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  1. Article: Landmark article Feb 25, 1939: Surgical ligation of a patent ductus arteriosus. Report of first successful case. By Robert E. Gross and John P. Hubbard.

    Gross, R E / Hubbard, J P

    JAMA

    1984  Volume 251, Issue 9, Page(s) 1201–1202

    MeSH term(s) Child ; Ductus Arteriosus, Patent/history ; Ductus Arteriosus, Patent/surgery ; Female ; History, 20th Century ; Humans ; Ligation ; United States
    Language English
    Publishing date 1984-03-02
    Publishing country United States
    Document type Biography ; Case Reports ; Historical Article ; Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0098-7484 ; 0254-9077 ; 0002-9955
    ISSN (online) 1538-3598
    ISSN 0098-7484 ; 0254-9077 ; 0002-9955
    DOI 10.1001/jama.251.9.1201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Book: Neurosurgical operative atlas / [...]

    Gross, Robert E. / Boulis, Nicholas

    2018  

    Title variant Functional neurosurgery
    Author's details [edited by] Robert E. Gross, Nicholas M. Boulis
    Keywords Central Nervous System / surgery ; Neurosurgical Procedures / methods ; Epilepsy / surgery ; Pain / surgery ; Movement Disorders / surgery
    Language English
    Size xx, 362 Seiten, Illustrationen
    Edition Third edition
    Publisher Thieme
    Publishing place New York
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT019711825
    ISBN 978-1-62623-111-5 ; 9781626231122 ; 1-62623-111-7 ; 1626231125
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2018 A 1036 available for loan (reading room) Lesesaal EG

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  3. Book ; Online ; E-Book: Laser Interstitial Thermal Therapy in Neurosurgery

    Chiang, Veronica L. / Danish, Shabbar F. / Gross, Robert E.

    2020  

    Abstract: This book serves as a foundation for MRI guided laser interstitial thermal therapy (LITT) across neurosurgical diseases. It provides state-of-the-art information on the latest indications and results for LITT in CNS applications, as well as prerequisite ... ...

    Author's details edited by Veronica L. Chiang, Shabbar F. Danish, Robert E. Gross
    Abstract This book serves as a foundation for MRI guided laser interstitial thermal therapy (LITT) across neurosurgical diseases. It provides state-of-the-art information on the latest indications and results for LITT in CNS applications, as well as prerequisite historical perspective and technical fundamentals. Written by experts in the field, the text reviews the historical development of LITT, the technical and technological components required to perform LITT, its indications and contraindications, areas that still require investigation, LITT complications, and challenges to starting up LITT within one’s practice. As early adopters of the technology, the authors provide sage advice that reflects the initial learning curves of many of the users. The book then concludes with a practical guide to starting up a LITT practice in the current medical socioeconomic environment. Laser Interstitial Thermal Therapy in Neurosurgery is a guide that will allow all neurosurgeons interested in LITT to successfully adopt the technology and incorporate its use seamlessly, safely and appropriately into their individual practices.
    Keywords Neurosurgery ; Oncology   ; Radiotherapy ; Oncology ; Neurocirurgia ; Braquiteràpia
    Subject code 617.480598
    Language English
    Size 1 online resource (XIII, 182 p.)
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-48047-X ; 3-030-48046-1 ; 978-3-030-48047-9 ; 978-3-030-48046-2
    DOI 10.1007/978-3-030-48047-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article: Functional Hemispherectomy in Adults: All We Have to Sphere Is Sphere Itself.

    Gross, Robert E

    Epilepsy currents

    2020  Volume 20, Issue 3, Page(s) 144–146

    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.1177/1535759720920836
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  5. Article: Seizure event detection using intravital two-photon calcium imaging data.

    Stern, Matthew A / Cole, Eric R / Gross, Robert E / Berglund, Ken

    Neurophotonics

    2024  Volume 11, Issue 2, Page(s) 24202

    Abstract: Significance: Intravital cellular calcium imaging has emerged as a powerful tool to investigate how different types of neurons interact at the microcircuit level to produce seizure activity, with newfound potential to understand epilepsy. Although many ... ...

