial infarction, neurovascular or viscera injury, or death. The VAS score significantly decreased from a mean preoperative of 7.5 (range 6-19) to 3.8 (range 3-5) immediately after surgery and 1.8 (range 1-3).
    Conclusion: We report the first clinical results in a series of six patients treated for VCF using the microsphere system after analyzing the clinical results produced by, and the complications that arose from, this new device. In patients with VCF, the VAP using titanium microspheres appears to be a feasible and safe procedure with a low risk of material leakage.
    Language English
    Publishing date 2023-05-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1152995
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  6. Article: Can Post-Operative Posterior Reversible Encephalopathy Syndrome (PRES) Be Considered an Insidious Rare Surgical Complication?

    Frati, Alessandro / Armocida, Daniele / Tartara, Fulvio / Cofano, Fabio / Corvino, Sergio / Paolini, Sergio / Santoro, Antonio / Garbossa, Diego

    Brain sciences

    2023  Volume 13, Issue 5

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-04-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13050706
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  7. Article ; Online: Letter: Improving Surgical Skills During Residency: A Scheduled and Certified Approach With Virtual-Augmented Reality and Life-Like Simulators: Experience in a Single School of Neurosurgery.

    Cofano, Fabio / Di Perna, Giuseppe / Zeppa, Pietro / Lanotte, Michele / Garbossa, Diego

    Neurosurgery

    2022  Volume 91, Issue 2, Page(s) e71–e73

    MeSH term(s) Augmented Reality ; Clinical Competence ; Computer Simulation ; Humans ; Internship and Residency ; Neurosurgery/education ; User-Computer Interface ; Virtual Reality
    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Letter
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000002055
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 539: Show issues

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  8. Article: Cervical Spine Inhomogeneously Enhancing Lesion: Avoiding Confirmation Bias.

    Penner, Federica / Zeppa, Pietro / Cofano, Fabio / Bianconi, Andrea / Ajello, Marco / Zenga, Francesco

    Journal of neurosciences in rural practice

    2022  Volume 13, Issue 1, Page(s) 134–136

    Abstract: Confirmation bias is the tendency to seek information and evidence in order to confirm a preexisting hypothesis while giving less importance and overlook an alternative solution. This report describes the case of a 52-year-old man with a long history of ... ...

    Abstract Confirmation bias is the tendency to seek information and evidence in order to confirm a preexisting hypothesis while giving less importance and overlook an alternative solution. This report describes the case of a 52-year-old man with a long history of neck pain and bilateral upper limbs paresthesias with a cervical intracanal inhomogeneously enhancing lesion. Despite all the preoperative radiological findings, a spinal meningioma an anterior approach was performed. The mass ended up being a large migrated hernia with the involvement of two levels. Before suggesting treatment, especially surgery, physicians and practitioners need to evaluate all of the possible alternatives in order to optimize patient outcome.
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2601242-X
    ISSN 0976-3155 ; 0976-3147
    ISSN (online) 0976-3155
    ISSN 0976-3147
    DOI 10.1055/s-0041-1741489
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  9. Article ; Online: Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: Risk-benefit profile and next steps for the market access.

    Giovannelli, Lorella / Bari, Elia / Jommi, Claudio / Tartara, Fulvio / Armocida, Daniele / Garbossa, Diego / Cofano, Fabio / Torre, Maria Luisa / Segale, Lorena

    Bioactive materials

    2023  Volume 29, Page(s) 16–35

    Abstract: Neurodegenerative diseases represent a growing burden on healthcare systems worldwide. Mesenchymal stem cells (MSCs) have shown promise as a potential therapy due to their neuroregenerative, neuroprotective, and immunomodulatory properties, which are, ... ...

    Abstract Neurodegenerative diseases represent a growing burden on healthcare systems worldwide. Mesenchymal stem cells (MSCs) have shown promise as a potential therapy due to their neuroregenerative, neuroprotective, and immunomodulatory properties, which are, however, linked to the bioactive substances they release, collectively known as secretome. This paper provides an overview of the most recent research on the safety and efficacy of MSC-derived secretome and extracellular vesicles (EVs) in clinical (if available) and preclinical models of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, acute ischemic stroke, and spinal cord injury. The article explores the biologically active substances within MSC-secretome/EVs, the mechanisms responsible for the observed therapeutic effects, and the strategies that may be used to optimize MSC-secretome/EVs production based on specific therapeutic needs. The review concludes with a critical discussion of current clinical trials and a perspective on potential future directions in translating MSC-secretome and EVs into the clinic, specifically regarding how to address the challenges associated with their pharmaceutical manufacturing, including scalability, batch-to-batch consistency, adherence to Good Manufacturing Practices (GMP) guidelines, formulation, and storage, along with quality controls, access to the market and relative costs, value for money and impact on total expenditure.
    Language English
    Publishing date 2023-06-28
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2452-199X
    ISSN (online) 2452-199X
    DOI 10.1016/j.bioactmat.2023.06.013
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  10. Article ; Online: Compartmental Cerebrospinal Fluid Events Occurring after Subarachnoid Hemorrhage: An "Heparin Oriented" Systematic Review.

    Tartara, Fulvio / Montalbetti, Andrea / Crobeddu, Emanuela / Armocida, Daniele / Tavazzi, Eleonora / Cardia, Andrea / Cenzato, Marco / Boeris, Davide / Garbossa, Diego / Cofano, Fabio

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: Subarachnoid hemorrhage (SAH) represents a severe acute event with high morbidity and mortality due to the development of early brain injury (EBI), secondary delayed cerebral ischemia (DCI), and shunt-related hydrocephalus. Secondary events (SSE) such as ...

    Abstract Subarachnoid hemorrhage (SAH) represents a severe acute event with high morbidity and mortality due to the development of early brain injury (EBI), secondary delayed cerebral ischemia (DCI), and shunt-related hydrocephalus. Secondary events (SSE) such as neuroinflammation, vasospasm, excitotoxicity, blood-brain barrier disruption, oxidative cascade, and neuronal apoptosis are related to DCI. Despite improvement in management strategies and therapeutic protocols, surviving patients frequently present neurological deficits with neurocognitive impairment. The aim of this paper is to offer to clinicians a practical review of the actually documented pathophysiological events following subarachnoid hemorrhage. To reach our goal we performed a literature review analyzing reported studies regarding the mediators involved in the pathophysiological events following SAH occurring in the cerebrospinal fluid (CSF) (hemoglobin degradation products, platelets, complement, cytokines, chemokines, leucocytes, endothelin-1, NO-synthase, osteopontin, matricellular proteins, blood-brain barrier disruption, microglia polarization). The cascade of pathophysiological events secondary to SAH is very complex and involves several interconnected, but also distinct pathways. The identification of single therapeutical targets or specific pharmacological agents may be a limited strategy able to block only selective pathophysiological paths, but not the global evolution of SAH-related events. We report furthermore on the role of heparin in SAH management and discuss the rationale for use of intrathecal heparin as a pleiotropic therapeutical agent. The combination of the anticoagulant effect and the ability to interfere with SSE theoretically make heparin a very interesting molecule for SAH management.
    MeSH term(s) Humans ; Heparin/therapeutic use ; Subarachnoid Hemorrhage/complications ; Vasospasm, Intracranial/complications ; Cerebral Infarction/complications ; Brain Ischemia/complications
    Chemical Substances Heparin (9005-49-6)
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24097832
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