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  1. Article ; Online: In Reply: Length of Stay Beyond Medical Readiness in a Neurosurgical Patient Population and Associated Healthcare Costs.

    Linzey, Joseph R / Pandey, Aditya S

    Neurosurgery

    2021  Volume 89, Issue 3, Page(s) E170

    MeSH term(s) Health Care Costs ; Humans ; Length of Stay ; Patient Discharge
    Language English
    Publishing date 2021-06-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyab200
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  2. Article ; Online: Commentary: Post-Market American Experience With Woven EndoBridge Device: Adjudicated Multicenter Case Series.

    Siddiqui, Fazeel M / Pandey, Aditya S

    Neurosurgery

    2021  Volume 89, Issue 2, Page(s) E112–E113

    MeSH term(s) Embolization, Therapeutic ; Humans ; Intracranial Aneurysm/therapy ; United States
    Language English
    Publishing date 2021-08-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyab203
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  3. Article ; Online: Device use trends in neuroendovascular procedures in the United States from 2015 to 2020.

    Adapa, Arjun Rohit / Siddiqui, Fazeel M / Pandey, Aditya S

    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

    2023  , Page(s) 15910199231196329

    Abstract: Background: Neuroendovascular therapies involve an everchanging landscape of new technologies. Understanding the real-world timeframe of adaptation of such technologies can provide further guidance on mechanisms that could be employed to shorten the ... ...

    Abstract Background: Neuroendovascular therapies involve an everchanging landscape of new technologies. Understanding the real-world timeframe of adaptation of such technologies can provide further guidance on mechanisms that could be employed to shorten the duration necessary for the widespread use of proven therapies. In this study, we aim to investigate the trends in the use of neuroendovascular technologies, utilizing the sales of neuroendovascular devices, as a proxy for procedural volume.
    Methods: Utilizing a device sales data registry from the Decision Resources Group, a healthcare research and consulting company, we examined trends in the sales of devices utilized in cerebrovascular thrombectomy, cerebral aneurysm treatment, and carotid stenting from the same 407 reporting hospitals in the United States between January 1, 2015, and January 1, 2020. Device sales per year were plotted as both the total number of devices sold per year as well as the percent of total device sales when compared against at least one other device. The Cochran-Armitage test for trend was performed when comparing at least two devices to each other. Analyses were performed using RStudio Version 1.1.456 (https://rstudio.com).
    Results: Between 2015 and 2020, there was a significant increase in the use of flow-diverting stents as well as nondiverting stents utilized for coil assistance. However, the total number of coils utilized over the years has declined. In terms of stroke therapy, between 2015 and 2020, there was a trend of increased use of both aspiration catheters as well as stent retrievers, which plateaued in 2020. The number of stents used for carotid procedures has also been gradually increasing over time.
    Conclusion: Our study demonstrates an increase in the use of flow-diverting stents, nondiverting stents, carotid stents, and reperfusion devices for acute ischemic stroke intervention between 2015 and 2020. Coil use for aneurysmal treatment has declined.
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1354913-3
    ISSN 2385-2011 ; 1591-0199 ; 1123-9344
    ISSN (online) 2385-2011
    ISSN 1591-0199 ; 1123-9344
    DOI 10.1177/15910199231196329
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  4. Article ; Online: Commentary: Access-Site Complications in Transfemoral Neuroendovascular Procedures: A Systematic Review of Incidence Rates and Management Strategies.

    Daou, Badih J / Pandey, Aditya S

    Operative neurosurgery (Hagerstown, Md.)

    2020  Volume 19, Issue 4, Page(s) E335–E336

    MeSH term(s) Endovascular Procedures/adverse effects ; Humans ; Incidence ; Radial Artery
    Language English
    Publishing date 2020-05-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1093/ons/opaa127
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    Zs.A 1424 -ON-: Show issues Location:
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  5. Article ; Online: The MSMEG_1586 of M. smegmatis Is a Penicillin-Interactive Enzyme That Can Potentially Hydrolyse Aztreonam and Cephalosporins.

    Panda, Aditya Prasad / Pandey, Satya Deo / Jain, Diamond / Ghosh, Anindya S

    Current microbiology

    2023  Volume 81, Issue 1, Page(s) 26

    Abstract: Mycobacteria are intrinsically resistant to beta-lactams as they possess several putative penicillin-interactive enzymes (PIEs), some of those are with dual-activity, namely DD-carboxypeptidase and beta-lactamase. Here, with help of molecular approaches, ...

    Abstract Mycobacteria are intrinsically resistant to beta-lactams as they possess several putative penicillin-interactive enzymes (PIEs), some of those are with dual-activity, namely DD-carboxypeptidase and beta-lactamase. Here, with help of molecular approaches, we elucidated the nature of one such putative PIE, MSMEG_1586, in Mycobacterium smegmatis. The in vivo expression of the membrane-bound form of MSMEG_1586 enhanced the beta-lactam resistance of a beta-lactamase deleted host E. coli strain (AM1OC), particularly for aztreonam (eight-fold) and cephalosporins (8-16 fold). To understand the reason for such elevation of resistance, soluble-form of MSMEG_1586 (sMSMEG_1586) was created by removing signal peptides and partially eliminating the amphipathic helix, and finally, expressed and purified. The purified sMSMEG_1586 was active and manifested a strong penicillin-binding affinity as shown by its ability to bind to fluorescent penicillin (Bocillin-FL). Interestingly, the steady-state kinetics apparently confirmed the hydrolytic ability of sMSMEG_1586 towards cefotaxime and aztreonam where hydrolysing aztreonam is a unique and rare behaviour among the beta-lactamases. However, sMSMEG_1586 was devoid of exerting DD-carboxypeptidase like activity. Finally, in silico analysis of MSMEG_1586 revealed a special folding that resembles class C beta-lactamase, except for the absence of a characteristic R2 loop. Overall, MSMEG_1586 could be categorized as a cephalosporinase with the ability to hydrolyse aztreonam.
    MeSH term(s) Cephalosporins/metabolism ; Aztreonam/pharmacology ; Escherichia coli/metabolism ; beta-Lactamases/genetics ; beta-Lactamases/chemistry ; Penicillins ; Carboxypeptidases ; Anti-Bacterial Agents
    Chemical Substances Cephalosporins ; Aztreonam (G2B4VE5GH8) ; beta-Lactamases (EC 3.5.2.6) ; Penicillins ; Carboxypeptidases (EC 3.4.-) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-12-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-023-03545-0
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    Zs.A 1446: Show issues Location:
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  6. Article ; Online: Targets for Payment Reform in Mechanical Thrombectomy.