    Abstract Significance: Intravital cellular calcium imaging has emerged as a powerful tool to investigate how different types of neurons interact at the microcircuit level to produce seizure activity, with newfound potential to understand epilepsy. Although many methods exist to measure seizure-related activity in traditional electrophysiology, few yet exist for calcium imaging.
    Aim: To demonstrate an automated algorithmic framework to detect seizure-related events using calcium imaging-including the detection of pre-ictal spike events, propagation of the seizure wavefront, and terminal spreading waves for both population-level activity and that of individual cells.
    Approach: We developed an algorithm for precise recruitment detection of population and individual cells during seizure-associated events, which broadly leverages averaged population activity and high-magnitude slope features to detect single-cell pre-ictal spike and seizure recruitment. We applied this method to data recorded using awake
    Results: We demonstrate that our detected recruitment times are concordant with visually identified labels provided by an expert reviewer and are sufficiently accurate to model the spatiotemporal progression of seizure-associated traveling waves.
    Conclusions: Our algorithm enables accurate cell recruitment detection and will serve as a useful tool for researchers investigating seizure dynamics using calcium imaging.
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2781943-7
    ISSN 2329-4248 ; 2329-423X
    ISSN (online) 2329-4248
    ISSN 2329-423X
    DOI 10.1117/1.NPh.11.2.024202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Trapping and Superficial Temporal Artery to Distal Middle Cerebral Artery Bypass for Excision of an Iatrogenic Middle Cerebral Artery Pseudoaneurysm After Placement of Epilepsy Depth Electrodes: 2-Dimensional Operative Video.

    Lamanna, Jason J / Gross, Robert E / Barrow, Daniel L

    Operative neurosurgery (Hagerstown, Md.)

    2023  Volume 24, Issue 6, Page(s) e439–e440

    MeSH term(s) Humans ; Middle Cerebral Artery/diagnostic imaging ; Middle Cerebral Artery/surgery ; Temporal Arteries/diagnostic imaging ; Temporal Arteries/surgery ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aneurysm, False/surgery ; Iatrogenic Disease ; Electrodes
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Video-Audio Media ; Journal Article
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1227/ons.0000000000000647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1424 -ON-: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Sensing-Enabled Deep Brain Stimulation in Epilepsy.

    Yang, Jimmy C / Yang, Andrew I / Gross, Robert E

    Neurosurgery clinics of North America

    2023  Volume 35, Issue 1, Page(s) 119–123

    Abstract: Deep brain stimulation has demonstrated efficacy in reducing seizure frequency in patients with drug-resistant epilepsy who may otherwise not be candidates for other surgical procedures. Recently, a clinical device that can monitor neural activity in the ...

    Abstract Deep brain stimulation has demonstrated efficacy in reducing seizure frequency in patients with drug-resistant epilepsy who may otherwise not be candidates for other surgical procedures. Recently, a clinical device that can monitor neural activity in the form of local field potentials around the deep brain stimulator lead implant site has been introduced. While this technology has been clinically adopted in other disorders treated with deep brain stimulation, such as Parkinson's disease, its application in epilepsy remains unclear. Previous research using investigational devices has suggested that specific frequency bands may correlate with clinical response to deep brain stimulation in epilepsy, but features of the clinical device may prevent its use. The authors present their experience with using this technology in epilepsy patients and describe some of its limitations. Ultimately, novel biomarkers will need to be identified to elucidate how neural activity at deep brain stimulation sites may change with clinical response.
    MeSH term(s) Humans ; Deep Brain Stimulation/methods ; Epilepsy/therapy ; Seizures/therapy ; Parkinson Disease/therapy
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196855-2
    ISSN 1558-1349 ; 1042-3680
    ISSN (online) 1558-1349
    ISSN 1042-3680
    DOI 10.1016/j.nec.2023.08.005
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  8. Article ; Online: Optimal hippocampal targeting in responsive neurostimulation for mesial temporal lobe epilepsy.

    Skelton, Henry M / Bullinger, Katie / Isbaine, Faical / Lau, Jonathan C / Willie, Jon T / Gross, Robert E

    Journal of neurosurgery

    2024  , Page(s) 1–10

    Abstract: Objective: The aim of this study was to identify features of responsive neurostimulation (RNS) lead configuration and contact placement associated with greater seizure reduction in mesial temporal lobe epilepsy (MTLE).: Methods: A single-center ... ...

    Abstract Objective: The aim of this study was to identify features of responsive neurostimulation (RNS) lead configuration and contact placement associated with greater seizure reduction in mesial temporal lobe epilepsy (MTLE).
    Methods: A single-center series of patients with MTLE treated with RNS were retrospectively analyzed to assess the relationship between anatomical targeting and seizure reduction. Targeting was determined according to both the preoperatively conceived lead configuration and the actual placement of RNS contacts. Three lead configurations were used: 1) single bilateral, with 1 depth lead in each hippocampus; 2) single unilateral, with 1 hippocampal depth lead and another implant outside the mesial temporal lobe; and 3) dual unilateral, with 2 leads in 1 hippocampus. Contact placement on postoperative imaging was measured according to the number of hippocampal contacts per targeted hippocampus (contact density) and per patient (contact count), distribution throughout the hippocampus, and proximity to the anteromedial hippocampus.
    Results: Dual unilateral lead placement resulted in significantly higher hippocampal contact density compared with the single hippocampal approaches, but only showed a nonsignificant trend toward a higher rate of response. However, those patients with more than 4 contacts in a single hippocampus, achievable only with dual unilateral leads, had a significantly higher rate of response. The higher likelihood of response was poorly explained by more widespread hippocampal coverage, but well correlated with proximity to the anteromedial hippocampus.
    Conclusions: Dual unilateral hippocampal implantation increased RNS contact density in patients with unilateral MTLE, which contributed to improved outcomes, not by stimulating more of the hippocampus, but instead by being more likely to stimulate a latent subtarget in the anterior hippocampus. It remains to be explored whether a single electrode targeted selectively to this region would also result in improved outcomes.
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2024.2.JNS231732
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  9. Article ; Online: Multitarget deep brain stimulation for epilepsy.