    Daou, Badih J / Koduri, Sravanthi / Pandey, Aditya S

    World neurosurgery

    2021  Volume 145, Page(s) 510–511

    MeSH term(s) Cost-Benefit Analysis ; Humans ; Ischemic Stroke/economics ; Ischemic Stroke/surgery ; Thrombectomy/economics
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type News
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.10.051
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  7. Article ; Online: Intracranial Pressure Monitoring: an Effective Technique to Balance Cerebral Perfusion and Blood Pressure Reduction in ICH Patients.

    Zhao, Jian-Lan / Holste, Katherine G / Pandey, Aditya S / Hu, Jin / Wu, Gang

    Translational stroke research

    2023  Volume 15, Issue 2, Page(s) 409–410

    MeSH term(s) Humans ; Blood Pressure ; Intracranial Pressure/physiology ; Hypotension ; Intracranial Hypertension ; Cerebrovascular Circulation
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Letter
    ZDB-ID 2541897-X
    ISSN 1868-601X ; 1868-4483
    ISSN (online) 1868-601X
    ISSN 1868-4483
    DOI 10.1007/s12975-023-01129-5
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  8. Article ; Online: The Role of Iron in Hemorrhagic Stroke.

    Koduri, Sravanthi / Keep, Richard F / Xi, Guohua / Chaudhary, Neeraj / Pandey, Aditya S

    Stroke (Hoboken, N.J.)

    2022  Volume 2, Issue 5

    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article
    ISSN 2694-5746
    ISSN (online) 2694-5746
    DOI 10.1161/svin.122.000419
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  9. Article ; Online: Commentary: Survival, Dependency, and Health-Related Quality of Life in Patients With Ruptured Intracranial Aneurysm: 10-Year Follow-up of the United Kingdom Cohort of the International Subarachnoid Aneurysm Trial.

    Daou, Badih J / Koduri, Sravanthi / Pandey, Aditya S

    Neurosurgery

    2021  Volume 88, Issue 6, Page(s) E548–E549

    MeSH term(s) Aneurysm, Ruptured ; Follow-Up Studies ; Humans ; Intracranial Aneurysm/therapy ; Quality of Life ; Subarachnoid Hemorrhage/therapy ; United Kingdom/epidemiology
    Language English
    Publishing date 2021-04-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyab076
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  10. Article ; Online: A comparison of ventricular volume and linear indices in predicting shunt dependence in aneurysmal subarachnoid hemorrhage.

    Talbot-Stetsko, Haley K / Hollon, Todd C / Maher, Cormac O / Pandey, Aditya S / Khalsa, Siri Sahib S

    World neurosurgery: X

    2023  Volume 19, Page(s) 100181

    Abstract: Background: Guidelines for determining shunt dependence after aneurysmal subarachnoid hemorrhage (aSAH) remain unclear. We previously demonstrated change in ventricular volume (VV) between head CT scans taken pre- and post-EVD clamping was predictive of ...

    Abstract Background: Guidelines for determining shunt dependence after aneurysmal subarachnoid hemorrhage (aSAH) remain unclear. We previously demonstrated change in ventricular volume (VV) between head CT scans taken pre- and post-EVD clamping was predictive of shunt dependence in aSAH. We sought to compare the predictive value of this measure to more commonly used linear indices.
    Methods: We retrospectively analyzed images of 68 patients treated for aSAH who required EVD placement and underwent one EVD weaning trial, 34 of whom underwent shunt placement. We utilized an in-house MATLAB program to analyze VV and supratentorial VV (sVV) in head CT scans obtained before and after EVD clamping. Evans' index (EI), frontal and occipital horn ratio (FOHR), Huckman's measurement, minimum lateral ventricular width (LV-Min.), and lateral ventricle body span (LV-Body) were measured using digital calipers in PACS. Receiver operating curves (ROC) were generated.
    Results: Area under the ROC curves (AUC) for the change in VV, sVV, EI, FOHR, Huckman's, LV-Min., and LV-Body with clamping were 0.84, 0.84, 0.65, 0.71.0.69, 0.67, and 0.66, respectively. AUC for post-clamp scan measurements were 0.75, 0.75, 0.74, 0.72, 0.72, 0.70, and 0.75, respectively.
    Conclusion: VV change with EVD clamping was more predictive of shunt dependence in aSAH than change in linear measurements with clamping and all post-clamp measurements. Measurement of ventricular size on serial imaging with volumetrics or linear indices utilizing multidimensional data points may therefore be a more robust metric than unidimensional linear indices in predicting shunt dependence in this cohort. Prospective studies are needed for validation.
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article
    ISSN 2590-1397
    ISSN (online) 2590-1397
    DOI 10.1016/j.wnsx.2023.100181
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