    Yang, Andrew I / Isbaine, Faical / Alwaki, Abdulrahman / Gross, Robert E

    Journal of neurosurgery

    2023  Volume 140, Issue 1, Page(s) 210–217

    Abstract: ... which included ANT, CM, and less-studied nuclei-i.e., mediodorsal nucleus, pulvinar, and subthalamic nucleus ... seizure frequency and/or convulsive seizure frequency (i.e., ≥ 50% reduction). Two patients had adverse ...

    Abstract Objective: Deep brain stimulation (DBS) is a rapidly growing surgical option for patients with drug-resistant epilepsy who are not candidates for resective/ablative surgery. Recent randomized controlled trials have demonstrated efficacy of DBS of the anterior nucleus of the thalamus (ANT), particularly in frontal or temporal epilepsy, whereas DBS of the centromedian (CM) nucleus appears to be most suitable in well-defined generalized epilepsy syndromes. At the authors' institution, DBS candidates who did not fit the populations represented in these trials were managed with DBS of multiple distinct targets, which included ANT, CM, and less-studied nuclei-i.e., mediodorsal nucleus, pulvinar, and subthalamic nucleus. The goal of this study was to present the authors' experience with these types of cases, and to motivate future investigations that can determine the long-term efficacy of multitarget DBS.
    Methods: This single-center retrospective study of adult patients with drug-resistant epilepsy who underwent multitarget DBS was performed to demonstrate the feasibility and safety of this approach, and to present seizure outcomes. Patients in this cohort had epilepsy with features that were difficult to treat with DBS of the ANT or CM nucleus alone, including multifocal/multilobar, diffuse-onset, and/or posterior-onset seizures; or both generalized and focal seizures.
    Results: Eight patients underwent DBS of 2-3 distinct thalamic/subthalamic nuclei. DBS was performed with 2 electrodes in each hemisphere. All leads in each patient were implanted with either frontal or parietal trajectories. There were no surgical complications. Among those with > 6 months of follow-up (n = 5; range 7-21 months), all patients were responders in terms of overall seizure frequency and/or convulsive seizure frequency (i.e., ≥ 50% reduction). Two patients had adverse stimulation effects, which resolved with further programming.
    Conclusions: Multitarget DBS is a procedurally feasible and safe treatment strategy to maximize outcomes in patients with complex epilepsy. The authors highlight their approach to inform future studies that are sufficiently powered to assess its efficacy.
    MeSH term(s) Adult ; Humans ; Deep Brain Stimulation ; Retrospective Studies ; Epilepsy/therapy ; Epilepsy/etiology ; Drug Resistant Epilepsy/therapy ; Seizures/etiology ; Electrodes, Implanted/adverse effects
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2023.5.JNS23982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Seizure Event Detection Using Intravital Two-Photon Calcium Imaging Data.

    Stern, Matthew A / Cole, Eric R / Gross, Robert E / Berglund, Ken

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Significance: Genetic cellular calcium imaging has emerged as a powerful tool to investigate how different types of neurons interact at the microcircuit level to produce seizure activity, with newfound potential to understand epilepsy. Although many ... ...

    Abstract Significance: Genetic cellular calcium imaging has emerged as a powerful tool to investigate how different types of neurons interact at the microcircuit level to produce seizure activity, with newfound potential to understand epilepsy. Although many methods exist to measure seizure-related activity in traditional electrophysiology, few yet exist for calcium imaging.
    Aim: To demonstrate an automated algorithmic framework to detect seizure-related events using calcium imaging - including the detection of pre-ictal spike events, propagation of the seizure wavefront, and terminal spreading waves for both population-level activity and that of individual cells.
    Approach: We developed an algorithm for precise recruitment detection of population and individual cells during seizure-associated events, which broadly leverages averaged population activity and high-magnitude slope features to detect single-cell pre-ictal spike and seizure recruitment. We applied this method to data recorded using awake
    Results: We demonstrate that our detected recruitment times are concordant with visually identified labels provided by an expert reviewer and are sufficiently accurate to model the spatiotemporal progression of seizure-associated traveling waves.
    Conclusions: Our algorithm enables accurate cell recruitment detection and will serve as a useful tool for researchers investigating seizure dynamics using calcium imaging.
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.28.558338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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